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Current Pharmaceutical Design

Volume 27, 46 Issues, 2021
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth reviews/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

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Volume 27

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Number 33





Review Article

COVID-19: Epidemiology, Pathology, Diagnosis, Treatment, and Impact

, 27(33): 3502 - 3525

Saimon Shahriar, Md. Sohel Rana, Md. Sabbir Hossain, Ariful Karim, Tasneem N. Mredula, Nadia Nourin, Md. Sahab Uddin* and Md. Shah Amran*


DOI: 10.2174/1381612827666210224142446


Review Article

Natural Products: A Rich Source of Antiviral Drug Lead Candidates for the Management of COVID-19

, 27(33): 3526 - 3550

Yasanandana S. Wijayasinghe, Pravin Bhansali, Ronald E. Viola, Mohammad A. Kamal and Nitesh K. Poddar*


DOI: 10.2174/1381612826666201118111151


Review Article







Current Pharmaceutical Design, Volume 27 (2021) - Number 40


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 39


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 38


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 37


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 36


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 35


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 27 (2021) - Number 34


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Nanotechnology-Based Strategies for the Management of COVID-19: Recent Developments and Challenges


Ritu Singh*, Monalisha Behera, Nisha Kumari, Sanjeev Kumar, Vishnu D. Rajput, Tatiana M Minkina, Mohd Adnan, Arif Jamal Siddiqui and Narendra Kumar


DOI: 10.2174/1381612827666210830105459
View Abstract View on PubMed






Outer Membrane Vesicles of Bordetella pertussis Encapsulated into Sodium Alginate Nanoparticles as Novel Vaccine Delivery System


Abbas Rami, Fatemeh Kazemi-Lomedasht, Ali Mirjalili, Mojtaba Noofeli, Fereshteh Shahcheraghi* and Naser Mohammadpour Dounighi*


DOI: 10.2174/1381612827666210907154715
View Abstract View on PubMed



A General Approach on Surfactants use and Properties in Drug Delivery Systems


Mysrayn Yargo de Freitas Araújo Reis, Renaly Ivyna de Araújo Rêgo, Beatriz Patrício Rocha, Gabryella Garcia Guedes, Ízola Morais de Medeiros Ramalho, Airlla Laana de Medeiros Cavalcanti, Geovani Pereira Guimarães and Bolívar Damasceno*


DOI: 10.2174/1381612827666210526091825
View Abstract View on PubMed


The Use of Lectins as Tools to Combat SARS-CoV-2


Daniela Martinez, Diego Amaral, David Markovitz and Luciano Pinto*


DOI: 10.2174/1381612827666210830094743
View Abstract View on PubMed


A Systematic Review of Functionalized Polymeric Nanoparticles to Improve Intestinal Permeability of Drugs and Biological Products


Myla Lôbo de Souza, Victor de Albuquerque Wanderley Sales, Larissa Alves, Widson Michael Santos, Leslie Raphael Ferraz, Gustavo Lima, Larissa Mendes, Larissa Araújo Rolim and Pedro José Rolim Neto*


DOI: 10.2174/1381612827666210804104205
View Abstract View on PubMed


Abstracts Ahead of Print

The Potential Therapeutic Value of Renin-Angiotensin System Inhibitors in the Treatment of Colorectal Cancer


Ehsan Tabatabai*, Majid Khazaei, Mohammad Reza Parizadeh, Mohammad Nouri, Seyed Mahdi Hassanian, Gordon A Ferns, Mohammad Rahmati and Amir Avan


DOI: 10.2174/1381612827666211011113308
View Abstract



Human Gut Microbiome: A New Frontier in Cancer Diagnostics & Therapeutics


Vibha Rani*, Shivani Singhal, Kumkum Sharma, Rohan Vaid, Kanishka Aggarwal, Renu Bhadana, Radhika Agarwal and Neha Atale


DOI: 10.2174/1381612827666211006152112
View Abstract


The impact of Traditional Chinese Medicine on mitophagy in disease models


Li-Ping Yu, Ting-Ting Shi, Yan-Qin Li, Jian-Kang Mu, Ya-Qin Yang, Wei-Xi Li, Jie Yu* and Xing-Xin Yang*


DOI: 10.2174/1381612827666211006150410
View Abstract



Electrosprayed Nanoparticles as Drug Delivery systems for Biomedical Applications


