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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 23, 10 Issues, 2020
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Ranking and Category

  • 67th of 79 in

    Biochemical Research Methods

  • 39th of 71 in

    Chemistry, Applied

  • 220th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 22

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Number 10



Biography   Open Access



Editorial   Open Access



Research Article



Research Article



Research Article



Research Article



Research Article



Research Article



Articles Ahead of Print






Effectiveness of Tolvaptan in the Treatment for Patients with Autosomal Dominant Polycystic Kidney Disease: A Meta-analysis


Xuan Xie, Qian Cai, Xiao-Yuan Guo, Dong-Hai Bai, Hai-Zhong Sheng, Bao-Kui Wang*, Kai Yan, An-Ming Lu and Xin-Ran Wang


DOI: 10.2174/1386207322666191203092715
View Abstract View on PubMed





Relating Substructures and Side Effects of Drugs with Chemical-Chemical Interactions


Bo Zhou*, Xian Zhao, Jing Lu, Zuntao Sun, Min Liu, Yilu Zhou, Rongzhi Liu and Yihua Wang


DOI: 10.2174/1386207322666190702102752
View Abstract


Abstracts Ahead of Print

Three differentially expressed miRNAs as potential biomarkers for lung adenocarcinoma prognosis


Wei Wang, Bin Liu, Xiaoran Duan, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Mingcui Ding, Qiao Zhang, Feifei Feng, Yongjun Wu, Wu Yao, Qi Wang and Yongli Yang*


DOI: 10.2174/1386207323666200124123103
View Abstract


Systematic Understanding of the Mechanisms of Flos Chrysanthemi Indici-mediated Eeffects on Hypertension via Computational Target Fishing


Ye-hui Chen, Shan-shan Lei, Bo Li, Rong Luo, Xinglishang He, Yu-zhi Wang, Fu-chen Zhou, Gui-yuan Lv* and Su-hong Chen*


DOI: 10.2174/1386207323666200122105410
View Abstract


Combinatorial Synthesis of Novel 9R-Acyloxyquinine Derivatives as Insecticidal Agents


Zhiping Che*, Jinming Yang, Di Sun, Yuee Tian, Shengming Liu, Xiaomin Lin, Jia Jiang and Genqiang Chen


DOI: 10.2174/1386207323666200120112714
View Abstract






Published Contents

Editor's Choice

Synthesis of 2-Substituted 4-Arylidene-5(4H)-oxazolones as Potential Cytotoxic Agents in the Presence of Lemon Juice as a Biocatalyst

, 2019; 22(9): 625 - 634

Malavattu G. Prasad, Chapala V. Lakshmi, Naresh K. Katari*, Krishnan Anand, Manojit Pal* and Sreekantha B. Jonnalagadda


DOI: 10.2174/1386207322666191024105150




Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique

, 2019; 22(7): 445 - 454

Kunhao Qin, Shengting Zhang, Jie Wang, Dongbo Liu, Yingying Xiang, Xiuling Ji and Yunlin Wei*


DOI: 10.2174/1386207322666190919143735





Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model

, 2019; 22(4): 256 - 265

Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Jie Li, Liyun Zheng, Fazong Wu, Dengke Zhang, Xihui Ying and Jiansong Ji*


DOI: 10.2174/1386207322666190530102245



Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma

, 2019; 22(3): 201 - 206

Jiangshan Lian, Xiaolin Zhang, Yingfeng Lu, Shaorui Hao, Zhe Zhang and Yida Yang*


DOI: 10.2174/1386207322666190404151020



Progress in Molecularly Imprinted Polymers for Biomedical Applications

, 2019; 22(2): 78 - 88

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526




Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review

, 2018; 21(10): 801 - 805

Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan* and Da Li*


DOI: 10.2174/1386207322666190103105938



Open Access Articles

Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*




Chemical Informatics and the Drug Discovery Knowledge Pyramid

, 2013; 16(10): 764 - 776

Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham







Alternative Medicine Safety: Agaricus blazei and Propolis

, 2011; 14(7): 616 - 621

Kenji Sorimachi* and Takaaki Nakamoto





Most Cited Articles




Review Article

Progress in molecularly imprinted polymers for biomedical applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526



Research Article

Statistical modelling outcome of in vitro fertilization and intracytoplasmic sperm injection: A single centre study

, 2019; 22(4): 225-231.

Boyun Xu, Chang Liu, Lianfen Qian, Yue Qu, Weijue Su, Jialing Xu and Junzhao Zhao*


DOI: 10.2174/1386207322666190404145448






Research Article

Identification of genes associated with lung adenocarcinoma prognosis

, 2019; 22(4): 220-224.

Zhe-Hao He, Wang Lv, Lu-Ming Wang, Yi-Qing Wang and Jian Hu*


DOI: 10.2174/1386207322666190404152140



Research Article

Recognition of lung adenocarcinoma-specific gene pairs based on genetic algorithm and establishment of a deep learning prediction model

, 2019; 22(4): 256-265.

Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Jie Li, Liyun Zheng, Fazong Wu, Dengke Zhang, Xihui Ying and Jiansong Ji*


DOI: 10.2174/1386207322666190530102245



Case Report

Closed loop duodenal obstruction secondary to pancreatic carcinoma: A case report

, 2019; 22(4): 280-286.

Zhihong Shen, Jianhua Yu, Haijun Tang and Baochun Lu*


DOI: 10.2174/1386207322666190411112412



Most Accessed Articles


Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379-386.

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*


DOI: 10.2174/1386207322666190704095602




Molecular Docking Supplements an In vitro Determination of the Leading CYP Isoform for Arylpiperazine Derivatives

, 2019; 22(6): 370-378.

Szymon Ulenberg, Tomasz Bączek*, Joanna Zieliñska, Mariusz Belka, Marek Król and Franciszek Herold


DOI: 10.2174/1386207322666190705143322


In Silico Molecular Docking, Synthesis of 4-(4-benzoylaminophenoxy) Phenol Derivatives as Androgen Receptor Antagonists

, 2019; 22(5): 307-316.

Ramakrishnan Elancheran*, Senthamaraikannan Kabilan*, Jibon Kotoky, Muthiah Ramanathan and Atanu Bhattacharjee


DOI: 10.2174/1386207322666190701124752



Substituted Furanocoumarins as Novel Class of Antibacterial Translation Inhibitors

, 2019; 22(6): 400-410.

Yan A. Ivanenkov, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Andrey A. Ayginin*, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Dmitry A. Skvortsov, Katerina S. Komarova, Alexey V. Chemeris, Liana F. Zainullina, Marina A. Maximova, Zulfiya R. Zileeva, Yulia V. Vakhitova, Alexey Kh. Baymiev, Andrey Kh. Baymiev, Alina A. Sofronova, Alexey E. Machulkin, Rostislav A. Petrov, Dmitry S. Bezrukov, Maria M. Puchinina, Dmitrii A. Lukianov and Olga A. Dontsova


DOI: 10.2174/1386207322666190723110539






Editor-in-Chief

Gerald H. Lushington
LiS Consulting, Lawrence
KS
USA

Biography View Full Editorial Board

Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
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Scopus CiteScore Metrics: 1.24

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