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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 18, 10 Issues, 2019
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

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Volume 18

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Number 3



Biography   Open Access



Review Article



Review Article



Review Article



Review Article



Research Article

Mitochondrial Dysfunction in Blood Platelets of Patients with Manic Episode of Bipolar Disorder

, 18(3): 222 - 231

Jana Hroudová*, Zdeněk Fišar, Hana Hansíková, Lucie Kališová, Eva Kitzlerová, Martina Zvěřová, Alena Lambertová and Jiří Raboch


DOI: 10.2174/1871527318666181224130011


Research Article

Short-Term Ultramicronized Palmitoylethanolamide Therapy in Patients with Myasthenia Gravis: a Pilot Study to Possible Future Implications of Treatment

, 18(3): 232 - 238

Emanuela Onesti, Vittorio Frasca, Marco Ceccanti, Giorgio Tartaglia, Maria Cristina Gori, Chiara Cambieri, Laura Libonati, Eleonora Palma and Maurizio Inghilleri*


DOI: 10.2174/1871527318666190131121827


Research Article

Bibliometrics of CNS & Neurological Disorders – Drug Targets: An International Evolution Along Time

, 18(3): 239 - 244

Mirna Rossi Barbosa Medeiros, Ana Carolina de Mello Alves Rodrigues, Mariana Rocha Alves, Roberto Cesar Faria e Silva, Lais Francielle Francisca Felício, Lara S.F. Carneiro, Daniel Ferreira Fagundes, Sérgio Machado and Renato Sobral Monteiro-Junior*


DOI: 10.2174/1871527318666181227123924


CNS & Neurological Disorders - Drug Targets , Volume 18 (2019) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print






Hydrolyzed Rutin Decreases Worsening of Anaplasia in Glioblastoma Relapse


Carlos Tadeu Parisi de Oliveira, Renato Colenci, Cesar Cozar Pacheco, Patrick Moro Mariano, Paula Ribeiro do Prado, Gustavo Pignatari Rosas Mamprin, Maycon Giovani Santana, Alessandra Gambero, Patrícia de Oliveira Carvalho and Denise Gonçalves Priolli*


View Abstract View on PubMed





Published Contents

Editor's Choice


Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway

, 2019; 18(2): 115 - 123

Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340



Motor Recovery after Chronic Spinal Cord Transection in Rats: A Proof-of-Concept Study Evaluating a Combined Strategy

, 2019; 18(1): 52 - 62

Antonio Ibarra*, Erika Mendieta-Arbesú, Paola Suarez-Meade, Elisa García-Vences, Susana Martiñón, Roxana Rodriguez-Barrera, Joel Lomelí, Adrian Flores-Romero, Raúl Silva-García, Vinnitsa Buzoianu-Anguiano, Cesar V. Borlongan and Tamara D. Frydman


DOI: 10.2174/1871527317666181105101756




Autophagy and Mitochondria: Targets in Neurodegenerative Disorders

, 2018; 17(9): 696 - 705

Ashutosh Kumar*, Amruta Dhawan, Alknanda Kadam and Akshada Shinde


DOI: 10.2174/1871527317666180816100203



Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders

, 2018; 17(8): 626 - 639

Heidi Ormstad*, Vesna Bryn, Robert Verkerk, Ola H. Skjeldal, Bente Halvorsen, Ola Didrik Saugstad, Jorn Isaksen and Michael Maes


DOI: 10.2174/1871527317666180720163221



Light-Emitting Diode (LED) Therapy Attenuates Neurotoxicity of Methanol-Induced Memory Impairment and Apoptosis in The Hippocampus

, 2018; 17(7): 528 - 538

Amir Ghanbari, Kazem Zibara, Sepideh Salari, Majid Ghareghani, Parastou Rad, Wael Mohamed, Elham Ebadi, Mohamad Malekzadeh and Hamdallah Delaviz*


DOI: 10.2174/1871527317666180703111643



Protective Effect of Kaempferol on the Transgenic Drosophila Model of Alzheimer’s Disease

, 2018; 17(6): 421 - 429

Tanveer Beg, Smita Jyoti, Falaq Naz, Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad and Yasir Hasan Siddique*


DOI: 10.2174/1871527317666180508123050



Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain

, 2018; 17(5): 348 - 360

Aldric Hama*, Takahiro Natsume, Shin`ya Ogawa, Yuji Awaga, Ikuo Hayashi, Akihisa Matsuda and Hiroyuki Takamatsu


DOI: 10.2174/1871527317666180515121350



Cerebrolysin and Aquaporin 4 Inhibition Improve Pathological and Motor Recovery after Ischemic Stroke

, 2018; 17(4): 299 - 308

Bogdan Catalin, Otilia-Constantina Rogoveanu, Ionica Pirici, Tudor Adrian Balseanu, Adina Stan, Valerica Tudorica, Maria Balea, Ion Mindrila, Carmen Valeria Albu, Guleed Mohamed, Daniel Pirici* and Dafin Fior Muresanu


DOI: 10.2174/1871527317666180425124340



Open Access Articles

Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins




Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid

, 2015; 14(10): 1343 - 1349

Evgeny E. Akkuratov, Jian Wu, David Sowa, Zahoor A. Shah and Lijun Liu






The Role of Neuroimaging in Our Understanding of the Suicidal Brain

, 2013; 12(7): 921 - 929

Stefanie Desmyter, Stijn Bijttebier and Kees van Heeringen






Glutamate Receptors in Microglia

, 2013; 12(6): 773 - 784

Madhuvika Murugan, Eng-Ang Ling and Charanjit Kaur






Most Cited Articles

Review Article

Oxidative stress: Major threat in traumatic brain injury

, 2018; 17(9): 689-695.

