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Medicinal Chemistry

Volume 18, 10 Issues, 2022
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

Aims & Scope

Medicinal Chemistry, a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles, short communications, letters and guest-edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts.

Medicinal Chemistry covers all areas of medicinal chemistry, including biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools, structural biological studies using X-ray, NMR, etc. of relevant ligands and biological targets, aiming at the investigation of molecular recognition processes involved in the action of bioactive compounds. The journal also covers chemical and analytical techniques used in rational drug design, synthetic chemistry, bioorganic chemistry of small molecules and naturally occurring compounds, structural characterization, drug-likeness, optimization of structure and properties, the effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation and toxicology of bioactive compounds including design, synthesis, and evaluation of novel types of prodrugs, quantitative structure-activity relationships, modelling studies, docking studies, new and emerging drug targets, pharmacogenomics, high-throughput screening, and combinatorial chemistry.

Medicinal Chemistry is an essential journal for all researchers involved in drug design and discovery.

Medicinal Chemistry

,

Volume 18

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Number 8



Mini-Review Article

Pyrazole Containing Anti-HIV Agents: An Update

, 18(8): 831 - 846

Sanjay Kumar*, Shiv Gupta*, Varsha Rani and Priyanka Sharma


DOI: 10.2174/1573406418666220106163846



Review Article





Research Article

Synthesis, Anticancer Activities, and Mechanism of N-heptyl-containing Biguanide Derivatives

, 18(8): 895 - 902

Wei Wang, Di Xiao, Sichun Zhou, Simeng Xu, Xinyi Tang, Xinchong Zhou, Jinbing Liu, Cangcang Xu, Mei Peng and Xiaoping Yang*


DOI: 10.2174/1573406418666220210111458



Medicinal Chemistry, Volume 18 (2022) - Number 9


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print






Synthesis Strategies and Medicinal Value of Pyrrole and its Fused Heterocyclic Compounds


Samar Said Fatahala, Mosaad Sayed Mohamed, Jaqueline Youssef Sabry* and Yara Esam El-Deen Mansour


DOI: 10.2174/1573406418666220325141952
View Abstract View on PubMed



Abstracts Ahead of Print

Novel Caffeic Acid - Zinc Acetate Complex: Studies on Promising Antidiabetic and Antioxidant Synergism Through Complexation


Godfrey R. Matowane, Limpho M. Ramorobi, Samson S. Mashele, Susanna L. Bonnet, Anwar E.M. Noreljaleel, Shasank S. Swain, Tshepiso J. Makhafola and Chika I. Chukwuma*


DOI: 10.2174/1573406418666220620144601
View Abstract


In vitro and in silico xanthine oxidase inhibitory activities of 3-aryl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives


Afshan Gul, Syed Muhammad Saad, Humaira Zafar, Atia-tul-Wahab, Khalid Mohammed Khan* and M. Iqbal Choudhary*


DOI: 10.2174/1573406418666220620124034
View Abstract



Exploring Therapeutic Potential of 1,3,4-Oxadiazole Nucleus as Anticancer Agents: A Mini-Review


Asma Bukhari*, Humaira Nadeem, Sadia Sarwar, Inzamam Abbasi, Muhammad Tariq Khan, Iqra Hamid and Uzma Bukhari


DOI: 10.2174/1573406418666220608120908
View Abstract


Design, synthesis and anti-breast cancer activity of novel fluorinated 7-O-modified genistein derivatives


Zhifang Yang, Yi Liu, Zhuo Liu, Qinfang Xu, Shun Liu, Kailin Jiang, Yuanlong Shi, Wenyu Xu, Zehua Yang, Pengbing Mi, Yijun Xiang, Xu Yao* and Xing Zheng*


DOI: 10.2174/1573406418666220607140651
View Abstract



Revisiting Purine Nucleoside Cholinesterase Inhibitors – An Experimental Glycon Structure/Activity Relationship Study


Vasco Cachatra, Maria Conceição Oliveira, Oscar Lopez, José G. Fernandez-Bolaños and Amélia Pilar Rauter*


