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Current Pharmaceutical Biotechnology

Volume 20, 15 Issues, 2019
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access

Ranking and Category

  • 259th of 298 in

    Biochemistry & Molecular Biology

  • 219th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology

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Volume 20

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Number 15



Biography   Open Access



Review Article   Open Access

Plant Phenolics and Lectins as Vaccine Adjuvants

, 20(15): 1236 - 1243

Hernández-Ramos Reyna-Margarita, Castillo-Maldonado Irais*, Rivera-Guillén Mario-Alberto, Ramírez-Moreno Agustina, Serrano-Gallardo Luis-Benjamín and Pedroza-Escobar David*


DOI: 10.2174/1389201020666190716110705


Review Article

Biotechnological Production of Statins: Metabolic Aspects and Genetic Approaches

, 20(15): 1244 - 1259

Roberval N.M. Neto , Edelvio de Barros Gomes , Lucas Weba-Soares , Léo R.L. Dias, Luís C.N. da Silva * and Rita de C.M. de Miranda


DOI: 10.2174/1389201020666190718165746


Review Article



Review Article



Research Article



Research Article



Acknowledgement   Open Access



Articles Ahead of Print

Production and Preliminary in vivo Evaluations of a Novel in silico- Designed L2-based Potential HPV Vaccine


Manica Negahdaripour, Navid Nezafat, Reza Heidari, Nasrollah Erfani, Nasim Hajighahramani, Mohammad Bagher Ghoshoon, Eskandar Shoolian, Mohammad Reza Rahbar, Sohrab Najafipour, Ali Dehshahri, Mohammad Hossein Morowvat and Younes Ghasemi*


DOI: 10.2174/1389201020666191114104850
View Abstract View on PubMed




Phytochemical Analysis and Assessment of Biological Properties of Essential Oils Obtained from Thyme and Rosmarinus Species


Amira Zairi*, Sahar Nouir, Mohamed Ali Khalifa, Bouraoui Ouni, Houda Haddad, Améni Khelifa, Lotfi Achour and Mounir Trabelsi


DOI: 10.2174/1389201020666191019124630
View Abstract View on PubMed


Design of Experiment, Preparation, and in vitro Biological Assessment of Human Amniotic Membrane Extract Loaded Nanoparticles


Avishan Shabani, Fatemeh Atyabi, Mohammad Reza Khoshayand, Reza Mahbod, Reza Ahangari Cohan*, Iman Akbarzadeh and Haleh Bakhshandeh


DOI: 10.2174/1389201020666191019122130
View Abstract



Microwave-assisted Single Step Cinnamic Acid Derivatization and Evaluation for Cytotoxic Potential


Sonali Mishra, Shilpi Singh, Arif Ali, Amit Chand Gupta, Karuna Shanker*, Dnyaneshwar U. Bawankule and Suaib Luqman


DOI: 10.2174/1389201020666191015161429
View Abstract View on PubMed


Multivariate Optimization of the Refolding Process of an Incorrectly Folded Fc-Fusion Protein in a Cell Culture Broth


Hossein Behrouz, Behnaz Molavi, Ata Tavakoli, Mansoureh Askari, Shayan Maleknia, Fereidoun Mahboudi and Mehdi Khodadadian


DOI: 10.2174/1389201020666191002144424
View Abstract View on PubMed




Abstracts Ahead of Print



Active targeting towards and inside the brain based on nanoparticles: A Review


Morteza Rabiei, Soheila Kashanian*, Seyedeh Sabereh Samavati, Shahriar Jamasb and Steven J. P. McInnes


DOI: 10.2174/1389201020666191203094057
View Abstract



Arthrophytum Scoparium Extract Improves Memory Impairment And Affects Acetylcholinesterase Activity In Mice Brain


Med Ali Smach*, Jawhar Hafsa, Bassem Charfeddine, Hedi Dridi, Khalifa Limem and Ben Aballah Jihene


