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Current Molecular Medicine

Volume 19, 10 Issues, 2019
ISSN: 1875-5666 (Online)
ISSN: 1566-5240 (Print)
This journal supports open access

Aims & Scope

Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

Current Molecular Medicine

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Volume 18

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Number 10



Review Article

Human Disease Modelling Techniques: Current Progress

, 18(10): 655 - 660

Victor Yu. Glanz, Alexander N. Orekhov* and Alexey V. Deykin


DOI: 10.2174/1566524019666190206204357


Research Article



Research Article

Estriol Inhibits Dermcidin Isoform-2 Induced Inflammatory Cytokine Expression Via Nitric Oxide Synthesis in Human Neutrophil

, 18(10): 672 - 678

Pradipta Jana, Md. Mobidullah Khan, Subrata Kumar De, Asru K. Sinha, Santanu Guha, Gausal A. Khan and Smarajit Maiti*


DOI: 10.2174/1566524019666190208095754


Research Article

Th1/Th17 Cytokine Profile is Induced by Macrophage Migration Inhibitory Factor in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients

, 18(10): 679 - 688

Samuel García-Arellano*, Luis Alexis Hernández-Palma*, Richard Bucala, Jorge Hernández-Bello, Ulises De la Cruz-Mosso, Trinidad García-Iglesias, Sergio Cerpa-Cruz, Jorge Ramón Padilla-Gutiérrez, Yeminia Valle, José Guadalupe Soñanez-Organis, Isela Parra-Rojas, Ana Laura Pereira-Suárez and José Francisco Muñoz-Valle


DOI: 10.2174/1566524019666190129123240


Research Article



Research Article

Naoxintong Retards Atherosclerosis by Inhibiting Foam Cell Formation Through Activating Pparα Pathway

, 18(10): 698 - 710

Zeng Wang, Junbo Ge *, Aijun Sun*, Huairui Shi, Huan Zhao, Zhen Dong, Buchang Zhao, Xinyu Weng, Rongle Liu, Xiao Li, Kai Hu and Yunzeng Zou


DOI: 10.2174/1566524019666190207143207


Research Article

Histone Deacetylase Inhibition Attenuates Cardiomyocyte Hypoxia-Reoxygenation Injury

, 18(10): 711 - 718

Aaron M. Williams, Wei He , Yongqing Li*, Umar F. Bhatti, Vahagn C. Nikolian, Panpan Chang, Zhigang Chang, Ihab Halaweish, Baoling Liu, Xin Cheng and Hasan B. Alam


DOI: 10.2174/1566524019666190208102729


Acknowledgement   Open Access



Articles Ahead of Print

The Prognostic and Clinicopathologic Characteristics of OCT4 and Lung Cancer: A Meta-Analysis


Hui Li, Liwen Wang, Shupeng Shi, Yadong Xu, Xuejiao Dai, Hongru Li, Jing Wang, Qiong Zhang, Yonggang Wang, Shuming Sun* and Yanping Li*


View Abstract View on PubMed



Bone Metabolism Markers in Thalassemia Major-Induced Osteoporosis: Results from a Cross-Sectional Observational Study


Athanasios N. Tsartsalis*, George I. Lambrou, Dimitrios N. Tsartsalis, Ioannis Papassotiriou, Evgenia Vlachou, Evaggelos Terpos, George P. Chrousos, Christina Kanaka-Gantenbein and Antonis Kattamis


View Abstract View on PubMed



Negative Correlation Between Serum Levels of Homocysteine and Apolipoprotein M


J. Wei, Y. Yu, Y. Feng, J. Zhang, Q. Jiang, L. Zheng, X. Zhang, N. Xu and G. Luo*


View Abstract View on PubMed



Glucose Oxidase- and UVA-Induced Changes in the Expression Patterns of Seven De-sumoylation Enzymes (SENPs) Are Associated with Cataract Development


Jia-Wen Xiang , Yuan Xiao, Yuwen Gan, Huimin Chen, Yunfei Liu, Ling Wang, Qian Nie, Fangyuan Liu, Xiaodong Gong, Jia-Ling Fu, Wen-Jie Qing, Lan Yang, Jie Xie, Zhongwen Luo, Ruili Qi, Zhigang Chen and David Wan-Cheng Li*


View Abstract


Stew in its Own Juice: Protein Homeostasis Machinery Inhibition Reduces Cell Viability in Multiple Myeloma Cell Lines


Mariana B. de Oliveira, Luiz Felipe G. Sanson, Angela I. P. Eugenio, Rebecca S. S. Barbosa-Dantas and Gisele W. B. Colleoni*


View Abstract


Association of ATG7 Polymorphisms and Clear Cell Renal Cell Carcinoma Risk


Zhenlong Wang, Lei Tao, Yuquan Xue, Li Xue, Ziming Wang and Tie Chong*


View Abstract



Abstracts Ahead of Print

Blood Circulating Exosomes Contain Distinguishable Fractions of Free and Cell-Surface-Associated Vesicles


