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Current Alzheimer Research

Volume 18, 14 Issues, 2021
ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)
This journal supports open access

Aims & Scope

Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer's disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive 'bird's-eye view' of the current state of Alzheimer's research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.

Current Alzheimer Research

,

Volume 18

-

Number 4



Research Article

Real-world Utilisation of the Rivastigmine Transdermal Patches Accompanying the Use of Risk Minimisation Tools in Patients with Dementia

, 18(4): 273 - 282

Fritjof Reinhardt, Nikolaos Scarmeas, Rajesh Karan, Uday K. Veldandi, Sunil Modali*, Krishna Duvvuri and Rashid K. Pathan


DOI: 10.2174/1567205018666210716120540


Research Article   Open Access

Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice

, 18(4): 283 - 297

Katherine R. Sadleir*, Jelena Popovoic, Wei Zhu, Cory T. Reidel, Ha Do, Richard B. Silverman and Robert Vassar


DOI: 10.2174/1567205018666210713125333


Research Article

Beneficial Effects of Choline Alphoscerate on Amyloid-β Neurotoxicity in an In vitro Model of Alzheimer’s Disease

, 18(4): 298 - 309

Chiara Burgaletto, Giulia Di Benedetto, Antonio Munafò, Renato Bernardini and Giuseppina Cantarella*


DOI: 10.2174/1567205018666210608093658


Research Article

High Fat Diet Aggravates AD-Related Pathogenic Processes in APP/PS1 Mice

, 18(4): 310 - 325

Xiaokang Gong, Zheng Liang, Wei Liu, Yang Zhao, Youhua Yang, Mengjuan Wu, Jinting Shang, Yifan Xiao, Yong Mei, Qiqi Su, Binlian Sun, Jian Bao* and Xiji Shu*


DOI: 10.2174/1567205018666210628100812


Research Article

The Absence of Myelin Basic Protein Reduces Non-Amyloidogenic Processing of Amyloid Precursor Protein

, 18(4): 326 - 334

Chika Seiwa*, Ichiro Sugiyama , Makoto Sugawa, Hiroaki Murase , Chiaki Kudoh and Hiroaki Asou


DOI: 10.2174/1567205018666210701162851


Research Article

Longitudinal Functional Magnetic Resonance Spectroscopy Study in Subjects with Mild Cognitive Impairment and Alzheimer’s Disease

, 18(4): 335 - 346

Soo-Hyun Cho, Hak Y. Rhee, Janghoon Oh, Jin S. Lee, Soonchan Park, Won C. Shin, Jong-Woo Paik, Chang-Woo Ryu, Key C. Park and Geon-Ho Jahng*


DOI: 10.2174/1567205018666210708145924




Current Alzheimer Research, Volume 18 (2021) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Determinants of Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study in a Community-based Cohort


François R. Herrmann, Marie-Louise Montandon, Valentina Garibotto, Cristelle Rodriguez, Sven Haller and Panteleimon Giannakopoulos*


DOI: 10.2174/1567205018666210930111806
View Abstract View on PubMed



Abstracts Ahead of Print

A Novel Probiotic Formula, BIOCG, Protects Against Alzheimer’s-Related Cognitive Deficits via Regulation of Dendritic Spine Dynamics


Miao Sun*, Wenchenyang Bao, Chengyu Huang, Ziyue Xia, Changliang Zhang, Guangxian Wang, Runxin Wang, Jiangyu Li, Shaun Roux, Qian Li, Dongmei Zou, Kai Ma* and Xiaofeng Bao*


DOI: 10.2174/1567205018666211022091110
View Abstract


Non-Ceruloplasmin Copper as a Stratification Biomarker of Alzheimer’s Disease Patients: How to Measure and Use It


Rosanna Squitti*, Mariacarla Ventriglia, Alberto Granzotto*, Stefano L. Sensi and Mauro Ciro Antonio Rongioletti


DOI: 10.2174/1567205018666211022085755
View Abstract





Exendin-4 Improves Cognitive Function of Diabetic Mice via Increasing Brain Insulin Synthesis


