Contents

Combinatorial Chemistry & High Throughput Screening, Volume 13 - Number 2

Editorial [Hot topic: Preclinical Profiling in Drug Discovery (Guest Editor: Larry C. Wienkers)]

, 13(2): 88 - 89

Larry C. Wienkers


DOI: 10.2174/138620710790596817




Preformulation Designed to Enable Discovery and Assess Developability

, 13(2): 90 - 100

Michael J. Hageman


DOI: 10.2174/138620710790596781




Solubility and Permeability Measurement and Applications in Drug Discovery

, 13(2): 101 - 111

Philip S. Burton and Jay T. Goodwin


DOI: 10.2174/138620710790596763




Evaluation of Drug Transporter Interactions in Drug Discovery and Development

, 13(2): 112 - 134

Yurong Lai, Kathleen E. Sampson and Jeffrey C. Stevens


DOI: 10.2174/138620710790596772




Enzyme Induction: Translating Multiple Approaches, Assays, Endpoints, and Opinions into a Valuable Induction Screening Strategy

, 13(2): 135 - 144

Adrian Fretland and Mario Monshouwer


DOI: 10.2174/138620710790596727




Application of Cytochrome P450 Drug Interaction Screening in Drug Discovery

, 13(2): 145 - 158

Robert S. Foti, Larry C. Wienkers and Jan L. Wahlstrom


DOI: 10.2174/138620710790596718




Scaling In Vivo Pharmacokinetics from In Vitro Metabolic Stability Data in Drug Discovery

, 13(2): 159 - 169

Wendy Klopf and Philip Worboys


DOI: 10.2174/138620710790596790




Plasma Protein Binding in Drug Discovery and Development

, 13(2): 170 - 187

Monique L. Howard, John J. Hill, Gerald R. Galluppi and Matthew A. McLean


DOI: 10.2174/138620710790596745




Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance

, 13(2): 188 - 206

James M. McKim Jr.


DOI: 10.2174/138620710790596736




Application of In Vivo Animal Models to Characterize the Pharmacokinetic and Pharmacodynamic Properties of Drug Candidates in Discovery Settings

, 13(2): 207 - 218

Benny M. Amore, John P. Gibbs and Maurice G. Emery


DOI: 10.2174/138620710790596808




Meet the Guest Editor

, 13(2): 219

Larry C. Wienkers


DOI: 10.2174/138620710790596754




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