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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 22, 10 Issues, 2019
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Ranking and Category

  • 67th of 79 in

    Biochemical Research Methods

  • 39th of 71 in

    Chemistry, Applied

  • 220th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 22

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Number 7



Biography   Open Access



Review Article

From the Explored to the Unexplored: Computer-Tailored Drug Design Attempts in the Discovery of Selective Caspase Inhibitors

, 22(7): 432 - 444

Ransford O. Kumi, Abdul R. Issahakua, Opeyemi S. Soremekun, Clement Agoni, Fisayo A. Olotu and Mahmoud E.S. Soliman*


DOI: 10.2174/1386207322666190927143026


Research Article

Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique

, 22(7): 445 - 454

Kunhao Qin, Shengting Zhang, Jie Wang, Dongbo Liu, Yingying Xiang, Xiuling Ji and Yunlin Wei*


DOI: 10.2174/1386207322666190919143735


Research Article



Research Article



Research Article



Research Article

Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Male Smokers

, 22(7): 496 - 501

Fatemeh Ahmadi-Motamayel*, Parisa Falsafi, Hamidreza Abolsamadi, Mohammad T. Goodarzi and Jalal Poorolajal


DOI: 10.2174/1386207322666190806123616


Case Report



Combinatorial Chemistry & High Throughput Screening, Volume 22 (2019) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print






Clustering and Sampling of the c-Met Conformational Space: A Computational Drug Discovery Study


Korosh Mashayekh, Shahrzad Sharifi, Tahereh Damghani, Maryam Elyasi, Mohammad Sadegh Avestan and Somayeh Pirhadi*


DOI: 10.2174/1386207322666191024103902
View Abstract


Synthesis of 2-substituted 4-arylidene-5(4H)-oxazolones as potential cytotoxic agents in the presence of lemon juice as a biocatalyst


Malavattu Giri Prasad, C. Vijaya Lakshmi, Naresh Kumar Katari*, K. Anand, Manojit Pal* and Sreekantha B. Jonnalagadda*


DOI: 10.2174/1386207322666191024105150
View Abstract


Exploration of the Hepatoprotective Effect and Mechanism of Swertia Mussotii Franch in an Acute Liver Injury Rat Model


Haixia Yun, Xianglan Duan, Wendou Xiong, Yiwei Ding, Xinyu Wu, Junhua Kang, Xiaoyan Pu, Yingzhong Yang and Zhi Chen*


DOI: 10.2174/1386207322666191106105725
View Abstract View on PubMed




Abstracts Ahead of Print


Effectiveness of Tolvaptan in treatment for Patients with Autosomal Dominant Polycystic Kidney Disease: A Meta-analysis


Xuan Xie, Qian Cai, Xiao-Yuan Guo, Dong-Hai Bai, Hai-Zhong Sheng, Bao-Kui Wang*, Kai Yan, An-Ming Lu and Xin-Ran Wang


DOI: 10.2174/1386207322666191203092715
View Abstract


Published Contents

Editor's Choice

Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique

, 2019; 22(7): 445 - 454

Kunhao Qin, Shengting Zhang, Jie Wang, Dongbo Liu, Yingying Xiang, Xiuling Ji and Yunlin Wei*


DOI: 10.2174/1386207322666190919143735





Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model

, 2019; 22(4): 256 - 265

Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Jie Li, Liyun Zheng, Fazong Wu, Dengke Zhang, Xihui Ying and Jiansong Ji*


DOI: 10.2174/1386207322666190530102245



Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma

, 2019; 22(3): 201 - 206

Jiangshan Lian, Xiaolin Zhang, Yingfeng Lu, Shaorui Hao, Zhe Zhang and Yida Yang*


DOI: 10.2174/1386207322666190404151020



Progress in Molecularly Imprinted Polymers for Biomedical Applications

, 2019; 22(2): 78 - 88

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526




Maxillary Metastasis of Esophageal Cancer: Report of the First Case and Literature Review

, 2018; 21(10): 801 - 805

Hong Hu, Jing Wang, Xiao-Yun Zhou, Meng-Ting Tong, Chong-Ya Zhai, Xin-Bing Sui, Yan-Hua Zhang, Xiao-Xi Xie, Hao Liu, Jian-Sheng Xie, Hong-Ming Pan* and Da Li*


DOI: 10.2174/1386207322666190103105938



Catalytic Conversion of Biorenewable Sugar Feedstocks into Market Chemicals

, 2018; 21(9): 616 - 630

Gary Diamond, Alfred Hagemeyer*, Vince Murphy and Valery Sokolovskii


DOI: 10.2174/1386207322666181219155050




Open Access Articles

Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*




Chemical Informatics and the Drug Discovery Knowledge Pyramid

, 2013; 16(10): 764 - 776

Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham







Alternative Medicine Safety: Agaricus blazei and Propolis

, 2011; 14(7): 616 - 621

Kenji Sorimachi* and Takaaki Nakamoto





Most Cited Articles

Research Article

Prediction of nitrated tyrosine residues in protein sequences by extreme learning machine and feature selection methods

, 2018; 21(6): 393-402.

