Articles Ahead of Print

Novel Biological Therapies in Severe Asthma: Targeting the Right Trait


Gilda Varricchi*, Giancarlo Marone, Giuseppe Spadaro, Michele Russo, Francescopaolo Granata, Arturo Genovese and Gianni Marone


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ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma


Maria Paula Ceballos Mancini, Juan Pablo Rigalli, Lucila Ines Cere, Mariana Semeniuk, Viviana Alicia Catania and Maria Laura Ruiz*


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Unfolding Cardiac Amyloidosis –From Pathophysiology to Cure


Klemens Ablasser, Nicolas Verheyen, Theresa Glantschnig, Giulio Agnetti and Peter P Rainer*


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Photodynamic Therapy in Melanoma - Where do we Stand?


Ioana Baldea*, Lorin Giurgiu, Ioana Diana Teacoe, Diana Elena Olteanu, Florin Catalin Olteanu, Simona Clichici and Gabriela Adriana Filip


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Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes


Valeria Pittala, Valeria Sorrenti, Giuseppe Romeo, A Acquaviva, Claudia Di Giacomo and Loredana Salerno


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Is There A Role For Lifestyle Interventions In Obsessive-Compulsive And Related Disorders?


Leonardo F. Fontenelle*, Julliana N. Quintas and Murat Yücel


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Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic


Samer Bayda, Mohamad Hadla, Stefano Palazzolo, Giuseppe Corona, Giuseppe Toffoli and Flavio Rizzolio*


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Olfactory Loss and Dysfunction in Ciliopathies: Molecular Mechanisms and Potential Therapies


Cedric R. Uytingco*, Warren W. Green and Jeffrey R. Martens


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Generation of Reactive Oxygen Species by Photosensitizers and their Modes of Action on Proteins


Itzhak Bilkis, Israel Silman and Lev Weiner*


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Neuroprotective Effects of Flavonoid Compounds on Neuronal Death Associated to Alzheimer’s Disease


Antoni Sureda*, Capo Xavier and Silvia Tejada


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Role of Redox Homeostasis and Inflammation in the Pathogenesis of Pulmonary Arterial Hypertension


Adriane Bello-Klein*, Daniele Mancardi, Alex Sander da Rosa Araujo, Paulo Cavalheiro Schenkel, Bruna Gazzi de Lima Seolin and Patrick Türck


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Prenylated Coumarins of the Genus Citrus: An Overview of the 2006- 2016 Literature Data


Salvatore Genovese, Vito Alessandro Taddeo, Francesco Epifano* and Serena Fiorito


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Fine-tuning of microRNAs in Type 2 Diabetes Mellitus


Juan A. Rosado, Raquel Diez-Bello, Gines Maria Salido and I. Jardin*


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New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus


Marta Olivera-Santa Catalina, Pedro C. Redondo, Carlos Cantonero , Maria P. Granados, Jose Sanchez-Collado, Letizia Albarran and Jose Javier Lopez*


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Omecamtiv Mecarbil: A Myosin Motor Activator Agent with Promising Clinical Performance and New in vitro Results


Peter Nanasi , Istvan Komaromi, Marta Gaburjakova and Janos Almassy*


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A Systematic Review of Evidence-based Treatment Strategies for Obsessive- compulsive Disorder Resistant to first-line Pharmacotherapy


Umberto Albert*, Donatella Marazziti, Gabriele Di Salvo, Francesca Solia, Gianluca Rosso and Giuseppe Maina


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Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations


Silvana Rocio Ferreira and Alicia Beatriz Motta*


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Use of Antibiotic Loaded Biomaterials for the Management of Bone Prosthesis Infections: Rationale and Limits


Matilde Tschon, Maria Sartori*, Deyanira Contartese, Gianluca Giavaresi, Nicolo Nicoli Aldini and Milena Fini


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Metallopharmaceuticals in Therapy - A New Horizon for Scientific Research


Agnieszka Chylewska *, Małgorzata Biedulska , Przemyslaw Sumczynski and Mariusz Makowski


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Critical Role of IL-8 Targeting in Gliomas


Marinos Kosmopoulos, Anthos Christofides , Dimitrios Drekolias, Phaedon D. Zavras , Antonios N. Gargalionis and Christina Piperi*


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Monitoring Interactions Inside Cells by Advanced Spectroscopies: Overview of Copper Transporters and Cisplatin


Alessia Lasorsa, Giovanni Natile*, Antonio Rosato, Francesco Tadini-Buoninsegni and Fabio Arnesano


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The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery


Rachel Johnson, Shaun Rawson, Martin McPhillie, Colin Fishwick and Stephen Muench*


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The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization


Agostino Bruno, Gabriele Costantino, Luca Sartori and Marco Radi*


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γ-AApeptides as a New Strategy for Therapeutic Development


Alekhya Nimmagadda, Yan Shi and Jianfeng Cai*


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Dynamic Localization of Hepatocellular Transporters: Role in Biliary Excretion and Impairment in Cholestasis


Marcelo Gabriel Roma*, Ismael R. Barosso, Gisel S. Miszczuk, Fernando A. Crocenzi and Enrique J. Sanchez Pozzi


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Potential Drug Targets in the Pentose Phosphate Pathway of Trypanosomatids


Ines Loureiro, Joana Faria, Nuno Santarem, Terry K. Smith, Joana Tavares and Anabela Cordeiro-da-Silva*


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Trends and Prospects of Plant Proteases in Therapeutics


Anastasia V. Balakireva, Natalia V. Kuznetsova, Anastasia I. Petushkova, Lyudmila Savvateeva and Andrey A. Zamyatnin *


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Recent Developments of 18F-FET PET in Neuro-oncology


Barbara Muoio, Luca Giovanella and Giorgio Treglia*


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Recent Advances for the Synthesis of Selenium-containing Small Molecules as Potent Antitumor Agents


