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Mini-Reviews in Medicinal Chemistry

Volume 22, 22 Issues, 2022
ISSN: 1875-5607 (Online)
ISSN: 1389-5575 (Print)
This journal supports open access

Aims & Scope

The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry, including quantitative structure-function relationships, synthetic chemistry, bioorganic chemistry, drug absorption, drug distribution, drug metabolism, new and emerging drug targets, pharmacogenomics, drug safety profile and drug-induced liver injury (DILI), drug discovery toxicology, high-throughput screening, combinatorial chemistry, structural characterization and organic syntheses of naturally occurring compounds, "nanosystem and nanocarriers", as well as chemical and analytical techniques used in rational drug design.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to remain informed and up-to-date with the latest and most important developments.

Mini-Reviews in Medicinal Chemistry


Volume 22


Number 9

Review Article (Mini-Review)

Modulation of Long Non-coding RNAs by Different Classes of Secondary Metabolites from Plants: A Mini-review on Antitumor Effects

, 22(9): 1232 - 1255

Tamires Cunha Almeida, Janaína Brandão Seibert , Tatiane Roquete Amparo , Gustavo Henrique Bianco de Souza , Glenda Nicioli da Silva and Orlando David Henrique dos Santos*

DOI: 10.2174/1389557521666211101161548

Review Article (Mini-Review)

Review Article (Mini-Review)

A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity

, 22(9): 1268 - 1280

Hiram Hernández-López, Christian Jairo Tejada-Rodríguez and Socorro Leyva-Ramos*

DOI: 10.2174/1389557522666220104150051

Review Article (Mini-Review)

Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A Review

, 22(9): 1289 - 1304

Rajnish Kumar*, Chanchal Singh, Avijit Mazumder, Salahuddin, Md. Mustaqeem Abdullah, Vivek Kumar and Pavan Prakash Giri

DOI: 10.2174/1389557521666211001122118

Review Article

The Role of LncRNA TUG1 in Obesity-related Diseases

, 22(9): 1305 - 1313

Mengzhen Xue, Fangqi Xia, Yaqi Wang, Leiqi Zhu, Yuanyang Li, Dengke Jia, Yan Gao, Yue Shi, Changcheng Zhang, Yumin He, Chaoqi Liu, Ding Yuan* and Chengfu Yuan*

DOI: 10.2174/1389557522666220117120228

Review Article

Therapeutic Journey and Recent Advances in the Synthesis of Coumarin Derivatives

, 22(9): 1314 - 1330

Shweta Sinha , Kuldeep Singh*, Akash Ved, Syed Misbahul Hasan and Samar Mujeeb

DOI: 10.2174/1389557521666211116120823

Mini-Reviews in Medicinal Chemistry, Volume 22 (2022) - Number 12

This issue is in progress but contains articles that are final and fully citable.

Mini-Reviews in Medicinal Chemistry, Volume 22 (2022) - Number 11

This issue is in progress but contains articles that are final and fully citable.

Mini-Reviews in Medicinal Chemistry, Volume 22 (2022) - Number 10

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

The Virulent Hypothetical Proteins: The Potential Drug Target Involved in Bacterial Pathogenesis

Muhammad Naveed*, Syeda Izma Makhdoom, Ghulam Abbas, Mohammadreza Safdari, Amin Farhadi, Solomon Habtemariam, Muhammad Aqib Shabbir, Khizra Jabeen, Muhammad Farrukh Asif and Sana Tehreem

DOI: 10.2174/1389557522666220413102107
View Abstract View on PubMed

A Concise and Useful Guide to Understand How Alpha1 Adrenoceptor Antagonists Work

Sidiane B. da Silva, Sidney G. D. Feitosa, Silvia M. de L. Alves, Ruth C. A. Santos, Janaína V. dos Anjos* and Alice V. Araújo*

DOI: 10.2174/1389557522666220504141949
View Abstract View on PubMed

MicroRNAs and Efferocytosis: Implications for Diagnosis and Therapy

Ali Mahmoudi, Fatemeh Moadab, Esmat Safdarian, Jamshid Gholizadeh Navashenaq, Mehdi Rezaee and Seyed Mohammad Gheibihayat*

DOI: 10.2174/1389557522666220330150937
View Abstract View on PubMed

Functional Ability of Dental Materials After Inclusion of Nanocarriers Containing Functional Substances: A Systematic Review

