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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 19, 18 Issues, 2019
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry

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Volume 18

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Number 15



Biography   Open Access



Review Article



Review Article

Cancer Nanotechnology-An Excursion on Drug Delivery Systems

, 18(15): 2078 - 2092

Mala Sharma, Chitranshu Pandey, Neha Sharma, Mohammad A. Kamal, Usman Sayeed and Salman Akhtar*


DOI: 10.2174/1871520618666180720164015


Review Article

The Role of Heat Shock Proteins in Cisplatin Resistance

, 18(15): 2093 - 2109

Zdzisław Krawczyk, Agnieszka Gogler-Pigłowska, Damian R. Sojka and Dorota Scieglinska*


DOI: 10.2174/1871520618666180817114952


Research Article



Research Article



Research Article



Research Article



Articles Ahead of Print

Biological and Toxicological Evaluation of N-(4methyl-phenyl)-4-methylphthalimide on Bone Cancer in Mice


José Roberto Santin, Gislaine Francieli da Silva, Maria Veronica Davila Pastor, Milena Fronza Broering, Roberta Nunes, Rodolpho Campos Braga, Iury Tércio Simões de Sousa, Dorimar Serafim Stiz, Kathryn Ana Bortolini Simão da Silva, Luis Carlos Stoeberl, Rogério Corrêa, Valdir Cechinel Filho, Carlos Eduardo Matos dos Santos and Nara Lins Meira Quintão*


View Abstract View on PubMed


Synthesis and Biological Evaluation of Novel Heterocyclic Imines Linked Coumarin- Thiazole Hybrids as Anticancer Agents


Nerella Sridhar Goud, S. Mahammad Ghouse, Jatoth Vishnu, Jakkula Pranay, Ravi Alvala, Venu Talla, Insaf A. Qureshi and Mallika Alvala*


View Abstract View on PubMed



NF-κB-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN


Sakir Akgun, Hakan Kucuksayan, Osman N. Ozes, Ozge Can, Arsenal S. Alikanoglu, Mustafa Yildiz and Hakan Akca*


View Abstract View on PubMed



Anti-Diarrheal Drug Repositioning In Tumour Cell Cytotoxicity


Jihene Elloumi-Mseddi, Dhouha Msalbi, Raouia Fakhfakh and Sami Aifa*


View Abstract View on PubMed


Adenosine Analogues as Opposite Modulators of the Cisplatin Resistance of Ovarian Cancer Cells


Katarzyna Bednarska-Szczepaniak*, Damian Krzyżanowski, Magdalena Klink* and Marek Nowak


View Abstract View on PubMed


Novel Fluorine Boron Hybrid Complex as Potential Antiproliferative Drugs on Colorectal Cancer Cell Line


Yasin Tülüce*, Hawro Dlawar Ismael Masseh, İsmail Koyuncu, Ahmet Kiliç, Mustafa Durgun and Halil Özkol


View Abstract View on PubMed


Synthesis and Screening of Pro-apoptotic and Angio-inhibitory Activity of Novel Benzisoxazole Derivatives Both In vitro and In vivo


Sathish Byrappa, Kavitha Rachaiah, Sumana Y. Kotian, Yashaswini Balaraju, Samudyata C. Prabhuswamimath, K. M. Lokanatha Rai and Bharathi P. Salimath*


View Abstract View on PubMed


Single-chain Antibody Against Reg4 Suppresses Gastric Cancer Cell Growth and Enhances 5-FU-induced Cell Death in vitro


Xue-Qing Zhang , Lu-Ting Yu, Pei Du, Tian-Qi Yin, Zhi-Yuan Zhang, Ying Xu , Xiang Li, You-Jie Li , Min Wang* and Chen Luo *


View Abstract View on PubMed


Abstracts Ahead of Print


Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools


Lurdes Gano, Teresa Pinheiro, António Pedro Matos, Francisco Tortosa, Tiago Filipe Jorge, Maria Salomé Gonçalves, Marta Martins, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, Maria Helena Garcia and Fernanda Marques*


View Abstract



2,4-Disubstituted Quinazoline Derivatives Act as Inducers of Tubulin Polymerization: Synthesis and Cytotoxicity


