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Endocrine, Metabolic & Immune Disorders - Drug Targets

Formerly: Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 22, 14 Issues, 2022
ISSN: 2212-3873 (Online)
ISSN: 1871-5303 (Print)
This journal supports open access

Aims & Scope

This journal is devoted to full-length/ mini-reviews and original articles based on experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Moreover, the topics related to the effects of food components and/or nutraceuticals on the endocrine-metabolic-immune axis and on microbiome composition are welcome. The journal’s scope also covers neuroendocrinology, reproductive endocrinology, hormone secretion, and their effects on different organs.

Endocrine, Metabolic & Immune Disorders - Drug Targets


Volume 22


Number 3

Review Article

Research Article

Sofosbuvir/Ledipasvir for Treatment of Chronic Hepatitis C Infection in Adult Patients with β- Thalassemia Major: A Real-Life Study

, 22(3): 290 - 296

Tamer A. Elbedewy, Sherief Abd-Elsalam*, Sahar Mohamed Mostafa, Raghda Samir Abdellatif, Amina Fouad, Mona Youssef, Yousry Esam-Eldin Abo-Amer and Mohamed A. Elsebaey

DOI: 10.2174/1871530321666210202150538

Research Article

Cannabis Sativa L. Flower and Bud Extracts Inhibited In vitro Cholinesterases and β-Secretase Enzymes Activities: Possible Mechanisms of Cannabis Use in Alzheimer Disease

, 22(3): 297 - 309

Teboho Mooko, Asis Bala, Satyajit Tripathy, Chethan S. Kumar, Chandrashekara P. Mahadevappa, Sushil K. Chaudhary and Motlalepula G. Matsabisa*

DOI: 10.2174/1871530321666210222124349

Research Article

Effect of Direct-Acting Antiviral Drugs on Erectile Functions among Hepatitis C Patients: A Prospective Interventional Study

, 22(3): 310 - 317

Mohamed Alhefnawy, Ahmed Mohey, Ahmed Fathi, Ahmed Mansour, Sherief Abd-Elsalam*, Ahmed Eissa, Ayman Hagras, Stefano Puliatti and Khaled Almekaty

DOI: 10.2174/1871530321666210212143932

Research Article

Association between Increased Bcl-2, Fas and FasL Levels and Inflammation Extent in Labial Salivary Glands During Primary Sjögren's Syndrome

, 22(3): 328 - 338

Sarah Benchabane*, Assia Slimani-Kaddouri, Dahbia Acheli, Thouraya Bendimerad-Iratene, Redouane Mesbah and Chafia Touil-Boukoffa*

DOI: 10.2174/1871530321666210809155147

Research Article

Endocrine, Metabolic & Immune Disorders - Drug Targets, Volume 22 (2022) - Number 5

This issue is in progress but contains articles that are final and fully citable.

Endocrine, Metabolic & Immune Disorders - Drug Targets, Volume 22 (2022) - Number 4

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Bilirubin and Epigenetic Modifications in Metabolic and Immunometabolic Disorders

Mostafa Moradi Sarabi, Esmaeel Babaeenezhad, Maral Amini, Mozhgan Kaviani and Fakhraddin Naghibalhossaini*

DOI: 10.2174/1871530321666211125102924
View Abstract View on PubMed

Endocrine Disruptors and Obesity: An Overview

Isanna Murro, Giuseppe Lisco, Carmen Di Noia, Luisa Lampignano, Roberta Zupo, Vito Angelo Giagulli, Edoardo Guastamacchia, Vincenzo Triggiani and Giovanni De Pergola*

DOI: 10.2174/1871530322666220328122300
View Abstract View on PubMed

Effects of Dapagliflozin on Adipose and Liver Fatty Acid Composition and mRNA Expression Involved in Lipid Metabolism in High-Fat-Fed Rats

Daisuke Sato*, Takao Nakamura, Jota Amarume, Mizuna Yano, Yuta Umehara, Atsuyoshi Nishina, Kazuhiko Tsutsumi, Zhonggang Feng and Masataka Kusunoki

DOI: 10.2174/1871530322666220307153618
View Abstract View on PubMed

Different Phenotypes of Schimke Immuno-Osseous Dysplasia (SIOD) in Two Sisters with the Same Mutation in the SMARCAL1 Gene

Ana Castellano-Martinez, Silvia Acuñas-Soto, Raquel De la Varga-Martinez, Moises Rodriguez-Gonzalez*, Francisco Mora-Lopez, Marianela Iriarte-Gahete and Virginia Roldan-Cano

DOI: 10.2174/1871530322666220223154028
View Abstract View on PubMed

Abstracts Ahead of Print

A new device for remote monitoring of vital parameters in acromegalic patients: pilot study

Denise Costa*, Tania D’Amico, Valeria Mercuri, Riccardo Schiaffini and Patrizia Gargiulo

DOI: 10.2174/1871530322666220516161753
View Abstract

Is Testosterone the “Fountain of Youth” for Aging Men?