Moan Jéfter Fernandes Costa, Francisca Jennifer Duarte de Oliveira, Renally Bezerra Wanderley e Lima and Boniek Castillo Dutra Borges*

DOI: 10.2174/1389557522666220330145130
View Abstract View on PubMed

Abstracts Ahead of Print

Recent Insights of Metformin on Hepatocellular Carcinoma (HCC)

Kaizhen Wang, Kuojun Zhang, Xiangyu Zhang, Dong Chen and Sheng Jiang*

DOI: 10.2174/1389557522666220623150717
View Abstract

Tannic Acid as a Green Crosslinker for Biomaterials Applications

S.Yasaman Zolfaghari Moghaddam, Esmaeil Biazar*, Javad Esmaeili, Bahareh Kheilnezhad, Fatemeh Goleij and Samaneh Heidari

DOI: 10.2174/1389557522666220622112959
View Abstract

Microbiota-Gut-Brain Axis in Neurological Disorders: From Leaky Barriers Microanatomical Changes to Biochemical Processes

Irene Neri, Elisa Boschetti*, Matilde Yung Follo, Roberto De Giorgio, Lucio Cocco, Lucia Manzoli and Stefano Ratti

DOI: 10.2174/1389557522666220622111501
View Abstract

Nutraceuticals, a Bridge Between Past and Future: Focus on Mushrooms Biological Activities and Myco-Chemistry

Gitishree Das, Roberta Budriesi, Han-Seung Shin, Francesco Urso, Sankhadip Bose, Sabyasachi Banerjee, Maria del Pilar Rodriguez-Torres, Laura Beatrice Mattioli, Jayanta Kumar Patra* and Matteo Micucci*

DOI: 10.2174/1389557522666220622104845
View Abstract

Alternative Methods for Pulmonary-Administered Drugs Metabolism: a Breath of Change

Érika Yoko Suzuki, Alice Simon, Thaisa Francielle Souza Domingos, Bárbara de Azevedo Abrahim Vieira, Alessandra Mendonça Teles de Souza, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Flávia Almada do Carmo and Lucio Mendes Cabral*

DOI: 10.2174/1389557522666220620125623
View Abstract

Potential Mechanisms of Melatonin in Osteosarcoma and Bone-Related Neoplasms: Updated Review

Parisa Maleki Dana, Fatemeh Sadoughi, Russel J. Reiter, Bahman Yousefi and Zatollah Asemi*

DOI: 10.2174/1389557522666220619232941
View Abstract

Targeting Virus-Induced Reprogrammed Cell Metabolism via Glycolytic Inhibitors: An Effective Therapeutic Approach Against SARS-CoV-2

Mamta Singh, Dolly Sharma, Rajat Gupta, Manoj Garg, Andrea Altieri, Alexander Kurkin, Vinit Kumar* and Reshma Rani*

DOI: 10.2174/1389557522666220616112042
View Abstract

Chitosan: Applications in Drug Delivery System

Suresh Kumar, Ruby Dhiman, Carlos R Prudencio, Antonio Charlys da Costa, Arpana Vibhuti, Elcio Leal, Chung-Ming Chang, V. Samuel Raj and Ramendra Pati Pandey*

DOI: 10.2174/1389557522666220609102010
View Abstract

Published Contents

Editor's Choice

Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights into its Regulatory Mechanisms

, 2021; 21(18): 2835 - 2847

Ehsan Dadgostar, Maryam Fallah, Fatemeh Izadfar, Reza Heidari-Soureshjani, Michael Aschner, Omid Reza Tamtaji* and Hamed Mirzaei*

DOI: 10.2174/1389557521666210406164758

Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity

, 2021; 21(17): 2420 - 2457

Priyanka Joshi, Sushil Joshi, Deepak Semwal, Akansha Bisht, Sarvesh Paliwal, Jaya Dwivedi and Swapnil Sharma*

DOI: 10.2174/1389557521666210122153823

Mediterranean Diet Polyphenols: Anthocyanins and Their Implications for Health

, 2021; 21(13): 1692 - 1700

Simona Martinotti, Gregorio Bonsignore, Mauro Patrone and Elia Ranzato*

DOI: 10.2174/1389557521999201230200813

Resistance to Intervention: Paclitaxel in Breast Cancer

, 2021; 21(10): 1237 - 1268

Vipin Mohan Dan, Reji Saradha Raveendran and Sabulal Baby*

DOI: 10.2174/1389557520999201214234421

Open Access Articles

Aptamers Against COVID-19: An Untested Opportunity

, 2022; 22: 1 - 8 (E-Pub Ahead of Print)