Ebrahim Saeedian Moghadam, Maryam Hossein poor Tehrani, René Csuk, Lucie Fischer, Mohammad Ali Faramarzi, Arezoo Rashidi, Iraj Javadi and Mohsen Amini*


View Abstract



Targeting Epidermal Growth Factor Receptor in Non-Small-Cell-Lung Cancer: Current State and Future Perspective


Shui-ming Bao, Qing-hui Hu, Wen-ting Yang, Yao Wang, Yin-ping Tong and Wen-Dai Bao*


View Abstract




The Role of Vitamin D and Sunlight Incidence in Cancer


Alice Barros Câmara* and Igor Augusto Brandãob


View Abstract



Editor's Choice

Biomarkers in Non-Small Cell Lung Cancer: Perspectives of Individualized Targeted Therapy

, 2018; 18(15): 2070 - 2077

Mateus N. Aoki*, Marla K. Amarante, Carlos E.C. de Oliveira and Maria A.E. Watanabe


DOI: 10.2174/1871520618666180827102101





Association of Phytol with Toxic and Cytotoxic Activities in an Antitumoral Perspective: A Meta-Analysis and Systemic Review

, 2018; 18(13): 1828 - 1837

Marcus V.O.B. Alencar, Muhammad T. Islam*, Eunus S. Ali, José V.O. Santos, Márcia F.C.J. Paz, João M.C. Sousa, Sandra M.M.M. Dantas, Siddhartha K. Mishra* and Ana A.C.M. Cavalcante


DOI: 10.2174/1871520618666180821113830



One-Pot Synthesis of Triazolo-Heterolignans: Biological Evaluation and Molecular Docking Studies as Tubulin Inhibitors

, 2018; 18(12): 1702 - 1710

Chada Raji Reddy*, Muppidi Subbarao, Jonnalagadda Vijaykumar, Surender Singh Jadav, Nilesh Sasane, Reddi Rani Valleti, Bhukya Supriya and Ramesh Ummanni*


DOI: 10.2174/1871520618666180718104647



Selection of a GPER1 Ligand via Ligand-based Virtual Screening Coupled to Molecular Dynamics Simulations and Its Anti-proliferative Effects on Breast Cancer Cells

, 2018; 18(11): 1629 - 1638

Alberto Martínez-Muñoz, Berenice Prestegui-Martel, David Méndez-Luna, Manuel J. Fragoso-Vázquez*, José Rubén García-Sánchez, Martiniano Bello, Marlet Martínez-Archundia, Alma Chávez-Blanco, Alfonso Dueñas-González, Irene Mendoza-Lujambio, José Trujillo-Ferrara and José Correa-Basurto*


DOI: 10.2174/1871520618666180510121431




68Ga-labeled HBED-CC Variant of uPAR Targeting Peptide AE105 Compared with 68Ga-NODAGA-AE105

, 2018; 18(9): 1289 - 1294

Kusum Vats, Rohit Sharma, Haladhar D. Sarma, Drishty Satpati* and Ashutosh Dash


DOI: 10.2174/1871520618666180316152618



Potential Pharmacological Inhibitors of Pim Kinase Under Clinical Trials

, 2018; 18(8): 1100 - 1114

Gomathi P. Jeyapal, Moola J.N. Chandrasekar*, Rajendiran Krishnasamy, Jubie Selvaraj, Manal Mohammad and Moola J. Nanjan


DOI: 10.2174/1871520618666180131113519



Design, Synthesis, and Biological Evaluation of New Azole Derivatives as Potent Aromatase Inhibitors with Potential Effects against Breast Cancer

, 2018; 18(7): 1016 - 1024

Fatemeh Kalalinia, Mohammad Jouya, Alireza K. Komachali, Seyed M. Aboutourabzadeh, Gholamreza Karimi*, Javad Behravan, Khalil Abnous, Leila Etemad, Hossein Kamali and Farzin Hadizadeh*


DOI: 10.2174/1871520618666180116105858



Open Access Articles

Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*




New Strategies for Therapeutic Cancer Vaccines

, 2018; 18: 1 - 9 (E-Pub Ahead of Print)

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi




The Use of Anthracyclines for Therapy of CNS Tumors

, 2015; 15(6): 721 - 727

Martina da Ros, Anna Lisa Iorio, Maurizio Lucchesi, Alessia Stival, Maurizio de Martino and Iacopo Sardi






Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment

, 2014; 14(8): 1121 - 1127

Bryan Oronsky, Neil Oronsky, Susan Knox, Gary Fanger and Jan Scicinski




Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

, 2014; 14(6): 840 - 851

Georgina A. Cardama, Maria J. Comin, Leandro Hornos, Nazareno Gonzalez, Lucas Defelipe, Adrian G. Turjanski, Daniel F. Alonso, Daniel E. Gomez and Pablo Lorenzano Menna




β2-Microglobulin-mediated Signaling as a Target for Cancer Therapy

, 2014; 14(3): 343 - 352

Takeo Nomura, Wen-Chin Huang, Haiyen E. Zhau, Sajni Josson, Hiromitsu Mimata and Leland W. K. Chung





Cytotoxicity and Apoptosis Induced by a Plumbagin Derivative in Estrogen Positive MCF-7 Breast Cancer Cells

, 2014; 14(1): 170 - 180

Sunil Sagar, Luke Esau, Basem Moosa, Niveen M. Khashab, Vladimir B. Bajic and Mandeep Kaur




Differential Effects of Polyphenols on Proliferation and Apoptosis in Human Myeloid and Lymphoid Leukemia Cell Lines

, 2013; 13(10): 1601 - 1613

Amani A Mahbub, Christine L. Le Maitre, Sarah L. Haywood-Small, Gordon J. McDougall, Neil A. Cross and Nicola Jordan-Mahy





Most Cited Articles

Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways

, 2014; 14(1): 77-96.

Andrzej T. Slominski, Michal A. Zmijewski, Igor Semak, Blazej Zbytek, Alexander Pisarchik, Wei Li, Jordan Zjawiony and Robert C. Tuckey


DOI: 10.2174/18715206113139990308




Chemical Metabolic Inhibitors for the Treatment of Blood-Borne Cancers

, 2014; 14(2): 223-232.

Martin Villalba, Nuria Lopez-Royuela, Ewelina Krzywinska, Moeez G. Rathore, Robert A. Hipskind, Houda Haouas and Nerea Allende-Vega


DOI: 10.2174/18715206113136660374


CCL21 and IFNγ Recruit and Activate Tumor Specific T cells in 3D Scaffold Model of Breast Cancer

, 2014; 14(2): 204-210.

Vy Phan-Lai, Forrest M. Kievit, Stephen J. Florczyk, Kui Wang, Mary L. Disis and Miqin Zhang


DOI: 10.2174/18715206113136660375




Most Accessed Articles



Determination of the Apoptotic Effect and Molecular Docking of Benzamide Derivative XT5 in K562 Cells

, 2018; 18(11): 1521-1530.

Tulin Ozkan*, Yalda Hekmatshoar*, Tugba Ertan-Bolelli, Andry N. Hidayat, Meral Beksac, Esin Aki-Yalcin, Ismail Yalcin and Asuman Sunguroglu


DOI: 10.2174/1871520618666171229222534




Induction of HT-29 Colon Cancer Cells Apoptosis by Pyrogallol with Growth Inhibiting Efficacy Against Drug-Resistant Helicobacter pylori

, 2018; 18(13): 1875-1884.

Seemaisamy Revathi, Faruck L. Hakkim*, Neelamegam R. Kumar, Hamid A. Bakshi, Luay Rashan, Mohammed Al-Buloshi, Sidgi S.A.A. Hasson, Muthukalingan Krishnan, Farideh Javid and Kayalvizhi Nagarajan*


DOI: 10.2174/1871520618666180806104902


BRCA1 as Target for Breast Cancer Prevention and Therapy

, 2015; 15(1): 4-14.

Alberto P.G. Romagnolo, Donato F. Romagnolo and Ornella I. Selmin


DOI: 10.2174/1871520614666141020153543


Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents

, 2018; 18(10): 1394-1404.

Ahmet Özdemir*, Sevtem Gökbulut, Belgin Sever, Gülşen A. Çiftçi and Mehlika D. Altıntop


DOI: 10.2174/1871520618666171206111923



Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091-1099.

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau


DOI: 10.2174/1871520617666171121115847



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