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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 22, 10 Issues, 2019
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Ranking and Category

  • 67th of 79 in

    Biochemical Research Methods

  • 39th of 71 in

    Chemistry, Applied

  • 220th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 22

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Number 6



Biography   Open Access



Current Frontiers   Open Access



Research Article

Molecular Docking Supplements an In vitro Determination of the Leading CYP Isoform for Arylpiperazine Derivatives

, 22(6): 370 - 378

Szymon Ulenberg, Tomasz Bączek*, Joanna Zieliñska, Mariusz Belka, Marek Król and Franciszek Herold


DOI: 10.2174/1386207322666190705143322


Research Article

Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, C ell Morphogenesis and Cancer Development

, 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*


DOI: 10.2174/1386207322666190704095602


Research Article



Research Article

Substituted Furanocoumarins as Novel Class of Antibacterial Translation Inhibitors

, 22(6): 400 - 410

Yan A. Ivanenkov, Renat S. Yamidanov, Ilya A Osterman, Petr V. Sergiev , Andrey A. Ayginin*, Vladimir A. Aladinskiy , Anastasia V. Aladinskaya , Victor A. Terentiev , Mark S. Veselov, Dmitry A. Skvortsov, Katerina S. Komarova , Alexey V. Chemeris, Liana F. Zainullina, Marina A. Maximova, Zulfiya R. Zileeva, Yulia V. Vakhitova, Alexey Kh. Baymiev, Andrey Kh. Baymiev, Alina A. Sofronova, Alexey E. Machulkin, Rostislav A. Petrov, Dmitry S. Bezrukov , Maria M. Puchinina, Dmitrii A. Lukianov and Olga A. Dontsova


DOI: 10.2174/1386207322666190723110539


Research Article



Research Article



Articles Ahead of Print

Role of Ischemia Modified Albumin Serum Levels as an Oxidative Stress Marker in Children with Diabetic Ketoacidosis


Mutlu Uysal Yazıcı*, Ganime Ayar, Senay Savas-Erdeve, Ebru Azapağası, Salim Neşelioğlu, Özcan Erel and Semra Çetinkaya


DOI: 10.2174/1386207322666191008214919
View Abstract View on PubMed



From the Explored to the Unexplored: Computer-Tailored Drug Design Attempts in the Discovery of Selective Caspase Inhibitors


Ransford Kumi Oduro, Abdul Rashid Issahakua, Opeyemi S. Soremekun, Clement Agoni, Fisayo A. Olotu and Mahmoud E. S. Soliman*


DOI: 10.2174/1386207322666190927143026
View Abstract View on PubMed





Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique


Kunhao Qin, Shengting Zhang, Jie Wang, Dongbo Liu, Yingying Xiang, Xiuling Ji and Yunlin Wei*


DOI: 10.2174/1386207322666190919143735
View Abstract View on PubMed


Same Target, Different Therapeutic Outcomes: The Case of CAY10471 and Fevipiprant on CRTh2 Receptor in Treatment of Allergic Rhinitis and Asthma


Abdul Rashid Issahaku, Clement Agoni, Opeyemi S. Soremekun, Patrick Appiah Kubi, Ransford K. Oduro, Fisayo A. Olotu and Mahmoud E. S. Soliman


DOI: 10.2174/1386207322666190919113006
View Abstract View on PubMed



Salivary Antioxidants and Oxidative Stress Markers in Male Smokers


Fatemeh Ahmadi-Motamayel*, Parisa Falsafi, Hamidreza Abolsamadi, Mohammad Taghi Goodarzi and Jalal Poorolajal


DOI: 10.2174/1386207322666190806123616
View Abstract View on PubMed


Abstracts Ahead of Print

Enrichment of Up-regulated and Down-regulated gene clusters using gene ontology, miRNAs and lncRNAs in colorectal cancer


Fahimeh Fattahi, Jafar Kiani, Mohsen Khosravi, Somayeh Vafaei, Asghar Mohammadi, Zahra Madjd* and Mohammad Najafi*


DOI: 10.2174/1386207321666191010114149
View Abstract


Published Contents

Editor's Choice



Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model

, 2019; 22(4): 256 - 265

Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Jie Li, Liyun Zheng, Fazong Wu, Dengke Zhang, Xihui Ying and Jiansong Ji*


DOI: 10.2174/1386207322666190530102245



Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma

, 2019; 22(3): 201 - 206

Jiangshan Lian, Xiaolin Zhang, Yingfeng Lu, Shaorui Hao, Zhe Zhang and Yida Yang*


