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Current Pharmaceutical Biotechnology

Volume 22, 15 Issues, 2021
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology

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Volume 22

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Number 14







Review Article

Insights from Pharmaceutical Biotechnology into Phenolic Biopharmaceuticals against COVID-19

, 22(14): 1848 - 1856

Nidia Cabral-Hipólito, Brenda Molina-Ramírez, María-de-la-Luz Sevilla-González, Rocío Meza-Velázquez, Rubén García-Garza, Sergio-Everardo Velázquez Gauna, Irais Castillo-Maldonado, Dealmy Delgadillo-Guzmán, Mario-Alberto Rivera-Guillén*, Luis-Benjamín Serrano-Gallardo, María-del-Carmen Vega-Menchaca, Agustina Ramírez-Moreno and David Pedroza-Escobar*


DOI: 10.2174/1389201021666201104144509


Research Article

Individual and Combined Assessment of Ser680Asn FSH Receptor and FSHβ-211 G>T Gene Polymorphisms in Ovarian Response in IVF/ICSI Program

, 22(14): 1857 - 1865

Elli Anagnostou, Alexia Kafkoutsou, Despina Mavrogianni, Ekaterini Domali, Evangelia Dimitroulia, Dimitris Mathiopoulos, Peter Drakakis and Dimitris Loutradis*


DOI: 10.2174/1389201021666201029153518






Research Article



Research Article



Current Pharmaceutical Biotechnology, Volume 22 (2021) - Number 15


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Diagnostic Accuracy and Validity of Serological and Molecular Tests for Hepatitis B and C


Moein Zangiabadian*, Amir Zamani, Mohammad Javad Nasiri, Elham Behzadi and Abbas Ali Imani Fooladi


DOI: 10.2174/1389201022666210719162802
View Abstract


Bacteriocins: Recent Advances in its Application as an Antimicrobial Alternative


Hadis Fathizadeh, Farzaneh Pakdel, Mahmood Saffari, Davoud Davoud Esmaeili, Mansooreh M. Heravi, Sounkalo Dao, Khudaverdi Ganbarov and Hossein S. Kafil*


DOI: 10.2174/1389201022666210907121254
View Abstract View on PubMed


The Prognostic Value of Long Non-Coding RNA SNHG7 in Human Cancer: A Meta-Analysis


Kexun Yu, Weijie Yuan, Changhao Huang, Lei Xiao, Runsha Xiao, Pengwei Zeng, Lu Chen* and Zihua Chen*


DOI: 10.2174/1389201022666210810100607
View Abstract View on PubMed






A Review of Chemistry and Pharmacology of Piperidine Alkaloids of Pinus and Related Genera


Lav Singh, Atul K. Upadhyay, Pooja Dixit, Arpit Singh, Divyanshu yadav, Apurv Chhavi, Suraj Konar, Ravi Prakash Srivastava, Shivaraman Pandey, Hari Prasad Devkota, Praveen C. Verma and Gauri Saxena*


DOI: 10.2174/1389201022666210812123815
View Abstract View on PubMed



Lipid Engineered Nanoparticle Therapy for Burn Wound Treatment


Abdul Qadir, Usama Ahmad, Asad Ali, Aisha Shahid, Mohd. Aqil, Nausheen Khan, Athar Ali, Waleed H Almalki, Saad Alghamdi, Md Abul Barkat and Sarwar Beg


DOI: 10.2174/1389201022666210823110532
View Abstract View on PubMed


Abstracts Ahead of Print


Xiaoyao Pill improves the Affective Dysregulation of Sleep-deprived Female Mice by inhibiting Brain Injury and regulating the Content of Monoamine Neurotransmitter


Yujie Li, Dandan Wei, Minghao Zhang, Tiantian Yue, Huimin Du, Qi Liu, Shihu Gan, Hanbin Liu, Yijie Dong, Xinyue Qiao, Yichi Zhang and Liping Yang*


DOI: 10.2174/1389201022666211012102501
View Abstract


Polymer-Based Nanotherapeutics for Burn Wounds


Rewati Raman Ujjwal, Awesh Yadav*, Shourya Tripathi and S.T.V. Sai Krishna


DOI: 10.2174/1389201022666210927103755
View Abstract


Protective effects of curcumin against iron-induced toxicity


Nastaran Moinipour, Mahdi Barati, Amirhosein Sahebkar*, Milad Iranshahy and Abolfazl Shakeri