Qi Miao, Jinyi Xu, Aijun Lin, Xiaoming Wu, Liang Wu and Weijia Xie*


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Histamine H3 Receptor Ligands in the Group of (Homo)piperazine Derivatives


Katarzyna Szczepanska, Kamil Kuder and Katarzyna Kiec-Kononowicz*


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The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents


Yan-Tao Yang , Jun-Fang Zhu , Guochao Liao , Hai-Jiang Xu and Bin Yu*


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Antidiabetics: Structural Diversity of Molecules with a Common Aim


Jelena B. Popovic–Dordevic *, Ivana I. Jevtic and Tatjana P. Stanojkovic


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Preventive and Therapeutic potentials of Anthocyanins in diabetes and associated complications


Swathi Putta, Nagendra Sastry Yarla, Eswar K. Kumar, Dhananjaya Bhadrapura Lakkappa , Mohammad A. Kamal, Luciana Scotti, Marcus T. Scotti, Ghulam Md Ashraf , George E. Barreto, B Sasi Bhusana Rao , D Sarala Kumari , Gorla V. Reddy, Vadim V. Tarasov, Sarat Babu Imandi and Gjumrakch Aliev*


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Role of Matrix Metalloproteinases in Degenerative Kidney Disorders


Shifa Narula, Chanderdeep Tandon and Simran Tandon *


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Synthetic Polymer-based Electrospun Fibers: Biofunctionalization Strategies and Recent Advances in Tissue Engineering, Drug Delivery and Diagnostics


Vincent Pertici , Guillaume Martrou, Didier Gigmes and Thomas Trimaille*


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In Silico Prediction of P-glycoprotein Binding: Insights from Molecular Docking Studies


Santiago Vilar*, Eduardo Sobarzo-Sanchez and Eugenio Uriarte


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New Strategy on Antimicrobial-resistance: Inhibitors of DNA Replication Enzymes


Lanhua Yi and Xin Lu*


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Plant-Made Antibodies: Properties and Therapeutic Applications


Tatiana V. Komarova, Ekaterina V Sheshukova and Yuri L Dorokhov*


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Carboxylesterase Inhibitors: An Update


Li-Wei Zou , Qiang Jin, Dan-Dan Wang, Qing-Kai Qian, Da-Cheng Hao, Guang-Bo Ge* and Ling Yang


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Adipokines and Myokines: A Pivotal Role in Metabolic and Cardiovascular Disorders


Hye Soo Chung and Kyung Mook Choi*


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Guanylate Cyclase C: A Current Hot Target, from Physiology to Pathology


Jose Antonio Uranga, Marta Castro and Raquel Abalo*


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Recent Evidence on the Role of Dietary PUFAs in Cancer Development and Prevention


Massimo D’Archivio *, Beatrice Scazzocchio, Rosaria Vari, Carmela Santangelo, Claudio Giovannini and Roberta Masella


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Anti-Aging Drugs – Prospect of Longer Life?


Blanka Klimova, Michal Novotny and Kamil Kuca*


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Sunitinib in the Treatment of Thyroid Cancer


Silvia Martina Ferrari, Marco Centanni, Camilla Virili, Mario Miccoli , Paola Ferrari, Ilaria Ruffilli , Francesca Ragusa, Alessandro Antonelli* and Poupak Fallahi


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Journey of 2′-deoxy-2′-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (FMAU): from Antiviral Drug to PET Imaging Agent


Mian M. Alauddin *


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Medical Applications of Collagen and Collagen-Based Materials


Anatoly Borisovich Shekhter, Alexey Leonidovich Fayzullin*, Marina Nikolaevna Vukolova, Tatyana Georgiyevna Rudenko, Varvara Dmitriyevna Osipycheva and Petr Francevich Litvitsky


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Metals and Parkinson's Disease: Mechanisms and Biochemical Processes


Geir Bjørklund*, Vera Stejskal, Mauricio A. Urbina , Maryam Dadar , Salvatore Chirumbolo and Joachim Mutter


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The Impact of Ultraviolet Radiation on Barrier Function in Human Skin: Molecular Mechanisms and Topical Therapeutics


Abdulaziz Alhasaniah, Michael J Sherratt and Catherine O’Neill*


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Metallic Nanoclusters for Cancer Imaging and Therapy


Qing Zhang, Mingying Yang, Ye Zhu and Chuanbin Mao


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Diagnostic Devices for Circulating Biomarkers Detection and Quantification


Chiara Bedin*, Sara Crotti, Ennio Tasciotti and Marco Agostini


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Diet and Contaminants: Driving the Rise to Obesity Epidemics?


Agostino Di Ciaula and Piero Portincasa*


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Molecular Mechanisms Triggered by Bile Acids on Intestinal Ca2+ Absorption


Ana Marchionatti , Maria Rivoira, Valeria Rodriguez, Adriana Perez and Nori Tolosa de Talamoni*


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Metallodrugs in Targeted Cancer Therapeutics. Aiming at Chemoresistance- related Patterns and Immunosuppressive Tumor Networks


Athanasios Salifoglou*, Savvas Petanidis and Efrosini Kioseoglou


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New Treatments for Allergy: Advances in Peptide Immunotherapy


David Calzada , Selene Baos , Lucia Cremades and Blanca Olombrada Cardaba *


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G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets


Katrina N. Estep*, Thomas J . Butler, Jun Ding and Robert M. Brosh


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The Validation Path of Hypoxia PET Imaging: Focus on Brain Tumours


Natale Quartuccio* and Marie-Claude Asselin


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Obsessive-compulsive Disorder with Comorbid Bipolar Disorders: Clinical Features and Treatment Implications


Federico Mucci*, Cristina Toni, Ettore Favaretto, Giulia Vannucchi, Donatella Marazziti and Giulio Perugi