Vito Angelo Giagulli, Vito Angelo Giagulli*, Giuseppe Lisco, Francesco Mariano, Anna De Tullio and Vincenzo Triggiani

DOI: 10.2174/1871530322666220516160435
View Abstract

Increased Salivary Cytokines and Nitric Oxide levels in Behçet’s Disease: Interleukin-32, a Novel Player in Disease Prognosis

Zohra Hadjimi, Houda Belguendouz, Sarah Benchabane, Nour El Houda Ghozali, Manel Amri, Racha Kocheida, Djenette Hakem, Ahmed Biad, Fifi Otmani, Yasmine Kemikem, Malika Terahi and Chafia Touil-Boukoffa*

DOI: 10.2174/1871530322666220512120948
View Abstract

Genistein in the Treatment of Hypertension: A Review

Paulina Sigowska, Michał Zimoch, Aleksandra Baska, Jakub Kazik, Kamil Leis and Grzegorz Grześk

DOI: 10.2174/1871530322666220510125115
View Abstract

Pancreatic Macrophages and their Diabetogenic Effects: Highlight on Several Metabolic Scenarios and Dietary Approach

Giuseppe Lisco, Vito Angelo Giagulli, Giovanni De Pergola, Edoardo Guastamacchia, Jirillo Emilio* and Vincenzo Triggiani

DOI: 10.2174/1871530322666220510123913
View Abstract

Antidiabetic Phytocompounds Acting as Glucose Transport Stimulators

Mourad Akdad, Rabii Ameziane, Farid Khallouki, Youssef Bakri and Mohamed Eddouks*

DOI: 10.2174/1871530322666220510093720
View Abstract

Effects of Semaglutide on Glycemic Control and Weight Loss in a Patient with Prader-Willi Syndrome: A Case Report

Elena Sani*, Giuliana Da Prato, Maria Grazia Zenti, Andrea Bordugo, Maddalena Trombetta and Enzo Bonora

DOI: 10.2174/1871530322666220509225637
View Abstract

Published Contents

Editor's Choice

Can Cytokines be used as an Activation Marker in Rheumatoid Arthritis?

, 2021; 21(8): 1459 - 1465

Fatih Öner Kaya, Yeşim Ceylan, Belkız Öngen İpek, Zeynep Güneş Özünal, Gülbüz Sezgin and Selim Nalbant*

DOI: 10.2174/1871530320666201019115030

Benfotiamine Reduces Dendritic Cell Inflammatory Potency

, 2021; 21(7): 1344 - 1351

Neda Djedovic, Iva Božić, Đorđe Miljković* and Irena Lavrnja

DOI: 10.2174/1871530320999200905114135

Acute Versus Chronic Administration of Calcineurin-Inhibitors Differentially Affect T-Cell Function

, 2021; 21(6): 1083 - 1089

Julia Kirchhof, Benjamin Wilde*, Justine Schmidt, Nils Mülling, Liubov Petrakova, Alexandra Brinkhoff, Manfred Schedlowski and Oliver Witzke

DOI: 10.2174/1871530320999200831161710

The Effects of Pemafibrate in Japanese Patients with Type 2 Diabetes Receiving HMG-CoA Reductase Inhibitors

, 2021; 21(5): 919 - 924

Masataka Kusunoki*, Takahiko Sakazaki, Kazuhiko Tsutsumi, Tetsuro Miyata and Yoshiharu Oshida

DOI: 10.2174/1871530320999200818135553

Downregulation of miR-140 is Correlated with Poor Prognosis and Progression of Thyroid Cancer

, 2021; 21(4): 749 - 755

Qianqian Yu, Wenhai Sun, Hui Hua, Yulian Chi, Xiaomin Liu, Anbing Dong, Yinghe Sun, Jianhua Zhang and Ge Guan*

DOI: 10.2174/1871530320666200724180742

T Cell Proliferative Responses and IgG Antibodies to β2GPI in Patients with Diabetes and Atherosclerosis