DOI: 10.2174/1389201022666210914122846
View Abstract



Escherichia coli and colorectal cancer: Unfolding the enigmatic relationship


Rogayeh Nouri, Alka Hasani, Kourosh Masnadi Shirazi, Mohammad Reza Aliand, Bita Sepehri, Simin Sotoodeh, Fatemeh Hemmati and Mohammad Ahangarzadeh Rezaee*


DOI: 10.2174/1389201022666210910094827
View Abstract


Bacterial proteomics and its application for pathogenesis studies


Mahdi Asghari Ozma, Ehsaneh Khodadadi, Mohammad Ahangarzadeh Rezaee, Mohammad Asgharzadeh, Mohammad Aghazadeh, Elham Zeinalzadeh, Khudaverdi Ganbarov and Hossein Kafil*


DOI: 10.2174/1389201022666210908153234
View Abstract


Rational design and evaluation of the recombinant multiepitope protein for serodiagnosis of rubella


Marilen Souza, Juliana Machado, Jonatas da Silva, Luana Ramos, Lais Nogueira, Patrícia Ribeiro, Daniel Dias, Josiane Santos, José Carlos Santos, Yanna Nóbrega, Amanda Souza, Sonia Freitas, Mariana Campos da Paz, Maria Felipe, Fernando Torres and Alexsandro Galdino*


DOI: 10.2174/1389201022666210907170921
View Abstract



Herbal Medicine for the Management of Laxative Activity


Muhammad Akram, Muthu Thiruvengadam*, Rida Zainab, Muhammad Daniyal, Marc Moboladji Bankole, Maksim Rebezov, Mohammad Ali Shariati* and Eleonora Okuskhanova


DOI: 10.2174/1389201022666210812121328
View Abstract


Published Contents

Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice


Green Synthesis and Applications of Nanomaterials

, 2021; 22(13): 1705 - 1747

N.B. Singh*, Preeti Jain, Anindita De and Richa Tomar


DOI: 10.2174/1389201022666210412142734



Recent Advances in Clinical Utility of Probiotics in Gastrointestinal Tract Disorders

, 2021; 22(12): 1559 - 1573

Prativa Biswasroy, Deepak Pradhan, Dipak K. Sahu, Amita Sahu, Goutam Ghosh and Goutam Rath*


DOI: 10.2174/1389201021666201029154239




Is Biotechnological Next-Generation Therapeutics Promising Enough in Clinical Development to Treat Advanced Colon Cancer?

, 2021; 22(10): 1287 - 1301

Sarubala Malayaperumal, Sushmitha Sriramulu, Antara Banerjee, M.K. Makalakshmi and Surajit Pathak*


DOI: 10.2174/1389201021666201126142716



Targeted Delivery of CRISPR/Cas13 as a Promising Therapeutic Approach to Treat SARS-CoV-2

, 2021; 22(9): 1149 - 1155

Kazem Abbaszadeh-Goudarzi, Mohammad H. Nematollahi, Hashem Khanbabaei, Hossein H. Nave, Hamid R. Mirzaei, Hossein Pourghadamyari* and Amirhossein Sahebkar *


DOI: 10.2174/1389201021666201009154517



Growing Preferences towards Analog-based Drug Discovery

, 2021; 22(8): 1030 - 1045

Mehak Dangi, Alka Khichi, Ritu Jakhar and Anil K. Chhillar*


DOI: 10.2174/1389201021666200908121409



Recent Advances in the Scaffold Engineering of Protein Binders

, 2021; 22(7): 878 - 891

Mohammad K.B. Ahmadi, Seyed A. Mohammadi, Manoochehr Makvandi, Morteza Mamouei, Mohammad Rahmati*, Hesam Dehghani and David W. Wood


DOI: 10.2174/1389201021999200824101035



Biogenesis and Application of Nickel Nanoparticles: A Review

, 2021; 22(6): 808 - 822

Siva S. Sana, Raghvendra P. Singh*, Minaxi Sharma, Atul K. Srivastava, Geetanjali Manchanda, Alok R. Rai and Zhi-Jun Zhang*


DOI: 10.2174/1389201022999210101235233




Open Access Articles


Investigation on the Antibacterial Activity of Electronic Cigarette Liquids (ECLs): A Proof of Concept Study

, 2021; 22(7): 983 - 994

Virginia Fuochi, Massimo Caruso , Rosalia Emma, Aldo Stivala, Riccardo Polosa, Alfio Distefano and Pio M. Furneri *




Analysis of the Differences in the Expression of mRNAs and miRNAs Associated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin

, 2021; 22(4): 541 - 548

Piotr Januszyk*, Krzysztof Januszyk, Magdalena Wierzbik-Strońska, Dariusz Boroń and Beniamin Grabarek




Leaf and Fruit Methanolic Extracts of Azadirachta indica Exhibit Antifertility Activity on Rats’ Sperm Quality and Testicular Histology

, 2021; 22(3): 400 - 407

Castillo-Maldonado Irais, Borjón-Ríos Claudia, Pedroza-Escobar David*, Sharma Ashutosh, García-Garza Rubén, Ramírez-Moreno Agustina, Vega-Menchaca M. del Carmen, Rivera-Guillén Mario-Alberto and Serrano-Gallardo Luis-Benjamín*




Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer

, 2021; 22(2): 317 - 326

Karol Talkowski*, Kamil Kiełbasiński, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń and Marcin Oplawski






Cisplatin Changes Expression of SEMA3B in Endometrial Cancer

, 2020; 21(13): 1368 - 1376

Wojciech Peszek*, Piotr Kras, Beniamin O. Grabarek, Dariusz Boroń and Marcin Oplawski




Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line

, 2020; 21(12): 1269 - 1277

Kamil Kiełbasiński*, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń, Magdalena Wierzbik-Strońska and Marcin Oplawski





Differences in the Expression Pattern of mRNA Protein SEMA3F in Endometrial Cancer in vitro under Cisplatin Treatment

, 2020; 21(11): 1119 - 1128

Przemysław Kieszkowski*, Dariusz Dąbruś, Beniamin O. Grabarek and Dariusz Boroń




Analysis of the Clinical Diagnostic Value of GMFB in Cerebral Infarction

, 2020; 21(10): 955 - 963

Zhaohu Yuan*, Zhiwu Yu, Yiyu Zhang and Huikuan Yang




Plant Phenolics as Pathogen-Carrier Immunogenicity Modulator Haptens

, 2020; 21(10): 897 - 905

Castillo-Maldonado Irais, Sevilla-González María-de-la-Luz, Delgadillo-Guzmán Dealmy, Ramírez-Moreno Agustina, Cabral-Hipólito Nidia, Rivera-Guillén Mario-Alberto, Serrano-Gallardo Luis-Benjamín*, Vega-Menchaca María-del-Carmen and Pedroza-Escobar David*





The Anti-Inflammatory Effects of Anacardic Acid on a TNF-α - Induced Human Saphenous Vein Endothelial Cell Culture Model

, 2020; 21(8): 710 - 719

Burak Önal*, Deniz Özen, Bülent Demir, Duygu Gezen Ak, Erdinç Dursun, Caner Demir, Ahmet Gökhan Akkan and Sibel Özyazgan





Most Cited Articles


Review Article

Current prospects of nutraceuticals: A review

, 2020; 21(10): 884-896.

Vedant Sachdeva, Arpita Roy and Navneeta Bharadvaja*


DOI: 10.2174/1389201021666200130113441






Research Article

Healthcare-associated infections due to multidrug-resistant organisms: A surveillance study on extra hospital stay and direct costs

, 2019; 20(8): 643-652.

Guglielmo Giraldi, Marzietta Montesano, Christian Napoli, Paola Frati, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti and Giovanni B. Orsi*


DOI: 10.2174/1389201020666190408095811


Review Article

Ginger: A novel strategy to battle cancer through modulating cell signalling pathways: A review

, 2019; 20(1): 5-16.

Ahmad Almatroudi, Mohammed A. Alsahli, Faris Alrumaihi, Khaled S. Allemailem and Arshad H. Rahmani*


DOI: 10.2174/1389201020666190119142331




Research Article

New rules on patient’s safety and professional liability for the Italian health service

, 2019; 20(8): 615-624.

Sara Albolino, Tommaso Bellandi, Simone Cappelletti, Marco Di Paolo, Vittorio Fineschi*, Paola Frati, Caterina Offidani, Michela Tanzini, Riccardo Tartaglia and Emanuela Turillazzi


DOI: 10.2174/1389201020666190408094016


Review Article

Functional biomolecule delivery systems and bioengineering in cartilage regeneration

, 2019; 20(1): 32-46.

Marta A. Szychlinska, Ugo D'Amora, Silvia Ravalli, Luigi Ambrosio, Michelino Di Rosa and Giuseppe Musumeci*


DOI: 10.2174/1389201020666190206202048


Research Article

Effect of pullulan on physicochemical, microbiological, and sensory quality of yogurts

, 2019; 20(6): 489-496.

