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Current Pharmaceutical Design

Volume 27, 46 Issues, 2021
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

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Volume 27

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Number 17





Review Article

Liposomes as Versatile Platform for Cancer Theranostics: Therapy, Bio-imaging, and Toxicological Aspects

, 27(17): 1977 - 1991

Swapnil Mehta, Sanjay Kulkarni, Ajinkya N. Nikam, Bharat S. Padya, Abhijeet Pandey and Srinivas Mutalik*


DOI: 10.2174/1381612827666210311142100






Review Article

Current Status of Mucoadhesive Gel Systems for Buccal Drug Delivery

, 27(17): 2015 - 2025

Neslihan Ü. Okur *, Ece Ö. Bülbül , Ayşe P. Yağcılar and Panoraia I. Siafaka


DOI: 10.2174/1381612824666210316101528






Meta-Analysis



Current Pharmaceutical Design, Volume 27 (2021) - Number 19


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 18


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Prevalence of Non-coronary Heart Disease in Patients with Familial Hypercholesterolemia: An Analysis from the HELLAS-FH


Panagiotis Anagnostis, Christos V. Rizos, Ioannis Skoumas, Loukianos Rallidis, Konstantinos Tziomalos, Emmanuel Skalidis, Vasileios Kotsis, Michalis Doumas, Genovefa Kolovou, George Sfikas, Eleni Bilianou, Iosif Koutagiar, Dimitrios Agapakis, Evangelos Zacharis, Christina Antza, Charalambos Koumaras, Chrysoula Boutari, George Liamis and Evangelos N. Liberopoulos*


DOI: 10.2174/1381612827666210216151645
View Abstract View on PubMed



Recent Advances in Diagnostic and Therapeutic Approaches for Breast Cancer: A Comprehensive Review


Fatima Noor, Ayesha Noor, Ali Raza Ishaq, Iqra Farzeen, Muhammad Hamzah Saleem, Kanwal Ghaffar, Muhammad Farhan Aslam, Sidra Aslam* and Jen‐Tsung Chen*


DOI: 10.2174/1381612827666210303141416
View Abstract View on PubMed


Identification of Butyrylcholinesterase and Monoamine Oxidase B Targeted Ligands and their Putative Application in Alzheimer’s Treatment: A Computational Strategy


Nasimudeen R Jabir, Md Tabish Rehman, Shams Tabrez*, Raed F. Alserihi, Mohamed F AlAjmi, Mohd Shahnawaz Khan, Fohad Mabood Husain and Bakrudeen Ali Ahmed*


DOI: 10.2174/1381612827666210226123240
View Abstract View on PubMed


Association of Viruses in the Development of Cardiovascular Diseases


Bisma Rauff *, Arif Malik, Yasir Ali Bhatti , Shafiq Ahmad Chudhary, Kaneez Fatima, Shafquat Rafiq , Aisha Tahir, Sumaira Sharif and Ishtiaq Qadri


DOI: 10.2174/1381612827666210426094502
View Abstract View on PubMed


Complex Treatment and Prosthetic Rehabilitation of an Acquired Maxillofacial Defect with Tumor Invasion: Brief Report


Li Jiajing, Ekaterina V. Kochurova, Narasimha M Beeraka, Natalya V. Lapina, Chang Weilong, Dmitrii M. Belousov, Elizaveta V. Mikhaylenko, Vladimir N. Nikolenko, Cristian Muresanu, Siva G. Somasundaram, Cecil E. Kirkland, Marco Avila-Rodríguez and Gjumrakch Aliev*


DOI: 10.2174/1381612827666210224141559
View Abstract View on PubMed




Genetic and Epigenetic Biomarkers for Diagnosis, Prognosis and Treatment of Metabolic Syndrome


Rosaria V. Giglio*, Anca P Stoian*, Angelo M. Patti*, Ali A. Rizvi, Vasily Sukhorukov, Marcello Ciaccio, Alexander Orekhov and Manfredi Rizzo


DOI: 10.2174/1381612827666210412145915
View Abstract View on PubMed


Osteogenic Differentiation Factors of Multipotent Mesenchymal Stromal Cells in the Current Understanding


Kristina А. Yurova , Elena S. Melashchenko, Olga G. Khaziakhmatova, Vladimir V. Malashchenko, Olga B. Melashchenko, Egor O. Shunkin, Igor K. Norkin, Pavel A. Ivanov, Igor A. Khlusov and Larisa S. Litvinova*


