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Current Cancer Drug Targets

Volume 22, 11 Issues, 2022
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access

Aims & Scope

Current Cancer Drug Targets aims to cover all the latest and outstanding developments in full spectrum of cancer drug discovery and development, including but not limited to cellular and molecular biology, genomics, proteomics, metabolomics, medicinal chemistry, pharmacology, toxicology, and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.

Current Cancer Drug Targets publishes original research articles, letters/commentary/perspectives, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.

As the discovery, identification, characterization and validation of novel drug targets for human anticancer drug discovery continues to grow, this journal has become essential reading for all biomedical and pharmaceutical scientists involved in drug discovery and development. Its scope covers publications related to prevention, diagnosis and treatment of all types of human cancers in various of basic and translational researches, including cancer etiology, signal transduction, biomarker, chemotherapy, hormone therapy, gene therapy, immunotherapy, radiotherapy, immunotherapy and combination therapy, stem cell, tumor environment, metabolism emphasizing on advanced mechanistic investigations.

Current Cancer Drug Targets

,

Volume 22

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Number 6



Review Article

Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities

, 22(6): 437 - 453

Mahnaz Rezaei, Natalia D. Danilova, Mojdeh Soltani, Lyudmila V. Savvateeva, Vadim V. Tarasov, Mazdak Ganjalikhani-Hakemi, Alexandr V. Bazhinf and Andrey A. Zamyatnin*


DOI: 10.2174/1568009622666220214103533





Articles Ahead of Print

Modulation of ATP8B1 Gene Expression in Colorectal Cancer Cells Suggest its Role as a Tumor Suppressor


Saleh Althenayyan, Amal AlGhamdi, Mohammed H. AlMuhanna, Esra Hawsa, Dalal Aldeghaither, Jahangir Iqbal, Sameer Mohammad and Mohammad Azhar Aziz*


DOI: 10.2174/1568009622666220517092340
View Abstract



Progress in Metabolic Studies of Gastric Cancer and Therapeutic Implications


Adriana Romo-Perez, Guadalupe Dominguez-Gomez, Alma Chavez-Blanco, Lucia Taja-Chayeb, Aurora Gonzalez-Fierro, Consuelo Diaz-Romero, Horacio Noe Lopez-Basave and Alfonso Duenas-Gonzalez


DOI: 10.2174/1568009622666220413083534
View Abstract View on PubMed



TROP2 Down-Regulated DSG2 to Promote Gastric Cancer Cell Invasion and Migration by EGFR/AKT and DSG2/PG/β-Catenin Pathways


Tingting Yang, Lizhou Jia, Susu Bian, Xinxia Chang, Qian Zhang, Qi Tang, Jing Zhu, Zhiping Yang* and Zhenqing Feng*


DOI: 10.2174/1568009622666220407111013
View Abstract View on PubMed




The Current and Evolving Role of Immunotherapy in Metastatic Colorectal Cancer


Virgilio S. Silva, Rachel P. Riechelmann*, Celso A. Mello, Tiago Felismino and Rodrigo Taboada


DOI: 10.2174/1568009622666220224110912
View Abstract View on PubMed


Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma


Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, Reshma Ravindran Nair and Lekshmi R. Nath*


DOI: 10.2174/1568009622666220317090552
View Abstract View on PubMed



Abstracts Ahead of Print



Recent Progress in Histone deacetylase (HDAC) 1 Inhibitors as Anticancer Agent.


Preeti Patel*, Simranpreet K. Wahan, S. Vishakha, Balak Das Kurmi, Ghanshyam Das Gupta, Harish Rajak and Vivek Asati


DOI: 10.2174/1568009622666220624090542
View Abstract


Cucurbitacin D inhibits the proliferation of HepG2 cells and induces apoptosis by modulating JAK/STAT3, PI3K/Akt/mTOR and MAPK signaling pathways


Muhammed Mehdi Üremiş, Nuray Üremiş, Emir Tosun, Merve Durhan, Yılmaz Çiğremiş, Ahmet Baysar and Yusuf Türköz*


DOI: 10.2174/1568009622666220623141158
View Abstract


Targeting the transforming growth factor-beta signaling pathway in the treatment of gynecologic cancer