Nidhi Khatri, Manisha Thakur, Vikas Pareek, Sandeep Kumar, Sunil Sharma and Ashok Kumar Datusalia*


DOI: 10.2174/1871527317666180627120501


Research Article

Protective effect of kaempferol on the transgenic drosophila model of Alzheimer’s disease

, 2018; 17(6): 421-429.

Tanveer Beg, Smita Jyoti, Falaq Naz, Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad and Yasir Hasan Siddique*


DOI: 10.2174/1871527317666180508123050


General Review Article

The underlying role of oxidative stress in neurodegeneration: A mechanistic review

, 2018; 17(3): 207-215.

Habib Yaribeygi, Yunes Panahi*, Behjat Javadi and Amirhossein Sahebkar*


DOI: 10.2174/1871527317666180425122557


Review Article

Neurotransplantation therapy and cerebellar reserve

, 2018; 17(3): 172-183.

Jan Cendelin, Hiroshi Mitoma* and Mario Manto


DOI: 10.2174/1871527316666170810114559


Review Article

Dl-3-n-butylphthalide (NBP): A promising therapeutic agent for ischemic stroke

, 2018; 17(5): 338-347.

Shan Wang, Fei Ma, Longjian Huang, Yong Zhang, Yuchen Peng, Changhong Xing, Yipu Feng, Xiaoliang Wang* and Ying Peng*


DOI: 10.2174/1871527317666180612125843



Research Article

Development of a nasal donepezil-loaded microemulsion for the treatment of Alzheimer’s disease: In vitro and Ex vivo characterization

, 2018; 17(1): 43-53.

Lupe C. Espinoza, Marisol Vacacela, Beatriz Clares*, Maria Luisa Garcia, Maria-Jose Fabrega and Ana C. Calpena


DOI: 10.2174/1871527317666180104122347


Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*


DOI: 10.2174/1871527316666170807130011



Review Article

Autophagy and mitochondria: Targets in neurodegenerative disorders

, 2018; 17(9): 696-705.

Ashutosh Kumar*, Amruta Dhawan, Alknanda Kadam and Akshada Shinde


DOI: 10.2174/1871527317666180816100203


Review Article

Metabolic syndrome and its effect on the brain: Possible mechanism

, 2018; 17(8): 595-603.

Nurul ‘Ain Arshad, Teoh Seong Lin and Mohamad Fairuz Yahaya*


DOI: 10.2174/1871527317666180724143258


Review Article

Therapeutic advancement in alzheimer disease: New hopes on the horizon?

, 2018; 17(8): 571-589.

Ajeet Singh, Abshar Hasan, Sakshi Tiwari and Lalit M. Pandey*


DOI: 10.2174/1871527317666180627122448



Research Article

Characterization of regulatory T-cells in multiple sclerosis patients treated with interferon beta-1a

, 2018; 17(2): 113-118.

Mohsen Ebrahimimonfared, Ali Ganji, Sara Zahedi, Parisa Nourbakhsh, Keyvan Ghasami and Ghasem Mosayebi*


DOI: 10.2174/1871527317666180327122435


Review Article

Cognitive impact of cerebellar damage: Is there a future for cognitive rehabilitation?

, 2018; 17(3): 199-206.

Kim van Dun, Frank V. Overwalle, Mario Manto* and Peter Marien


DOI: 10.2174/1871527317666180110125043



Most Accessed Articles

Cariprazine in Bipolar Depression and Mania: State of the Art

, 2018; 17(10): 723-727.

Marianna Mazza*, Giuseppe Marano, Gianandrea Traversi, Valentina Carocci, Benedetta Romano and Luigi Janiri


DOI: 10.2174/1871527317666180828120256



Autophagy and Mitochondria: Targets in Neurodegenerative Disorders

, 2018; 17(9): 696-705.

Ashutosh Kumar*, Amruta Dhawan, Alknanda Kadam and Akshada Shinde


DOI: 10.2174/1871527317666180816100203


Efficacy of Celecoxib Adjunct Treatment on Bipolar Disorder: Systematic Review and Meta-Analysis

, 2019; 18(1): 19-28.

Daniela V. Bavaresco, Tamy Colonetti, Antônio J. Grande, Francesc Colom, Samira S. Valvassori, João Quevedo and Maria I. da Rosa*


DOI: 10.2174/1871527317666181105162347




Effects of Exercise on Anxiety and Depression Disorders: Review of Meta- Analyses and Neurobiological Mechanisms

, 2014; 13(6): 1002-1014.

Mirko Wegner, Ingo Helmich, Sergio Machado, Antonio E. Nardi, Oscar Arias-Carrion and Henning Budde


DOI: 10.2174/1871527313666140612102841



Noncoding RNAs and Intracerebral Hemorrhage

, 2019; 18(3): 205-211.

Lingzhi Li, Pingping Wang, Haiping Zhao* and Yumin Luo*


DOI: 10.2174/1871527318666190204102604


Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway

, 2019; 18(2): 115-123.

Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340



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