DOI: 10.2174/1386207322666190404151020



Progress in Molecularly Imprinted Polymers for Biomedical Applications

, 2019; 22(2): 78 - 88

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526




Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review

, 2018; 21(10): 801 - 805

Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan* and Da Li*


DOI: 10.2174/1386207322666190103105938



Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals

, 2018; 21(9): 616 - 630

Gary Diamond, Alfred Hagemeyer*, Vince Murphy and Valery Sokolovskii


DOI: 10.2174/1386207322666181219155050





Open Access Articles

Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*




Chemical Informatics and the Drug Discovery Knowledge Pyramid

, 2013; 16(10): 764 - 776

Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham







Alternative Medicine Safety: Agaricus blazei and Propolis

, 2011; 14(7): 616 - 621

Kenji Sorimachi* and Takaaki Nakamoto




The Design and Application of Target-Focused Compound Libraries

, 2011; 14(6): 521 - 531

C. John Harris, Richard D. Hill, David W. Sheppard*, Martin J. Slater and Pieter F.W. Stouten





Most Cited Articles

Research Article

Prediction of nitrated tyrosine residues in protein sequences by extreme learning machine and feature selection methods

, 2018; 21(6): 393-402.

Lei Chen*, ShaoPeng Wang, Yu-Hang Zhang , Lai Wei , XianLing Xu, Tao Huang * and Yu-Dong Cai *


DOI: 10.2174/1386207321666180531091619




Research Article

Prediction of drug combinations with a network embedding method

, 2018; 21(10): 789-797.

Tianyun Wang, Lei Chen* and Xian Zhao


DOI: 10.2174/1386207322666181226170140




Research Article

One-pot synthesis of novel 2-pyrazolo-3-phenyl-1,3-thiazolidine-4-ones using DSDABCOC as an effective media

, 1 January 2018; 21(1): 5-13.

Mostafa Fathollahi, Shahnaz Rostamizadeh* and Ali M. Amani


DOI: 10.2174/138620732166618012409405


Research Article

Identification of human acetylcholinesterase inhibitors from the constituents of EGb761 by modeling docking and molecular dynamics simulations

, 1 January 2018; 21(1): 41-49.

Lihu Zhang, Dongdong Li, Fuliang Cao, Wei Xiao*, Linguo Zhao*, Gang Ding and Zhen zhong Wang


DOI: 10.2174/1386207320666171123201910




Research Article

Pyrazole schiff base hybrids as anti-malarial agents: Synthesis, in vitro screening and computational study

, 2018; 21(3): 194-203.

Shilpy Aggarwal, Deepika Paliwal, Dhirender Kaushik, Girish Kumar Gupta and Ajay Kumar*


DOI: 10.2174/1386207321666180213092911




Research Article

Serum interleukin-33 as a biomarker in predicting neonatal sepsis in premature infants

, 2018; 21(7): 510-515.

Halit Halil*, Cuneyt Tayman, Mehmet Buyuktiryaki, Nilufer Okur, Ufuk Cakır and Utku Serkant


DOI: 10.2174/1386207321666180911090656




Most Accessed Articles

Facile Synthesis and Cytotoxicity of Phenazine-Chromene Hybrid Molecules Derived from Phenazine Natural Product

, 2019; 22(1): 35-40.

Mei-Chen Zhang, Shu-Hui Gu, Guang-Pan Liu, Chen-Cheng Li, Han-Mei Xu*, Zhong-Xi Wu, Bo-Ping Ye, Yuan-Yuan Lu, De-Chun Huang, Zhi-Xiang Wang and Feng Jiang*


DOI: 10.2174/1386207322666190307125015


Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379-386.

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*


DOI: 10.2174/1386207322666190704095602






Ultrastructural Analysis of Human Gallstones using Synchrotron Radiation µCT

, 2019; 22(1): 13-17.

Weixin Chen, Riming Liu, Suo Tao, Weixing Shen, Weihong Zhou, Chao Song, Huanhua Lu and Chungen Xing*


DOI: 10.2174/1386207322666190222122007


Progress in Molecularly Imprinted Polymers for Biomedical Applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526


Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer

, 2019; 22(2): 113-122.

Xin-guo Zhang*, Guo-Yan Ma, Fei Kou, Wen-Jie Liu, Qiao-Yun Sun, Guang-Jun Guo, Xiao-Di Ma, Si-Jia Guo and Zhu Jian-Ning


DOI: 10.2174/1386207322666190415100618





Editor-in-Chief

Gerald H. Lushington
LiS Consulting, Lawrence
KS
USA

Biography View Full Editorial Board

Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
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