E-Pub Articles Ahead of Print ::: Current Cancer Drug Targets

ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)


Volume 17, 9 Issues, 2017


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Current Cancer Drug Targets

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Editor-in-Chief:
Ruiwen Zhang
Center for Drug Discovery
University of Houston
3455 Cullen Blvd.
Houston, TX 77204
USA


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Articles Ahead of Print

Degradation of Androgen Receptor through Small Molecules for Prostate Cancer


Raoling Ge, Xi Xu, Pengfei Xu, Lei Li, Zhiyu Li* and Jinlei Bian


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Oxidative Stress and Cancer: The Role of Nrf2


Sajadimajd Soraya and Khazaei Mozafar*


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Development of Drug Targeting and Delivery in Cervical Cancer


Urvashi Aggarwal, Amit Kumar Goyal and Goutam Rath*


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Ponatinib: A Review of Efficacy and Safety


Fulvio Massaro, Matteo Molica and Massimo Breccia*


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The PI3K Pathway at the Crossroads of Cancer and the Immune System: Strategies for Next Generation Immunotherapy Combinations


Dearbhaile Collins, Maxime Chenard-Poirier and Juanita Lopez*


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Neoisoliquiritigenin Inhibits Tumor Progression by Targeting GRP78-β- catenin Signaling in Breast Cancer


Hailin Tang*, Fu Peng, Xiaojia Huang, Xinhua Xie, Bo Chen, Jiangang Shen, Fei Gao, Jieshu You, Xiaoming Xie and Jianping Chen


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Involvement of CD24 in Multiple Cancer Related Pathways Makes It an Interesting New Target for Cancer Therapy


Shirin Eyvazi, Bahram Kazemi, Siavoush Dastmalchi* and Mojgan Bandehpour*


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Clinical Evidence on the Magnitude of Change in Growth Pathway Activity in Relation to Tamoxifen Resistance is Required


Sepideh Mansouri, Leila Farahmand, Azin Teymourzadeh and Keivan Majidzadeh-A*


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Aldose Reductase Inhibitor, Fidarestat Prevents High-fat Diet-induced Intestinal Polyps in ApcMin/+ Mice


Ashish Saxena, Ravinder Tammali, Kota V Ramana and Satish K. Srivastava*


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Evaluation of Anti-cancer Activity of Stilbene and Methoxydibenzo[b,f] oxepin Derivatives


Damian Garbicz , Damian Mielecki , Michał Wrzesiński , Tomasz Pilżys, Michał Marcinkowski , Jan Piwowarski , Janusz Dębski, Ewelina Palak, Przemysław Szczeciński, Hanna Krawczyk and Elżbieta Grzesiuk*


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An Update on Circumventing Multidrug Resistance in Cancer by Targeting P-Glycoprotein


Xiaoqian Yang, Xiaoduan Li, Zhenfeng Duan and Xipeng Wang*


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The Structural Bioinformatics Analysis of Biophenolic Lignan-Estrogen Receptor Interaction


Farzaneh Mohamadyar-Toupkanlou*, Mina Esfandiari, Mahshid Sadat Kashef-Saberi, Mahboubeh Kabiri Renani and Masoud Soleimani


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TGF-β1 Causes EMT by Regulating N-Acetyl Glucosaminyl Transferases via Downregulation of Non Muscle Myosin II-A through JNK/P38/PI3K Pathway in Lung Cancer


Ghulam Jilany Khan, Yingsheng Gao, Ming Gu, Lai Wang, Sara Khan, Farah Naeem, Herve Semukunzi, Debmalya Roy, Shengtao Yuan* and Li Sun*


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Cell-derived Exosomes as Promising Carriers for Drug Delivery and Targeted Therapy


Xinyi Wang*, Haiyang Zhang, Haiou Yang, Ming Bai, Tao Ning, Shuang Li, Jialu Li, Ting Deng, Guoguang Ying and Yi Ba


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The Safety, Efficacy and Therapeutic Potential of Histone Deacetylase Inhibitors with Special Reference to Panobinostat in Gastrointestinal Tumors: A Review of Preclinical and Clinical Studies


Avineesh Singh, Preeti Patel, Jageshwar, Vijay Kumar Patel, Deepak Kumar Jain, M Kamal and Harish Rajak*


