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Current Topics in Medicinal Chemistry

Volume 22, 32 Issues, 2022
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry


Volume 22


Number 11

Review Article

Phenanthrene Dimers: Promising Source of Biologically Active Molecules

, 22(11): 939 - 956

Antonino De Natale, Antonino Pollio, Anna De Marco, Giovanni Luongo, Giovanni Di Fabio and Armando Zarrelli*

DOI: 10.2174/1568026621666210813113918

Review Article

Garlic (Allium sativum L.): Its Chemistry, Nutritional Composition, Toxicity, and Anticancer Properties

, 22(11): 957 - 972

Abdur Rauf, Tareq Abu-Izneid, Muthu Thiruvengadam*, Muhammad Imran, Ahmed Olatunde, Mohammad Ali Shariati, Saud Bawazeer, Saima Naz, Samira Shirooie, Ana Sanches-Silva, Umar Farooq and Galiya Kazhybayeva

DOI: 10.2174/1568026621666211105094939

Current Topics in Medicinal Chemistry, Volume 22 (2022) - Number 14

This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 22 (2022) - Number 13

This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 22 (2022) - Number 12

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Prospective Medicines Against the Widespread, Emergent, and Multi-drug-Resistant Opportunistic Fungal Pathogen Candida auris: A Breath of Hope

Lívia de Souza Ramos, Laura Nunes Silva, Thaís Pereira de Mello, Heloísa Freire Frota, Marta Helena Branquinha and André Luis Souza dos Santos*

DOI: 10.2174/1568026622666220520153748
View Abstract View on PubMed

Anxiolytic and Antidepressant-Like Effects of Monoterpene Tetrahydro-linalool and In Silico Approach of New Potential Targets

Pablo Rayff da Silva, Natalia Diniz Nunes Pazos, Thallita Karla Silva do Nascimento Gonzaga, Jéssica Cabral de Andrade, Álefe Brito Monteiro, Anne Caroline Ribeiro Portela, Hugo Fernandes Oliveira Pires, Mayara dos Santos Maia, Diogo Vilar da Fonsêca, Marcus T. Scotti, José Maria Barbosa Filho, Damião Pergentino de Sousa, Cícero Francisco Bezerra Felipe, Reinaldo Nóbrega de Almeida and Luciana Scotti*

DOI: 10.2174/1568026622666220505104726
View Abstract View on PubMed

Evaluation of Biological Activities of Quinone-4-oxoquinoline Derivatives Against Pathogens of Clinical Importance

Francislene Juliana Martins, Fernanda Savacini Sagrillo, Rafaelle Josiane Vinturelle Medeiros, Alan Gonçalves de Souza, Amanda Rodrigues Pinto Costa, Juliana Silva Novais, Leonardo Alves Miceli, Vinícius R. Campos, Agnes Marie Sá Figueiredo, Anna Claudia Cunha, Natalia Lidmar von Ranke, Murilo Lamim Bello, Bárbara de A. Abrahim-Vieira, Alessandra M.T. De Souza, Norman A Ratcliffe, Fernanda da Costa Santos Boechat, Maria Cecília Bastos Vieira de Souza*, Carlos Rangel Rodrigues* and Helena Carla Castro*

DOI: 10.2174/1568026622666220504124710
View Abstract View on PubMed

Decreasing Tryptophan and Increasing Neopterin Plasma Levels During Pregnancy are Associated with High First Trimester Porphyromonas gin-givalis K-Serotype IgG Serointensity in a Cohort of Hispanic Women

Teodor T. Postolache*, Sanjaya K. Upadhyaya, Anna M. Spector, Iqra Mohyuddin, Niel Constantine, Robert K. Ernst, Abhishek Wadhawan, Samia Valeria Ozorio Dutra, Aline Dagdag, Hina Makkar, Christopher A. Lowry, Faisal Akram, Dietmar Fuchs, Lisa A. Brenner, Maureen W. Groer* and Mark A. Reynolds*

DOI: 10.2174/1568026622666220404115543
View Abstract View on PubMed

Abstracts Ahead of Print

Phytochemical Based Modulation of Endoplasmic Reticulum Stress in Alzheimer's Disease.