DOI: 10.2174/1389201020666191202142226
View Abstract




Fastidious Anatomization of Biota Procured Compounds on Cancer Drug Discovery


Anand Thirupathi*, Chandra Mohan Shanmugavadivelu and Sampathkumar Natarajan


DOI: 10.2174/1389201020666191128145015
View Abstract


Comparison on profiling of hairy root of two Tibetan medicinal plants Przewalskia tangutica Maxim and Anisodus tanguticus Maxim


Tianxiang Lei, Huan Wang, Songling Li, Xiaojian Cai, Shilong Chen, Tingfeng Cheng, Jianwei Shen, Shengbo Shi and Dangwei Zhou*


DOI: 10.2174/1389201020666191127125842
View Abstract



Published Contents

Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice

Biotechnological Production of Statins: Metabolic Aspects and Genetic Approaches

, 2019; 20(15): 1244 - 1259

Roberval N.M. Neto , Edelvio de Barros Gomes , Lucas Weba-Soares , Léo R.L. Dias, Luís C.N. da Silva * and Rita de C.M. de Miranda


DOI: 10.2174/1389201020666190718165746




A Review on Targeting Nanoparticles for Breast Cancer

, 2019; 20(13): 1087 - 1107

Hasanain Gomhor J. Alqaraghuli, Soheila Kashanian* and Ronak Rafipour


DOI: 10.2174/1389201020666190731130001



In Vitro Anti-Viral Effects of Small Heat Shock Proteins 20 and 27: A Novel Therapeutic Approach

, 2019; 20(12): 1011 - 1017

Rouhollah Vahabpour, Sepehr Soleymani, Farzin Roohvand, Rezvan Zabihollahi and Azam Bolhassani*


DOI: 10.2174/1389201020666190729104648





Species Specificity on Interaction between IgE and FcεRI

, 2019; 20(9): 690 - 695

Xiangsheng Li, Nannan Wang, Yang Zhao, Yanfen Zhang* and Zhongcheng Liu*


DOI: 10.2174/1389201020666190619122325



Expanding the Biotherapeutics Realm via miR-34a: “Potent Clever Little” Agent in Breast Cancer Therapy

, 2019; 20(8): 665 - 673

Mohsen Mohammady, Seyed I. Ghetmiri, Mahtab Baharizade, Mohammad H. Morowvat* and Susan Torabi


DOI: 10.2174/1389201020666190617162042




Tuberculosis: Current Status, Diagnosis, Treatment and Development of Novel Vaccines

, 2019; 20(6): 446 - 458

Jyoti Yadav, Sonali Verma, Darshna Chaudhary, Pawan K. Jaiwal and Ranjana Jaiwal*


DOI: 10.2174/1389201020666190430114121



Open Access Articles

Plant Phenolics and Lectins as Vaccine Adjuvants

, 2019; 20(15): 1236 - 1243

Hernández-Ramos Reyna-Margarita, Castillo-Maldonado Irais*, Rivera-Guillén Mario-Alberto, Ramírez-Moreno Agustina, Serrano-Gallardo Luis-Benjamín and Pedroza-Escobar David*




Preparation of Chitosan/Alginate-ellagic Acid Sustained-release Microspheres and their Inhibition of Preadipocyte Adipogenic Differentiation

, 2019; 20(14): 1213 - 1222

Chengshi Ding, Haidan Bi, Deya Wang, Meiling Kang, Zhongjing Tian, Yingxia Zhang, Hongkai Wang, Tianshun Zhu* and Jing Ma*




Changes in the Density of Corneal Endothelial Cells in Elderly Diabetic Patients After Combined Phacovitrectomy and Ex-PRESS Glaucoma Implants

, 2019; 20(12): 1037 - 1043

Anita Lyssek-Boroń*, Katarzyna Krysik, Magdalena Kijonka, Mateusz Osuch, Beniamin O. Grabarek and Dariusz Dobrowolski