Annekathrin Haberland* and Johannes Müller

Association between Vitamin D Levels and Nonalcoholic Fatty Liver Disease: Potential Confounding Variables

, 2019; 19(4): 310 - 332

Lucia Pacifico, John F. Osborn, Enea Bonci, Pasquale Pierimarchi and Claudio Chiesa*

Adenosine: Synthetic Methods of Its Derivatives and Antitumor Activity

, 2018; 18(20): 1684 - 1701

Francisco Z. Valdés, Víctor Z. Luna, Bárbara R. Arévalo, Nelson V. Brown and Margarita C. Gutiérrez*

Nutlin-3, A p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment

, 2018; 18(2): 173 - 183

Voon Yee-Lin*, Wong Pooi-Fong and Alan Khoo Soo-Beng

G4 Aptamers: Trends in Structural Design

, 2016; 16(16): 1321 - 1329

Anna Varizhuk, Nikolay Ilyinsky, Igor Smirnov and Galina Pozmogova

Augmentation of Creatine in the Heart

, 2016; 16(1): 19 - 28

Sevasti Zervou, Hannah J. Whittington, Angela J. Russell and Craig A. Lygate

Intramolecular Immunological Signal Hypothesis Revived - Structural Background of Signalling Revealed by Using Congo Red as a Specific Tool

, 2014; 14(13): 1104 - 1113

A. Jagusiak, L. Konieczny, M. Krol, P. Marszalek, B. Piekarska, P. Piwowar, I. Roterman, J. Rybarska, B. Stopa and G. Zemanek

Attachment of Rod-Like (BAR) Proteins and Membrane Shape

, 2011; 11(4): 272 - 282

D. Kabaso, E. Gongadze, P. Elter, U. van Rienen, J. Gimsa, V. Kralj-Iglic and A. Iglic

Most Cited Articles

Review Article

Research progress of glycyrrhizic acid on antiviral activity

, 2019; 19(10): 826-832.

Zhi-Gang Sun*, Ting-Ting Zhao, Na Lu, Yong-An Yang and Hai-Liang Zhu*

DOI: 10.2174/1389557519666190119111125

Review Article

Radicals, oxidative/nitrosative stress and preeclampsia

, 2019; 19(3): 178-193.

Seyithan Taysi*, Ayse Saglam Tascan, Mete Gurol Ugur and Mustafa Demir

DOI: 10.2174/1389557518666181015151350

Systemic Review Article

Pharmacological aspects and potential use of phloretin: A systemic review

, 2019; 19(13): 1060-1067.

Arokia V.A. Mariadoss*, Ramachandran Vinyagam, Vinothkumar Rajamanickam, Vijayalakshmi Sankaran, Sathish Venkatesan and Ernest David*

DOI: 10.2174/1389557519666190311154425

Review Article

A review exploring therapeutic worth of 1,3,4-Oxadiazole tailored compounds

, 2019; 19(6): 477-509.

Garima Verma, Mohemmed F. Khan, Wasim Akhtar, Mohammad Mumtaz Alam, Mymoona Akhter and Mohammad Shaquiquzzaman*

DOI: 10.2174/1389557518666181015152433

Systemic Review Article

Clinical management of oral lichen planus: A systematic review

, 2019; 19(13): 1049-1059.

Luca Oberti, Lucchese Alberta, Petruzzi Massimo, Carinci Francesco and Lauritano Dorina*

DOI: 10.2174/1389557519666190301144157

Review Article

Protective role of natural products in cisplatin-induced nephrotoxicity

, 2019; 19(14): 1134-1143.

Nurul Raudzah Adib Ridzuan, Norhashima Abd Rashid, Faizah Othman, Siti Balkis Budin, Farida Hussan and Seong Lin Teoh*

DOI: 10.2174/1389557519666190320124438

Review Article

A review on anticancer potentials of benzothiazole derivatives

, 2020; 20(1): 12-23.

Nandini Pathak, Ekta Rathi, Nitesh Kumar*, Suvarna G. Kini and C. Mallikarjuna Rao

DOI: 10.2174/1389557519666190617153213

Review Article

Benzimidazole: A milestone in the field of medicinal chemistry

, 2020; 20(7): 532-565.