DOI: 10.2174/1871520622666220527150712
View Abstract


Synthesis and Potential Antidiabetic Properties of Curcumin-Based Derivatives: An In Vitro and In Silico Study of α-Glucosidase and α-Amylase Inhibition


Mohammad Ezati, Fahimeh Ghavamipour, Narges Khosravi, Reza H. Sajedi, Maryam Chalabi, Alireza Farokhi, Hadi Adibi* and Reza Khodarahmi*


DOI: 10.2174/1573406418666220509101854
View Abstract




Published Contents

Open Access Articles


Prospects for Discovering the Secondary Metabolites of <i>Cordyceps</i> Sensu Lato by the Integrated Strategy

, 2021; 17(2): 97 - 120

Shabana Bibi, Yuan-Bing Wang, De-Xiang Tang, Mohammad Amjad Kamal and Hong Yu*




Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*





Most Cited Articles



Research Article

Synthesis and structural elucidation of novel benzothiazole derivatives as anti-tubercular agents: In-silico screening for possible target identification

, 2019; 15(3): 311-326.

Katharigatta N. Venugopala*, Sandeep Chandrashekharappa, Melendhran Pillay, Subhrajyoti Bhandary, Mahmoud Kandeel, Fawzi M. Mahomoodally , Mohamed A. Morsy, Deepak Chopra , Bandar E. Aldhubiab, Mahesh Attimarad, Osama I. Alwassil , Sree Harsha, Koleka Mlisana and Bharti Odhav


DOI: 10.2174/1573406414666180703121815


Review Article

Thiazole compounds as antiviral agents: An update

, 2020; 16(1): 4-23.

Inder P. Singh*, Shiv Gupta and Sanjay Kumar


DOI: 10.2174/1573406415666190614101253


Research Article

New hybrid scaffolds based on hydrazinyl thiazole substituted coumarin; as novel leads of dual potential; In Vitro α-amylase inhibitory and antioxidant (DPPH and ABTS radical scavenging) activities

, 2019; 15(1): 87-101.

Uzma Salar, Khalid M. Khan*, Sridevi Chigurupati, Shazia Syed, Shantini Vijayabalan, Abdul Wadood, Muhammad Riaz, Mehreen Ghufran and Shahnaz Perveen


DOI: 10.2174/1573406414666180903162243


Research Article

Helminthicidal and larvicidal potentials of biogenic silver nanoparticles synthesized from medicinal plant momordica charantia

, 2019; 15(7): 781-789.

Amruta Shelar, Jaiprakash Sangshetti, Shampa Chakraborti*, Ajay Vikram Singh*, Rajendra Patil* and Suresh Gosavi*


DOI: 10.2174/1573406415666190430142637


Research Article

ZnO nanoparticles catalyst in the synthesis of bioactive fused pyrimidines as anti-breast cancer agents targeting VEGFR-2

, 2019; 15(3): 277-286.

Dina H. Dawood, Eman M.H. Abbas, Thoraya A. Farghaly*, Mamdouh M. Ali and Mohammed F. Ibrahim


DOI: 10.2174/1573406414666180912113226


Research Article

iATP: A sequence based method for identifying anti-tubercular peptides

, 2020; 16(5): 620-625.

Wei Chen*, Pengmian Feng and Fulei Nie


DOI: 10.2174/1573406415666191002152441




Research Article

Synthesis, molecular modelling and biological studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one derivatives as HIV-1 integrase inhibitors

, 2019; 15(7): 755-770.

Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian


DOI: 10.2174/1573406415666181219113225


Research Article

The inhibition of polysialyltranseferase ST8SiaIV through heparin binding to polysialyltransferase domain (pstd)

, 2019; 15(5): 486-495.

Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*


DOI: 10.2174/1573406415666181218101623


Research Article

Rational design of colchicine derivatives as anti-HIV agents via QSAR and molecular docking

, 2019; 15(4): 328-340.

Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul


DOI: 10.2174/1573406414666180924163756



Research Article

Pyrano[3,2-c]quinoline derivatives as new class of α-glucosidase inhibitors to treat type 2 diabetes: Synthesis, in vitro biological evaluation and kinetic study

, 2019; 15(1): 8-16.

Zahra Heydari, Maryam Mohammadi-Khanaposhtani, Somaye Imanparast, Mohammad A. Faramarzi, Mohammad Mahdavi *, Parviz R. Ranjbar* and Bagher Larijani


DOI: 10.2174/1573406414666180528110104



Most Accessed Articles

The Introduction of Hydrazone, Hydrazide, or Azepane Moieties to the Triterpenoid Core Enhances an Activity Against M. tuberculosis

, 2021; 17(2): 134-145.

Kazakova, Oxana B.; Medvedeva, Natalya, I; Smirnova, Irina E.; Lopatina, Tatyana, V; Veselovsky, Alexander V.


DOI: 10.2174/1573406416666200115161700





Synthesis of thiazolyl-N-phenylmorpholine Derivatives and their Biological Activities

, 2021; 17(7): 790-805.

Al-Soliemy, Amerah M.; Farghaly, Thoraya A.; Abbas, Eman M. H.; Shaaban, Mohamed R.; Zayed, Mohie E. M.; El-Naggar, Tarek B. A.


DOI: 10.2174/1573406416666200517103435



Curcumin-based Antioxidant and Glycohydrolase Inhibitor Compounds: Synthesis and In Vitro Appraisal of the Dual Activity Against Diabetes

, 2021; 17(7): 677-698.

Esmaeili, Sajjad; Ghobadi, Nazanin; Nazari, Donya; Pourhossein, Alireza; Rasouli, Hassan; Adibi, Hadi; Khodarahmi, Reza


DOI: 10.2174/1573406416666200506083718


Structure-Based Virtual Screening of New Benzoic Acid Derivatives as Trypanosoma cruzi Trans-sialidase Inhibitors

, 2021; 17(7): 724-731.

Karina Vazquez-Jimenez, Lenci; Delia Paz-Gonzalez, Alma; Juarez-Saldivar, Alfredo; Laura Uhrig, Maria; Agusti, Rosalia; Reyes-Arellano, Alicia; Nogueda-Torres, Benjamin; Rivera, Gildardo


DOI: 10.2174/1573406416666200506084611



Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study

, 2021; 17(5): 442-452.

Riswanto, Florentinus D. O.; Rawa, Mira S. A.; Murugaiyah, Vikneswaran; Salin, Nurul H.; Istyastono, Enade P.; Hariono, Maywan; Wahab, Habibah A.


DOI: 10.2174/1573406415666191206095032


Features, Pharmacological Chemistry, Molecular Mechanism and Health Benefits of Lemon

, 2021; 17(3): 187-202.

Singh, Nitika; Yarla, Nagendra Sastry; Siddiqi, Nikhat Jamal; Pereira, Maria de Lourdes; Sharma, Bechan


DOI: 10.2174/1573406416666200909104050


Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Deriva-tives as Antibacterial and Antifungal Agents

, 2021; 17(6): 638-645.

Abbas, Samir Y.; El-Sharief, Marwa A. M. Sh; Al-Harbi, Reem A. K.; El-Gammal, Eman W.; El-Sharief, Ahmed M. S.


DOI: 10.2174/1573406416666191227112648




Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies

, 2021; 17(8): 834-843.

Ben Hadda, Taibi; Deniz, Fatma Sezer Senol; Orhan, Ilkay Erdogan; Zgou, Hsaine; Rauf, Abdur; Mabkhot, Yahia Nasser; Bennani, Brahim; Emam, Dalia R.; Kheder, Nabila Abdelshafy; Asayari, Abdulrhman; Bin Muhsinah, Abdullatif; Maalik, Aneela


DOI: 10.2174/1573406416666200610185654




Editor-in-Chief

graphic
Dimitra Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy
Aristotle University of Thessaloniki
Thessaloniki
(Greece)
Biography
View Full Editorial Board

Nobel Laureate on Editorial Board

graphic
Prof. Ferid Murad
(USA)

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