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Drug Metabolism Letters

Volume 13, 3 Issues, 2019
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access

Aims & Scope

Drug Metabolism Letters publishes letters, original research articles, mini-reviews, thematic issues based on mini-reviews and letters, commentaries, technical notes and drug clinical trial studies on major advances in all areas of drug metabolism and disposition.

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; bioactivation; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Drug Metabolism Letters

,

Volume 13

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Number 1



Biography   Open Access



Preface   Open Access



Review Article   Open Access



Research Article   Open Access



Research Article   Open Access



Research Article   Open Access



Research Article   Open Access

“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip

, 13(1): 45 - 52

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan


DOI: 10.2174/1872312813666181129100950


Research Article   Open Access

Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)

, 13(1): 53 - 63

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch


DOI: 10.2174/1872312812666181022114622


Articles Ahead of Print

Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH


Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*


View Abstract View on PubMed



Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Editor's Choice











Open Access Articles


Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)

, 2019; 13(1): 53 - 63

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch




“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip

, 2019; 13(1): 45 - 52

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan






Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines

, 2019; 13(1): 25 - 36

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*





Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH

, 2019; 13: 1 - 9 (E-Pub Ahead of Print)

Jaurès Blanc Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*




A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery

, 2019; 13: 1 - 16 (E-Pub Ahead of Print)

Liyue Huang*, Mary C. Wells and Zhiyang Zhao




Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification

, 2018; 12(2): 93 - 100

William L. Fitch*, Cyrus Khojasteh, Ignacio Aliagas and Kevin Johnson




Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy

, 2018; 12(2): 145 - 152

Michael Z. Liao, Chunying Gao, Deepak Kumar Bhatt, Bhagwat Prasad and Qingcheng Mao*




Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line

, 2018; 12(2): 138 - 144

Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon*, Adrivanio Baranoski, Giuliana C. Coatti and Mario S. Mantovani






In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone

, 2018; 12(2): 101 - 116

Poonam Giri, Lakshmikant Gupta, Sneha Naidu, Vipul Joshi, Nirmal Patel, Shyamkumar Giri and Nuggehally R. Srinivas*





Most Cited Articles

Research Article

Utility of pooled cryopreserved human enterocytes as an in vitro model for assessing intestinal clearance and drug-drug interactions

, 2018; 12(1): 3-13.

Susan Wong, Utkarsh Doshi, Peter Vuong , Ning Liu, Suzanne Tey, Hoa Le, Mika Kosaka, Jane R. Kelly, Albert P. Li and Zhengyin Yan*


DOI: 10.2174/1872312812666171213114422






Research Article

In vitro drug-drug interaction potential of sulfoxide and/or sulfone metabolites of albendazole, triclabendazole, aldicarb, methiocarb, montelukast and ziprasidone

, 2018; 12(2): 101-116.

Poonam Giri, Lakshmikant Gupta, Sneha Naidu, Vipul Joshi, Nirmal Patel, Shyamkumar Giri and Nuggehally R. Srinivas*


DOI: 10.2174/1872312812666180816164626


Research Article

Evaluation of herb-drug interaction of synacinn™ and individual biomarker through cytochrome 450 inhibition assay

, 2018; 12(1): 62-67.

Nur Syukriah Ab Rahman, Fadzilah Adibah Abd Majid*, Mohd Effendy Abd Wahid, Ain Nabihah Zainudin, Siti Nurazwa Zainol, Hassan Fahmi Ismail, Tet Soon Wong, Nirbhay Kumar Tiwari and Sanjeev Giri


DOI: 10.2174/1872312812666180314112457


Research Article

LC-MS/MS identification and structural characterization of main biodegradation products of nitroproston-A novel prostaglandin-based pharmaceutical compound

, 2018; 12(1): 54-61.

Natalia V. Mesonzhnik*, Natalia E. Moskaleva, Ksenia M. Shestakova, Ksenya O. Kurynina, Pavel A. Baranov, Natalia M. Gretskaya, Igor V. Serkov, Igor I. Lyubimov, Vladimir V. Bezuglov and Svetlana A. Appolonova


DOI: 10.2174/1872312812666180309160927





Research Article

Transport of bupropion and its metabolites by the model CHO and HEK293 cell lines

, 2019; 13(1): 25-36.

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*


DOI: 10.2174/1872312813666181129101507


Preface

Preface

, 2019; 13(1): 2-2.

Suresh Balani


DOI: 10.2174/187231281301190430103757


Research Article

Genistein affects expression of cytochrome p450 (Cyp450) genes in hepatocellular carcinoma (hepg2/c3a) cell line

, 2018; 12(2): 138-144.

Sandra R. Lepri , Daniele Sartori , Simone C. Semprebon*, Adrivanio Baranoski , Giuliana C. Coatti and Mario S. Mantovani


DOI: 10.2174/1872312812666180709150440




Most Accessed Articles


“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip

, 2019; 13(1): 45-52.

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan


DOI: 10.2174/1872312813666181129100950


Transport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines

, 2019; 13(1): 25-36.

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*


DOI: 10.2174/1872312813666181129101507



Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS)

, 2019; 13(1): 53-63.

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch


DOI: 10.2174/1872312812666181022114622








Editor-in-Chief

Zhiyang Zhao
Alliance Pharma
Malvern, PA
USA

Biography View Full Editorial Board

Journal History

Drug Metabolism Letters was launched in 2007. Dr. Zhiyang Zhao serves as the Editor-in-Chief of the journal.
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