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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 20, 18 Issues, 2020
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access
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In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Articles Ahead of Print



The Identification of a Novel Unsymmetrical Azine as an Apoptosis Inducer in Colorectal Cancer


Fahad M. Almutairi , Ayat G. Ali , Abdou O. Abdelhamid, Adel I. Alalawy, Mai K. Bishr and Mervat S. Mohamed*


DOI: 10.2174/1871520620666200824095314
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Botanical Therapeutics (Part II): Antimicrobial and In Vitro Anticancer Activity against MCF7 Human Breast Cancer Cells of Chamomile, Parsley and Celery Alcoholic Extracts


Corina Danciu, Oana Cioanca, Claudia Watz (Farcaș)*, Monica Hancianu, Roxana Racoviceanu, Delia Muntean, Istvan Zupko, Camelia Oprean, Calin Tatu, Virgil Paunescu, Maria Proks, Zorita Diaconeasa, Codruta Soica, Iulia Pinzaru and Cristina Dehelean


DOI: 10.2174/1871520620666200807213734
View Abstract





Antiproliferative Activity and Apoptotic Efficiency of Syzygium cumini Bark Methanolic Extract against EAC Cells In Vivo


Mst. Ayesha Siddika, Plabon K. Das, Saharia Y. Asha, Suraiya Aktar, Abu Rahyan M. Tareq, Ayesha Siddika, Md. Abdur Rakib, Farhadul Islam* and Jahan Ara Khanam


DOI: 10.2174/1871520620666200811122137
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Novel Dihydropyrimidinone-Derived Selenoesters as Potential Cytotoxic Agents to Human Hepatocellular Carcinoma: Molecular docking and DNA Fragmentation


Jean C. Benassi, Flavio A.R. Barbosa, Valdelúcia M.A.S. Grinevicius, Fabiana Ourique, Daniela Coelho, Karina B. Felipe, Antônio L. Braga, Danilo W. Filho and Rozangela C. Pedrosa*


DOI: 10.2174/1871520620666200728124640
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On the Cytotoxicity of Chiral Ruthenium Complexes Containing Sulfur Amino Acids Against Breast Tumor Cells (MDA-231 and MCF-7)


Celisnolia M. Leite, João Honorato de Araujo-Neto*, Rodrigo S. Corrêa, Legna Colina-Vegas, Diego Martínez-Otero, Paulo R. Martins, Cristiane G. Silva and Alzir A. Batista


DOI: 10.2174/1871520620666200824114816
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Tailored Quinolines Demonstrates Flexibility to Exert Antitumor Effects through Varied Mechanisms - A Medicinal Perspective


Sachin Sharma, Arshdeep Singh, Sahil Sharma, Ram Sharma, Jagjeet Singh, Nihar Kinarivala, Kunal Nepali* and Jing Ping Liou


DOI: 10.2174/1871520620666200908104303
View Abstract


Fluorinated-NHC Transition Metal Complexes Leading Characters as Potential Anticancer Metallodrugs


Ernesto Rufino-Felipe, Raúl Colorado-Peralta, Viviana Reyes-Márquez , Hugo Valdés and David Morales-Morales*


DOI: 10.2174/1871520620666200908103452
View Abstract


Transcriptionomic Study on Apoptosis of SKOV-3 Cells Induced by Phycoerythrin from Gracilaria lemaneiformis


Jun Ying*, Zhouhao Tang, Guanan Zhao, Xia Li, Ruowang Pan, Shuangxiang Lin, Yang Lou, Wanping Wang, Peizhen Li, Qiyu Bao and Chunxia Yan


DOI: 10.2174/1871520620666200908102621
View Abstract



New Developments in Anti-Angiogenic Therapy of Cancer, Review and Update


Samaneh Ghasemali, Safar Farajnia*, Abolfazl Barzegar, Mohammad Rahmati-Yamchi, Roghayyeh Baghba, Leila Rahbarnia and Hamid R.Y. Nodeh


DOI: 10.2174/1871520620666200817103219
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Scutellarin Suppresses RPMI7951 Melanoma Cell Proliferation by Targeting TOPK


Xin Mu, Lijuan Wang, Zixi Zhang, Rui Ge, Jian Zhang, Kuanhou Mou, Wenli Liu and Shemin Lv*


DOI: 10.2174/1871520620666200811112156
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New Formulation and Evaluation of Camptothecin Encapsulated and/or Dispersed Suppository