DOI: 10.2174/1381612827666210406150027
View Abstract View on PubMed


Abstracts Ahead of Print


Application of machine learning methods for the development of antidiabetic drugs


Juanjuan Zhao, Pengcheng Xu, Xiujuan Liu, Xiaobo Ji*, Minjie Li, Sooranna Dev, Xiaosheng Qu*, Wencong Lu* and Bing Niu*


DOI: 10.2174/1381612827666210622104428
View Abstract



An Overview of nano delivery systems for targeting RNA interference-based therapy in ulcerative colitis


Iman Alfagih*, Basmah Aldosari , Bushra AlQuadeib , Alanood Almurshedi and Murtaza Tambuwala*


DOI: 10.2174/1381612827666210617120302
View Abstract



MiR-92a-3p promotes the malignant progression of hepatocellular carcinoma by mediating the PI3K/AKT/mTOR signaling pathway


Libing Wang, Mingxin Cui, Fengzhi Qu, Daming Cheng, Jingkun Yu, Zhaoyuan Tang, Ling Cheng, Yanbing Wei, Xiaotang Wu and Xiaogang Liu*


DOI: 10.2174/1381612827666210612054156
View Abstract


Long non-coding RNA AFAP1-AS1 facilitates prostate cancer progression by regulating miR-15b/IGF1R axis


Bo Liu*, Hui-Yang Jiang*, Tao Yuan, Wei-Dong Zhou, Zhen-Dong Xiang, Qi-Quan Jiang and Deng-Long Wu*


DOI: 10.2174/1381612827666210612052317
View Abstract


Exploring the Role of Monoamine Oxidase Activity in Aging and Alzheimer’s Disease


Md. Sohanur Rahman, Md. Sahab Uddin*, Md. Ataur Rahman, Md. Samsuzzaman, Tapan Behl, Abdul Hafeez, Asma Perveen, George E. Barreto and Ghulam Md Ashraf


DOI: 10.2174/1381612827666210612051713
View Abstract


Metabolic syndrome and myocardial infarction in women


Djuro Macut*, Sanja Ognjanović, Milika Ašanin, Gordana Krljanac and Tatjana Milenković


DOI: 10.2174/1381612827666210610114029
View Abstract


Neurodegenerative Diseases: A Multidisciplinary Approach


Pilar Marcos Rabal*, Joaquín González-Fuentes, Lucía Castro-Vázquez, María Victoria Lozano, Virginia Rodríguez-Robledo, Manuel J. Santander-Ortega, Jorge Selva-Clemente, Noemí Villaseca-González and María del Mar Arroyo-Jiménez


DOI: 10.2174/1381612827666210608152745
View Abstract


Published Contents

Editor's Choice


Imaging Techniques as an Aid in the Early Detection of Cardiac Amyloidosis

, 2021; 27(16): 1878 - 1889

M.F. Santarelli*, M. Scipioni, D. Genovesi, A. Giorgetti, P. Marzullo and L. Landini


DOI: 10.2174/1381612826666200813133557



Naphthoquinones and Derivatives for Chemotherapy: Perspectives and Limitations of their Anti-trypanosomatids Activities

, 2021; 27(15): 1807 - 1824

Luíza Dantas-Pereira, Edézio F. Cunha-Junior, Valter V. Andrade-Neto, John F. Bower, Guilherme A.M. Jardim, Eufrânio N. da Silva Júnior, Eduardo C. Torres-Santos and Rubem F.S. Menna-Barreto*


DOI: 10.2174/1381612826666201109111802



Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity

, 2021; 27(14): 1733 - 1740

Martin C. Taylor, Alexander I. Ward, Francisco Olmo, Amanda F. Francisco, Shiromani Jayawardhana, Fernanda C. Costa, Michael D. Lewis and John M. Kelly*


DOI: 10.2174/1381612826666201124113214





Bioactive Peptides Originating from Gastrointestinal Endogenous Proteins in the Growing Pig: In Vivo Identification

, 2021; 27(11): 1382 - 1395

Lakshmi A. Dave, Maria Hayes, Leticia Mora, Shane M. Rutherfurd, Carlos A. Montoya and Paul J. Moughan*


DOI: 10.2174/1381612826666201207111209



Prediction Models and Scores in Pulmonary Hypertension: A Review

, 2021; 27(10): 1266 - 1276

Sophia Anastasia Mouratoglou, Ahmed A. Bayoumy and Anton Vonk Noordegraaf*


DOI: 10.2174/1381612824999201105163437



The Computational Intervention of Macrolide Antibiotics in the Treatment of COVID-19