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Recent Updates on the Therapeutic Potential of HER2 Tyrosine Kinase Inhibitors for the Treatment of Breast Cancer


Heena Singla, Anjana Munshi*, Raja Paramjit Singh Banipal and Vinod Kumar*


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p53-Mdm2 Interaction Inhibitors as Novel Nongenotoxic Anticancer Agents


Surendra Kumar Nayak*, Gopal L. Khatik, Rakesh Narang, Vikramdeep Monga and Harish Kumar Chopra


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Therapeutic Approaches for the Treatment of Epidermal Growth Factor Receptor Mutated Lung Cancer


Dhaval Sanchala, Lokesh K Bhatt* and Kedar S Prabhavalkar


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MicroRNA Key to Angiogenesis Regulation: MiRNA Biology and Therapy


Ankit Tiwari, Bratati Mukherjee and Manjusha Dixit*


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Synthetic Lethality: From Research to Precision Cancer Nanomedicine


Anuradha Gupta, Anas Ahmad, Aqib Iqbal Dar and Rehan Khan*


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Regulation of MicroRNAs by Phytochemicals: A Promising Strategy for Cancer Chemoprevention


Sadegh Babashah*, Babak Bakhshinejad, Maryam Tahmasebi Birgani , Katayoon Pakravan and William C Cho*


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DNA Fragmentation, Cell Cycle Arrest, and Docking Study of Novel Bis Spiro-cyclic 2-oxindole of Pyrimido[4,5-b]quinoline-4,6-dione Derivatives Against Breast Carcinoma


Magda F. Mohamed, Amr Mohamed Abdelmoniem, Ahmed H. M. Elwahy and Ismail A. Abdelhamid*


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JQ1, a BET Inhibitor, Synergizes with Cisplatin and Induces Apoptosis in Highly Chemoresistant Malignant Pleural Mesothelioma Cells


Ilaria Zanellato*, Donato Colangelo and Domenico Osella


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Significant Role of MUC1 in Development of Resistance to Currently Existing Anti-cancer Therapeutic Agents


Leila Farahmand, Parnaz Merikhian, Neda Jalili, Behrad Darvishi and Keivan Majidza*


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Pharmacoinformatic Approaches to Design Novel Inhibitors of Protein Kinase B Pathways in Cancer


Noreen Akhtar and Ishrat Jabeen*


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Cancer-Targeted Oncolytic Adenoviruses for Modulation of the Immune System


Vincenzo Cerullo*, Cristian Capasso, Markus Vähä-Koskela, Otto Hemminki and Akseli Hemminki*


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Crizotinib Versus Chemotherapy on ALK-positive NSCLC: A Systematic Review of Efficacy and Safety


Mingxia Wang, Guanqi Wang, Haiyan Ma and Baoen Shan*


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Oncolytic Tanapoxvirus Expressing Interleukin-2 is Capable of Inducing the Regression of Human Melanoma Tumors in the Absence of T Cells


Tiantian Zhang, Dennis H Kordish, Yogesh R Suryawanshi, Rob R Eversole, Steven Kohler, Charles D Mackenzie and Karim Essani*


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Chemosensitizing Activity of Histone Deacetylases Inhibitory Cyclic Hydroxamic Acids for Combination Chemotherapy of Lymphatic Leukemia


Denis V. Mishchenko, Margarita E. Neganova, Elena N. Klimanova, Tatyana E. Sashenkova, Elena F. Shevtsova, Igor V. Vystorop, Vadim V. Tarasov, Ghulam Md Ashraf , Nagendra Sastry Yarla and Gjumrakch Aliev*


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Fertility Drugs and Ovarian Cancer


Aus Tariq Ali*


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The Complexity of DEK Signaling in Cancer Progression


Yong Teng*, Liwei lang and Catherine E Jauregui


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Autophagy Inhibition in Childhood Nephroblastoma and the Therapeutic Significance


Lin-Jie Li , Yi-Long Wang, Lin-Qing Yuan, Wei-Zhong Gu, Kun Zhu, Min Yang, Duo Zhou, Yao Lv, Min-Ju Li, Zheng-Yan Zhao, Jin-Hu Wang* and Xi Chen*