Lei Chen*, ShaoPeng Wang, Yu-Hang Zhang , Lai Wei , XianLing Xu, Tao Huang * and Yu-Dong Cai *


DOI: 10.2174/1386207321666180531091619



Research Article

One-pot synthesis of novel 2-pyrazolo-3-phenyl-1,3-thiazolidine-4-ones using DSDABCOC as an effective media

, 1 January 2018; 21(1): 271-280.

Mohammad A. Ghasemzadeh*, Mohammad H. Abdollahi-Basir and Zahra Elyasi


DOI: 10.2174/138620732166618012409405



Research Article

Pyrazole schiff base hybrids as anti-malarial agents: Synthesis, in vitro screening and computational study

, 2018; 21(3): 194-203.

Shilpy Aggarwal, Deepika Paliwal, Dhirender Kaushik, Girish Kumar Gupta and Ajay Kumar*


DOI: 10.2174/1386207321666180213092911



Research Article

Prediction of drug combinations with a network embedding method

, 2018; 21(10): 789-797.

Tianyun Wang, Lei Chen* and Xian Zhao


DOI: 10.2174/1386207322666181226170140


Research Article

An integrated feature selection algorithm for cancer classification using gene expression data

, 2018; 21(9): 631-645.

Saeed Ahmed*, Muhammad Kabir, Zakir Ali, Muhammad Arif, Farman Ali and Dong-Jun Yu


DOI: 10.2174/1386207322666181220124756



Research Article

Hybrid feature selection algorithm mRMR-ICA for cancer classification from microarray gene expression data

, 2018; 21(6): 420-430.

Shuaiqun Wang*, Wei Kong, Aorigele, Jin Deng, Shangce Gao and Weiming Zeng


DOI: 10.2174/1386207321666180601074349




Research Article

Identification of human acetylcholinesterase inhibitors from the constituents of EGb761 by modeling docking and molecular dynamics simulations

, 1 January 2018; 21(1): 41-49.

Lihu Zhang, Dongdong Li, Fuliang Cao, Wei Xiao*, Linguo Zhao*, Gang Ding and Zhen zhong Wang


DOI: 10.2174/1386207320666171123201910


Research Article

Predictive and descriptive CoMFA models: The effect of variable selection

, 2018; 21(2): 117-124.

Bakhtyar Sepehri, Nematollah Omidikia, Mohsen Kompany-Zareh and Raouf Ghavami*


DOI: 10.2174/1386207321666180212162028




Most Accessed Articles


Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379-386.

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*


DOI: 10.2174/1386207322666190704095602



Reynoutria Japonica from Traditional Chinese Medicine: A Source of Competitive Adenosine Deaminase Inhibitors for Anticancer

, 2019; 22(2): 113-122.

Xin-guo Zhang*, Guo-Yan Ma, Fei Kou, Wen-Jie Liu, Qiao-Yun Sun, Guang-Jun Guo, Xiao-Di Ma, Si-Jia Guo and Zhu Jian-Ning


DOI: 10.2174/1386207322666190415100618


Progress in Molecularly Imprinted Polymers for Biomedical Applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526



In Silico Molecular Docking, Synthesis of 4-(4-benzoylaminophenoxy) Phenol Derivatives as Androgen Receptor Antagonists

, 2019; 22(5): 307-316.

Ramakrishnan Elancheran*, Senthamaraikannan Kabilan*, Jibon Kotoky, Muthiah Ramanathan and Atanu Bhattacharjee


DOI: 10.2174/1386207322666190701124752


Molecular Docking Supplements an In vitro Determination of the Leading CYP Isoform for Arylpiperazine Derivatives

, 2019; 22(6): 370-378.

Szymon Ulenberg, Tomasz Bączek*, Joanna Zieliñska, Mariusz Belka, Marek Król and Franciszek Herold


DOI: 10.2174/1386207322666190705143322






Editor-in-Chief

Gerald H. Lushington
LiS Consulting, Lawrence
KS
USA

Biography View Full Editorial Board

Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
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Scopus CiteScore Metrics: 1.09

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