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Current Drug Metabolism

Volume 20, 14 Issues, 2019
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 20

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Number 2



Biography   Open Access



Review Article



Review Article   Open Access



Review Article   Open Access

Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*


DOI: 10.2174/1389200219666181003143312


Review Article



Review Article



Review Article



Review Article   Open Access



Current Drug Metabolism, Volume 20 (2019) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Current Drug Metabolism, Volume 20 (2019) - Number 3


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print




Effects of Radiation on Drug Metabolism: A Review


Xiangyang Li*, Jianxin Yang, Yijie Qiao, Yabin Duan, Yuanyao Xin, Yongqiong Nian, Lin Zhu and Guiqin Liu


View Abstract View on PubMed


Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure


Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato


View Abstract View on PubMed



Iron Oxide Nanoparticles for Breast Cancer Theranostics


Md Salman Shakil, Md Ashraful Hasan and Satya Ranjan Sarker*


View Abstract View on PubMed



Nanotherapeutics for the Treatment of Cancer and Arthritis


Pal Patel, Nikita Meghani, Krupa Kansara and Ashutosh Kumar*


View Abstract View on PubMed



Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice




Sodium Oxybate Therapy for Alcohol Withdrawal Syndrome and Keeping of Alcohol Abstinence

, 2018; 19(13): 1056 - 1064

Carmen Mannucci, Simona Pichini, Elvira Ventura Spagnolo, Fabrizio Calapai, Sebastiano Gangemi, Michele Navarra and Gioacchino Calapai*


DOI: 10.2174/1389200219666171207122227









Open Access Articles

Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum




A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics?

, 2014; 15(6): 581 - 598

Lorena Baietto, Silvia Corcione, Giovanni Pacini, Giovanni Di Perri, Antonio D’Avolio and Francesco Giuseppe De Rosa




Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

, 2014; 15(2): 209 - 217

Kelly E. Caudle, Teri E. Klein, James M. Hoffman, Daniel J. Muller, Michelle Whirl-Carrillo, Li Gong, Ellen M. McDonagh, Katrin Sangkuhl, Caroline F. Thorn, Matthias Schwab, Jose A.G. Agundez, Robert R. Freimuth, Vojtech Huser, Ming Ta Michael Lee, Otito F. Iwuchukwu, Kristine R. Crews, Stuart A. Scott, Mia Wadelius, Jesse J. Swen, Rachel F. Tyndale, C. Michael Stein, Dan Roden, Mary V. Relling, Marc S. Williams and Samuel G. Johnson







Most Cited Articles

Review Article

Medicinal and therapeutic potential of herbs and plant metabolites/extracts countering viral pathogens-current knowledge and future prospects

, 2018; 19(3): 236-263.

Kuldeep Dhama*, Kumaragurubaran Karthik, Rekha Khandia, Ashok Munjal, Ruchi Tiwari, Rajneesh Rana, Sandip Kumar Khurana, Sana Ullah, Rifat Ullah Khan, Mahmoud Alagawany, Mayada Ragab Farag, Maryam Dadar and Sunil Kumar Joshi


DOI: 10.2174/1389200219666180129145252


Review Article

Long circulating polymeric nanoparticles for gene/drug delivery

, 2018; 19(9): 723-738.

Jiaming Hu, Yan Sheng*, Junfeng Shi, Bohao Yu, Zhiqiang Yu and Guochao Liao*


DOI: 10.2174/1389200219666171207120643


Review Article

Herbal immunomodulators - A remedial panacea for designing and developing effective drugs and medicines: Current scenario and future prospects

, 2018; 19(3): 264-301.

Ruchi Tiwari*, Shyma K. Latheef, Ishtiaq Ahmed, Hafiz M.N. Iqbal, Mohammed Hussen Bule, Kuldeep Dhama, Hari Abdul Samad, Kumaragurubaran Karthik, Mahmoud Alagawany, Mohamed Ezzat Abd El-Hack, Mohd. Iqbal Yatoo and Mayada Ragab Farag


DOI: 10.2174/1389200219666180129125436



Review Article

An insight into the therapeutic potential of major coffee components

, 2018; 19(6): 544-556.