, 2021; 27(9): 1202 - 1210

Firoz Anwar*, Hisham N. Altayb, Fahad A. Al-Abbasi, Vikas Kumar and Mohammad A. Kamal*


DOI: 10.2174/1381612827666210125121954




Open Access Articles

Marine Bioactive Peptides in Supplements and Functional Foods - A Commercial Perspective

, 2021; 27(11): 1353 - 1364

Ragnhild Dragøy Whitaker*, Themis Altintzoglou, Kjersti Lian and Estefania Noriega Fernandez




Anti-malarial Drugs are Not Created Equal for SARS-CoV-2 Treatment: A Computational Analysis Evidence

, 2021; 27(10): 1323 - 1329

Simone Ronsisvalle, Federica Panarello, Rosaria Di Mauro, Renato Bernardini, Giovanni Li Volti* and Giuseppina Cantarella




Effects of an Integrative Mind-Body-Medicine Group Program on Breast Cancer Patients During Chemotherapy: An Observational Study

, 2021; 27(8): 1112 - 1120

Heidemarie Haller, Kyung-Eun Choi, Silke Lange, Sherko Kümmel, Anna Paul, Holger Cramer, Gustav Dobos and Petra Voiss*







The Pathogenic Subpopulation of Th17 Cells in Obesity

, 2021; 27: 1 - 15 (E-Pub Ahead of Print)

Natalia Todosenko, Maria Vulf*, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova*




Exosome Limitations in the Treatment of Inflammatory Diseases

, 2021; 27: 1 - 17 (E-Pub Ahead of Print)

Daria Skuratovskaia*, Maria Vulf, Olga Khaziakhmatova, Vladimir Malashchenko, Aleksandra Komar, Egor Shunkin, Natalia Gazatova and Larisa Litvinova




Treatment of Anderson-Fabry Disease

, 2020; 26(40): 5089 - 5099

Irene Simonetta*, Antonino Tuttolomondo, Mario Daidone, Salvatore Miceli and Antonio Pinto





Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders

, 2020; 26(36): 4569 - 4579

Tejashree Waghule, Vamshi Krishna Rapalli, Srividya Gorantla, Ranendra Narayan Saha, Sunil Kumar Dubey, Anu Puri and Gautam Singhvi*




A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats

, 2020; 26(31): 3884 - 3894

Branka Petković*, Srđan Kesić, Slavica Ristić, Željko Pavković, Jelena Podgorac, Gordana Stojadinović and Vesna Pešić





γ-Aminobutyric Acid and Derivatives Reduce the Incidence of Acute Pain after Herpes Zoster - A Systematic Review and Meta-analysis

, 2020; 26(25): 3026 - 3038

Wuttapon Sadaeng, Katalin Márta, Péter Mátrai, Péter Hegyi, Barbara Tóth, Balázs Németh, László M. Czumbel, Thanyaporn Sang-Ngoen, Zoltán Gyöngyi, Gábor Varga*, Péter Révész, István Szanyi, Kázmér Karádi and Gábor Gerber




Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis

, 2020; 26(25): 3015 - 3025

Beáta Kerémi, Katalin Márta, Kornélia Farkas, László M. Czumbel, Barbara Tóth, Zsolt Szakács, Dezső Csupor, József Czimmer, Zoltán Rumbus, Péter Révész, Adrienn Németh, Gábor Gerber, Péter Hegyi and Gábor Varga*





Most Cited Articles

General Review Article

Long non-coding RNAs as epigenetic regulators in cancer

, 2019; 25(33): 3563-3577.

Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Soheila Mohammadi, Sima Fathullahzadeh, Hamid R. Mirzaei, Afshin Namdar, Amir Savardashtaki* and Hamed Mirzaei*


DOI: 10.2174/1381612825666190830161528


Review Article

Synthesis of silver nanoparticles and their biomedical applications a comprehensive review

, 2019; 25(24): 2650-2660.

Rajasree Shanmuganathan, Indira Karuppusamy, Muthupandian Saravanan, Harshiny Muthukumar, Kumar Ponnuchamy, Vijayan Sri Ramkumar and Arivalagan Pugazhendhi*


DOI: 10.2174/1381612825666190708185506


Review Article

Cholinesterase inhibitors for Alzheimer's disease: Multitargeting strategy based on anti-Alzheimer's drugs repositioning

, 2019; 25(33): 3519-3535.