Sairish Malik, Sundarrajan Subramanian*, Tanveer Hussain, Ahsan Nazir and Seeram Ramakrishna*


DOI: 10.2174/1381612827666210929114621
View Abstract



Therapeutic potential of galectin-1 and galectin-3 in autoimmune diseases


Yi-Sheng He, Yu-Qian Hu, Kun Xiang, Yue Chen, Ya-Ting Feng, Kang-Jia Yin, Ji-Xiang Huang, Jie Wang, Zheng-Dong Wu, Gui-Hong Wang* and Hai-Feng Pan*


DOI: 10.2174/1381612827666210927164935
View Abstract




Published Contents

Editor's Choice


In Silico Studies Reveal Antiviral Effects of Traditional Indian Spices on COVID-19

, 2021; 27(32): 3462 - 3475

Brijesh Kumar, Sama Zaidi, Shafiul Haque, Nandita Dasgupta, Arif Hussain, Sreepoorna Pramodh, Vineeta Singh* and Bhartendu N. Mishra*


DOI: 10.2174/1381612826666201223095548



Emerging Therapeutic Approaches to COVID-19

, 2021; 27(31): 3370 - 3388

Indrakant K. Singh, Pratibha Kumari, Pooja Mittal, Amit Kumar, Bharti Singal, Gulam M. Hasan, Rajiv Aggarwal, Md. Amjad Kamal, Archana Singh* and Md. Imtaiyaz Hassan*


DOI: 10.2174/1381612827666210125160703



Suicide and Genetic Biomarkers: Toward Personalized Tailored-treatment with Lithium and Clozapine

, 2021; 27(30): 3293 - 3304

Domenico De Berardis*, Federica Vellante, Mauro Pettorruso, Lorenza Lucidi, Antonio Tambelli, Ilenia Di Muzio, Giulia Gianfelice, Antonio Ventriglio, Michele Fornaro, Gianluca Serafini, Maurizio Pompili, Giampaolo Perna, Silvia Fraticelli, Giovanni Martinotti and Massimo di Giannantonio


DOI: 10.2174/1381612827666210603143353



Sex Differences in Clinical Outcomes of Patients with Stable Coronary Artery Disease after Percutaneous Coronary Intervention

, 2021; 27(29): 3180 - 3185

Emmanuel P. Vardas, Evangelos Oikonomou, Gerasimos Siasos, Panagiotis Theofilis, Polychronis Dilaveris, Angelos Papanikolaou and Dimitris Tousoulis*


DOI: 10.2174/1381612827666210303142901








Open Access Articles

The Intracellular Mechanism of Berberine-induced Inhibition of CYP3A4 Activity

, 2021; 27(40): 4179 - 4185

Pan-Feng Feng, Long-Xun Zhu, Jing Jie, Peng-Xiang Yang and Xia Chen*




The Pathogenic Subpopulation of Th17 Cells in Obesity

, 2021; 27(37): 3924 - 3938

Natalia Todosenko, Maria Vulf, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova*





Exosome Limitations in the Treatment of Inflammatory Diseases

, 2021; 27(28): 3105 - 3121

Daria Skuratovskaia*, Maria Vulf, Olga Khaziakhmatova, Vladimir Malashchenko, Aleksandra Komar, Egor Shunkin, Natalia Gazatova and Larisa Litvinova




Marine Bioactive Peptides in Supplements and Functional Foods - A Commercial Perspective

, 2021; 27(11): 1353 - 1364

Ragnhild Dragøy Whitaker*, Themis Altintzoglou, Kjersti Lian and Estefania Noriega Fernandez




Anti-malarial Drugs are Not Created Equal for SARS-CoV-2 Treatment: A Computational Analysis Evidence

, 2021; 27(10): 1323 - 1329

Simone Ronsisvalle, Federica Panarello, Rosaria Di Mauro, Renato Bernardini, Giovanni Li Volti* and Giuseppina Cantarella









Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines

, 2021; 27: 1 - 10 (E-Pub Ahead of Print)

Magy Gouda, Majed Bawzeer, Lamees Hegazy, Mohamed Azab, Mohamed Elagawany, Mostafa Rateb, Mohammed Yaseen and Bahaa Elgendy*




The Efficacy and Safety of Topical Tranexamic Acid for Spinal Surgery

, 2021; 27: 1 - 8 (E-Pub Ahead of Print)

Tai Guo, Wenxia Xuan, Haoyu Feng, Junjie Wang and Xun Ma*





Treatment of Anderson-Fabry Disease

, 2020; 26(40): 5089 - 5099

Irene Simonetta*, Antonino Tuttolomondo, Mario Daidone, Salvatore Miceli and Antonio Pinto





Most Cited Articles

General Review Article

Long non-coding RNAs as epigenetic regulators in cancer

, 2019; 25(33): 3563-3577.

Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Soheila Mohammadi, Sima Fathullahzadeh, Hamid R. Mirzaei, Afshin Namdar, Amir Savardashtaki* and Hamed Mirzaei*


DOI: 10.2174/1381612825666190830161528


Review Article

Pollution, toxicity and carcinogenicity of organic dyes and their catalytic bio-remediation

, 2019; 25(34): 3645-3663.

Muhammad Ismail, Kalsoom Akhtar, M.I. Khan, Tahseen Kamal, Murad A. Khan, Abdullah M. Asiri, Jongchul Seo and Sher B. Khan*


DOI: 10.2174/1381612825666191021142026


Review Article

Synthesis of silver nanoparticles and their biomedical applications a comprehensive review

, 2019; 25(24): 2650-2660.

Rajasree Shanmuganathan, Indira Karuppusamy, Muthupandian Saravanan, Harshiny Muthukumar, Kumar Ponnuchamy, Vijayan Sri Ramkumar and Arivalagan Pugazhendhi*


DOI: 10.2174/1381612825666190708185506


Review Article

Cholinesterase inhibitors for Alzheimer's disease: Multitargeting strategy based on anti-Alzheimer's drugs repositioning

, 2019; 25(33): 3519-3535.

Md. Tanvir Kabir, Md. Sahab Uddin*, Mst. Marium Begum, Shanmugam Thangapandiyan, Md. Sohanur Rahman, Lotfi Aleya, Bijo Mathew, Muniruddin Ahmed, George E. Barreto and Ghulam Md. Ashraf


DOI: 10.2174/1381612825666191008103141


Review Article

NMDA receptor antagonists: Repositioning of memantine as a multitargeting agent for Alzheimer's therapy

, 2019; 25(33): 3506-3518.

Md. Tanvir Kabir, Mohammad A. Sufian, Md. Sahab Uddin*, Mst. Marium Begum, Shammi Akhter, Ariful Islam, Bijo Mathew, Md. Siddiqul Islam, Md. Shah Amran and Ghulam Md. Ashraf*


DOI: 10.2174/1381612825666191011102444


Review Article

Alginate nanoparticles for drug delivery and targeting

, 2019; 25(11): 1312-1334.

Patricia Severino, Classius F. da Silva, Luciana N. Andrade, Daniele de Lima Oliveira, Joana Campos and Eliana B. Souto*


DOI: 10.2174/1381612825666190425163424


Review Article

Emerging potential of naturally occurring autophagy modulators against neurodegeneration

, 2020; 26(7): 772-779.

Md. Ataur Rahman*, Md Rezanur Rahman, Toyfiquz Zaman, Md. Sahab Uddin, Rokibul Islam, Mohamed M. Abdel-Daim and Hyewhon Rhim*


DOI: 10.2174/1381612826666200107142541




Review Article

Composition and potential health benefits of pomegranate: A review

, 2019; 25(16): 1817-1827.

Vesna Vučić*, Milkica Grabež, Armen Trchounian and Aleksandra Arsić


DOI: 10.2174/1381612825666190708183941


General Review Article

Ethnobotany, phytochemistry and traditional uses of curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): A Review

, 2019; 25(8): 871-935.

Zahra Ayati, Mahin Ramezani , Mohammad Sadegh Amiri, Ali Tafazoli Moghadam, Hoda Rahimi, Aref Abdollahzade, Amirhossein Sahebkar * and Seyed Ahmad Emami *


DOI: 10.2174/1381612825666190402163940


Review Article

Metal/metal oxide nanoparticles: Toxicity, applications, and future prospects

, 2019; 25(37): 4013-4029.