Xuemin Peng, Xiaoli Shi, Jiaojiao Huang, Shujun Zhang, Yongli Yan, Delin Ma, Weijie Xu, Weijie Xu, Kun Dong, Jing Tao, Mengni Li and Yan Yang*


DOI: 10.2174/1567205018666210929150004
View Abstract


The Janus-like Association Between Proton Pump Inhibitors and Dementia


Anna Papazoglou, Muhammad Imran Arshaad, Christina Henseler, Johanna Daubner, Karl Broich, Britta Haenisch and Marco Weiergräber*


DOI: 10.2174/1567205018666210929144740
View Abstract


Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ɛ4 Allele in Alzheimer's Disease


Babić Leko M, Nikolac Perković M, Nedić Erjavec G, Klepac N, Švob Štrac D, Borovečki F, Pivac N, Hof PR and Šimić G.*


DOI: 10.2174/1567205018666210917162843
View Abstract



Palmitoylated prolactin-releasing peptide reduced Aβ plaques and microgliosis in the cerebellum: APP/PS1 mice study


Anna Mengr, Lucie Hrubá, Aneta Exnerová, Martina Holubová, Andrea Popelová, Blanka Železná, Jaroslav Kuneš and Lenka Maletínská*


DOI: 10.2174/1567205018666210922110652
View Abstract


Published Contents

Editor's Choice

High Fat Diet Aggravates AD-Related Pathogenic Processes in APP/PS1 Mice

, 2021; 18(4): 310 - 325

Xiaokang Gong, Zheng Liang, Wei Liu, Yang Zhao, Youhua Yang, Mengjuan Wu, Jinting Shang, Yifan Xiao, Yong Mei, Qiqi Su, Binlian Sun, Jian Bao* and Xiji Shu*


DOI: 10.2174/1567205018666210628100812



123I-Ioflupane SPECT and 18F-FDG PET Combined Use in the Characterization of Movement and Cognitive Associated Disorders in Neurodegenerative Diseases

, 2021; 18(3): 196 - 207

Susanna Nuvoli*, Giovanna Tanda, Maria L. Stazza, Barbara Palumbo, Viviana Frantellizzi, Giuseppe De Vincentis, Angela Spanu and Giuseppe Madeddu


DOI: 10.2174/1567205018666210608112302




Cerebrospinal Fluid Inflammatory Markers in Alzheimer’s Disease: Influence of Comorbidities

, 2021; 18(2): 157 - 170

Ying Wang, Ceren Emre, Helena Gyllenhammar-Schill, Karin Fjellman, Helga Eyjolfsdottir, Maria Eriksdotter, Marianne Schultzberg and Erik Hjorth*


DOI: 10.2174/1567205018666210330162207



Retinal Changes in Transgenic Mouse Models of Alzheimer’s Disease

, 2021; 18(2): 89 - 102

Li Guo*, Nivedita Ravindran, Ehtesham Shamsher, Daniel Hill and M. Francesca Cordeiro


DOI: 10.2174/1567205018666210414113634



Clinical Application of the Vestibular Stimulation Effect on Balance Disorders with Dementia

, 2021; 18(1): 1 - 7

Kiyotaka Nakamagoe*, Shiori Yamada, Rio Kawakami, Takami Maeno, Tadachika Koganezawa and Akira Tamaoka


DOI: 10.2174/1567205018666210324105642



APP/PS1 Gene-Environment Noise Interaction Aggravates AD-like Neuropathology in Hippocampus Via Activation of the VDAC1 Positive Feedback Loop

, 2021; 18(1): 14 - 24

Huimin Chi, Qingfeng Zhai, Ming Zhang, Donghong Su, Wa Cao, Wenlong Li, Xiaojun She, Honglian Yang, Kun Wang, Xiujie Gao, Kefeng Ma, Bo Cui* and Yugang Qiu*


DOI: 10.2174/1567205018666210324114153



Nanoparticle-Encapsulated Bryostatin-1 Activates α-Secretase and PKC Isoforms In vitro and Facilitates Acquisition and Retention of Spatial Learning in an Alzheimer's Disease Mouse Model