Sofiane Fatmi*, Lamia Taouzinet, Malika Lahiani-Skiba, Mohamed Skiba and Mokrane Iguer-Ouada


DOI: 10.2174/1871520620666200903150635
View Abstract








Thymoquinone Inhibits Proliferation and Migration of MDA-MB-231 Triple Negative Breast Cancer Cells by Suppressing Autophagy, Beclin-1 and LC3


Tuba Dilay Ünal, Zuhal Hamurcu, Nesrin Delibaşı, Venhar Çınar, Ahsen Güler, Sevda Gökçe, Nursultan Nurdinov and Bulent Ozpolat*


DOI: 10.2174/1871520620666200807221047
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Therapeutic Applications of Curcumin and its Novel Formulations in the Treatment of Bladder Cancer: A Review of Current Evidence


Mohammad Hossein Pourhanifeh, Reza Mottaghi, Zahra Sadat Razavi, Alimohammad Shafiee, Sarah Hajighadimi and Hamed Mirzaei*


DOI: 10.2174/1871520620666200807223832
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The Antitumor Efficiency of Zinc Finger Nuclease combined with Cisplatin and Trichostatin A in Cervical Cancer Cells


Ci Ren, Chun Gao, Xiaomin Li, Jinfeng Xiong, Hui Shen, Da Zhu, Liming Wang, Peng Wu, Wencheng Ding and Hui Wang*


DOI: 10.2174/1871520620666200804102300
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Proapoptotic Effects of triazol-1,4-Naphthoquinones Involve Intracellular ROS Production and MAPK/ERK Pathway in Human Leukemia Cells


Tangbadioa H. Coulidiati, Bruna B. Dantas, Glaucia V. Faheina-Martins, Enéas Ricardo de Morais Gomes, Juan C.R. Gonçalves* and Demetrius A. Machado de Araújo


DOI: 10.2174/1871520620666200721124221
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Interaction of a Vanadyl Schiff Base Complex with DNA and BSA: A Combination of Experimental and Computational Studies


Hamid Bakhshi Aliabad, Maryam Mohamadi, Soudeh Khanamani Falahati-Pour, Mohamad Reza Hajizadeh, Danial Abdollahdokht, Mohammad Hadi Nematollahi and Mehdi Mahmoodi*


DOI: 10.2174/1871520620666200721105134
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Rotundic Acid Regulates the Effects of Let-7f-5p on Caco2 Cell Proliferation


Yuan Feng, Xinran Liu, Yueqing Han, Mantian Chen, Lin Zhang, Yuling Hu, Liya Chen, Gang Chen and Ning Li*


DOI: 10.2174/1871520620999200730165829
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Antibody-Based Targeted Interventions for the Diagnosis and Treatment of Skin Cancers


Suresh Madheswaran, Neelakshi Mungra, Fleury A.N. Biteghe, Jean De la Croix Ndong, Afolake T. Arowolo, Henry A. Adeola, Dharanidharan Ramamurthy, Krupa Naran, Nonhlanhla P. Khumalo and Stefan Barth*


DOI: 10.2174/1871520620666200728123006
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Apoptotic Effects of N-(2-hydroxyphenyl)-2-propylpentanamide on U87-MG and U-2 OS Cells and Antiangiogenic Properties


Paola Castillo-Juárez, Sebastián C. Sanchez, Alma D. Chávez-Blanco*, Humberto Mendoza-Figueroa and José Correa-Basurto


DOI: 10.2174/1871520620666200728125356
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Design, Synthesis, Molecular Docking, and Anticancer Evaluation of Pyrazole Linked Pyrazoline Derivatives with Carbothioamide Tail as EGFR Kinase Inhibitors


Farah Nawaz, Ozair Alam*, Ahmad Perwez, Moshahid A. Rizvi, Mohd. Javed Naim, Nadeem Siddiqui, Jannat ul Firdaus, Shakilur Rahman, Mukund Jha and Aadil A. Sheikh


DOI: 10.2174/1871520620666200727093613
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The Anti-Breast Cancer Effects of Green-Synthesized Zinc Oxide Nanoparticles Using Carob Extracts


Vahid Pouresmaeil*, Shaghayegh Haghighi, Asieh S. Raeisalsadati, Ali Neamati and Masoud Homayouni-Tabrizi


DOI: 10.2174/1871520620666200721132522
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Fused and Substituted Pyrimidine Derivatives as Profound Anti-cancer Agents


