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Current Pharmaceutical Biotechnology

Volume 21, 15 Issues, 2020
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access

Ranking and Category

  • 259th of 298 in

    Biochemistry & Molecular Biology

  • 219th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology

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Volume 21

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Number 1



Biography   Open Access



Preface   Open Access



Review Article



Research Article



Research Article



Research Article

Assessment of the Usefulness of the SEMA5A Concentration Profile Changes as a Molecular Marker in Endometrial Cancer

, 21(1): 45 - 51

Konrad Dziobek*, Marcin Opławski, Beniamin O. Grabarek, Nikola Zmarzły, Przemysław Kieszkowski, Piotr Januszyk, Kamil Kiełbasiński, Robert Kiełbasiński and Dariusz Boroń*


DOI: 10.2174/1389201020666190911113611


Review Article   Open Access

Variances in the Level of COX-2 and iNOS in Different Grades of Endometrial Cancer

, 21(1): 52 - 59

Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin O. Grabarek, Robert Kiełbasiński, Przemysław Kieszkowski, Piotr Januszyk, Karol Talkowski, Michał Schweizer, Piotr Kras, Andrzej Plewka and Dariusz Boroń


DOI: 10.2174/1389201020666190918104105


Research Article



Current Pharmaceutical Biotechnology, Volume 21 (2020) - Number 2


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Comparison of Profiling of Hairy Root of Two Tibetan Medicinal Plants Przewalskia tangutica Maxim. and Anisodus tanguticus Maxim.


Tianxiang Lei, Huan Wang, Songling Li, Xiaojian Cai, Shilong Chen, Tingfeng Cheng, Jianwei Shen, Shengbo Shi and Dangwei Zhou*


DOI: 10.2174/1389201020666191127125842
View Abstract View on PubMed



Comparison of Vascular Responses to Vasoconstrictors in Human Placenta in Preeclampsia between Preterm and Later Term


Xueqin Feng, Yumeng Zhang, Jianying Tao, Likui Lu, Yingying Zhang, Jingliu Liu, Meng Zhao, Jun Guo, Dan Zhu, Jianguo Zhu and Zhice Xu*


DOI: 10.2174/1389201021666191217114111
View Abstract View on PubMed


Saponins of Panax japonicus Confer Neuroprotection against Brain Aging through Mitochondrial Related Oxidative Stress and Autophagy in Rats


Jing-zhi Wan, Rui Wang, Zhi-yong Zhou, Li-li Deng, Chang-cheng Zhang, Chao-qi Liu, Hai-xia Zhao, Dong-fan Wang, Cheng-fu Yuan, Yu-min He, Yao-yan Dun, Ding Yuan* and Ting Wang*


DOI: 10.2174/1389201021666191216114815
View Abstract View on PubMed


In Silico Studies on Anti-Stress Compounds of Ethanolic Root Extract of Hemidesmus indicus L.


Jayasimha Rayalu Daddam, Basha Sreenivasulu, Katike Umamahesh*, Kotha Peddanna and Dowlathabad Muralidhara Rao


DOI: 10.2174/1389201021666191211152754
View Abstract View on PubMed


Hypodopaminergia and “Precision Behavioral Management” (PBM): It is a Generational Family Affair


L. Fried, EJ Modestino, D. Siwicki, L. Lott, PK. Thanos, D. Baron, RD. Badgaiyan, J. Valdez Ponce , J. Giordano, BW. Downs, MC. Gondré-Lewis, Bruce Steinberg, Eric R Braverman, Brent Boyett and Kenneth Blum*


DOI: 10.2174/1389201021666191210112108
View Abstract View on PubMed




The Anti-Inflammatory Effects of Anacardic Acid on a TNF-α - Induced Human Saphenous Vein Endothelial Cell Culture Model


Burak Önal*, Deniz Özen, Bülent Demir, Duygu Gezen Ak, Erdinç Dursun, Caner Demir, Ahmet Gökhan Akkan and Sibel Özyazgan


DOI: 10.2174/1389201020666191105154619
View Abstract View on PubMed


The Possible Role of Pathogenic and non-Pathogenic Bacteria in Initiation and Exacerbation of Celiac Disease; A Comprehensive Review


Taher Azimi, Ahmad Nasser, Aref Shariati, Seyedeh Marzieh Jabbari Shiadeh, Hossein Safari, Mahmood Alizade-Sani, Ali Taghipour and Amin Dehghan*