Venzil Lavie Dsouza, Apoorva Bettagere Shivakumar, Nikshitha Kulal, Gireesh Gangadharan, Dileep Kumar and Shama Prasada Kabekkodu*

DOI: 10.2174/1568026622666220624155357
View Abstract

Phenolic Acids - Versatile Natural Moiety With Numerous Biological Applications

Renu Sehrawat, Priyanka Rathee, Esra Küpelli Akkol, Sarita Khatkar, Amit Lather, Neelam Redhu and Anurag Khatkar*

DOI: 10.2174/1568026622666220623114450
View Abstract

Clinical Indicators of Oral Frailty: A Domain-specific Frailty Phenotype

Vittorio Dibello*, Madia Lozupone, Rodolfo Sardone, Andrea Ballini, Antonio Dibello, Antonio Daniele and Francesco Panza*

DOI: 10.2174/1568026622666220615145647
View Abstract

A Review on Green Synthesis of Silver Nanoparticles and its Role Against Cancer.

Neeraj Rani, Rajeev K Singla*, Rakesh Redhu, Sonia Narwal, Sonia and Alok Bhatt

DOI: 10.2174/1568026622666220601165005
View Abstract

COVID-19 in G6PD-deficient patients, oxidative stress, and neuropathology

Beatriz Hernández-Ochoa, Daniel Ortega-Cuellar, Abigail González-Valdez, Noemí Cárdenas-Rodríguez, Julieta Griselda Mendoza-Torreblanca, Itzel Jatziri Contreras-García, Luz Adriana Pichardo-Macías, Cindy Bandala and Saúl Gómez-Manzo*

DOI: 10.2174/1568026622666220516111122
View Abstract

Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*

DOI: 10.2174/1568026618666180821145215

A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*

DOI: 10.2174/1568026618666180516123229

Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*

DOI: 10.2174/1568026618666180604082610

Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao

DOI: 10.2174/1568026618666180410151518

Open Access Articles

Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review

, 2021; 21(1): 28 - 47

Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga and Martin O. Onani*

Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward

, 2020; 20(32): 2959 - 2969

Danny Feijtel, Marion de Jong and Julie Nonnekens*

Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening

, 2020; 20(18): 1582 - 1592

Carlos Garcia-Hernandez, Alberto Fernández* and Francesc Serratosa

Telomere-related Markers for Cancer

, 2020; 20(6): 410 - 432

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*

Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*

Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*

Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*

Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*

Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*

Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*

InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley

LncRNA as a Therapeutic Target for Angiogenesis

, 2017; 17(15): 1750 - 1757

Mohan M. Kumar and Ravi Goyal*

Most Cited Articles

Review Article

Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases

, 2019; 19(19): 1694-1711.

Viktoriya Ivasiv, Claudia Albertini, Ana E. Gonçalves, Michele Rossi and Maria L. Bolognesi*

DOI: 10.2174/1568026619666190619115735

Review Article

Biological signatures of alzheimer’s disease

, 2020; 20(9): 770-781.

Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode* and Faheem H. Pottoo

DOI: 10.2174/1568026620666200228095553

Review Article

Discovery and development of anti-HIV therapeutic agents: Progress towards improved HIV medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*

DOI: 10.2174/1568026619666190712204603

Review Article

STAT3: A potential drug target for tumor and inflammation

, 2019; 19(15): 1305-1317.

Yang Sheng Hu, Xu Han and Xin Hua Liu*

DOI: 10.2174/1568026619666190620145052

Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen

DOI: 10.2174/1568026619666190122144217

Review Article

Virtual screening techniques in drug discovery: Review and recent applications

, 2019; 19(19): 1751-1767.