Sadaf Ghanaatgar-Kasbi*, Farzaneh Pouya*, Negar Khoshghamat*, Ghazaleh Ghorbannezhad*, Majid Khazaei*, Malihe Hasanzadeh, Gordon A Ferns and Amir Avan*


DOI: 10.2174/1568009622666220623115614
View Abstract



Review: Aminopeptidases in Cancer, Biology and Prospects for Pharmacological Intervention


Sarah A. Holstein, Caroline A. Heckman, Faith E. Davies, Gareth J. Morgan, Stefan Svensson Gelius and Fredrik Lehmann*


DOI: 10.2174/1568009622666220623112605
View Abstract



Combined inhibition of KIF11 and KIF15 as an effective therapeutic strategy for gastric cancer


Ruo-Fei Sun, Na He, Geng-Yuan Zhang, Ze-Yuan Yu, Lian-Shun Li, Zhi-Jian Ma and Zuo-Yi Jiao


DOI: 10.2174/1568009622666220616122846
View Abstract


Genome-wide CRISPR-Cas9 screening and identification of potential genes promoting prostate cancer growth and metastasis.


Wei Wang*, Dongbo Yuan*, Kehua Jiang, Ruidong Li, Han Qu, Fu-Neng Jiang, Wei-De Zhong, Fa Sun, Zhenyu Jia and Jianguo Zhu


DOI: 10.2174/1568009622666220615154137
View Abstract


Published Contents

Editor's Choice

Metastatic Breast Cancer, Organotropism and Therapeutics: A Review

, 2021; 21(10): 813 - 828

Ajaz Ahmad Waza*, Najeebul Tarfeen, Sabhiya Majid, Yasmeena Hassan, Rashid Mir, Mohd Younis Rather and Naseer Ue Din Shah


DOI: 10.2174/1568009621666210806094410






Cholangiocarcinoma Therapeutics: An Update

, 2021; 21(6): 457 - 475

Mai Ly Thi Nguyen, Nguyen Linh Toan, Maria Bozko, Khac Cuong Bui* and Przemyslaw Bozko*


DOI: 10.2174/1568009621666210204152028




PROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug Resistance

, 2021; 21(4): 306 - 325

Sarah F. Giardina*, Elena Valdambrini, J. David Warren and Francis Barany


DOI: 10.2174/1568009621666210203110857



Novel MicroRNA Binding Site SNPs and the Risk of Clear Cell Renal Cell Carcinoma (ccRCC): A Case-Control Study

, 2021; 21(3): 203 - 212

Irina R. Gilyazova, Narasimha M. Beeraka, Elizaveta A. Klimentova, Kirill V. Bulygin, Vladimir N. Nikolenko, Adel A. Izmailov, Gulshat R. Gilyazova, Valentin N. Pavlov, Elsa K. Khusnutdinova, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568009620666201120151226



Immunotherapy: A Potential Approach to Targeting Cancer Stem Cells

, 2021; 21(2): 117 - 131

Wenjun Wang, Ling Bai, Dongsheng Xu, Wei Li and Jiuwei Cui*


DOI: 10.2174/1568009620666200504111914



C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors

, 2021; 21(1): 2 - 20

Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*


DOI: 10.2174/1568009620666201016121005



Open Access Articles


Durable Disease-Free Survival in a Patient with Metastatic Triple-Negative Breast Cancer Treated with Olaparib Monotherapy

, 2022; 22: 1 - 7 (E-Pub Ahead of Print)

Xue Wang, Nanlin Hu, Lina Cui, Yiran Si, Jian Yue, Fangchao Zheng, Yikun Kang and Peng Yuan*




Re-Sensitizing Tumor Cells to Cancer Drugs with Epigenetic Regulators

, 2021; 21(4): 353 - 359

Stefanie Rauscher, Richard Greil and Roland Geisberger*




Tumor Penetrating Peptide-Functionalized Tenascin-C Antibody for Glioblastoma Targeting

, 2021; 21(1): 70 - 79

Prakash Lingasamy, Anett-Hildegard Laarmann and Tambet Teesalu *




Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL

, 2020; 20(10): 811 - 817

Sven Nilsson, Alexander Stein, Christian Rolfo, Anne L. Kranich, Julia Mann, Konstantinos Papadimitriou, Susann Theile, Stefanie Amberg and Carsten Bokemeyer*