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Electrochemical MIP-Sensors for Drugs


Aysu Yarman*, Sevinc Kurbanoglu, Katharina J. Jetzschmann, Sibel A. Ozkan, Ulla Wollenberger and Frieder Scheller


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Overview on Anticancer Drug Design and Development


Sureyya Olgen*


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Catestatin: A Master Regulator of Cardiovascular Functions


Sushil K. Mahata*, Malapaka Kiranmayi and Nitish R. Mahapatra


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Biodegradable Black Phosphorus-based Nanomaterials in Biomedicine: Theranostic Applications


Zhen Wang, Zhiming Liu, Chengkang Su, Biwen Yang, Xixi Fei, Yi Li, Yuqing Hou, Henan Zhao, Yanxian Guo, Zhengfei Zhuang*, Huiqing Zhong and Zhouyi Guo*


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Potential Triazole-based Molecules for the Treatment of Neglected Diseases


Susimaire Pedersoli Mantoani, Peterson de Andrade, Talita Perez Cantuaria Chierrito, Andreza Silva Figueredo and Ivone Carvalho*


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Recent Advances in Peptide-Based Approaches for Cancer Treatment


Anne C. Conibear, Alanca Schmid, Meder Kamalov, Christian F.W. Becker and Claudia Bello*


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Electrochemical Nucleic Acid-Based Biosensing of Drugs of Abuse and Pharmaceuticals


Susana Campuzano, Maia Pedrero* and Jose M. Pingarron


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Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays


Lucie Korecka*, Karel Vytras and Zuzana Bilkova


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High-Throughput Screening Strategies for the Development of Anti- Virulence Inhibitors Against Staphylococcus aureus


Xiaodan Cai, Weihao Zheng and Zigang Li*


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Recent Progress of Crosslinking Strategies for Polymeric Micelles with Enhanced Drug Delivery in Cancer Therapy


Wei Fan, Luye Zhang, Yiwen Li and Haoxing Wu*


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Recent Advances and Challenges in Steroid Metabolomics for Biomarker Discovery


Alicja Kotlowska* and Piotr Szefer


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The Glutamate and the Immune Systems: New Targets for the Pharmacological Treatment of OCD


Donatella Marazziti*, Umberto Albert, Federico Mucci and Armando Piccinni


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Recent Developments on Phenstatins as Potent Antimitotic Agents


Xing Chen , Shi-Meng Wang , Gajjela Bharath Kumar, Grant A. L. Bare, Jing Leng, Syed Nasir Abbas Bukhari* and Hua-Li Qin*


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Antimicrobial Peptides of Marine Crustaceans: The Potential and Challenges of Developing Therapeutic Agents


Negar Talaei Zanjani , Monica Miranda-Saksena , Anthony L. Cunningham and Fariba Dehghani *


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New Molecular Targets and Strategies for Antimalarial Discovery


Anna Caroline Aguiar, Lorena R. F. de Sousa, Celia R. S. Garcia, Glaucius Oliva and Rafael V. C. Guido*


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Hairy Root Cultures for the Production of Anti-cancer Naphthoquinone Compounds


Małgorzata Jeziorek, Katarzyna Sykłowska-Baranek* and Agnieszka Pietrosiuk


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Inflammatory Biomarkers in Atrial Fibrillation


Effimia Zacharia, Nikolaos Papageorgiou*, Adam Ioannou, Gerasimos Siasos, Manolis Vavuranakis, George Latsios, Charalampos Vlachopoulos, Konstantinos Toutouzas, Spyridon Deftereos, Rui Providência and Dimitris Tousoulis


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Next Generation Antineoplastic Agents: A Review on Structurally Modified Vinblastine (VBL) Analogues


Ashanul Haque , Md. Ataur Rahman , Md. Serajul Haque Faizi and Muhammad S. Khan*


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Fluorescein-Inspired Near-Infrared Chemodosimeter for Luminescence Bioimaging


Hai-Yan Wang, Huisheng Zhang, Siping Chen* and Yi Liu


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Biomarkers of Atrial Fibrillation in Hypertension


Costas Tsioufis*, Dimitrios Konstantinidis, Elias Nikolakopoulos, Evi Vemou, Theodoros Kalos, Georgios Georgiopoulos, Nikos Vogiatzakis, Aristos Ifantis, Konstantinos Konstantinou, V. Gennimata and Dimitris Tousoulis


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Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases


Ana Cristina Lima Leite*, José Wanderlan Pontes Espíndola, Marcos Veríssimo de Oliveira Cardoso and Gevanio Bezerra de Oliveira Filho


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Modern Approach to Medical Diagnostics - the Use of Separation Techniques in Microorganisms Detection


Agnieszka Chylewska*, Malgorzata Ogryzek and Mariusz Makowski


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An Update on Potential Molecular Mechanisms Underlying the Actions of Snake Venom L-amino Acid Oxidases (LAAOs)


Mauro Valentino Paloschi , Adriana Silva Pontes , Andreimar Martins Soares and Juliana Pavan Zuliani *


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Optical Sensors for Detection of Amino Acids


Aafrin M. Pettiwala and Prabhat K. Singh*


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Spirolactones: Recent Advances in Natural Products, Bioactive Compounds and Synthetic Strategies


Arianna Quintavalla*


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Ligand and Structure-based Modeling of Passive Diffusion through the Blood-Brain Barrier


Santiago Vilar*, Eduardo Sobarzo-Sánchez, Lourdes Santana and Eugenio Uriarte


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SIRT1 as a Therapeutic Target in Diabetic Complications


Justyna Strycharz , Żaneta Rygielska , Ewa Świderska , Józef Drzewoski , Janusz Szemraj , Leszek Szmigiero and Agnieszka Śliwińska *