, 2021; 21(3): 495 - 503

Mohammad R. Monjezi, Hamed Fouladseresht, Shirin Farjadian, Behrouz Gharesi-Fard, Shahdad Khosropanah and Mehrnoosh Doroudchi*

DOI: 10.2174/1871530320666200505115850

Positive Correlation between Circulating Fetuin-A and Severity of Coronary Artery Disease in Men

, 2021; 21(2): 338 - 344

Reza Afrisham, Maliheh Paknejad, Davod Ilbeigi, Sahar Sadegh-Nejadi, Sattar Gorgani-Firuzjaee* and Mahmoud Vahidi*

DOI: 10.2174/1871530320666200601164253

Open Access Articles

The Skeletal Effects of Gonadotropin-Releasing Hormone Antagonists: A Concise Review

, 2021; 21(10): 1713 - 1720

Nur-Vaizura Mohamad, Soelaiman Ima-Nirwana and Kok-Yong Chin*

How Much Vitamin D is Too Much? A Case Report and Review of the Literature

, 2021; 21(9): 1653 - 1659

Sara De Vincentis*, Antonino Russo, Marta Milazzo, Amedeo Lonardo, Maria C. De Santis, Vincenzo Rochira, Manuela Simoni and Bruno Madeo

False Positive of <sup>68</sup>Ga-DOTATATE PET-CT in a Paraganglioma

, 2021; 21(7): 1352 - 1355

Benedetta Zampetti, Roberto Attanasio*, Marco Boniardi and Renato Cozzi

Effects of a Low Carb Diet and Whey Proteins on Anthropometric, Hematochemical, and Cardiovascular Parameters in Subjects with Obesity

, 2020; 20(10): 1719 - 1725

Giovanni De Pergola*, Roberta Zupo, Luisa Lampignano, Silvia Paradiso, Isanna Murro, Annagrazia Cecere, Nicola Bartolomeo, Marco M. Ciccone, Gianluigi Giannelli and Vincenzo Triggiani

The Association between Peripheral Blood Cells and the Frailty Syndrome in Patients with Cardiovascular Diseases

, 2020; 20(9): 1419 - 1433

Constantin Bodolea, Elisabeta I. Hiriscau*, Elena-Cristina Buzdugan, Alin I. Grosu, Laurențiu Stoicescu, Ștefan Vesa and Omar Cauli

Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 2: Therapeutic Issues

, 2020; 20(8): 1144 - 1155

Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson

Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 1: Diagnostic and Clinical Issues

, 2020; 20(8): 1133 - 1143

Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson

Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

, 2020; 20(7): 1117 - 1132

Abdelaziz M. Hussein*, Elsayed A. Eid, Ismaeel Bin-Jaliah, Medhat Taha and Lashin S. Lashin

Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway

, 2020; 20(5): 771 - 780

Shuang Yao, Jun Zhang, Yuxia Zhan, Yuanping Shi, Yang Yu, Lu Zheng, Ning Xu* and Guanghua Luo*

Future Perspective of Diabetic Animal Models

, 2020; 20(1): 25 - 38

Shashank Pandey and Magdalena C. Dvorakova*

Pioglitazone Therapy and Fractures: Systematic Review and Meta- Analysis

, 2018; 18(5): 502 - 507

Velichka Pavlova*, Elena Filipova, Katya Uzunova, Krassimir Kalinov and Toni Vekov

Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Assessment of Response to Treatment and Follow-Up in Gastroenteropancreatic Neuroendocrine Neoplasms

, 2018; 18(5): 419 - 449

Franco Grimaldi*, Nicola Fazio*, Roberto Attanasio, Andrea Frasoldati, Enrico Papini, Nadia Cremonini, Maria V. Davi, Luigi Funicelli, Sara Massironi, Francesca Spada, Vincenzo Toscano, Annibale Versari, Michele Zini, Massimo Falconi and Kjell Oberg

Shift from Levothyroxine Tablets to Liquid Formulation at Breakfast Improves Quality of Life of Hypothyroid Patients

, 2018; 18(3): 235 - 240

Rinaldo Guglielmi, Franco Grimaldi, Roberto Negro, Andrea Frasoldati, Irene Misischi, Filomena Graziano, Claudia Cipri, Edoardo Guastamacchia, Vincenzo Triggiani* and Enrico Papini

GH Supplementation Effects on Cardiovascular Risk in GH Deficient Adult Patients: A Systematic Review and Meta-analysis

, 2017; 17(4): 285 - 296

Vito A. Giagulli*, Marco Castellana, Raffaella Perrone, Edoardo Guastamacchia, Massimo Iacoviello and Vincenzo Triggiani

Most Cited Articles

Research Article

Probiotics efficacy on oxidative stress values in inflammatory bowel disease: A randomized double-blinded placebo-controlled pilot study

, 2019; 19(3): 373-381.