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Specific Targeting of HER2-Positive Head and Neck Squamous Cell Carcinoma Line HN5 by Idarubicin-ZHER2 Affibody Conjugate


Marzieh Ghanemi, Aminollah Pourshohod, Mohammad Ali Ghaffari , Alireza kheirollah, Mansour Amin, Majid Zeinali* and Mostafa Jamalan*


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The Development of Oncoltyic Adenovirus Therapy in the Past and Future - For the case of pancreatic cancer


Mizuho Sato-Dahlman and Masato Yamamoto*


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CX-4945, a Selective Inhibitor of Casein Kinase 2, Synergizes with B Cell Receptor Signaling Inhibitors in Inducing Diffuse Large B Cell Lymphoma Cell Death


Elisa Mandato, Sara Canovas Nunes, Fortunato Zaffino, Alessandro Casellato, Paolo Macaccaro, Laura Quotti Tubi, Andrea Visentin, Livio Trentin, Gianpietro Semenzato and Francesco Piazza*


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Effects of PHA-665752 and Cetuximab Combination Treatment on In Vitro and Murine Xenograft Growth of Human Colorectal Cancer Cells with KRAS or BRAF Mutations


Yi-Tao Jia, Dong-hai Yang, Zhaolong Zhao, Xiao-hui Bi, Wei-hua Han, Bo Feng, Jie Zhi, Bin Gu, Zhihui Duan, Jian-Hua Wu, Ying-Chao Ju, Ming-Xia Wang and Zhong-Xin Li*


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Redox Biotransformation and Delivery of Anthracycline Anticancer Antibiotics: How Interpretable Structure-activity Relationships of Lethality Using Electrophilicity and the London Formula for Dispersion Interaction Work


Siu-Kwong Pang*


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Obesity and Cancer: Biological Links and Treatment Implications


Alessandro Ottaiano*, Chiara De Divitiis, Monica Capozzi, Antonio Avallone, Carmela Pisano, Sandro Pignata and Salvatore Tafuto


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Targeting STEAP1 Protein in Human Cancer: Current Trends and Future Challenges


Jorge Barroca-Ferreira , João Pedro Pais, Margarida Maria Santos, Ana Margarida Gonçalves, Inês Margarida Gomes, Inês Margarida Sousa, Sandra Moreira Rocha, Luís António Passarinha and Cláudio Maia*


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Elaborating the Role of Natural Products on the Regulation of Autophagy and their Potentials in Breast Cancer Therapy


Xunian Zhou, Grace Gar-Lee Yue, Stephen Kwok-Wing Tsui, Jianxin Pu, Kwok-Pui Fung and Clara Bik-San Lau*


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Oncolytic Virotherapy and Gene Therapy Strategies for Hepatobiliary Cancers


Takeshi Yamada, Yukako Hamano, Naoyuki Hasegawa, Kazunari K. Yokoyama*, Ichinosuke Hyodo and Masato Abei


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Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation


Samantha L. Martin, Rishabh Kala and Trygve O. Tollefsbol


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HIF1A is Overexpressed in Medulloblastoma and its Inhibition Reduces Proliferation and Increases EPAS1 and ATG16L1 Methylation


Gustavo Alencastro Veiga Cruzeiro, Maristella Bergamo dos Reis, Vanessa Silva Silveira, Régia Caroline Peixoto Lira, Carlos Gilberto Carlotti Jr, Luciano Neder, Ricardo Santos Oliveira, José Andres Yunes, Silvia Regina Brandalise, Simone Aguiar, Agda Karina Eterovic, Luiz Gonzaga Tone, Carlos Alberto Scrideli* and Elvis Terci Valera


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The Role of Target Therapy in the Treatment of Gastrointestinal Non Colorectal Cancers: Clinical Impact and Cost Consideration


Massimiliano Berretta, Raffaele Di Francia, Chiara De Diviitis, Guglielmo Nasti, Vincenzo Canzonieri, Michele Caraglia, Gaetano Facchini and Umberto Tirelli


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Emergence of Ad-Mediated Combination Therapy Against Cancer: What to Expect?