, 2020; 17(14): 1302 - 1310

Lisa Schrott, Ping Yi, Kasey Jackson, Gabriel S. Jackson, Christopher Webb, Alireza Minagar, J. Winny Yun, Geoffrey Purdum, David J. Rios, Theodore A. Tyler, Maria I. Vizcanio, Judith L. Castor, Trevor Castor and Jonathan S. Alexander*


DOI: 10.2174/1567205018666210218155835




Diagnosis of Mild Cognitive Impairment Using Cognitive Tasks: A Functional Near-Infrared Spectroscopy Study

, 2020; 17(13): 1145 - 1160

So-Hyeon Yoo, Seong-Woo Woo, Myung-Jun Shin, Jin A. Yoon, Yong-Il Shin and Keum-Shik Hong*


DOI: 10.2174/1567205018666210212154941



Open Access Articles


Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice

, 2021; 18(4): 283 - 297

Katherine R. Sadleir*, Jelena Popovoic, Wei Zhu, Cory T. Reidel, Ha Do, Richard B. Silverman and Robert Vassar




Clinical Phenotype and Mutation Spectrum of Alzheimer’s Disease with Causative Genetic Mutation in a Chinese Cohort

, 2021; 18(3): 265 - 272

Chenhui Mao, Jie Li, Liling Dong, Xinying Huang, Dan Lei, Jie Wang, Shanshan Chu, Caiyan Liu, Bin Peng, Gustavo C. Román, Liying Cui and Jing Gao*





Cerebrospinal Fluid Inflammatory Markers in Alzheimer’s Disease: Influence of Comorbidities

, 2021; 18(2): 157 - 170

Ying Wang, Ceren Emre, Helena Gyllenhammar-Schill, Karin Fjellman, Helga Eyjolfsdottir, Maria Eriksdotter, Marianne Schultzberg and Erik Hjorth*





Statins, Risk of Death and Ischemic Stroke in Patients with Dementia: A Registry-Based Observational Cohort Study

, 2020; 17(10): 881 - 892

Bojana Petek*, Hong Xu, Marta Villa-Lopez, Bengt Winblad, Milica G. Kramberger, Maria Eriksdotter and Sara Garcia-Ptacek*




Cerebrospinal Fluid and Blood CX3CL1 as a Potential Biomarker in Early Diagnosis and Prognosis of Dementia

, 2020; 17(8): 709 - 721

Agnieszka Kulczyńska-Przybik*, Agnieszka Słowik, Piotr Mroczko, Bartłomiej Borawski, Magdalena Groblewska, Renata Borawska and Barbara Mroczko




Presenilin 1 and APP Gene Mutations in Early-Onset AD Families from a Southeast Region of China

, 2020; 17(6): 540 - 546

Jiajia Zhou, Yi Chen, Fanxia Meng, Kan Zhang, Xiaoyan Liu and Guoping Peng*




The Parietal Atrophy Score on Brain Magnetic Resonance Imaging is a Reliable Visual Scale

, 2020; 17(6): 534 - 539

David Silhan, Ales Bartos*, Jana Mrzilkova, Olga Pashkovska, Ibrahim Ibrahim and Jaroslav Tintera





Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model

, 2020; 17(3): 285 - 296

Gernot Riedel , Jochen Klein , Grazyna Niewiadomska, Constantin Kondak , Karima Schwab , Dilyara Lauer , Mandy Magbagbeolu , Marta Steczkowska, Maciej Zadrozny , Malgorzata Wydrych , Anna Cranston , Valeria Melis, Renato X. Santos , Franz Theuring , Charles R. Harrington and Claude M. Wischik*




Dangerous Liaisons: Tau Interaction with Muscarinic Receptors

, 2020; 17(3): 224 - 237

Adrianna Wysocka, Ewelina Palasz, Marta Steczkowska and Grazyna Niewiadomska*




Association Between Anemia and Dementia: A Nationwide, Populationbased Cohort Study in Taiwan