Nahid Abbas*, Gurubasavaraja S.P. Matada, Prasad S. Dhiwar, Shilpa Patel and Giles Devasahayam


DOI: 10.2174/1871520620666200721104431
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Nitrogen-Containing Heterocycles as Anticancer Agents: An Overview


Damanpreet K. Lang, Rajwinder Kaur*, Rashmi Arora, Balraj Saini and Sandeep Arora


DOI: 10.2174/1871520620666200705214917
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A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors


Ebru Zeytün, Mehlika D. Altıntop*, Belgin Sever, Ahmet Özdemir, Doha E. Ellakwa, Zeynep Ocak, Halil I. Ciftci, Masami Otsuka, Mikako Fujita and Mohamed O. Radwan


DOI: 10.2174/1871520620666200824100408
View Abstract



FOXM1-Dependent Transcriptional Regulation of EZH2 Induces Proliferation and Progression in Prostate Cancer


Juan-Hua Tian, Li-Jun Mu, Mei-Yu Wang, Jin Zeng, Qing-Zhi Long, Bing Guan, Wen Wang, Yu Mei Jiang, Xiao-Jing Bai and Yue-Feng Du*


DOI: 10.2174/1871520620666200731161810
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HCA587 Protein Vaccine Induces Specific Antitumor Immunity Mediated by CD4+ T-cells Expressing Granzyme B in a Mouse Model of Melanoma


Weiming Yang, Weiheng Zhang, Xiaozhong Wang, Liming Tan, Hua Li, Jiemin Wu, Qiong Wu, Wanlei Sun, Juanjuan Chen* and Yanhui Yin


DOI: 10.2174/1871520620666200728131951
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Therapy Resistance in Cancers: Phenotypic, Metabolic, Epigenetic and Tumour Microenvironmental Perspectives


Tasnim Zahan, Plabon K. Das, Syeda F. Akter, Rowshanul Habib, Md. Habibur Rahman, Md. Rezaul Karim and Farhadul Islam*


DOI: 10.2174/1871520620999200730161829
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Synthesis and in vitro Cytotoxicity Evaluation of Phenanthrene Linked 2,4- Thiazolidinediones as Potential Anticancer Agents


Upasana Yadav, Yogesh Vanjari, Kritika Laxmikeshav, Ramya Tokala, Praveen Kumar Niggula, Manoj Kumar, Venu Talla, Ahmed Kamal and Nagula Shankaraiah*


DOI: 10.2174/1871520620666200714142931
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New Hybrid Scaffolds Based on Carbazole-Chalcones as Potent Anticancer Agents


Faisal Rashid, Sumera Zaib, Aliya Ibrar, Syeda Abida Ejaz, Aamer Saeed, Jamshed Iqbal and Imtiaz Khan*


DOI: 10.2174/1871520620666200721110732
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ATF4, DLX3, FRA1, MSX2, C/EBP-ζ, and C/EBP-α Shape the Molecular Basis of Therapeutic Effects of Zoledronic Acid in Bone Disorders


Faroogh Marofi , Jalal Choupani , Saeed Solali , Ghasem Vahedi , Ali Hassanzadeh , Tohid Gharibi and Majid Farshdousti Hagh*


DOI: 10.2174/1871520620666200721101904
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Encapsulation by Electrospraying of Anticancer Compounds from Jackfruit Extract (Artocarpus heterophyllus Lam): Identification, Characterization and Antiproliferative Properties


José Oscar Rivera-Aguilar, Montserrat Calderón-Santoyo, Elda Margarita González-Cruz, Jorge Alberto Ramos-Hernández and Juan Arturo Ragazzo-Sánchez*


DOI: 10.2174/1871520620666200804102952
View Abstract




Anticancer Activity Assessment and DNA Binding Properties of Two Binuclear Platinum (II) Complexes using Spectroscopic and Molecular Simulation Approaches


M. Mehdi Alavianmehr, Abolfazal Ashrafi*, Reza Yousefi, Mohsen G. Haghighi, Samira S. Abolmaali, Mohammad N.S. Rad and Ali A. Moosavi-Movahedi


DOI: 10.2174/1871520620666200705221325
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Natural Products: Implication in Cancer Prevention and Treatment through Modulating Various Biological Activities


Shehwaz Anwar, Ahmad Almatroudi, Mohammed A. Alsahli, Masood A. Khan, Amjad A. Khan and Arshad H. Rahmani*