Muhammad Torequl Islam*, Shams Tabrez*, Nasimudeen R. Jabir, Murtaza Ali, Mohammad Amjad Kamal, Lidiane da Silva Araujo, Jose Victor De Oliveira Santos, Ana Maria Oliveira Ferreira Da Mata, Rai Pablo Sousa De Aguiar and Ana Amelia de Carvalho Melo Cavalcante


DOI: 10.2174/1389200219666180302154551


Review Article

Role of mitochondrial mechanism in chemotherapy-induced peripheral neuropathy

, 1 January 2018; 19(1): 47-54.

Mohammad Waseem, Pooja Kaushik, Heena Tabassum* and Suhel Parvez


DOI: 10.2174/1389200219666171207121313


Review Article

Adverse events of proton pump inhibitors: Potential mechanisms

, 2018; 19(2): 142-154.

Andrea Corsonello*, Fabrizia Lattanzio, Silvia Bustacchini, Sabrina Garasto, Annalisa Cozza, Roberto Schepisi, Federica Lenci, Filippo Luciani, Marcello Giuseppe Maggio, Andrea Ticinesi, Valeria Butto, Sara Tagliaferri and Francesco Corica


DOI: 10.2174/1389200219666171207125351


Review Article

Current state of in vitro cell-based renal models

, 2018; 19(4): 310-326.

Elnaz Gozalpour* and Katherine S. Fenner


DOI: 10.2174/1389200219666180119115133


Review Article

Current therapeutic approaches for targeting inflammation in depression and cardiovascular disease

, 2018; 19(8): 674-687.

Pedro Zuzarte, Angela Duong, Maria L. Figueira, Atilio Costa-Vitali and Gustavo Scola*


DOI: 10.2174/1389200219666180305143501


Review Article

Replacing GHB with GBL in recreational settings: A new trend in chemsex

, 2018; 19(13): 1080-1085.

Francesco Paolo Busardò*, Massimo Gottardi, Anastasio Tini, Adele Minutillo, Ascanio Sirignano, Enrico Marinelli and Simona Zaami


DOI: 10.2174/1389200219666180925090834


General Review Article

Anti-cancer effects of metformin: Recent evidences for its role in prevention and treatment of cancer

, 2018; 19(9): 793-797.

Masoumeh Kheirandish, Hamidreza Mahboobi*, Maryam Yazdanparast, Warda Kamal and Mohammad Amjad Kamal


DOI: 10.2174/1389200219666180416161846



Review Article

Plant-derived polyphenols in human health: Biological activity, metabolites and putative molecular targets

, 2018; 19(4): 351-369.

Marilo Olivares-Vicente, Enrique Barrajon-Catalan*, Maria Herranz-Lopez, Antonio Segura-Carretero, Jorge Joven, Jose Antonio Encinar and Vicente Micol


DOI: 10.2174/1389200219666180220095236


Review Article

Pharmacokinetics, metabolism, distribution and permeability of nanomedicine

, 2018; 19(4): 327-334.

Selvan Ravindran*, Jitendra Kumar Suthar , Rutuja Rokade, Pooja Deshpande, Pooja Singh, Ashutosh Pratinidhi, Rajeshree Khambadkhar and Srushti Utekar


DOI: 10.2174/1389200219666180305154119


Research Article

Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 individuals

, 2018; 19(4): 370-381.

Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Marc van Dijk, Yongjie Zhang, Stefan J. Dekker, Lukas Wijaya, Nico P.E. Vermeulen, Lysiane Richert, Jan N.M. Commandeur and J. Chris Vos*


DOI: 10.2174/1389200219666180108160046



Most Accessed Articles






Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

, 2009; 10(5): 470-481.

Jorg Thomas Hartmann, Michael Haap, Hans-Georg Kopp and Hans-Peter Lipp


DOI: 10.2174/138920009788897975




Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver

, 2007; 8(1): 33-45.

Zoe E. Barter, Martin K. Bayliss, Philip H. Beaune, Alan R. Boobis, David J. Carlile, Robert J. Edwards, J. Brian Houston, Brian G. Lake, John C. Lipscomb, Olavi R. Pelkonen, Geoffrey T. Tucke and Amin Rostami-Hodjegan


DOI: 10.2174/138920007779315053


Pharmacokinetic and Pharmacodynamic Properties of Anti-VEGF Drugs After Intravitreal Injection

, 2015; 16(7): 572-584.

Francesco Semeraro, Francesco Morescalchi, Sarah Duse, Elena Gambicorti, Anna Cancarini and Ciro Costagliola


DOI: 10.2174/1389200216666151001120831



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