DOI: 10.2174/1389201021666191219160729
View Abstract View on PubMed


Abstracts Ahead of Print



Assessment of expression of Homeobox A5 in endometrial cancer on the mRNA and protein level


Konrad Dziobek*, Marcin Oplawski, Nikola Zmarzły, Beniamin Oskar Gabarek, Robert Kiełbasiński, Kamil Kiełbasiński, Przemysław Kieszkowski, Karol Talkowski and Dariusz Boroń


DOI: 10.2174/1389201021666191227121627
View Abstract









Published Contents

Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice


Biotechnological Production of Statins: Metabolic Aspects and Genetic Approaches

, 2019; 20(15): 1244 - 1259

Roberval N.M. Neto , Edelvio de Barros Gomes , Lucas Weba-Soares , Léo R.L. Dias, Luís C.N. da Silva * and Rita de C.M. de Miranda


DOI: 10.2174/1389201020666190718165746




A Review on Targeting Nanoparticles for Breast Cancer

, 2019; 20(13): 1087 - 1107

Hasanain Gomhor J. Alqaraghuli, Soheila Kashanian* and Ronak Rafipour


DOI: 10.2174/1389201020666190731130001



In Vitro Anti-Viral Effects of Small Heat Shock Proteins 20 and 27: A Novel Therapeutic Approach

, 2019; 20(12): 1011 - 1017

Rouhollah Vahabpour, Sepehr Soleymani, Farzin Roohvand, Rezvan Zabihollahi and Azam Bolhassani*


DOI: 10.2174/1389201020666190729104648





Species Specificity on Interaction between IgE and FcεRI

, 2019; 20(9): 690 - 695

Xiangsheng Li, Nannan Wang, Yang Zhao, Yanfen Zhang* and Zhongcheng Liu*


DOI: 10.2174/1389201020666190619122325



Expanding the Biotherapeutics Realm via miR-34a: “Potent Clever Little” Agent in Breast Cancer Therapy

, 2019; 20(8): 665 - 673

Mohsen Mohammady, Seyed I. Ghetmiri, Mahtab Baharizade, Mohammad H. Morowvat* and Susan Torabi


DOI: 10.2174/1389201020666190617162042




Open Access Articles

Relationship between SNP rs1764391 and Susceptibility, Risk Factors, Gene-environment Interactions of Acute Myocardial Infarction in Guangxi Han Chinese Population

, 2020; 21(1): 79 - 88

Jun Li, Rui Qin, Wei Wang*, Zhou Huang, Dong-Ling Huang, Tian Li, Fan Wang, Xiang-tao Zeng, Zhong-yi Sun, Xue-feng Liu, Feng Huang and Tao Guo




Variances in the Level of COX-2 and iNOS in Different Grades of Endometrial Cancer

, 2020; 21(1): 52 - 59

Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin O. Grabarek, Robert Kiełbasiński, Przemysław Kieszkowski, Piotr Januszyk, Karol Talkowski, Michał Schweizer, Piotr Kras, Andrzej Plewka and Dariusz Boroń




Plant Phenolics and Lectins as Vaccine Adjuvants

, 2019; 20(15): 1236 - 1243

Hernández-Ramos Reyna-Margarita, Castillo-Maldonado Irais*, Rivera-Guillén Mario-Alberto, Ramírez-Moreno Agustina, Serrano-Gallardo Luis-Benjamín and Pedroza-Escobar David*




Preparation of Chitosan/Alginate-ellagic Acid Sustained-release Microspheres and their Inhibition of Preadipocyte Adipogenic Differentiation

, 2019; 20(14): 1213 - 1222

Chengshi Ding, Haidan Bi, Deya Wang, Meiling Kang, Zhongjing Tian, Yingxia Zhang, Hongkai Wang, Tianshun Zhu* and Jing Ma*




Changes in the Density of Corneal Endothelial Cells in Elderly Diabetic Patients After Combined Phacovitrectomy and Ex-PRESS Glaucoma Implants

, 2019; 20(12): 1037 - 1043

Anita Lyssek-Boroń*, Katarzyna Krysik, Magdalena Kijonka, Mateusz Osuch, Beniamin O. Grabarek and Dariusz Dobrowolski