Andrea Ballini, Luigi Santacroce*, Stefania Cantore, Lucrezia Bottalico, Gianna Dipalma, Skender Topi, Rajiv Saini, Danila De Vito and Francesco Inchingolo

DOI: 10.2174/1871530319666181221150352

Research Article

Hypoglycemic and hypolipemic effects of a new lecithin formulation of bergamot polyphenolic fraction: A double blind, randomized, placebo- controlled study

, 2019; 19(2): 136-143.

Vincenzo Mollace*, Miriam Scicchitano, Sara Paone, Francesca Casale, Carla Calandruccio, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Jessica Maiuolo, Saverio Nucera, Antonella Riva, Pietro Allegrini, Massimo Ronchi, Giovanna Petrangolini and Ezio Bombardelli

DOI: 10.2174/1871530319666181203151513

Review Article

BPA and nutraceuticals, simultaneous effects on endocrine functions

, 2019; 19(5): 594-604.

Stefania D'Angelo, Marika Scafuro and Rosaria Meccariello*

DOI: 10.2174/1871530319666190101120119

Clinical Trial

The neuromodulatory effects of ω-3 fatty acids and nano-curcumin on the COX-2/ iNOS network in migraines: A clinical trial study from gene expression to clinical symptoms

, 2019; 19(6): 874-884.

Mina Abdolahi, Arash Jafarieh, Payam Sarraf, Mohsen Sedighiyan, Abolghasem Yousefi, Abbas Tafakhori, Hamed Abdollahi, Farahnaz Salehinia and Mahmoud Djalali*

DOI: 10.2174/1871530319666190212170140

Research Article

Evaluation of TG-HDL ratio instead of HOMA ratio as insulin resistance marker in overweight and children with obesity

, 2019; 19(5): 676-682.

Eman G. Behiry*, Nazih Mohamed El Nady, Omima M. AbdEl Haie, May Kamel Mattar and Amira Magdy

DOI: 10.2174/1871530319666190121123535

Research Article

Predictors for fibrosis regression in chronic HCV patients after the treatment with DAAS: Results of a real-world cohort study

, 2020; 20(1): 104-111.

Hanan Soliman, Dina Ziada, Marwa Salama, Manal Hamisa, Rehab Badawi, Nehad Hawash, Amal Selim and Sherief Abd-Elsalam*

DOI: 10.2174/1871530319666190826150344

General Research Article

25 hydroxyvitamin D levels are negatively and independently associated with fat mass in a cohort of healthy overweight and obese subjects

, 2019; 19(6): 838-844.

Giovanni De Pergola*, Tommaso Martino, Roberta Zupo, Domenico Caccavo, Claudio Pecorella, Silvia Paradiso, Franco Silvestris and Vincenzo Triggiani

DOI: 10.2174/1871530319666190122094039

Research Article

Anti-cancerous effect of rutin against HPV-C33A cervical cancer cells via g0/g1 cell cycle arrest and apoptotic induction

, 2020; 20(3): 409-418.

Fahad Khan, Pratibha Pandey*, Tarun K. Upadhyay, Asif Jafri, Niraj K. Jha, Rashmi Mishra and Vineeta Singh

DOI: 10.2174/1871530319666190806122257

General Research Article

Elucidation of the chemopreventive role of stigmasterol against Jab1 in gall bladder carcinoma

, 2019; 19(6): 826-837.

Pratibha Pandey, Preeti Bajpai*, Mohammad H. Siddiqui, Uzma Sayyed, Rohit Tiwari, Rafia Shekh, Kumudesh Mishra and V.K. Kapoor

DOI: 10.2174/1871530319666190206124120

Review Article (Mini-Review)

Quality of life in individuals with diabetic foot syndrome

, 2020; 20(9): 1365-1372.

Emmanuel Navarro-Flores and Omar Cauli*

DOI: 10.2174/1871530320666200128154036

Research Article

Overexpression of hepassocin in diabetic patients with nonalcoholic fatty liver disease may facilitate increased hepatic lipid accumulation

, 2019; 19(2): 185-188.