Mahesh S. Vasava, Manoj N. Bhoi, Sanjay K. Rathwa, Divya J. Jethava, Prachi T. Acharya, Dhaval B. Patel and Hitesh D. Patel*

DOI: 10.2174/1389557519666191122125453

Review Article

A review on quinoline derived scaffolds as anti-HIV agents

, 2019; 19(6): 510-526.

Nisha Chokkar, Sourav Kalra, Monika Chauhan and Raj Kumar*

DOI: 10.2174/1389557518666181018163448

Review Article

Parkinson’s disease: A review from pathophysiology to treatment

, 2020; 20(9): 754-767.

Bianca L.B. Marino, Lucilene R. de Souza, Kessia P.A. Sousa, Jaderson V. Ferreira, Elias C. Padilha, Carlos H.T.P. da Silva, Carlton A. Taft and Lorane I.S. Hage-Melim*

DOI: 10.2174/1389557519666191104110908

Review Article

Marine natural product bis-indole alkaloid caulerpin: Chemistry and biology

, 2019; 19(9): 751-761.

Jignesh Lunagariya, Poonam Bhadja, Shenghui Zhong, Rohit Vekariya and Shihai Xu*

DOI: 10.2174/1389557517666170927154231

General Review Article

Biological nanofactories: Using living forms for metal nanoparticle synthesis

, 2021; 21(2): 245-265.

Shilpi Srivastava, Zeba Usmani, Atanas G. Atanasov, Vinod Kumar Singh, Nagendra Pratap Singh, Ahmed M. Abdel-Azeem, Ram Prasad, Govind Gupta, Minaxi Sharma* and Atul Bhargava*

DOI: 10.2174/1389557520999201116163012

Review Article

Synthesis and biological activity of hydrazones and derivatives: A review

, 2020; 20(5): 342-368.

Juliana de Oliveira Carneiro Brum*, Tanos Celmar Costa França, Steven R. LaPlante and José Daniel Figueroa Villar

DOI: 10.2174/1389557519666191014142448

Most Accessed Articles

Biological Nanofactories: Using Living Forms for Metal Nanoparticle Synthesis

, 2021; 21(2): 245-265.

Srivastava, Shilpi; Usmani, Zeba; Atanasov, Atanas G.; Singh, Vinod Kumar; Singh, Nagendra Pratap; Abdel-Azeem, Ahmed M.; Prasad, Ram; Gupta, Govind; Sharma, Minaxi; Bhargava, Atul

DOI: 10.2174/1389557520999201116163012

Current and Advanced Nanomaterials in Dentistry as Regeneration Agents: An Update

, 2021; 21(7): 899-918.

Yazdanian, Mohsen; Rahmani, Aghil; Tahmasebi, Elahe; Tebyanian, Hamid; Yazdanian, Alireza; Mosaddad, Seyed Ali

DOI: 10.2174/1389557520666201124143449

Virtual Screening of Natural Products Database

, 2021; 21(18): 2655-2728.

de Sousa Luis, Jose Alixandre; Costa Barros, Renata Priscila; de Sousa, Natalia Ferreira; Muratov, Eugene; Scotti, Luciana; Scotti, Marcus Tullius

DOI: 10.2174/1389557520666200730161549

Current Insights into the Chemistry and Antitubercular Potential of Benzimidazole and Imidazole Derivatives

, 2021; 21(5): 633-647.

Parwani, Deepa; Bhattacharya, Sushanta; Rathore, Akash; Mallick, Chaitali; Asati, Vivek; Agarwal, Shivangi; Rajoriya, Vaibhav; Das, Ratnesh; Kashaw, Sushil Kumar

DOI: 10.2174/1389557520666201102094401

Effectiveness of Azithromycin as add-on Therapy in COVID-19 Management

, 2021; 21(19): 2860-2873.

Wahab, Shadma; Ahmad, Md Faruque; Hussain, Arshad; Usmani, Shazia; Shoaib, Ambreen; Ahmad, Wasim

DOI: 10.2174/1389557521666210401093948


Muhammad Iqbal Choudhary
(34605 citations)
H.E.J. Research Institute of Chemistry
University of Karachi
Alessandro Granito
University of Bologna
Diparitmento Di Scienze Mediche E Chirurgiche
Davide Barreca
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences
University of Messina
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