Changes in Expression Pattern of SEMA3F Depending on Endometrial Cancer Grade - Pilot Study

, 2019; 20(9): 727 - 732

Konrad Dziobek*, Marcin Opławski, Beniamin Grabarek, Nikola Zmarzły, Robert Kiełbasiński, Ewa Leśniak, Piotr Januszyk, Krzysztof Januszyk, Iwona Adwent, Dariusz Dąbruś, Przemysław Kieszkowski, Kamil Kiełbasiński, Agnieszka Kuś-Kierach and Dariusz Boroń




Does Nimodipine, a Selective Calcium Channel Blocker, Impair Chondrocyte Proliferation or Damage Extracellular Matrix Structures?

, 2019; 20(6): 517 - 524

Necati Kaplan, Ibrahim Yilmaz, Numan Karaarslan*, Yasin E. Kaya, Duygu Y. Sirin and Hanefi Ozbek




Evaluation of Changes in the Expression Pattern of EDIL3 in Different Grades of Endometrial Cancer

, 2019; 20(6): 483 - 488

Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin Grabarek, Barbara Tomala, Ewa Leśniak, Iwona Adwent, Piotr Januszyk, Dariusz Dąbruś and Dariusz Boroń




Fenoldopam Mesylate: A Narrative Review of Its Use in Acute Kidney Injury

, 2019; 20(5): 366 - 375

Annalisa Noce*, Giulia Marrone, Valentina Rovella, Andrea Busca, Caterina Gola, Michele Ferrannini and Nicola Di Daniele*




Expression of NRP-1 and NRP-2 in Endometrial Cancer

, 2019; 20(3): 254 - 260

Marcin Oplawski*, Konrad Dziobek, Beniamin Grabarek, Nikola Zmarzły, Dariusz Dąbruś, Piotr Januszyk, Ryszard Brus, Barbara Tomala and Dariusz Boroń




Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules

, 2019; 20(3): 245 - 253

Liliya V. Fedulova, Alexandr A. Basov, Ekaterina R. Vasilevskaya and Stepan S. Dzhimak*




Effect of Powdered Activated Carbon as Advanced Step in Wastewater Treatments on Antibiotic Resistant Microorganisms

, 2019; 20(1): 63 - 75

Damiana Ravasi, Roger König, Pamela Principi, Giuseppe Perale and Antonella Demarta*





Expression Profile of Endoglin in Different Grades of Endometrial Cancer

, 2018; 19(12): 990 - 995

Marcin Opławski*, Konrad Dziobek, Iwona Adwent, Dariusz Dąbruś, Beniamin Grabarek, Nikola Zmarzły, Andrzej Plewka and Dariusz Boroń




Enzymatic Hydrolysis of Hyaluronic Layer before Drug Dosing

, 2018; 19(12): 963 - 972

Anna Trusek*, Anita Niesobska and Damian Semba





Most Cited Articles


Research Article

Healthcare-associated infections due to multidrug-resistant organisms: A surveillance study on extra hospital stay and direct costs

, 2019; 20(8): 643-652.

Guglielmo Giraldi, Marzietta Montesano, Christian Napoli, Paola Frati, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti and Giovanni B. Orsi*


DOI: 10.2174/1389201020666190408095811


Research Article

Catheter-related bloodstream infections: A root cause analysis in a series of simultaneous Ochrobactrum anthropi infections

, 2019; 20(8): 609-614.

Benedetto Caroleo, Pasquale Malandrino, Aldo Liberto, Dario Condorelli, Federico Patanè, Aniello Maiese, Filomena Casella, Diego Geraci, Pietrantonio Ricci and Giulio Di Mizio*


DOI: 10.2174/1389201020666190405182025


Research Article

New rules on patient’s safety and professional liability for the Italian health service

, 2019; 20(8): 615-624.

Sara Albolino, Tommaso Bellandi, Simone Cappelletti, Marco Di Paolo, Vittorio Fineschi*, Paola Frati, Caterina Offidani, Michela Tanzini, Riccardo Tartaglia and Emanuela Turillazzi


DOI: 10.2174/1389201020666190408094016



Research Article

Effect of pullulan on physicochemical, microbiological, and sensory quality of yogurts

, 2019; 20(6): 489-496.