The Roles of Alternative Splicing in Tumor-immune Cell Interactions

, 2020; 20(10): 729 - 740

Yue Wang, Honglei Zhang*, Baowei Jiao*, Jianyun Nie*, Xiyin Li, Wenhuan Wang and Hairui Wang




Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer

, 2019; 19(1): 74 - 80

Peng Liu, Hailin Tang, Jiali Wu, Xingsheng Qiu, Yanan Kong, Lijuan Zhang, Xinhua Xie* and Xiangsheng Xiao*




Role of MicroRNAs in Treatment Response in Prostate Cancer

, 2018; 18(10): 929 - 944

Anshuli Razdan, Paul de Souza* and Tara Laurine Roberts




Noxa: Role in Cancer Pathogenesis and Treatment

, 2018; 18(10): 914 - 928

Rami Z. Morsi, Rouba Hage-Sleiman, Hadile Kobeissy and Ghassan Dbaibo*





Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer

, 2016; 16(4): 346 - 356

Xue-Qing Hu, Yang Sun, Eric Lau, Ming Zhao and Shi-Bing Su





Most Cited Articles

Review Article

Polyploid giant cancer cells (PGCCs): The evil roots of cancer

, 2019; 19(5): 360-367.

Junsong Chen, Na Niu, Jing Zhang, Lisha Qi , Weiwei Shen , Krishna Vanaja Donkena, Zhenqing Feng and Jinsong Liu *


DOI: 10.2174/1568009618666180703154233


Review Article

Old and new approaches to target the hsp90 chaperone

, 2020; 20(4): 253-270.

Jackee Sanchez, Trever R. Carter, Mark S. Cohen* and Brian S.J. Blagg


DOI: 10.2174/1568009619666191202101330


Review Article

Resveratrol as an adjuvant for normal tissues protection and tumor sensitization

, 2020; 20(2): 130-145.

Keywan Mortezaee, Masoud Najafi*, Bagher Farhood*, Amirhossein Ahmadi*, Dheyauldeen Shabeeb and Ahmed E. Musa


DOI: 10.2174/1568009619666191019143539


Review Article

HSF1 as a cancer biomarker and therapeutic target

, 2019; 19(7): 515-524.

Richard L. Carpenter* and Yesim Gokmen-Polar


DOI: 10.2174/1568009618666181018162117


Review Article

Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment?

, 2019; 19(1): 26-40.

A.P. Alves, A.C. Mamede, M.G. Alves, P.F. Oliveira, S.M. Rocha, M.F. Botelho and C.J. Maia*


DOI: 10.2174/1568009618666180430144441


Review Article

The RNA binding protein hur: A promising drug target for anticancer therapy

, 2019; 19(5): 382-399.

Mingxia Wu, Christy W.S. Tong, Wei Yan, Kenneth K.W. To* and William C.S. Cho*


DOI: 10.2174/1568009618666181031145953


Review Article

Mesoporous silica nanoparticles as a prospective and promising approach for drug delivery and biomedical applications

, 2019; 19(4): 285-295.

Xiaohui Pu, Jia Li, Peng Qiao, Mengmeng Li, Haiyan Wang, Lanlan Zong*, Qi Yuan and Shaofeng Duan*


DOI: 10.2174/1568009619666181206114904




Research Article

Interactions of vascular endothelial growth factor and p53 with mir-195 in thyroid carcinoma: Possible therapeutic targets in aggressive thyroid cancers

, 2019; 19(7): 561-570.

Hamidreza Maroof , Soussan Irani , Armin Arianna, Jelena Vider, Vinod Gopalan and Alfred King-yin Lam *


DOI: 10.2174/1568009618666180628154727


Research Article

c-Myc inhibitor 10074-G5 induces murine and human hematopoietic stem and progenitor cell expansion and HDR modulator Rad51 expression

, 2019; 19(6): 479-494.