Md. Tanvir Kabir, Md. Sahab Uddin*, Mst. Marium Begum, Shanmugam Thangapandiyan, Md. Sohanur Rahman, Lotfi Aleya, Bijo Mathew, Muniruddin Ahmed, George E. Barreto and Ghulam Md. Ashraf


DOI: 10.2174/1381612825666191008103141


Review Article

Pollution, toxicity and carcinogenicity of organic dyes and their catalytic bio-remediation

, 2019; 25(34): 3645-3663.

Muhammad Ismail, Kalsoom Akhtar, M.I. Khan, Tahseen Kamal, Murad A. Khan, Abdullah M. Asiri, Jongchul Seo and Sher B. Khan*


DOI: 10.2174/1381612825666191021142026


Review Article

NMDA receptor antagonists: Repositioning of memantine as a multitargeting agent for Alzheimer's therapy

, 2019; 25(33): 3506-3518.

Md. Tanvir Kabir, Mohammad A. Sufian, Md. Sahab Uddin*, Mst. Marium Begum, Shammi Akhter, Ariful Islam, Bijo Mathew, Md. Siddiqul Islam, Md. Shah Amran and Ghulam Md. Ashraf*


DOI: 10.2174/1381612825666191011102444


Review Article

Emerging potential of naturally occurring autophagy modulators against neurodegeneration

, 2020; 26(7): 772-779.

Md. Ataur Rahman*, Md Rezanur Rahman, Toyfiquz Zaman, Md. Sahab Uddin, Rokibul Islam, Mohamed M. Abdel-Daim and Hyewhon Rhim*


DOI: 10.2174/1381612826666200107142541


Review Article

Alginate nanoparticles for drug delivery and targeting

, 2019; 25(11): 1312-1334.

Patricia Severino, Classius F. da Silva, Luciana N. Andrade, Daniele de Lima Oliveira, Joana Campos and Eliana B. Souto*


DOI: 10.2174/1381612825666190425163424




Review Article

Metal/metal oxide nanoparticles: Toxicity, applications, and future prospects

, 2019; 25(37): 4013-4029.

Ratiram G. Chaudhary*, Ganesh S. Bhusari, Ashish D. Tiple, Alok R. Rai, Subhash R. Somkuvar, Ajay K. Potbhare, Trimurti L. Lambat, Prashant P. Ingle and Ahmed A. Abdala*


DOI: 10.2174/1381612825666191111091326



General Review Article

Ethnobotany, phytochemistry and traditional uses of curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): A Review

, 2019; 25(8): 871-935.

Zahra Ayati, Mahin Ramezani , Mohammad Sadegh Amiri, Ali Tafazoli Moghadam, Hoda Rahimi, Aref Abdollahzade, Amirhossein Sahebkar * and Seyed Ahmad Emami *


DOI: 10.2174/1381612825666190402163940


Review Article

Expression profile of MicroRNA: An emerging hallmark of cancer

, 2019; 25(6): 642-653.

Uzma Zaheer, Muhammed Faheem, Ishtiaq Qadri, Nargis Begum, Hadi M. Yassine, Asmaa A. Al Thani and Shilu Mathew*


DOI: 10.2174/1386207322666190325122821


Review Article

Extracellular vesicles as drug delivery systems - Methods of production and potential therapeutic applications

, 2019; 25(2): 132-154.

Magdalena Surman, Anna Drożdż, Ewa Stępień and Małgorzata Przybyło*


DOI: 10.2174/1381612825666190306153318




Most Accessed Articles

Blood Cell Count Indexes of Systemic Inflammation in Carotid Artery Disease: Current Evidence and Future Perspectives

, 2021; 27(18): 2170-2179.

Paola Dettori, Panagiotis Paliogiannis*, Rosa M. Pascale, Angelo Zinellu, Arduino A. Mangoni and Gianfranco Pintus


DOI: 10.2174/1381612826666201222155630


Comparative Analysis of Risk Stratification Scores in Atrial Fibrillation

, 2021; 27(10): 1298-1310.

Athanasios Samaras, Ioannis Doundoulakis *, Christina Antza, Stefanos Zafeiropoulos, Ioannis Farmakis and Apostolos Tzikas


DOI: 10.2174/1381612826666201210113328


Novel Phytochemical Constituents and their Potential to Manage Diabetes

, 2021; 27(6): 775-788.