Anna Chlebowska-Śmigiel, Katarzyna Kycia, Katarzyna Neffe-Skocińska, Marek Kieliszek*, Małgorzata Gniewosz and Danuta Kołożyn-Krajewska


DOI: 10.2174/1389201020666190416151129


Review Article

Recent insights into effective nanomaterials and biomacromolecules conjugation in advanced drug targeting

, 2019; 20(7): 526-541.

Abbas H. Azandaryani , Soheila Kashanian * and Tahereh Jamshidnejad-Tosaramandani


DOI: 10.2174/1389201020666190417125101


Review Article

Blood brain barrier permeability prediction using machine learning techniques: An update

, 2019; 20(14): 1163-1171.

Deeksha Saxena, Anju Sharma, Mohammed H. Siddiqui and Rajnish Kumar*


DOI: 10.2174/1389201020666190821145346



Most Accessed Articles

Targeting Macrophages in Atherosclerosis

, 2021; 22(15): 2008-2018.

Dan Hu, Zengyan Wang, Yuzhong Wang* and Caihong Liang*


DOI: 10.2174/1389201022666210122142233


Is Hospital Autopsy Auditing Suitable for Clinical Risk Management? Actualities and Perspectives of Auditing in the Autopsy Room Following Italian Law 24/2017 on Patient Safety

, 2021; 22(15): 1964-1970.

Martina Zanon, Eleonora Valentinuz, Martina Montanaro, Davide Radaelli, Alessandro Manfredi, Diana Bonuccelli, Massimo Martelloni and Stefano D’Errico*


DOI: 10.2174/1389201021666201208115525




Synthesis of Silymarin-Gold Nanoparticle Conjugate and Analysis of its Liver-Protecting Activity

, 2021; 22(15): 2001-2007.

Sergey Staroverov, Sergey Kozlov, Alexander Fomin, Konstantin Gabalov, Alexey Volkov, Ivan Domnitsky, Lev Dykman and Olga Guliy*


DOI: 10.2174/1389201022666210101163734







Identification of Potential Targets for Thymidylate Synthase and Amp-C β-lactamase from Non-alkaloidal Fractions of Moringa oleifera Leaves

, 2021; 22(15): 2085-2093.

Chandresh Kumari, Amanpreet K. Virk, Swati Kumari, Tanvi Gupta, Rajan Rolta, Xiangkai Li and Saurabh Kulshrestha*


DOI: 10.2174/1389201022666210111120208


Production of Chemotherapeutic Enzyme L-asparaginase from a Fungal Source

, 2021; 22(15): 2031-2037.

Girish B. Pendharkar*, Harshal G. Sonawane, Kalpesh A. Khare and Dhananjay Yadav*


DOI: 10.2174/1389201022666210211124232


Individual and Combined Assessment of Ser680Asn FSH Receptor and FSHβ-211 G>T Gene Polymorphisms in Ovarian Response in IVF/ICSI Program

, 2021; 22(14): 1857-1865.

Elli Anagnostou, Alexia Kafkoutsou, Despina Mavrogianni, Ekaterini Domali, Evangelia Dimitroulia, Dimitris Mathiopoulos, Peter Drakakis and Dimitris Loutradis*


DOI: 10.2174/1389201021666201029153518


Efficacy of a Chitosan-curcumin Mixture in Treating Indomethacininduced Acute Gastric Ulcer in Rats

, 2021; 22(14): 1919-1931.

Sineenat Kuadkaew, Suwipa Ungphaiboon, Narubodee Phdoongsombut, Sireewan Kaewsuwan and Sirima Mahattanadul*


DOI: 10.2174/1389201022666210127115427


Production and Immunological Evaluation of Epitope-based Preventative Pneumococcal Candidate Vaccine Comprising Immunodominant Epitopes from PspA, CbpA, PhtD and PiuA Antigens

, 2021; 22(14): 1900-1909.

Hesam Dorosti, Navid Nezafat, Reza Heidari, Mohammad B. Ghoshoon, Ahmad Gholami, Ali Dehshahri, Nasrollah Erfani, Mohammad R. Rahbar and Younes Ghasemi*


DOI: 10.2174/1389201022666201231112029




Editor-in-Chief

graphic
Nikolaos Labrou
School of Food, Biotechnology and Development
Department of Biotechnology
Agricultural University of Athens
Athens
(Greece)
Biography
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Journal History

Current Pharmaceutical Biotechnology was launched in 2000. Dr. Nikolaos Labrou serves as the Editor-in-Chief of the journal.

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