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Cysteine-rich Proteins for Drug Delivery and Diagnosis


Guang Yang, Yue Lu, Hunter N. Bomba and Zhen Gu*


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Endothelial and Circulating Progenitor Cells in Hematological Diseases and Allogeneic Hematopoietic Stem Cell Transplantation


Annalisa Ruggeri*, Annalisa Paviglianiti, Fernanda Volt, Chantal Kenzey, Hanadi Rafii, Vanderson Rocha and Eliane Gluckman


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Hyphenated Mass Spectrometry Techniques in the Diagnosis of Amyloidosis


Marta Spodzieja, Sylwia Rodziewicz-Motowidło and Aneta Szymanska*


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Peptides and their Metal Complexes in Neurodegenerative Diseases: from Structural Studies to Nanomedicine Prospects


Giuseppe Trapani, Cristina Satriano* and Diego La Mendola


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Benzothiazole-based Compounds in Antibacterial Drug Discovery


Marina Gjorgjieva, Tihomir Tomašič, Danijel Kikelj and Lucija Peterlin Masic*


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Autologous Cell Therapy for Vascular Regeneration: The Role of Proangiogenic Cells


Vanessa Bianconi, Francesca Fallarino, Massimo Raffaele Mannarino, Francesco Bagaglia, Meisam Naeimi Kararoudi, Caterina Oriana Aragona, Rita Romani and Matteo Pirro*


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Nanotechnology in Personalized Medicine: A Promising Tool for Alzheimer’s Disease Treatment


Laura de Matteis, Rafael Martin-Rapun and Jesus M De la Fuente*


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Click Reactions in Chemistry of Triterpenes – Advances Towards Development of Potential Therapeutics


Jan Pokorný , Lucie Borková and Milan Urban*


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The Use of Naphthoquinones and Furano-naphthoquinones as Antiinvasive Agents


Nga Yi Tsang, Wai I Chik, Lai Pan Sze, Siu Wai Tsang and Hongjie Zhang*


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Collagenolytic Enzymes and their Applications in Biomedicine


Anatoly Borisovich Shekhter*, Anastasia V. Balakireva, Natalia V. Kuznetsova, Marina N. Vukolova, Petr F. Litvitsky and Andrey A. Zamyatnin


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Potential of Plant-sourced Phenols for Inflammatory Bowel Disease


Hai-tao Xiao, Bo Wen, Xiang-Chun Shen and Zhao-xiang Bian*


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Metabolomics and Heart Diseases: From Basic to Clinical Approach


Ignasi Barba*, Mireia Andres and D Garcia Dorado


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Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry


Arlette Yumba Mpanga, Wiktoria Struck-Lewicka, Renata Bujak, Marcin Markuszewski, Marek Roslan, Roman Kaliszan and Michał Jan Markuszewski*


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Recent Applications of Silver Amalgam Electrodes for Analysis of Pharmaceuticals and Vitamins


Sylwia Smarzewska, Radovan Metelka*, Bogusław Baś and Karel Vytřas


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Virome and Inflammasomes, a Finely Tuned Balance with Important Consequences for the Host Health


Giulia Freer, Fabrizio Maggi and Mauro Pistello*


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Recent Developments in the Separation of Low Molecular Weight Heparin Anticoagulants


Radosław Sadowski, Renata Gadzała-Kopciuch* and Bogusław Buszewski


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Platelet Oxidative Stress and its Relationship with Cardiovascular Diseases in Type 2 Diabetes Mellitus Patients


Mohammed El Haouari*


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Electronic Noses in Medical Diagnostics


Wojciech Wojnowski*, Anna Partyka, Tomasz Dymerski, Jacek Gębicki and Jacek Namieśnik


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Biomarkers of Alcohol Consumption in Body Fluids - Possibilities and Limitations of Application in Toxicological Analysis


Mateusz K. Woźniak*, Marek Wiergowski, Jacek Namieśnik and Marek Biziuk


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Recent Research Trends on Bismuth Compounds in Cancer Chemoand Radiotherapy


Mateusz Kowalik, Joanna Masternak and Barbara Barszcz*


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Gaultheria Ethnobotany and Bioactivity: Blueberry Relatives with Anti- inflammatory, Antioxidant, and Anticancer Constituents


Bin-sheng Luo, Rong-hui Gu, Edward J. Kennelly* and Chunlin Long


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Circulating MicroRNAs: Valuable Biomarkers for the Diagnosis and Prognosis of Gastric Cancer


Najibeh Shekari , Behzad Baradaran , Dariush Shanehbandi and Tohid Kazemi*


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Exposing “Bright” Metals: Promising Advances in Photoactivated Anticancer Transition Metal Complexes


Aleksandra Bjelosevic, Benjamin J. Pages, Lawson K. Spare, Krishant M. Deo, Dale L. Ang and Janice R. Aldrich-Wright*


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Polyphenols in Food: Cancer Prevention and Apoptosis Induction


Ashita Sharma, Mandeep Kaur, Jatinder Kaur Katnoria and Avinash Kaur Nagpal*


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Influenza Virus: Small Molecule Therapeutics and Mechanisms of Antiviral


Julianna Han, Jasmine Perez, Adam Schafer, Han Cheng, Norton Peet, Lijun Rong and Balaji Manicassamy*


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Structural Design and Physicochemical Foundations of Hydrogels for Biomedical Applications


Qingyong Li , Wen Li , Jie Xu, Zhengxiang Ning, Jiaoyan Ren* and Wenzhen Liao*


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Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity


Maricela Viola-Rhenals*, Kush Rohit Patel, Laura Jaimes-Santamaria, Guojun Wu, Jinbao Liu and Q Ping Dou


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Development of Potential Small Molecule Therapeutics for Treatment of Ebola Virus