DOI: 10.2174/1871520620666200705220307
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Prospective Anti-cancer Agents: A Recent Update on Drug Repurposing


Anjali S. Sabale, Unnati M. Patel, Ankita A. Gorhe, Vinayak R. Bodhankar, Mahesh N. Shinde, Gaurav A. Sonawane, Hitesh S. Raotole, Rohit Y. Pande and Abhijeet D. Kulkarni*


DOI: 10.2174/1871520620666200728123729
View Abstract



Anticancer Active Heterocyclic Chalcones: Recent Developments


Prasad Dandawate, Khursheed Ahmed, Subhash Padhye, Aamir Ahmad* and Bernhard Biersack


DOI: 10.2174/1871520620666200705215722
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Discovery of a Highly Potent and Novel Gambogic Acid Derivative as an Anticancer Drug Candidate


Huiping Ling, Hong Li, Meijun Chen, Baolong Lai, Haiming Zhou, Hui Gao, Jiangye Zhang, Yan Huang and Yiwen Tao*


DOI: 10.2174/1871520620666200408080040
View Abstract View on PubMed





Paris Saponin VII Induces Apoptosis and Cell Cycle Arrest in Erythroleukemia Cells by a Mitochondrial Membrane Signaling Pathway


Xin Lin, Babu Gajendran, Krishnapriya M. Varier, Wuling Liu, Jingrui Song, Qing Rao, Chunlin Wang, Jianfei Qiu, Wei Ni, XuJie Qin, Min Wen, Haiyang Liu and Yanmei Li*


DOI: 10.2174/1871520620666200615134039
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Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid


Agnieszka Siebert, Milena Deptuła, Mirosława Cichorek, Anna Ronowska, Grzegorz Cholewiński* and Janusz Rachon


DOI: 10.2174/1871520620666200516151456
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New Spirocyclic Hydroxamic Acids as Effective Antiproliferative Agents


Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova, Vladimir N. Osipov, Dmitry V. Avdeev, Alexandr V. Gromyko, Sergey A. Pukhov and Gjumrakch Aliev*


DOI: 10.2174/1871520620666200527132420
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MiR-­‐372-3p Predicts Response of TACE Patients Treated with Doxorubicin and Enhances Chemosensitivity in Hepatocellular Carcinoma


Marwa H. Soliman, Mohamed A. Ragheb, Emad M. Elzayat, Mervat S. Mohamed, Nada El-Ekiaby, Ahmed I. Abdelaziz and Abdelhady A. Abdelwahab*


DOI: 10.2174/1871520620666200516145830
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MiR-520c-3p Modulates Doxorubicin-Chemosensitivity in HepG2 Cells


Mohamed A. Ragheb, Marwa H. Soliman, Emad M. Elzayat, Mervat S. Mohamed, Nada El-Ekiaby, Ahmed I. Abdelaziz and Abdelhady A. Abdelwahab*


DOI: 10.2174/1871520620666200502004817
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Isoquinolines: Important Cores in Many Marketed and Clinical Drugs


Chunying Luo, Maxwell Ampomah-Wireko, Huanhuan Wang, Chunli Wu*, Qing Wang, Hui Zhang and Yaquan Cao


DOI: 10.2174/1871520620666200424132248
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A Review of Chemotherapy and Photodynamic Therapy for Lung Cancer Treatment


Ahmed El-Hussein*, Sello L. Manoto, Saturnin Ombinda-Lemboumba, Ziya A. Alrowaili and Patience Mthunzi-Kufa


DOI: 10.2174/1871520620666200403144945
View Abstract View on PubMed





STK33-Dependent Transcriptional Regulation of SFTA3 Induces Cisplatin- Resistance in Lung Adenocarcinoma


Kuilong Zhou, Runzhi Dong, Zhiheng Wang, Zhian Tang, Xuezhen Gao, Yaqing Du, Xiaoli Zhang, Xiangying Li and Qingfan Xie*


DOI: 10.2174/1871520619666190507100912
View Abstract View on PubMed





Ruxolitinib Regulates the Autophagy Machinery in Multiple Myeloma Cells


Alican Kusoglu*, Bakiye G. Bagca*, Neslihan P. Ozates Ay, Guray Saydam and Cigir B. Avci


DOI: 10.2174/1871520620666200218105159
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Editor-in-Chief

Yong Sang Song
Seoul National University
College of Medicine
Seoul
(South Korea)

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Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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