JinWoo Hong and Chae-Ok Yun


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Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects


Pavlos Msaouel, Mateusz Opyrchal, Angela Dispenzieri, Kah Whye Peng, Mark J. Federspiel, Stephen J. Russell and Evanthia Galanis


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Multimodal HDAC Inhibitors with Improved Anticancer Activity


Rainer Schobert and Bernhard Biersack


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The Real Impact of Target Therapy in Breast Cancer Patients: Between Hope and Reality


Sebastiano Bordonaro, Massimiliano Berretta, Antonino Carmelo Tralongo, Silvia Clementi, Brigida Stanzione and Paolo Tralongo


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Lung Cancer Stem Cells: An Epigenetic Perspective


Samriddhi Shukla, Sajid Khan, Sonam Sinha and Syed Musthapa Meeran*


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Outlook on Epigenetic Therapeutic Approaches for Treatment of Gastric Cancer


Petra Hudler


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Epigenetics in Clinical Management of Children and Adolescents with Brain Tumors


Andres Morales La Madrid and Mark W. Kieran


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Transforming Cancer Epigenetics Using Nutritive Approaches and Noncoding RNAs


Centdrika R. Dates and Trygve O. Tollefsbol


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Epigenetic Regulation of EMT in Non-Small Cell Lung Cancer


Karen O’Leary, Alice Shia and Peter Schmid


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Current and Emerging Treatments for Metastatic Renal Cell Carcinoma


Carla Cavaliere, Carmine D`Aniello, Chiara Della Pepa, Salvatore Pisconti, Massimiliano Berretta and Gaetano Facchini


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Oncolytic Virus: Regulatory Aspects from Quality Control to Clinical Studies


Teruhide Yamaguchi and Eriko Uchida


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Optimal Management of Prostate Cancer Based on its Natural Clinical History


Gaetano Facchini, Francesco Perri, Gabriella Misso, Carmine D`Aniello, Giuseppina Della Vittoria Scarpati, Sabrina Rossetti, Chiara Della Pepa, Salvatore Pisconti, Gerhard Unteregger, Alessia Cossu, Michele Caraglia, Massimiliano Berretta and Carla Cavaliere


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Clinical Effectiveness and Cost-effectiveness of Target Therapies for Adult Patients with Locally Advanced or Metastatic Non-small Cell Lung Cancer: A Systematic Review


Alessandra Bearz, Massimiliano Berretta and Umberto Tirelli


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Oncolytic Viruses: The Best is Yet to Come


Chantal G. Lemay, Brian A. Keller, Robert E. Edge, Masato Abei and John C. Bell


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Metastatic Colorectal Cancer: Role of Target Therapies and Future Perspectives


Anna Nappi, Massimiliano Berretta, Carmela Romano, Salvatore Tafuto, Antonino Cassata, Rossana Casaretti, Lucrezia Silvestro, Chiara De Divitiis, Lara Alessandrini, Francesco Fiorica, Alessandro Ottaiano and Guglielmo Nasti


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Melanoma Adjuvant Treatment: Current Insight and Clinical Features


Carmine D`Aniello, Francesco Perri, Giuseppina Della Vittoria Scarpati, Chiara Della Pepa, Salvatore Pisconti, Vincenzo Montesarchio, Nicolas Wernert, Mayra Rachele Zarone, Michele Caraglia, Gaetano Facchini, Massimiliano Berretta and Carla Cavaliere


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Pharmacological Profile and Pharmacogenomics of Anti-Cancer Drugs Used for Targeted Therapy


Raffaele Di Francia, Angela De Monaco, Mariangela Saggese, Giancarla Iaccarino, Stefania Crisci, Ferdinando Frigeri, Rosaria De Filippi, Massimiliano Berretta and Antonio Pinto


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Oncolytic Herpes Simplex Virus Vectors Fully Retargeted to Tumor- Associated Antigens


Hiroaki Uchida, Hirofumi Hamada, Kenji Nakano, Heechung Kwon, Hideaki Tahara, Justus B. Cohen and Joseph C. Glorioso


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Is there a Role for Epigenetic Enhancement of Immunomodulatory Approaches to Cancer Treatment?


Kirsty J Flower, Sadaf Ghaem-Maghami and Robert Brown


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LRIGs: a Prognostically Significant Family with Emerging Therapeutic Competence against Cancers


Uzma Malik and Aneela Javed


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