Adam Michael Schafer, Han Cheng, Charles Lee, Ruikun Du, Julianna Han, Jasmine Perez, Norton Peet, Balaji Manicassamy and Lijun Rong*


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Smart Organic-Inorganic Nanogels for Activatable Theranostics


Fangyuan Li, Zeyu Liang and Daishun Ling*


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Old Drugs and New Targets as an Outlook for the Treatment of Tuberculosis


Jan Zitko* and Martin Doležal


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Molecular Mechanisms of Epigenetic Regulators as Activatable Targets in Cancer Theranostics


Yinglu Li*, Zhiming Li and Wei-Guo Zhu*


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Protective Effects of the Caffeine Against Neurodegenerative Diseases


Ester Tellone*, Antonio Galtieri, Annamaria Russo and Silvana Ficarra


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Rutin as Neuroprotective Agent: From Bench to Bedside


Barbara Budzynska, Caterina Faggio, Marta Kruk-Slomka, Dunja Samec, Seyed Fazel Nabavi, Antoni Sureda, Kasi Pandima Devi and Seyed Mohammad Nabavi*


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Pharmacotranscriptomic Biomarkers in Glucocorticoid Treatment of Pediatric Inflammatory Bowel Disease


Marianna Lucafò, Biljana Stankovic, Nikola Kotur, Alessia Di Silvestre, Stefano Martelossi, Alessandro Ventura, Branka Zukic, Sonya Pavlovic* and Giuliana Decorti


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Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines


Resmi C Panicker, Anthony G. Coyne and Rajavel Srinivasan*


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Role of Positron Emission Tomography for Central Nervous System Involvement in Systemic Autoimmune Diseases: Status and Perspectives


Daniele Mauro *, Gaetano Barbagallo , Salvatore D’Angelo, Sannino Pasqualina, Saverio Naty , Caterina Bruno, Ignazio Olivieri , Rosa Daniela Grembiale and Francesco Ursini


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Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites


Francesco Miceli, Maria Virginia Soldovieri, Paolo Ambrosino, Laura Manocchio, Alessandro Medoro, Ilaria Mosca and Maurizio Taglialatela*


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Pathophysiological Role of Mitochondrial Potassium Channels and their Modulation by Drugs


Valentina Citi, Vincenzo Calderone, Alma Martelli, Maria Cristina Breschi and Lara Testai*


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The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-obesity Effect


Qiu Jin , Huahua Yu and Pengcheng Li *


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The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations


Anutthaman Parthasarathy, Sasikala K. Anandamma and Karunakaran A. Kalesh*


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Biomarkers of Atrial Fibrillation in Metabolic Syndrome


Christos Georgakopoulos, Charalambos Vlachopoulos*, Georgios Lazaros and Dimitris Tousoulis


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The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes


Stefano Palazzolo, Samer Bayda, Mohamad Hadla, Isabella Caligiuri, Giuseppe Corona, Giuseppe Toffoli and Flavio Rizzolio*


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Hemicellulose from Plant Biomass in Medical and Pharmaceutical Application: A Critical Review


Xinxin Liu, Qixuan Lin, Yuhuan Yan, Fenf Peng, Runcang Sun and Junli Ren*


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Endocytosis of Nanoscale Systems for Cancer Treatments


Kai Chen, Xue Li, Hongyan Zhu, Qiyong Gong and Kui Luo*


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Improving Metabolic Control Through Functional Foods


John G. Jones* and Joao C.P. Silva


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Effects of Isolated Isoflavones Intake on Health


Antonella Smeriglio*, Antonella Calderaro, Marcella Denaro, Giuseppina Laganà and Ersilia Bellocco


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Current Progress of Lipid Analysis in Metabolic Diseases by Mass Spectrometry Methods


Adriana Mika*, Tomasz Sledzinski and Piotr Stepnowski


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Recent Advances in the Development of Pharmaceutical Agents for Metabolic Disorders: A Computational Perspective


Sridhara Janardhan, Varvara Dubovskaja, Alexey Lagunin, Venkateswara Rao, Narahari Sastry and Vladimir Poroikov*


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Cannabis Phenolics and their Bioactivities


Federica Pollastro*, Alberto Minassi and Luigia Grazia Fresu


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Phenolic Compounds from Edible Algae: Bioactivity and Health Benefits


Lidia Montero , Andrea del Pilar Sánchez-Camargo, Elena Ibáñez* and Bienvenida Gilbert-López


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Gut Microbiota as a Therapeutic Target for Metabolic Disorders


Hirofumi Okubo , Yusuke Nakatsu, Akifumi Kushiyama , Takeshi Yamamotoya , Yasuka Matsunaga , Masa-ki Inoue, Midori Fujishiro, Hideaki Sakoda , Haruya Ohno , Masayasu Yoneda, Hiraku Ono and Tomoichiro Asano *


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Circulating Stem/Progenitor Cells as Prognostic Biomarkers in Macro- and Microvascular Disease a Narrative Review of Prospective Observational Studies


Mauro Rigato and Gian Paolo Fadini*


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Modulation of ABC Transporters by Nuclear Receptors: Physiological, Pathological and Pharmacological Aspects


Juan Pablo Rigalli, Guillermo Nicolás Tocchetti and Johanna Weiss*


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Structure-based Approaches Targeting Parasite Cysteine Proteases


Rafael Pinto Vieira, Viviane Corrêa Santos and Rafaela Salgado Ferreira*


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Anesthetic Agents and Neuronal Autophagy. What We Know and What We Don’t.