, 2020; 17(2): 196 - 204

Chien-Tai Hong, Yi-Chen Hsieh, Hung-Yi Liu, Hung-Yi Chiou and Li-Nien Chien*




Joint Effect of ABCA7 rs4147929 and Body Mass Index on Progression from Mild Cognitive Impairment to Alzheimer’s Disease: The Shanghai Aging Study

, 2020; 17(2): 185 - 195

Jianxiong Xi, Ding Ding*, Qianhua Zhao, Xiaoniu Liang, Li Zheng, Qihao Guo, Zhen Hong, Hua Fu, Jianfeng Xu and Qianyi Xiao*





Most Cited Articles





Review Article

Mitigating Alzheimer’s disease with natural polyphenols: A review

, 2019; 16(6): 529-543.

Roger Gaudreault* and Normand Mousseau*


DOI: 10.2174/1567205016666190315093520



Review Article

Learning from the past: A review of clinical trials targeting amyloid, tau and neuroinflammation in Alzheimer’s disease

, 2020; 17(2): 112-125.

Kelly Ceyzériat, Thomas Zilli, Philippe Millet, Giovanni B. Frisoni, Valentina Garibotto and Benjamin B. Tournier*


DOI: 10.2174/1567205017666200304085513


Research Article

Resveratrol rescues tau-induced cognitive deficits and neuropathology in a mouse model of tauopathy

, 2019; 16(8): 710-722.

Xiao-Ying Sun, Quan-Xiu Dong, Jie Zhu, Xun Sun, Li-Fan Zhang, Mandy Qiu, Xiao-Lin Yu* and Rui-Tian Liu*


DOI: 10.2174/1567205016666190801153751


Review Article

Neuroinflammation in alzheimer’s disease: Microglia, molecular participants and therapeutic choices

, 2019; 16(7): 659-674.

Haijun Wang, Yin Shen, Haoyu Chuang, Chengdi Chiu, Youfan Ye and Lei Zhao*


DOI: 10.2174/1567205016666190503151648



Systemic Review Article

Midlife modifiable risk factors for dementia: A systematic review and meta-analysis of 34 prospective cohort studies

, 2019; 16(14): 1254-1268.

Xiao-Ying Li , Min Zhang*, Wei Xu, Jie-Qiong Li, Xi-Peng Cao , Jin-Tai Yu * and Lan Tan*


DOI: 10.2174/1567205017666200103111253


Research Article

The temporal relationship between pain intensity and pain interference and incident dementia

, 2019; 16(2): 109-115.

Ali Ezzati*, Cuiling Wang, Mindy J. Katz, Carol A. Derby, Andrea R. Zammit, Molly E. Zimmerman, Jelena M. Pavlovic, Martin J. Sliwinski and Richard B. Lipton


DOI: 10.2174/1567205016666181212162424


Research Article

A pilot study of exenatide actions in alzheimer’s disease

, 2019; 16(8): 741-752.

Roger J. Mullins, Maja Mustapic, Chee W. Chia, Olga Carlson, Seema Gulyani, Joyce Tran, Yazhou Li, Mark P. Mattson, Susan Resnick, Josephine M. Egan, Nigel H. Greig and Dimitrios Kapogiannis*


DOI: 10.2174/1567205016666190913155950


Review Article

Biomarkers for alzheimer’s disease

, 2019; 16(6): 518-528.

Leonardo Guzman-Martinez, Ricardo B. Maccioni*, Gonzalo A. Farías, Patricio Fuentes and Leonardo P. Navarrete


DOI: 10.2174/1567205016666190517121140


Systematic Review Article

Physical activity as a moderator of alzheimer pathology: A systematic review of observational studies

, 2019; 16(4): 362-378.

Kristian Steen Frederiksen*, Le Gjerum, Gunhild Waldemar and Steen Gregers Hasselbalch


DOI: 10.2174/1567205016666190315095151



Most Accessed Articles

Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk

, 2021; 18(5): 443-451.

P.D. Fransquet, P. Lacaze, R. Saffery, R.C. Shah, R. Vryer, A. Murray, R.L. Woods and J. Ryan*


DOI: 10.2174/1567205018666210823100721




Risk Factors for Alzheimer’s Disease: An Epidemiological Study

, 2021; 18(5): 372-379.