Shaik I. Khalivulla*, Arifullah Mohammed* and Kokkanti Mallikarjuna


DOI: 10.2174/1381612826666201222154159


Mechanisms for Cardiorenal Protection of SGLT-2 Inhibitors

, 2021; 27(8): 1043-1050.

Panagiotis I. Georgianos, Vasilios Vaios, Evangelia Dounousi, Marios Salmas, Theodoros Eleftheriadis and Vassilios Liakopoulos*


DOI: 10.2174/1381612827666210119102409


Risk Prediction Models and Scores in Hypertrophic Cardiomyopathy

, 2021; 27(10): 1254-1265.

Thomas D. Gossios*, Konstantinos Savvatis, Thomas Zegkos, Despina Parcharidou, Haralambos I. Karvounis and Georgios K. Efthimiadis


DOI: 10.2174/1381612827666210125121115


Cardio-protective Effects of Glucagon-like Peptide-1 Receptor Agonists: An Overview of Systematic Reviews and Publication Overlap

, 2021; 27(8): 1068-1079.

Stefanos Zafeiropoulos, Areti Pagiantza, Ioannis Doundoulakis, Nikolaos Stalikas, Ioannis Farmakis, Athanasios Samaras, Christina Antza and George Giannakoulas*


DOI: 10.2174/1381612827666210119103153


Data Sharing and Privacy in Pharmaceutical Studies

, 2021; 27(7): 911-918.

Rufan Chen, Yi Zhang, Zuochao Dou, Feng Chen, Kang Xie and Shuang Wang*


DOI: 10.2174/1381612827999210112204732


Zacopride Exerts an Antiarrhythmic Effect by Specifically Stimulating the Cardiac Inward Rectifier Potassium Current in Rabbits: Exploration of a New Antiarrhythmic Strategy

, 2020; 26(44): 5746-5754.

Yuanyuan Lin, Junhu Li, Baozhong Zhu, Qinghua Liu, Xiaojie Bai, Bingmei Chang, Yanlin Guo, Qilong Feng*, Xuewen Li*, Bowei Wu and Jimin Cao


DOI: 10.2174/1381612826666200701135508


Stem Cell Based Preclinical Drug Development and Toxicity Prediction

, 2021; 27(19): 2237-2251.

Dhruv Kumar*, Prakash Baligar, Rajpal Srivastav, Priyanka Narad, Sibi Raj, Chanderdeep Tandon and Simran Tandon*


DOI: 10.2174/1381612826666201019104712




Ferulic Acid Activity in Topical Formulations: Technological and Scientific Prospecting

, 2021; 27(19): 2289-2298.

Gabriela R. Cavalcanti, Fernanda I.C. Duarte, Attilio Converti and Ádley A.N. de Lima*


DOI: 10.2174/1381612826666201020163331



Suicide and Suicide Attempts in Elderly Patients: An Epidemiological Analysis of Risk Factors and Prevention

, 2021; 27(19): 2231-2236.

Marta Makara-Studzińska, Siva G. Somasundaram, Joanna Halicka, Agata Madej, Jerzy Leszek, Mohd Rehan, Ghulam M. Ashraf, Liliya V. Gavryushova, Vladimir N. Nikolenko, Liudmila M. Mikhaleva, Cristian Muresanu, Cecil E. Kirkland, Marco Avila-Rodriguez* and Gjumrakch Aliev*


DOI: 10.2174/1381612826999201126202008


Hypothetical Role of Growth Factors to Reduce Intervertebral Disc Degeneration Significantly through Trained Biological Transformations

, 2021; 27(19): 2221-2230.

Cristian Muresanu*, Siva G. Somasundaram, Sergey V. Vissarionov, Liliya V. Gavryushova, Vladimir N. Nikolenko, Liudmila M. Mikhaleva, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1381612826666201019104201




Editor-in-Chief

graphic
Alessandro Antonelli
(12,288 citations)
Department of Clinical and Experimental Medicine
Laboratory of Primary Human Cells
University of Pisa
Pisa
(Italy)
Biography
View Full Editorial Board

Executive Editor

graphic
Atta-ur-Rahman, FRS
(32052 citations)
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
(UK)
Biography

Nobel Laureates on Editorial Board

graphic
Andrew V. Schally
(USA)

COPE Compliant

Cope Logo

Journal History

Current Pharmaceutical Design was introduced in 1995 with the assistance of Dr. William A. Banks.

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