Sheisi F.L. da Silva Rocha, Carolina G. Olanda, Harold H. Fokoue and Carlos M.R. Sant'Anna*

DOI: 10.2174/1568026619666190816101948

Review Article

Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

, 2019; 19(5): 337-355.

Anil Kumar Saxena* and Anamika Singh

DOI: 10.2174/1568026619666190219105722

Review Article

Zinc-depend ent deacetylase (HDAC) inhibitors with different zinc binding groups

, 2019; 19(3): 223-241.

Yan Li, Fang Wang, Xiaoxue Chen, Jie Wang, Yonglong Zhao, Yongjun Li and Bin He*

DOI: 10.2174/1568026619666190122144949

Most Accessed Articles

A Review on Natural Sources Derived Protein Nanoparticles as Anti-cancer Agents

, 2021; 21(12): 1014-1026.

Bhattacharya, Tanima; Maishu, Samka P.; Akter, Rokeya; Rahman, Md. H.; Akhtar, Muhammad F.; Saleem, Ammara; Bin-Jumah, May; Kamel, Mohamed; Abdel-Latif, Mervat A.; Abdel-Daim, Mohamed M.

DOI: 10.2174/1568026621666210412151700

Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Syste- matic Review

, 2021; 21(12): 1067-1095.

Egbuna, Chukwuebuka; Awuchi, Chinaza G.; Kushwaha, Garima; Rudrapal, Mithun; Patrick-Iwuanyanwu, Kingsley C.; Singh, Omkar; Odoh, Uchenna E.; Khan, Johra; Jeevanandam, Jaison; Kumarasamy, Suresh; Chukwube, Vincent O.; Narayanan, Mathiyazhagan; Palai, Santwana; Gaman, Mihnea-Alexandru; Uche, Chukwuemelie Z.; Ogaji, Daprim S.; Ezeofor, Nebechi J.; Mtewa, Andrew G.; Patrick-Iwuanyanwu, Chinyere C.; Kesh, Shyam S.; Shivamallu, Chandan; Saravanan, Kaliyaperumal; Tijjani, Habibu; Akram, Muhammad; Ifemeje, Jonathan C.; Olisah, Michael C.; Chikwendu, Chukwudi J.

DOI: 10.2174/1568026621666210509161059

Docking Paradigm in Drug Design

, 2021; 21(6): 507-546.

Sulimov, Vladimir B.; Kutov, Danil C.; Taschilova, Anna S.; Ilin, Ivan S.; Tyrtyshnikov, Eugene E.; Sulimov, Alexey, V

DOI: 10.2174/1568026620666201207095626

Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host-Directed Therapies

, 2021; 21(6): 547-570.

Borah, Pobitra; Deb, Pran Kishore; Venugopala, Katharigatta N.; Al-Shar'i, Nizar A.; Singh, Vinayak; Deka, Satyendra; Srivastava, Amavya; Tiwari, Vinod; Mailavaram, Raghu Prasad

DOI: 10.2174/1568026621999201211200447

ENTPDases from Pathogenic Trypanosomatids and Purinergic Signaling: Shedding Light towards Biotechnological Applications

, 2021; 21(3): 213-226.

da Silva, Walmir; Torres, Nancy da Rocha; Agripino, Joice de Melo; Ferraz da Silva, Victor Hugo; Alves de Souza, Anna Claudia; Ribeiro, Isadora Cunha; de Oliveira, Tatiana Aparecida; de Souza, Luciana Angelo; Ramos Andrade, Lethicia Kelly; Badaro de Moraes, Joao Victor; Diogo, Marcel Arruda; de Castro, Raissa Barbosa; Poleto, Marcelo Depolo; Crocco Afonso, Luis Carlos; Rangel Fietto, Juliana Lopes

DOI: 10.2174/1568026620666201005125146


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
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