Changes in Expression Pattern of SEMA3F Depending on Endometrial Cancer Grade - Pilot Study

, 2019; 20(9): 727 - 732

Konrad Dziobek*, Marcin Opławski, Beniamin Grabarek, Nikola Zmarzły, Robert Kiełbasiński, Ewa Leśniak, Piotr Januszyk, Krzysztof Januszyk, Iwona Adwent, Dariusz Dąbruś, Przemysław Kieszkowski, Kamil Kiełbasiński, Agnieszka Kuś-Kierach and Dariusz Boroń




Does Nimodipine, a Selective Calcium Channel Blocker, Impair Chondrocyte Proliferation or Damage Extracellular Matrix Structures?

, 2019; 20(6): 517 - 524

Necati Kaplan, Ibrahim Yilmaz, Numan Karaarslan*, Yasin E. Kaya, Duygu Y. Sirin and Hanefi Ozbek




Evaluation of Changes in the Expression Pattern of EDIL3 in Different Grades of Endometrial Cancer

, 2019; 20(6): 483 - 488

Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin Grabarek, Barbara Tomala, Ewa Leśniak, Iwona Adwent, Piotr Januszyk, Dariusz Dąbruś and Dariusz Boroń




Fenoldopam Mesylate: A Narrative Review of Its Use in Acute Kidney Injury

, 2019; 20(5): 366 - 375

Annalisa Noce*, Giulia Marrone, Valentina Rovella, Andrea Busca, Caterina Gola, Michele Ferrannini and Nicola Di Daniele*




Expression of NRP-1 and NRP-2 in Endometrial Cancer

, 2019; 20(3): 254 - 260

Marcin Oplawski*, Konrad Dziobek, Beniamin Grabarek, Nikola Zmarzły, Dariusz Dąbruś, Piotr Januszyk, Ryszard Brus, Barbara Tomala and Dariusz Boroń




Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules

, 2019; 20(3): 245 - 253

Liliya V. Fedulova, Alexandr A. Basov, Ekaterina R. Vasilevskaya and Stepan S. Dzhimak*




Effect of Powdered Activated Carbon as Advanced Step in Wastewater Treatments on Antibiotic Resistant Microorganisms

, 2019; 20(1): 63 - 75

Damiana Ravasi, Roger König, Pamela Principi, Giuseppe Perale and Antonella Demarta*





Variances in the Level of COX-2 and iNOS in Different Grades of Endometrial Cancer

, 2019; 20: 1 - 8 (E-Pub Ahead of Print)

Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin Grabarek, Robert Kiełbasiński, Przemysław Kieszkowski, Piotr Januszyk, Karol Talkowski, Andrzej Plewka and Dariusz Boroń




Expression Profile of Endoglin in Different Grades of Endometrial Cancer

, 2018; 19(12): 990 - 995

Marcin Opławski*, Konrad Dziobek, Iwona Adwent, Dariusz Dąbruś, Beniamin Grabarek, Nikola Zmarzły, Andrzej Plewka and Dariusz Boroń




Enzymatic Hydrolysis of Hyaluronic Layer before Drug Dosing

, 2018; 19(12): 963 - 972

Anna Trusek*, Anita Niesobska and Damian Semba






Most Cited Articles

Review Article

Car T-cell therapy: A new era in cancer immunotherapy

, 2018; 19(1): 5-18.

Miliotou N. Androulla and Papadopoulou C. Lefkothea*


DOI: 10.2174/1389201019666180418095526


Review Article

Analytical approaches in fatal intoxication cases involving new synthetic opioids

, 2018; 19(2): 113-123.

Enrico Gerace*, Alberto Salomone and Marco Vincenti


DOI: 10.2174/1389201019666180405162734



Review Article

Naringenin and its nano-formulations for fatty liver: Cellular modes of action and clinical perspective

, 2018; 19(3): 196-205.