Anna Chlebowska-Śmigiel, Katarzyna Kycia, Katarzyna Neffe-Skocińska, Marek Kieliszek*, Małgorzata Gniewosz and Danuta Kołożyn-Krajewska


DOI: 10.2174/1389201020666190416151129


Review Article

Valorization of fruits by-products to unconventional sources of additives, oil, biomolecules and innovative functional foods

, 2019; 20(10): 776-786.

Charalampia Dimou, Haralabos C. Karantonis, Dimitrios Skalkos and Antonios E. Koutelidakis*


DOI: 10.2174/1389201020666190405181537


Letter

The combination of dimorphandra gardneriana galactomannan and mangiferin inhibits herpes simplex and poliovirus

, 2019; 20(3): 215-221.

Daniele Z. Rechenchoski, Nayara L. Samensari, Ligia C. Faccin-Galhardi, Raimundo R. de Almeida, Arcelina P. Cunha, Nágila M.P.S. Ricardo, Carlos Nozawa and Rosa E.C. Linhares*


DOI: 10.2174/1389201020666190307130431



Review Article

Food components with the potential to be used in the therapeutic approach of mental diseases

, 2019; 20(2): 100-113.

María J.F. Fernández*, Estefanía Valero-Cases and Laura Rincon-Frutos


DOI: 10.2174/1389201019666180925120657


General Review Article

Role of probiotics in prophylaxis of Helicobacter pylori infection

, 2019; 20(2): 137-145.

Kashyapi Chakravarty and Smriti Gaur*


DOI: 10.2174/1389201020666190227203107


Review Article

Functional biomolecule delivery systems and bioengineering in cartilage regeneration

, 2019; 20(1): 32-46.

Marta A. Szychlinska, Ugo D'Amora, Silvia Ravalli, Luigi Ambrosio, Michelino Di Rosa and Giuseppe Musumeci*


DOI: 10.2174/1389201020666190206202048


Research Article

Impact of the transfersome delivered human growth hormone on the dermal fibroblast cells

, 2019; 20(14): 1194-1202.

Minoo Azimi, Mahvash Khodabandeh*, Abdolkhalegh Deezagi and Fatemeh Rahimi


DOI: 10.2174/1389201020666190809120333



Review Article

Nanoparticles and zeolites: Antibacterial effects and their mechanism against pathogens

, 2019; 20(13): 1074-1086.

Maryam Azizi-lalabadi, Ali Ehsani*, Mahmood Alizadeh-Sani, Arezou Khezerlou, Mina Mirzanajafi-Zanjani, Baharak Divband, Hajar Zolfaghari and Vahid Bagheri


DOI: 10.2174/1573397115666190708120040



Most Accessed Articles

CAR T-cell Therapy: A New Era in Cancer Immunotherapy

, 2018; 19(1): 5-18.

Androulla N. Miliotou and Lefkothea C. Papadopoulou*


DOI: 10.2174/1389201019666180418095526




Catheter-related Bloodstream Infections: A Root Cause Analysis in a Series of Simultaneous Ochrobactrum anthropi Infections

, 2019; 20(8): 609-614.

Benedetto Caroleo, Pasquale Malandrino, Aldo Liberto, Dario Condorelli, Federico Patanè, Aniello Maiese, Filomena Casella, Diego Geraci, Pietrantonio Ricci and Giulio Di Mizio*


DOI: 10.2174/1389201020666190405182025


Mitogen-Induced Interferon Gamma Production in Human Whole Blood: The Effect of Heat and Cations

, 2019; 20(7): 562-572.

Ji-Hyun Nam, Bomi Cha, Jun-Young Park, Fukushi Abekura, Cheorl-Ho Kim* and Jeong-Ran Kim*


DOI: 10.2174/1389201020666190528093432



Phage Therapy in Clinical Practice: Treatment of Human Infections

, 2010; 11(1): 69-86.

Elizabeth Kutter, Daniel De Vos, Guram Gvasalia, Zemphira Alavidze, Lasha Gogokhia, Sarah Kuhl and Stephen T. Abedon


DOI: 10.2174/138920110790725401







Editor-in-Chief

Nikolaos Labrou
Department of Biotechnology
Agricultural University of Athens
Athens
Greece

Biography View Full Editorial Board

Journal History

Current Pharmaceutical Biotechnology was launched in 2000. Dr. Davide Prosperi serves as the Editor-in-Chief of the journal.
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Scopus CiteScore Metrics: 1.96

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