Svetlana Tamkovich*, Oleg Tutanov, Anastasia Efimenko, Alina Grigor’eva, Elena Ryabchikova, Natalia Kirushina, Valentin Vlassov, Vsevolod Tkachuk and Pavel Laktionov


View Abstract


Diagnostic Value of MiR-125b as a Potential Biomarker for Stage I Lung Adenocarcinoma Lung Adenocarcinoma


Arife Zeybek*, Necdet Öz, Serdar Kalemci , Tuba Edgünlü, Mehmet Kızıltuğ, Kürşad Tosun, Mustafa Tunç, Leyla Tekin and Mehmet Emin Erdal


View Abstract




Editor's Choice


Altered Expression Patterns of the Sumoylation Enzymes E1, E2 and E3 Are Associated with Glucose Oxidase- and UVA-Induced Cataractogenesis

, 2018; 18(8): 542 - 549

Qian Nie, Ling Wang , Xiaodong Gong, Jia-Wen Xiang, Yuan Xiao, Jie Xie, Lan Yang, Huimin Chen, Yuwen Gan, Zhigang Chen and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190111152324



Generation of a Primary Hyperoxaluria Type 1 Disease Model Via CRISPR/Cas9 System in Rats

, 2018; 18(7): 436 - 447

Rui Zheng, Xiaoliang Fang, Lei He, Yanjiao Shao, Nana Guo, Liren Wang, Mingyao Liu, Dali Li* and Hongquan Geng*


DOI: 10.2174/1566524019666181212092440



Digitoxin Suppresses Store Operated Calcium Entry by Modulating Phosphorylation and the Pore Region of Orai1

, 2018; 18(6): 392 - 399

Lijuan Zhou, Xiangxiang Chi, Yaping Zhu, Tian Zhang, Jindou Liu, Guolin Ma, Lian He, Shuce Zhang, Ping Gao, Yubin Zhou*, Jin Liu* and Youjun Wang


DOI: 10.2174/1566524018666181113111316



Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells

, 2018; 18(4): 199 - 206

J. Castillo Bennett, P. Silva, S. Martinez, V.A. Torres* and A.F.G. Quest*


DOI: 10.2174/1566524018666180926163218







Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment

, 2017; 17(10): 668 - 688

N.M. Salkho, R.Z. Turki, O. Guessoum, A.M. Martins, R.F. Vitor and G.A. Husseini*


DOI: 10.2174/1566524018666180416100142



Open Access Articles

Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation

, 2018; 18(3): 160 - 165

L. Ulivi, M. Maccarrone, N. Giannini, E. Ferrari, M.C. Caselli, V. Montano, L. Chico, A. Casani, E. Navari, N. Cerchiai, G. Siciliano, U. Bonuccelli and M. Mancuso*




Decreased Expression of TIM-3 on Th17 Cells Associated with Ophthalmopathy in Patients with Graves’ Disease

, 2018; 18(2): 83 - 90

J. Zhao, B. Lin, H. Deng, X. Zhi, Y. Li, Y. Liu, P.W. Bible, Q. Li, B. Xu, L. Wei, H. Yang* and D. Huang*




ZNF424 Induces Apoptosis and Inhibits Proliferation in Lung Carcinoma Cells

, 2018; 18(2): 109 - 115

W. Liu, W. Yuan, X. Li, J. Zhuang, X. Mo, G. Dai, Y. Wang, J. Chen, Y. Wan, Y. Li, X. Zhu, Y. Chen, S. Luo, Z. Jiang, Y. Shi, F. Chen, L. Cao, X. Ye, X. Fan*, P. Zhu*, K. Zhang* and X. Wu*




Decreased Expression of MYPT1 Contributes to Tumor Angiogenesis and Poor Patient Prognosis in Human Prostate Cancer

, 2018; 18(2): 100 - 108

Y. Liang, Y. Zhuo, Z. Lin, F. Jiang, Q. Dai, J. Lu, W. Dong, X. Zhu, Z. Han* and W. Zhong*






Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development

, 2017; 17(9): 627 - 636

F. Chen, W. Yuan, X. Mo, J. Zhuang, Y. Wang, J. Chen, Z. Jiang, X. Zhu, Q. Zeng, Y. Wan, F. Li, Y. Shi, L. Cao, X. Fan, S. Luo, X. Ye, Y. Chen, G. Dai, J. Gao, X. Wang, H. Xie*, P. Zhu*, Y. Li* and X. Wu*




The bHLH Protein Nulp1 is Essential for Femur Development Via Acting as a Cofactor in Wnt Signaling in Drosophila