Lili Xu , Jianjun Shen , Patrick M. McQuillan and Zhiyong Hu *


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Recent Advances and Perspectives in Liposomes for Cutaneous Drug Delivery


Amanda C. Caritá , Josimar O. Eloy , Marlus Chorilli, Robert J. Lee and Gislaine Ricci Leonardi*


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Bisphenol A in Reproduction: Epigenetic Effects


Rosanna Chianese, Jacopo Troisi, Sean Richards, Marika Scafuro , Silvia Fasano, Maurizio Guida , Riccardo Pierantoni and Rosaria Meccariello*


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Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients


Paola Savoia*, Elisa Zavattaro and Ottavio Cremona


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Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy


Aleksandra Hecel, Paulina Kolkowska, Karolina Krzywoszynska, Agnieszka Szebesczyk, Magdalena Rowinska-Zyrek and Henryk Kozlowski*


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Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose


Zhentao Huang, Qingxin Yao, Simin Wei, Jiali Chen and Yuan Gao*


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Organic Nanotheranostics for Photoacoustic Imaging-Guided Phototherapy


Houjuan Zhu , Chen Xie , Peng Chen and Kanyi Pu*


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Protozoan Parasites Glycosylphosphatidylinositol Anchors: Structures, Functions and Trends for Drug Discovery


Ana Luísa Malaco Morotti, Maristela Braga Martins-Teixeira and Ivone Carvalho*


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Role of Infrared Spectroscopy and Imaging in Cancer Diagnosis


Saroj Kumar *, Alagiri Srinivasan and Fredrik Nikolajeff


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New Drugs from Old Natural Compounds: Scarcely Investigated Sesquiterpenes as New Possible Therapeutic Agents


Stefania Suta, Filippo Maggi, Marcello Nicoletti, Valeria Baldan and Stefano Dall`Acqua*


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ATP-binding Cassette Exporters: Structure and Mechanism with a Focus on P-glycoprotein and MRP1


Maite Rocío Arana and Guillermo Altenberg*


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The Renal Outer Medullary Potassium Channel (ROMK): An Intriguing Pharmacological Target for an Innovative Class of Diuretic Drugs


Vincenzo Calderone*, Alma Martelli, Eugenia Piragine, Valentina Citi, Lara Testai and Maria Cristina Breschi


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Fighting Type-2 Diabetes: Present and Future Perspectives


Cai-Guo Yu , Ying Fu, Yuan Fang , Ning Zhang, Rong-Xin Sun , Dong Zhao, Ying-Mei Feng and Bao-Yu Zhang*


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Biological Therapy of Hematologic Malignancies: Toward a Chemotherapy- free Era


Pavel Klener*, Tomas Etrych and Pavel Klener


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Multicolorful Carbon Dots for Tumor Theranostics


Haitao Wang, Jingran Bi, Beiwei Zhu and Mingqian Tan*


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Nanoscale Functional Biomaterials for Cancer Theranostics


Linying Liu, Xiaoshuang Li, Lei Chen and Xin Zhang*


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Nutraceuticals and "Repurposed" Drugs of Phytochemical Origin in Prevention and Interception of Chronic Degenerative Disease and Cancer


Adriana Albini, Barbara Bassani, Denisa Baci, Katiuscia Dallaglio, Matteo Gallazzi, Paola Corradino, Antonino Bruno and Douglas Noonan*


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Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems


Xiao Sun, Guilong Zhang and Zhengyan Wu*


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From Ocean to Bedside: the Therapeutic Potential of Molluscan Hemocyanins


Negar Talaei Zanjani, Monica Miranda Saksena , Fariba Dehghani * and Anthony L. Cunningham *


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Polymer Conjugated Gold Nanoparticles in Biomedical Applications


Stanley Anniebell and Subash C.B. Gopinath


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Recent Advances in New Discovered Molecular Targets in Testicular Germ Cell Tumors


Paolo Chieffi*


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Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy


Qicai Xiao, Juan Wu , Xin Pang, Yue Jiang , Pan Wang, Albert Wingnang Leung, Liqian Gao , Sheng Jiang and Chuanshan Xu*


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In Vitro and In Vivo Experimental Model-based Approaches for Investigating Anti-inflammatory Properties of Coumarins


Silvana Virginia Gagliotti Vigil de Mello and Tânia Silvia Fröde *


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Cu2+ Biological Imaging Probes Based on Different Sensing Mechanisms


Jiawei Li, Fangjun Huo and Caixia Yin*


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Untargeted Metabolomics Provides Insight into the Mechanisms Underlying Resistant Hypertension


Renata Bujak, Arlette Yumba-Mpanga, Wiktoria Struck-Lewicka, Marta Kordalewska, Katarzyna Polonis, Małgorzata Patejko, Monika Mironiuk, Anna Szyndle, Marzena Chrostowska, Michał Hoffmann, Ryszard T. Smoleński, Roman Kaliszan, Krzysztof Narkiewicz and Michał J. Markuszewski*


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Amino Acid Degrading Enzymes and their Application in Cancer Therapy


Vadim S Pokrovsky*, Olga E Chepikova, Denis Zh Davydov, Andrey A Zamyatnin, Alexander N Lukashev and Elena V Lukasheva


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Bacterial Protein Mimetic of Peptide Hormone as a New Class of Protein- based Drugs


S. O. Fetissov*, Romain Legrand and Nicolas Lucas


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Steroidal Oximes: Useful Compounds with Antitumor Activities


Catarina Canário, Samuel Silvestre, Amílcar Falcão and Gilberto Alves*


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Cardioprotective Potential of Iron Chelators and Prochelators


Hana Jansova and Tomas Simunek*


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MicroRNAs in Neuroblastoma: Biomarkers with Therapeutic Potential


Angela Galardi, Marta Colletti , Pietro Businaro , Concetta Quintarelli , Franco Locatelli and Angela Di Giannatale*


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Inflammation and Cancer: In Medio Stat Nano


Roberto Molinaro, Claudia Corbo, Megan Livingston, Michael Evangelopoulos, Alessandro Parodi, Christian Boada, Marco Agostini and Ennio Tasciotti*