Ratiram G. Chaudhary*, Ganesh S. Bhusari, Ashish D. Tiple, Alok R. Rai, Subhash R. Somkuvar, Ajay K. Potbhare, Trimurti L. Lambat, Prashant P. Ingle and Ahmed A. Abdala*


DOI: 10.2174/1381612825666191111091326


Review Article

Expression profile of MicroRNA: An emerging hallmark of cancer

, 2019; 25(6): 642-653.

Uzma Zaheer, Muhammed Faheem, Ishtiaq Qadri, Nargis Begum, Hadi M. Yassine, Asmaa A. Al Thani and Shilu Mathew*


DOI: 10.2174/1386207322666190325122821





Most Accessed Articles

Exosome Limitations in the Treatment of Inflammatory Diseases

, 2021; 27(28): 3105-3121.

Daria Skuratovskaia*, Maria Vulf, Olga Khaziakhmatova, Vladimir Malashchenko, Aleksandra Komar, Egor Shunkin, Natalia Gazatova and Larisa Litvinova


DOI: 10.2174/1381612826666201210120444




The Pathogenic Subpopulation of Th17 Cells in Obesity

, 2021; 27(37): 3924-3938.

Natalia Todosenko, Maria Vulf, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova*


DOI: 10.2174/1381612826666210101154913


CA125: An Increasingly Promising Biomarker of Heart Failure

, 2021; 27(37): 3871-3880.

Chunqi Pan, Mengyun Zhou, Ying Jian, Yuanyuan Zeng, Mingwei Wang* and Feng Chen*


DOI: 10.2174/1381612827666210118122521


Recent Updates on Current and Upcoming Biomarkers for Cardiovascular Diseases

, 2021; 27(37): 3881-3900.

Ashif Iqubal, Aamir Khan, Adeeba laeeq, Kabil Malhotra, Mohd. A. Ansari and Syed E. Haque*


DOI: 10.2174/1381612827666210224143047



Polycystic Ovary Syndrome: A Contemporary Clinical Approach

, 2021; 27(36): 3812-3820.

Jelica Bjekić-Macut*, Tamara Vukašin, Zelija Velija-Ašimi, Azra Bureković, Marija Zdravković, Zoran Andrić, Marija Branković, Slobodanka Crevar-Marinović, Tatjana Madić, Olivera Stanojlović, Danijela V. Milutinović, Sarantis Livadas and George Mastorakos


DOI: 10.2174/1381612827666210119104721



Silybin B and Cianidanol Inhibit Mpro and Spike Protein of SARS-CoV-2: Evidence from in silico Molecular Docking Studies

, 2021; 27(32): 3476-3489.

Rashi Srivastava, Shubham Tripathi, Sreepoorna Unni, Arif Hussain, Shafiul Haque, Nandita Dasgupta, Vineeta Singh* and Bhartendu N. Mishra*


DOI: 10.2174/1381612826666201210122726



In Silico Studies Reveal Antiviral Effects of Traditional Indian Spices on COVID-19

, 2021; 27(32): 3462-3475.

Brijesh Kumar, Sama Zaidi, Shafiul Haque, Nandita Dasgupta, Arif Hussain, Sreepoorna Pramodh, Vineeta Singh* and Bhartendu N. Mishra*


DOI: 10.2174/1381612826666201223095548



Nutrition and NSCLC; Should We Administer Food Supplements?

, 2021; 27(34): 3602-3608.

Paul Zarogoulidis*, Christoforos Kosmidis, Isaak Kesisoglou, Kosmas Tsakiridis, Wolfgang Hohenforst-Schmidt, Haidong Huang, Κonstantinos Romanidis, Anastasios Vagionas and Konstantinos Sapalidis


DOI: 10.2174/1381612827999210111193133





Editor-in-Chief

graphic
Alessandro Antonelli
(12,288 citations)
Department of Clinical and Experimental Medicine
Laboratory of Primary Human Cells
University of Pisa
Pisa
(Italy)
Biography
View Full Editorial Board

Executive Editor

graphic
Atta-ur-Rahman, FRS
(32052 citations)
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
(UK)
Biography

Nobel Laureates on Editorial Board

graphic
Andrew V. Schally
(USA)

COPE Compliant

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Journal History

Current Pharmaceutical Design was introduced in 1995. Prof. Alessandro Antonelli serves as the Editor-in-Chief of the journal.

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