, 2017; 17(7): 509 - 517

Q. Zeng, Y. Wan, P. Zhu, M. Zhao, F. Jiang, J. Chen, M. Tang, X. Zhu, Y. Li, H. Zha, Y. Wang, M. Hu, X. Mo, Y. Zhang, Y. Chen, Y. Chen, X. Ye, R. Bodmer, K. Ocorr, Z. Jiang*, J. Zhuang*, W. Yuan* and X. Wu*






Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells

, 2017; 17(3): 189 - 199

X. Tan, C. Chen, Y. Zhu, J. Deng, X. Qiu, S. Huang, F. Shang, B. Cheng* and Y. Liu*





Serum miRNAs Signature Plays an Important Role in Keloid Disease

, 2016; 16(5): 504 - 514

Y. Luan, Y. Liu, C. Liu, Q. Lin, F. He, X. Dong and Z. Xiao




STAT3 Activation in Circulating Monocytes Contributes to Neovascular Age-Related Macular Degeneration

, 2016; 16(4): 412 - 423

M. Chen, J. Lechner, J. Zhao, L. Toth, R. Hogg, G. Silvestri, A. Kissenpfennig, U. Chakravarthy and H. Xu




DREADD in Parvalbumin Interneurons of the Dentate Gyrus Modulates Anxiety, Social Interaction and Memory Extinction

, 2016; 16(1): 91 - 102

D. Zou, L. Chen, D. Deng, D. Jiang, F. Dong, C. McSweeney, Y. Zhou, L. Liu, G. Chen, Y. Wu and Y. Mao





Most Cited Articles


DREADD in Parvalbumin Interneurons of the Dentate Gyrus Modulates Anxiety, Social Interaction and Memory Extinction

, 2016; 16(1): 91-102.

D. Zou, L. Chen, D. Deng, D. Jiang, F. Dong, C. McSweeney, Y. Zhou, L. Liu, G. Chen, Y. Wu and Y. Mao


DOI: 10.2174/1566524016666151222150024


Modulation of intracellular pH in human ovarian cancer.

, 2016; 16(1): 23-32.

C. Sanhueza, J. Araos, L. Naranjo, R. Villalobos, F. Westermeier, C. Salomon, A.R. Beltrán, M.A. Ramírez, J. Gutiérrez, F. Pardo, A. Leiva and L. Sobrevia


DOI: 10.2174/1566524016666151222143437










Most Accessed Articles

Spinal Muscular Atrophy: More than a Disease of Motor Neurons?

, 2016; 16(9): 779-792.

L. A. Nash, J. K. Burns, J. Warman Chardon, R. Kothary and R. J. Parks


DOI: 10.2174/1566524016666161128113338


VEGFR2 and VEGF-C Suppresses the Epithelial-Mesenchymal Transition Via YAP in Retinal Pigment Epithelial Cells

, 2018; 18(5): 273-286.

Y. Du, Q. Chen, L. Huang, S. Wang, X. Yin, L. Zhou, Z. Ye, X. Ren, Y. Cai, X. Ding, H. Ouyang, X. Li* and R. Ju*


DOI: 10.2174/1566524018666181004115304



Genetic Modifiers of Fetal Haemoglobin (HbF) and Phenotypic Severity in β-Thalassemia Patients

, 2018; 18(5): 295-305.

S.A.A. Razak, N.A.A. Murad*, F. Masra, D.L.S. Chong, N. Abdullah, N. Jalil, H. Alauddin, R.Z.A.R. Sabudin, A. Ithnin, L.C. Khai, N.A. Aziz, Z. Muda, H. Ibrahim and Z.A. Latiff*


DOI: 10.2174/1566524018666181004121604


Serotonin and Cancer: What Is the Link?

, 2015; 15(1): 62-77.

D. Sarrouilhe, J. Clarhaut, N. Defamie and M. Mesnil


DOI: 10.2174/1566524015666150114113411


Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells

, 2018; 18(4): 199-206.

J. Castillo Bennett, P. Silva, S. Martinez, V.A. Torres* and A.F.G. Quest*


DOI: 10.2174/1566524018666180926163218



DREADD in Parvalbumin Interneurons of the Dentate Gyrus Modulates Anxiety, Social Interaction and Memory Extinction

, 2016; 16(1): 91-102.

D. Zou, L. Chen, D. Deng, D. Jiang, F. Dong, C. McSweeney, Y. Zhou, L. Liu, G. Chen, Y. Wu and Y. Mao


DOI: 10.2174/1566524016666151222150024


Seven Novel and Three Known Mutations in FOXL2 in 10 Chinese Families with Blepharophimosis Syndrome

, 2018; 18(3): 152-159.

B. Lin, B. Zeng, J. Zhao, T. Xu, Y. Wang, B. Hu, F. Li, Q. Zhao, R. Liu, J. Liu, J.M. Chen, D. Huang* and Y. Wang*


DOI: 10.2174/1566524018666180907162619




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