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Current Drug Metabolism

Volume 20, 14 Issues, 2019
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

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Volume 20

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Number 1



Biography   Open Access



Preface   Open Access



Editorial   Open Access



Review Article



Review Article



Review Article

The Therapeutic Role of Xenobiotic Nuclear Receptors Against Metabolic Syndrome

, 20(1): 15 - 22

Shuqi Pu, Xiaojie Wu, Xiaoying Yang, Yunzhan Zhang, Yunkai Dai, Yueling Zhang, Xiaoting Wu, Yan Liu, Xiaona Cui, Haiyong Jin, Jianhong Cao, Ruliu Li, Jiazhong Cai, Qizhi Cao*, Ling Hu* and Yong Gao*


DOI: 10.2174/1389200219666180611083155


Review Article



Review Article

The Role of Xenobiotic Receptors on Hepatic Glycolipid Metabolism

, 20(1): 29 - 35

Ke Chen, Jinwei Zhong, Lin Hu, Ruliu Li, Qun Du, Jiazhong Cai, Yanwu Li, Yong Gao, Xiaona Cui, Xiaoying Yang, Xiaojie Wu, Lu Yao, Juji Dai, Yan Wang and Haiyong Jin*


DOI: 10.2174/1389200219666180918152241


Articles Ahead of Print


Genitourinary Tumors: Update on Molecular Biomarkers for Diagnosis, Prognosis and Prediction of Response to Therapy


Alessia Cimadamore, Marina Scarpelli, Matteo Santoni, Francesco Massari, Francesca Tartari, Roy Cerqueti, Antonio Lopez-Beltran, Liang Cheng and Rodolfo Montironi*


View Abstract View on PubMed



Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis


Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*


View Abstract View on PubMed


Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer/ Accelerator Mass Spectrometry


Clemens Muehlan*, Hartmut Fischer, Dieter Zimmer, Hamed Aissaoui, Julien Grimont, Christoph Boss, Marie Croft, Joop van Gerven, Stephan Krähenbühl and Jasper Dingemanse


View Abstract View on PubMed




Iron Oxide Nanoparticles for Breast Cancer Theranostics


Md Salman Shakil, Md Ashraful Hasan and Satya Ranjan Sarker*


View Abstract View on PubMed




Abstracts Ahead of Print

Editor's Choice



Sodium Oxybate Therapy for Alcohol Withdrawal Syndrome and Keeping of Alcohol Abstinence

, 2018; 19(13): 1056 - 1064

Carmen Mannucci, Simona Pichini, Elvira Ventura Spagnolo, Fabrizio Calapai, Sebastiano Gangemi, Michele Navarra and Gioacchino Calapai*


DOI: 10.2174/1389200219666171207122227









Regulation of Mammalian UDP-Glucuronosyltransferases

, 2018; 19(6): 490 - 501

Hong Wang, Guoxiu Cao, Guangji Wang* and Haiping Hao*


DOI: 10.2174/1389200219666180307122945



Open Access Articles

Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2018; 19: 1 - 9 (E-Pub Ahead of Print)

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*




Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum




A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics?

, 2014; 15(6): 581 - 598

Lorena Baietto, Silvia Corcione, Giovanni Pacini, Giovanni Di Perri, Antonio D’Avolio and Francesco Giuseppe De Rosa




Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

, 2014; 15(2): 209 - 217

Kelly E. Caudle, Teri E. Klein, James M. Hoffman, Daniel J. Muller, Michelle Whirl-Carrillo, Li Gong, Ellen M. McDonagh, Katrin Sangkuhl, Caroline F. Thorn, Matthias Schwab, Jose A.G. Agundez, Robert R. Freimuth, Vojtech Huser, Ming Ta Michael Lee, Otito F. Iwuchukwu, Kristine R. Crews, Stuart A. Scott, Mia Wadelius, Jesse J. Swen, Rachel F. Tyndale, C. Michael Stein, Dan Roden, Mary V. Relling, Marc S. Williams and Samuel G. Johnson











Most Cited Articles

Bile Acids in Physiology, Pathology and Pharmacology

, 2016; 17(1): 4-29.

Jose J.G. Marin, Rocio I.R. Macias, Oscar Briz, Jesus M. Banales and Maria J. Monte


DOI: 10.2174/1389200216666151103115454


Cannabinoids and Cytochrome P450 Interactions

, 2016; 17(3): 206-226.

Ondřej Zendulka, Gabriela Dovrtělová, Kristýna Nosková, Miroslav Turjap, Alexandra Šulcová, Lumír Hanuš and Jan Juřica


DOI: 10.2174/1389200217666151210142051


Delivery of Nanoparticles for Treatment of Brain Tumor

, 2016; 17(8): 745-754.

Chen Kang, Yuan Sun, Jing Zhu, Wen Li, Aili Zhang, Tairong Kuang, Jing Xie and Zhaogang Yang


DOI: 10.2174/1389200217666160728152939



Diabetic Nephropathy: Focus on Current and Future Therapeutic Strategies

, 2016; 17(5): 497-502.

Riccardo Pofi, Francesca Di Mario, Antonietta Gigante, Edoardo Rosato, Andrea M. Isidori, Antonio Amoroso, Rosario Cianci and Biagio Barbano


DOI: 10.2174/138920021705160324165553



Actively Targeted Nanoparticles for Drug Delivery to Tumor

, 2016; 17(8): 763-782.

Ye Bi, Fei Hao, Guodong Yan, Lesheng Teng, Robert J. Lee and Jing Xie


DOI: 10.2174/1389200217666160619191853



Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism

, 2016; 17(5): 412-429.

Nóra Török, Zsófia Majláth, Ferenc Fülöp, József Toldi and László Vécsei


DOI: 10.2174/1389200217666151222155043




Most Accessed Articles





Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

, 2009; 10(5): 470-481.

Jorg Thomas Hartmann, Michael Haap, Hans-Georg Kopp and Hans-Peter Lipp


DOI: 10.2174/138920009788897975






Pharmacokinetic and Pharmacodynamic Properties of Anti-VEGF Drugs After Intravitreal Injection

, 2015; 16(7): 572-584.

Francesco Semeraro, Francesco Morescalchi, Sarah Duse, Elena Gambicorti, Anna Cancarini and Ciro Costagliola


DOI: 10.2174/1389200216666151001120831



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