Mehdi Zobeiri, Tarun Belwal, Fatemeh Parvizi, Rozita Naseri, Mohammad H. Farzaei*, Seyed F. Nabavi, Antoni Sureda and Seyed M. Nabavi


DOI: 10.2174/1389201019666180514170122




General Review Article

Recent progress and future perspectives of antibiofilm drugs immobilized on nanomaterials

, 2018; 19(8): 631-643.

Fazlurrahman Khan, Mohammad M. Khan and Young-Mog Kim*


DOI: 10.2174/1389201019666180828090052


General Review Article

Apoptosis: Mediator molecules, interplay with other cell death processes and therapeutic potentials

, 2018; 19(8): 644-663.

Jiban Barman, Ritesh Kumar, Gundappa Saha, Kartikeya Tiwari and Vikash K. Dubey*


DOI: 10.2174/1389201019666180821093239



Review Article

Intestinal crosstalk between microbiota and serotonin and its impact on gut motility

, 2018; 19(3): 190-195.

Xiaolong Ge, Junhai Pan, Yichang Liu, Hongkan Wang, Wei Zhou* and Xianfa Wang


DOI: 10.2174/1389201019666180528094202




Review Article

Angiogenic imbalance as a contributor of Preeclampsia

, 2018; 19(10): 797-815.

Weronika Dymara-Konopka*, Marzena Laskowska and Anna Błażewicz


DOI: 10.2174/1389201019666180925115559


Research Article

Changes in the expression profile of JAK/STAT signaling pathway genes and mirnas regulating their expression under the adalimumab therapy

, 2018; 19(7): 556-565.

Beniamin Grabarek, Dominika Wcislo-Dziadecka*, Joanna Gola, Celina Kruszniewska-Rajs, Ligia Brzezinska-Wcislo, Nikola Zmarzly and Urszula Mazurek


DOI: 10.2174/1389201019666180730094046


Review Article

Development of MTL-CEBPA: Small activating RNA drug for hepatocellular carcinoma

, 2018; 19(8): 611-621.

Ryan L. Setten, Helen L. Lightfoot, Nagy A. Habib and John J. Rossi*


DOI: 10.2174/1389201019666180611093428



Most Accessed Articles

CAR T-cell Therapy: A New Era in Cancer Immunotherapy

, 2018; 19(1): 5-18.

Androulla N. Miliotou and Lefkothea C. Papadopoulou*


DOI: 10.2174/1389201019666180418095526





Tuberculosis: Current Status, Diagnosis, Treatment and Development of Novel Vaccines

, 2019; 20(6): 446-458.

Jyoti Yadav, Sonali Verma, Darshna Chaudhary, Pawan K. Jaiwal and Ranjana Jaiwal*


DOI: 10.2174/1389201020666190430114121



Mitogen-Induced Interferon Gamma Production in Human Whole Blood: The Effect of Heat and Cations

, 2019; 20(7): 562-572.

Ji-Hyun Nam, Bomi Cha, Jun-Young Park, Fukushi Abekura, Cheorl-Ho Kim* and Jeong-Ran Kim*


DOI: 10.2174/1389201020666190528093432


Catheter-related Bloodstream Infections: A Root Cause Analysis in a Series of Simultaneous Ochrobactrum anthropi Infections

, 2019; 20(8): 609-614.

Benedetto Caroleo, Pasquale Malandrino, Aldo Liberto, Dario Condorelli, Federico Patanè, Aniello Maiese, Filomena Casella, Diego Geraci, Pietrantonio Ricci and Giulio Di Mizio*


DOI: 10.2174/1389201020666190405182025






Editor-in-Chief

Davide Prosperi
Department of Biotechnology and Bioscience
University of Milano-Bicocca
Milano
Italy

Biography View Full Editorial Board

Journal History

Current Pharmaceutical Biotechnology was launched in 2000. Dr. Davide Prosperi serves as the Editor-in-Chief of the journal.
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Scopus CiteScore Metrics: 1.60

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