Merve Aksoz, Esra Albayrak, Galip Servet Aslan, Raife Dilek Turan, Lamia Yazgi Alyazici, Pınar Siyah, Emre Can Tuysuz, Serli Canikyan, Dogacan Yucel, Neslihan Meric, Zafer Gulbas, Fikrettin Sahin and Fatih Kocabas*


DOI: 10.2174/1568009618666180905100608


Review Article

Ursolic acid in cancer treatment and metastatic chemoprevention: From synthesized derivatives to nanoformulations in preclinical studies

, 2019; 19(4): 245-256.

Junjie Zou, Juanfang Lin, Chao Li, Ruirui Zhao, Lulu Fan, Jesse Yu and Jingwei Shao*


DOI: 10.2174/1568009618666181016145940


Review Article

Focal adhesion kinase in ovarian cancer: A potential therapeutic target for platinum and taxane-resistant tumors

, 2019; 19(3): 179-188.

Arkene Levy*, Khalid Alhazzani, Priya Dondapati, Ali Alaseem, Khadijah Cheema, Keerthi Thallapureddy, Paramjot Kaur, Saad Alobid and Appu Rathinavelu


DOI: 10.2174/1568009618666180706165222


Review Article

COVID-19 pandemic: Experiences in China and implications for its prevention and treatment worldwide

, 2020; 20(6): 410-416.

Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*


DOI: 10.2174/1568009620666200414151419




Most Accessed Articles




CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma

, 2021; 21(10): 870-880.

Xiaohua Zhang, Tianying Zhang, Xiaojuan Han, Zhongying Qiu, Jianghong Cheng, Xingchun Gao and Xingchun Gou*


DOI: 10.2174/1568009621666210602164225




Role of ZEB Family Members in Proliferation, Metastasis, and Chemoresistance of Prostate Cancer Cells: Revealing Signaling Networks

, 2021; 21(9): 749-767.

Leyla soleymani, Ali Zarrabi, Farid Hashemi, Fardin Hashemi, Amirhossein Zabolian, Seyed Mohammad Banihashemi, Shirin Sabouhi Moghadam, Kiavash Hushmandi, Saeed Samarghandian, Milad Ashrafizadeh* and Haroon Khan*


DOI: 10.2174/1568009621666210601114631



Role of Exosomes in Breast Cancer Management: Evidence-Based Review

, 2021; 21(8): 666-675.

Razan B. Al-Humaidi, Bahgat Fayed, Suleiman I. Sharif, Ayman Noreddin and Sameh S.M. Soliman*


DOI: 10.2174/1568009621666210601115707


The Clinical Application of Circulating Tumor Cells and DNAs as Prognostic and Predictive Biomarkers in Gastrointestinal Cancer

, 2021; 21(8): 676-688.

Sara Memarpour*, Ghazaleh Khalili-Tanha*, Awa Alizadeh Ghannad, Masoud Sharifian Razavi, Mona Joudi, Marjan Joodi, Gordon A. Ferns, Seyed Mahdi Hassanian, Majid Khazaei and Amir Avan*


DOI: 10.2174/1568009621666210311090531




DDX39B Predicts Poor Survival and Associated with Clinical Benefit of Anti-PD-L1 Therapy in ccRCC

, 2021; 21(10): 849-859.

Jinhuan Wei, Jun Lu, Yun Cao, Gaosheng Yao, Yong Huang, Hongwei Zhao, Yihui Pan, Zihao Feng, Zhenhua Chen, Wei Chen, Junhang Luo* and Jiazheng Cao*


DOI: 10.2174/1568009621666210811115054


Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy

, 2021; 21(8): 640-665.

Milad Ashrafizadeh, Md Shahinozzaman, Sima Orouei, Vahideh Zarrin, Kiavash Hushmandi, Farid Hashemi, Anuj Kumar, Saeed Samarghandian, Masoud Najafi* and Ali Zarrabi*


DOI: 10.2174/1568009621666210203110305


MiR-129-5p Promotes Radio-sensitivity of NSCLC Cells by Targeting SOX4 and RUNX1

, 2021; 21(8): 702-712.

Tongqing Xue, Gang Yin, Weixuan Yang, Xiaoyu Chen, Cheng Liu, Weixi Yang* and Jun Zhu*


DOI: 10.2174/1568009621666210415094350




Editor-in-Chief

graphic
Ruiwen Zhang
Center for Drug Discovery
University of Houston
Houston, TX
(USA)
Biography
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