Contents

Combinatorial Chemistry & High Throughput Screening, Volume 12 - Number 1

Editorial [Hot Topic: Ion Channels: Applications in Ion Channel Drug Discovery(Guest Editor: Douglas S. Krafte)]

, 12(1): 1

Douglas S. Krafte


DOI: 10.2174/138620709787048046




Evolution of the Human Ion Channel Set

, 12(1): 2 - 23

Surendra K. Nayak, Serge Batalov, Timothy J. Jegla and Christian M. Zmasek


DOI: 10.2174/138620709787047957




Port-a-Patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology

, 12(1): 24 - 37

Niels Fertig, Andrea Bruggemann, Mohamed Kreir, Michael George, Sonja Stoelzle, Claudia Haarmann, Cecilia Farre and Alison Haythornthwaite


DOI: 10.2174/138620709787047966




High Throughput Electrophysiology with Xenopus Oocytes

, 12(1): 38 - 50

Cathy Smith-Maxwell and Roger L. Papke


DOI: 10.2174/138620709787047975




Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels

, 12(1): 51 - 63

Mads P.G. Korsgaard, Dorte Strobaek and Palle Christophersen


DOI: 10.2174/138620709787048037




HCN Channels as Targets for Drug Discovery

, 12(1): 64 - 72

Alan D. Wickenden, Sandra R. Chaplan, Adrienne E. Dubin, Hong-Qing Guo, Nyan-Tsz Wu and Michael P. Maher


DOI: 10.2174/138620709787048028




The Chiptip: A Novel Tool for Automated Patch Clamp

, 12(1): 73 - 77

Andjelko Golubovic, Martina Knirsch, Uwe Czubayko, Alexander Hummer, Albrecht Lepple-Wienhues and Dirck Lassen


DOI: 10.2174/138620709787047984




QPatch: The Missing Link Between HTS and Ion Channel Drug Discovery

, 12(1): 78 - 95

Yi Liu, Chris Mathes, Soren Friis and Michael Finley


DOI: 10.2174/138620709787047948




Use of Planar Array Electrophysiology for the Development of Robust Ion Channel Cell Lines

, 12(1): 96 - 106

Jeffrey J. Clare, Mao Xiang Chen, David L. Downie, Derek J. Trezise and Andrew J. Powell


DOI: 10.2174/138620709787048000




Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms

, 12(1): 107 - 122

Neil Castle, David Printzenhoff, Shannon Zellmer, Brett Antonio, Alan Wickenden and Christopher Silvia


DOI: 10.2174/138620709787047993




Meet The Guest Editor

, 12(1): 123

Douglas S. Krafte


DOI: 10.2174/138620709787048019




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