Contents

CNS & Neurological Disorders - Drug Targets , Volume 13 - Number 1

Message from Editor-in-Chief

, 13(1): 1

Stephen D. Skaper


DOI: 10.2174/187152731301140210113429




Conference Report: (13th International Congress on Amino Acids, Peptides and Proteins (ICAPP); Neurobiology Symposium, October 5-7, 2013; Galveston TX, USA.)

, 13(1): 2 - 3

Hari Sharma, Dafin F Muresanu and Aruna Sharma


DOI: 10.2174/187152731301140210114550




Commentary: (Research Highlights Inflammation, Demyelination and Neurodegeneration: Risky Buddies in Multiple Sclerosis)

, 13(1): 4 - 5

Susanna Amadio and Cinzia Volonte


DOI: 10.2174/18715273113126660148




Editorial (Thematic Issues: Pharmacological Intervention for Down Syndrome Cognitive Deficits: Emerging Drug Targets)

, 13(1): 6 - 7

Maria Luz Montesinos


DOI: 10.2174/18715273113126660187




Reducing Gabaergic Inhibition Restores Cognitive Functions in a Mouse Model of Down Syndrome

, 13(1): 8 - 15

Marie-Claude Potier, Jerome Braudeau, Luce Dauphinot and Benoit Delatour


DOI: 10.2174/18715273113126660185




The Glutamatergic Hypothesis for Down Syndrome: The Potential Use of N-Methyl-D-Aspartate Receptor Antagonists to Enhance Cognition and Decelerate Neurodegeneration

, 13(1): 16 - 25

Alberto C.S. Costa


DOI: 10.2174/18715273113126660183




DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies

, 13(1): 26 - 33

Walter Becker, Ulf Soppa and Francisco J. Tejedor


DOI: 10.2174/18715273113126660186




The Akt-mTOR Pathway in Down’s Syndrome: The Potential Use of Rapamycin/Rapalogs for Treating Cognitive Deficits

, 13(1): 34 - 40

Jose Antonio Troca-Marin, Juan Jose Casanas, Itziar Benito and Maria Luz Montesinos


DOI: 10.2174/18715273113126660184




Editorial: Current Strategies in Targeting Brain Disorders

, 13(1): 41

Perumal Yogeeswari


DOI: 10.2174/18715273113126660193




Necroptosis: Who Knew There were so Many Interesting Ways to Die?

, 13(1): 42 - 51

S.M. Fayaz, V.S. Suvanish Kumar and G.K. Rajanikant


DOI: 10.2174/18715273113126660189




Recent Approaches for Studying the Role of Glia

, 13(1): 52 - 62

Seyeon Park


DOI: 10.2174/18715273113126660191




Future Directions in the Treatment of Neuropathic Pain: A Review on Various Therapeutic Targets

, 13(1): 63 - 81

Matharasala Gangadhar, Ram Kumar Mishra, Dharmarajan Sriram and Perumal Yogeeswari


DOI: 10.2174/18715273113126660192




Insights on the Neuromodulatory Propensity of Selaginella (Sanjeevani) and its Potential Pharmacological Applications

, 13(1): 82 - 95

Girish Chandran and Muralidhara


DOI: 10.2174/18715273113126660188




Regulatory Triangle of Neurodegeneration, Adult Neurogenesis and MicroRNAs

, 13(1): 96 - 103

Tanisha Singh, Abhishek Jauhari, Ankita Pandey, Parul Singh, Aditya B Pant, Devendra Parmar and Sanjay Yadav


DOI: 10.2174/18715273113126660190




Blockade of MK-801-Induced Heat Shock Protein 72/73 in Rat Brain by Antipsychotic and Monoaminergic Agents Targeting D2, 5-HT1A, 5-HT2A and α1-Adrenergic Receptors

, 13(1): 104 - 111

Tamara Romon, Anna M. Planas and Albert Adell


DOI: 10.2174/18715273113129990110




Pathogenesis of Alzheimer Disease: Role of Oxidative Stress, Amyloid-β Peptides, Systemic Ammonia and Erythrocyte Energy Metabolism

, 13(1): 112 - 119

Elena A. Kosenko, Iliya N. Solomadin, Lyudmila A. Tikhonova, V. Prakash Reddy, Gjumrakch Aliev and Yury G. Kaminsky


DOI: 10.2174/18715273113126660130




Pharmacological Prolyl Hydroxylase Domain Inhibition as a Therapeutic Target for Parkinson’s Disease

, 13(1): 120 - 125

Subramanian Rajagopalan, Shankar J. Chinta and Julie K. Andersen


DOI: 10.2174/18715273113126660131




Reconceptualizing Adult Neurogenesis: Role for Sphingosine-1-Phosphate and Fibroblast Growth Factor-1 in Co-Ordinating Astrocyte-Neuronal Precursor Interactions

, 13(1): 126 - 136

George Anderson and Michael Maes


DOI: 10.2174/18715273113126660132




TRYCAT Pathways Link Peripheral Inflammation, Nicotine, Somatization and Depression in the Etiology and Course of Parkinson’s Disease

, 13(1): 137 - 149

George Anderson and Michael Maes


DOI: 10.2174/18715273113129990082




Anxiety: A Systematic Review of Neurobiology, Traditional Pharmaceuticals and Novel Alternatives from Medicinal Plants

, 13(1): 150 - 165

Erica Aparecida Gelfuso, Daiane Santos Rosa, Ana Lúcia Fachin, Márcia Renata Mortari, Alexandra Olimpio Siqueira Cunha and Rene Oliveira Beleboni


DOI: 10.2174/18715273113129990102




Two Nitrogen-containing Ligands as Inhibitors of Metal-Induced Amyloid β-Peptide Aggregation

, 13(1): 166 - 172

Tingting Chen, Shajun Zhu, Siyuan Liu, Yapeng Lu and Li Zhu


DOI: 10.2174/18715273113129990076




Searching for Disease-Modifying Drugs in AD: Can We Combine Neuropsychological Tools with Biological Markers?

, 13(1): 173 - 186

Filippo Caraci, Sabrina Castellano, Salvatore Salomone, Filippo Drago, Paolo Bosco and Santo Di Nuovo


DOI: 10.2174/18715273113129990103




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