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Endothelial Progenitor Cells at the Interface of Chronic Kidney Disease: From Biology to Therapeutic Advancement


Giuseppe Coppolino*, Valeria Cernaro, Giordano Placida, Giuseppe Leonardi, Giorgio Basile and Davide Bolignano


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Stem Cell Differentiation Stage Factors and their Role in Triggering Symmetry Breaking Processes during Cancer Development: A Quantum Field Theory Model for Reprogramming Cancer Cells to Healthy Phenotypes


Pier Mario Biava*, Fabio Burigana, Roberto Germano, Philip Kurian, Claudio Verzegnassi and Giuseppe Vitiello


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Pollution and Sun Exposure: A Deleterious Synergy. Mechanisms and Opportunities for Skin Protection


Laurent Marrot*


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Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations


Roman V Kholodenko*, Daniel V. Kalinovsky, Igor I Doronin, Eugene D Ponomarev and Irina V Kholodenko


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Histone Deacetylase Inhibitors in Tumor Immunotherapy


Li-Ming Zhao* and Jie-Huan Zhang


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Endothelial Progenitor Cells as Mediators of the Crosstalk between Vascular Repair and Immunity: Lessons from Systemic Autoimmune Diseases


Javier Rodríguez-Carrio*, Patricia López and Ana Suárez


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Tungsten or Wolfram: Friend or Foe?


Maria Antonietta Zoroddu*, Serenella Medici, Massimiliano Peana, Valeria Marina Nurchi, Joanna I. Lachowicz, F Laulicht-Glickc and Max Costa


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Hydrogel Dressings for Advanced Wound Management


Antonio Francesko, Petya Petkova and Tzanko Tzanov*


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Applications of Multi-Target Computer-Aided Methodologies in Molecular Design of CNS Drugs


Oleg A. Raevsky, Azat Mukhametov, Veniamin Y. Grigorev, Alexey Ustyugov, Shwu-Chen Tsay, Reuben Jih-Ru Hwu, Nagendra Sastry Yarla, George E. Barreto, Gjumrakch Aliev* and Sergey O Bachurin


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Mechanisms and Drug Targets for Pancreatic Cancer Chemoprevention


Deepanshi Dhar, Komal Raina and Rajesh Agarwal*


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Recent Advances in the Cancer Bioimaging with Graphene Quantum Dots


Keheng Li, Xinna Zhao, Gang Wei and Zhiqiang Su


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Biomarkers in Atrial Fibrillation and Heart Failure


Evangelos Oikonomou*, Theodoros Zografos, Georgios-Angelos Papamikroulis, Gerasimos Siasos , Georgia Vogiatzi , Panagiotis Theofilis, Alexandros Briasoulis, Spyridon Papaioannou, Manolis Vavuranakis, Vasiliki Gennimata and Dimitris Tousoulis


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The Role of Cannabinoid Receptors in Renal Diseases


Hélène François* and Lola Lecru


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Cancer Treatment by Using Traditional Chinese Medicine: Probing Active Compounds in Anti-multidrug Resistance During Drug Therapy


Jian-shu Lou, Ping Yao and Karl W.K. Tism*


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MicroRNAs in Atrial Fibrillation


Alexandros Briasoulis*, Shikha Sharma, Tesfaye Telila, Sagar Mallikethi-Reddy, Nikolaos Papageorgiou, Evangelos Oikonomou and Dimitris Tousoulis


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Anticancer and Reversing Multidrug Resistance Activities of Natural Isoquinoline Alkaloids and their Structure-activity Relationship


Zhi-Xing Qing, Jia-Lu Huang, Xue-Yi Yang, Jing-Hong Liu, Hua-Liang Cao, Feng Xiang, Pi Cheng and Jian-Guo Zeng*


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Perspectives of Plant Natural Products in Inhibition of Cancer Invasion and Metastasis by Regulating Multiple Signaling Pathways


Md Shahid Sarwar, Hong-Jie Zhang and Siu Wai Tsang*


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In Silico Models for Nanomedicine: Recent Developments


Pietro Mascheroni and Bernhard Aribo Schrefler*


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Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice


Annalisa Marcuzzi, Claudia Loganes, Claudio Celeghini and Giulio Kleiner*


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Repositioning Drugs for Rare Immune Diseases: Hopes and Challenges for a Precision Medicine


Erica Valencic, Alenka Smid, Ziga Jakopin, Alberto Tommasini and Irena Mlinaric-Rascan*


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TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis


Sally E. Dickinson and Georg T. Wondrak*


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Known Triterpenes and their Derivatives as Scaffolds for the Development of New Therapeutic Agents for Cancer


Gregorio Peron*, Giovanni Marzaro and Stefano Dall’Acqua


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Atrial Fibrillation: Biomarkers Determining Prognosis


Savas Mazaris, Gerasimos Siasos*, Evangelos Oikonomou, Vicky Tsigkou, Manolis Vavuranakis, Eleni Kokkou, Marina Zaromitidou, Georgios-Angelos Papamikroulis, Athanasios G Papavassiliou, Spyridon Papaioannou, Nikolaos Papageorgiou, George Latsios, Christodoulos Stefanadis and Dimitris Tousoulis


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Tyrosinase Electrochemical Biosensors Monitoring Medicinally Significant Substances


Milan Sýs and Karel Vytřas*


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The Battle for Iron Between Humans and Microbes


Peggy L. Carver*


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Biosensing Technologies for Therapeutic Drug Monitoring


Anna Meneghello, Stefano Tartaggia, Maria Domenica Alvau, Federico Polo* and Giuseppe Toffoli


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Transient Production of Recombinant Pharmaceutical Proteins in Plants: Evolution and Perspectives


Lilya Kopertekh* and Joachim Schiemann


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Tackling Chronic Pain and Inflammation through the Purinergic System