Jana Janoutová*, Martina Kovalová, Ondřej Machaczka, Petr Ambroz, Anna Zatloukalová, Kateřina Němček and Vladimír Janout


DOI: 10.2174/1567205018666210820124135


Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-Brain Barrier in Alzheimer’s Disease

, 2021; 18(5): 428-442.

Rui Zhou, Li-li Chen, Hai Yang, Ling Li, Juan Liu, Le Chen, Wen-Juan Hong, Cong-guo Wang, Jing-Jing Ma, Jie Huang, Xin-Fu Zhou, Dong Liu and Hua-Dong Zhou*


DOI: 10.2174/1567205018666210906092940


Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study

, 2021; 18(5): 399-413.

Bibek Gyanwali, Benedict Lui, Chuen S. Tan, Eddie J.Y. Chong, Henri Vrooman, Christopher Chen and Saima Hilal*


DOI: 10.2174/1567205018666210820125543


Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity

, 2021; 18(5): 414-427.

Anne Kasus-Jacobi*, Jennifer L. Washburn, Craig A. Land and H. Anne Pereira


DOI: 10.2174/1567205018666210823095044


Clinical Phenotype and Mutation Spectrum of Alzheimer’s Disease with Causative Genetic Mutation in a Chinese Cohort

, 2021; 18(3): 265-272.

Chenhui Mao, Jie Li, Liling Dong, Xinying Huang, Dan Lei, Jie Wang, Shanshan Chu, Caiyan Liu, Bin Peng, Gustavo C. Román, Liying Cui and Jing Gao*


DOI: 10.2174/1567205018666210608120339




Association of Dietary Habits with Mild Cognitive Impairment among Elderly in Rural Area of North China

, 2021; 18(3): 256-264.

Huilian Duan, Changqing Sun, Yun Zhu, Qian Liu, Yue Du, Hongyan Lin, Mengdi Jin, Jingzhu Fu, Fei Ma, Wen Li, Huan Liu, Jing Yan, Yongjie Chen, Guangshun Wang and Guowei Huang*


DOI: 10.2174/1567205018666210617152205


Parkinson’s Symptoms and Caregiver Affiliate Stigma: A Multinational Study

, 2021; 18(3): 222-231.

Richard S. Henry, Paul B. Perrin*, Sarah K. Lageman, Teresita Villaseñor, Annahir N. Cariello, Mickeal Pugh, Erin R. Smith, Monica Arroyo, Alejandra Zarate, Judith Avila and Jose A. Soto-Escageda


DOI: 10.2174/1567205018666210608100917


Reading Fluency in Spanish Patients with Alzheimer’s Disease

, 2021; 18(3): 243-255.

María del Carmen Pérez-Sánchez, María González-Nosti*, Fernando Cuetos, Carmen Martínez and Marta Álvarez-Cañizo


DOI: 10.2174/1567205018666210608102012



123I-Ioflupane SPECT and 18F-FDG PET Combined Use in the Characterization of Movement and Cognitive Associated Disorders in Neurodegenerative Diseases

, 2021; 18(3): 196-207.

Susanna Nuvoli*, Giovanna Tanda, Maria L. Stazza, Barbara Palumbo, Viviana Frantellizzi, Giuseppe De Vincentis, Angela Spanu and Giuseppe Madeddu


DOI: 10.2174/1567205018666210608112302




Editor-in-Chief

graphic
Prof. Debomoy K. Lahiri
(16607 citations)
Neuroscience Research Center
Indianapolis, IN 46202
(USA)
Biography
View Full Editorial Board

Nobel Laureates on Editorial Board

graphic
Prof. Jean-Marie Lehn
(France)

graphic
Prof. Ferid Murad
(USA)

COPE Compliant

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Journal History

Current Alzheimer Research was introduced in 2004 with the assistance of Dr. Debomoy K. Lahiri, who is the current Editor-in-Chief serving since 2004.
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Frontiers in Clinical Drug Research – Alzheimer Disorders



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