Ghada Abdelmoemen, Samy Abdelkader Khodeir, Ahmed Nabil Zaki, Maha Kassab, Sabry Abou-Saif and Sherief Abd-Elsalam*

DOI: 10.2174/1871530318666180716100543

Research Article

Sex-specific association between serum uric acid and elevated alanine aminotransferase in a military cohort: The chief study

, 2019; 19(3): 333-340.

Jia-Wei Lin, Kun-Zhe Tsai, Kai-Wen Chen, Fang-Ying Su, Yi-Hwei Li, Yen-Po Lin, Chih-Lu Han, Felicia Lin, Yu-Kai Lin, Chung-Bao Hsieh and Gen-Min Lin*

DOI: 10.2174/1871530319666181129163802

Most Accessed Articles

Rebalancing the Oral Microbiota as an Efficient Tool in Endocrine, Metabolic and Immune Disorders

, 2021; 21(5): 777-784.

Isacco, Ciro Gargiulo; Ballini, Andrea; De Vito, Danila; Kieu Cao Diem Nguyen; Cantore, Stefania; Bottalico, Lucrezia; Quagliuolo, Lucio; Boccellino, Mariarosaria; Di Domenico, Marina; Santacroce, Luigi; Arrigoni, Roberto; Dipalma, Gianna; Inchingolo, Francesco

DOI: 10.2174/1871530320666200729142504

A Review of AEG-1 Oncogene Regulating MicroRNA Expression in Colon Cancer Progression

, 2021; 21(1): 27-34.

Malayaperumal, Sarubala; Sriramulu, Sushmitha; Jothimani, Ganesan; Banerjee, Antara; Pathak, Surajit

DOI: 10.2174/1871530320666200618104116

Tanta Protocol for Management of COVID-19: Perspectives from a Devel- oping Country

, 2021; 21(10): 1775-1780.

Abd-Elsalam, Sherief; Esmail, Eslam Saber; Khalaf, Mai; El-Sarnagawy, Ghada N.; Shalaby, Shahinaz M.; Ghafar, Mohamed Samir Abd El; Elbahnasawy, Mohamed; Elfert, Asem; Soliman, Hanan; El-kalla, Ferial; Ghoneim, Ahmed

DOI: 10.2174/1871530320999201117142305

Clinical, Immunologic and Molecular Spectrum of Patients with Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome: A Systematic Review

, 2021; 21(4): 664-672.

Kiaee, Fatemeh; Zaki-Dizaji, Majid; Hafezi, Nasim; Almasi-Hashiani, Amir; Hamedifar, Haleh; Sabzevari, Araz; Shirkani, Afshin; Zian, Zeineb; Jadidi-Niaragh, Farhad; Aghamahdi, Fatemeh; Goudarzvand, Mahdi; Yazdani, Reza; Abolhassani, Hassan; Aghamohammadi, Asghar; Azizi, Gholamreza

DOI: 10.2174/1871530320666200613204426

Coronaviruses and Endocrine System: A Systematic Review on Evidence and Shadows

, 2021; 21(7): 1242-1251.

Parolin, Matteo; Parisotto, Matteo; Zanchetta, Francesca; Sartorato, Paola; De Menis, Ernesto

DOI: 10.2174/1871530320666200905123332

The Cannabis Spread throughout the Continents and its Therapeutic Use in History

, 2021; 21(3): 407-417.

Charitos, Ioannis A.; Gagliano-Candela, Roberto; Santacroce, Luigi; Bottalico, Lucrezia

DOI: 10.2174/1871530320666200520095900

Historical Anecdotes and Breakthroughs of Histamine: From Discovery to Date

, 2021; 21(5): 801-814.

Charitos, Ioannis A.; Castellaneta, Francesca; Santacroce, Luigi; Bottalico, Lucrezia

DOI: 10.2174/1871530320666200729150124

Theranostic Nanoparticles for Pancreatic Cancer Treatment

, 2021; 21(2): 203-214.

Jaidev, Leela R.; Chede, Laxmi S.; Kandikattu, Hemanth K.

DOI: 10.2174/1871530320666200516164911


Emilio Jirillo
Department of Basic Medical Sciences Neuroscience and Sensory Organs
University of Bari “Aldo Moro”
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Targets - Immune, Endocrine & Metabolic Disorders was launched in 2001 and later renamed in 2006 as Endocrine, Metabolic & Immune Disorders - Drug Targets.
Society Accreditations

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Society Name: The official Journal of Associazione Medici Endocrinologi

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