Giulia Magni, Daniele Riccio and Stefania Ceruti*


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Recent Advances on Cellulose-Based Nano-Drug Delivery Systems: Design of Prodrugs and Nanoparticles


Lin Dai and Chuanling Si*


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Chronic Wounds: Innovations in Diagnostics and Therapeutics


Marieke Haalboom*


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Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management


Manee Patanaponpibul and Qiao-Hong Chen*


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Advances in the Prediction of Protein Aggregation Propensity


Irantzu Pallarès* and Salvador Ventura


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Clinical Approach to Diabetic Cardiomyopathy: A Review of Human Studies


Roberto Tarquini , Laura Pala , Simona Brancati , Giulia Vannini, Salvatore De Cosmo , Gianluigi Mazzoccoli* and Carlo Maria Rotella


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Review on Anti-Cancer Activity in Wild Plants of the Middle East


Einav Mayzlish-Gati, Marcelo Fridlender, Rameshprabu Nallathambi, Gopinath Selvaraj, Stalin Nadarajan and Hinanit Koltai*


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Lipid Oxidation Products in the Pathogenesis of Inflammation-related Gut Diseases


Barbara Sottero, Daniela Rossin, Giuseppe Poli and Fiorella Biasi*


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New Perspectives on Biomedical Applications of Iron Oxide Nanoparticles


Massimiliano Magro, Davide Baratella, Emanuela Bonaiuto, Jessica de Almeida Roger and Fabio Vianello*


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Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals


Mirjana B. Čolović, Vesna M. Vasić, Dragan M. Djuric and Danijela Z. Krstić*


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Pigment Epithelium-Derived Factor: A Novel Therapeutic Target for Cardiometabolic Diseases and Related Complications


Sho-ichi Yamagishi* and Takanori Matsui


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Anticancer Polyphenols from Cultured Plant Cells: Production and New Bioengineering Strategies


Victor Bulgakov*, Yulia V. Vereshchagina and Galina N. Veremeichik


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EPC Dysfunction and Immune Networks: Translating Opportunities for Clinical Setting in Personalized Medicine


Javier Rodríguez-Carrio*, Patricia López and Ana Suárez


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Metabolic Imbalance of Homocysteine and Hydrogen Sulfide in Kidney Disease


Karmin O* and Yaw L. Siow


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The Role of Dietary Approach in Irritable Bowel Syndrome


Piero Portincasa*, Antony Lembo, Ornella De Bari, Domenica M. Di Palo, Anna Maggio, Ilaria Cataldo and Giuseppe Calamita


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Overview of Cantharidin and its Analogues


Guofang Wang , Jian Dong and Liping Deng *


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Chemopreventive Properties of Tolfenamic Acid: A Mechanistic Review


David Feldman, Elizabeth Leahy and Seong-Ho Lee *


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Sulfur Containing Acridine Derivatives in Preclinical Studies with Cancer Cell Lines


Salem Othman and Kožurková Mária *


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Hepatic AMP Kinase as a Potential Target for Treating Nonalcoholic Fatty Liver Disease: Evidence from Studies of Natural Products


Gang Xu , Kaixun Huang and Jun Zhou *


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Design and Discovery of New Antibacterial Agents: Advances, Perspectives, Challenges


Josef Jampilek*


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Dihydroresveratrol Type Dihydrostilbenoids: Chemical Diversity, Chemosystematics, and Bioactivity


Sara Vitalini, Serhat Sezai Cicek, Sebastian Granica and Christian Zidorn*


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Anti-inflammatory Natural Prenylated Phenolic Compounds - Potential Lead Substances


Viliam Brezáni, Karel Šmejkal*, Jan Hošek and Veronika Tomášová


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Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus


Silvia Tejada, Samuel Pinya , Miquel Martorell, Xavier Capó, Josep A. Tur, Antoni Pons and Antoni Sureda*


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Fungal Production and Manipulation of Plant Hormones


Sandra Fonseca, Dhanya Radhakrishnan, Kalika Prasad and Andrea Chini*


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Innovative Opioid Peptides and Biased Agonism: Novel Avenues for More Effective and Safer Analgesics to Treat Chronic Pain


Andrea Bedini* and Santi Mario Spampinato


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Piperine as a Potential Anti-cancer Agent: A Review on Preclinical Studies


Azadeh Manayi, Seyed Mohammad Nabavi, William N. Setzer and Samineh Jafari*


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Effects of Diets on Adipose Tissue


Silvia Ezquerro, Amaia Rodríguez, Piero Portincasa and Gema Frühbeck*


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Immunoprevention of Pancreatic Cancer


Chinthalapally Rao, Altaf Mohammed, Adam Asch and Naveena Janakiram


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Lignocellulosic Biomass Derived Functional Materials: Synthesis and Applications in Biomedical Engineering


Lei Zhang, Linxin Zhong, Weitian Chua, Zhihua Xiang and Runcang Sun*


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Autophagy as a Molecular Target of Flavonoids Underlying their Protective Effects in Human Disease


Néstor Prieto-Domínguez, María V García-Mediavilla , Sonia Sánchez-Campos, José Luis Mauriz and Javier González-Gallego*


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Therapeutic Drug Monitoring in Pediatric IBD: Current Application and Future Perspectives


Sara Lega, Matteo Bramuzzo and Marla Dubinsky*


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Stimuli-responsive Carriers for Controlled Intracellular Drug Release


Yan Sheng*, Jiaming Hu, Junfeng Shi and Ly James Lee


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Induced Pluripotent Stem Cells as a Model for Therapy Personalization of Pediatric Patients: Disease Modeling and Drug Adverse Effects Prevention


Elena Genova, Marco Pelin, Katsunori Sasaki*, Yue Fengming, Gaetana Lanzi, Stefania Masneri, Alessandro Ventura, Gabriele Stocco and Giuliana Decorti


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