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Current Topics in Medicinal Chemistry

Volume 20, 32 Issues, 2020
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Ranking and Category

  • 20th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

,

Volume 20

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Number 5



Perspectives in Medicinal Chemistry   Open Access



Editorial   Open Access



Review Article

PEGylation and Cell-Penetrating Peptides: Glimpse into the Past and Prospects in the Future

, 20(5): 337 - 348

Sumit Kumar, Devender Singh, Pooja Kumari, Rajender Singh Malik, Poonam, Keykavous Parang and Rakesh Kumar Tiwari*


DOI: 10.2174/1568026620666200128142603


Review Article

Outwitting an Old Neglected Nemesis: A Review on Leveraging Integrated Data-Driven Approaches to Aid in Unraveling of Leishmanicides of Therapeutic Potential

, 20(5): 349 - 366

Samuel K. Kwofie*, Emmanuel Broni, Bismark Dankwa, Kweku S. Enninful, Gabriel B. Kwarko, Louis Darko, Ravi Durvasula, Prakasha Kempaiah, Brijesh Rathi, Whelton A. Miller III, Abu Yaya and Michael D. Wilson


DOI: 10.2174/1568026620666200128160454


Review Article

Mathematical Modeling to Address Challenges in Pancreatic Cancer

, 20(5): 367 - 376

Prashant Dogra, Javier R. Ramírez, María J. Peláez, Zhihui Wang, Vittorio Cristini, Gulshan Parasher and Manmeet Rawat*


DOI: 10.2174/1568026620666200101095641


Research Article



Review Article

Focusing on DNA Repair and Damage Tolerance Mechanisms in Mycobacterium tuberculosis: An Emerging Therapeutic Theme

, 20(5): 390 - 408

Pooja Mittal, Rajesh Sinha, Amit Kumar, Pooja Singh, Moses Rinchui Ngasainao, Archana Singh* and Indrakant K. Singh*


DOI: 10.2174/1568026620666200110114322


Current Topics in Medicinal Chemistry, Volume 20 (2020) - Number 10


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 20 (2020) - Number 9


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 20 (2020) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 20 (2020) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 20 (2020) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Antibacterial Assessment of Zinc Sulfide Nanoparticles against Streptococcus pyogenes and Acinetobacter baumannii.


Zeinab Morshedtalab, Ghasem Rahimi, Asieh Emami-Nejad, Alireza Farasat, Azita Mohammadbeygi, Nahid Ghaedamini and Masoud Negahdary*


DOI: 10.2174/1381612826666200406095246
View Abstract







Enzymes as reservoir of host defence peptides


Bosso Andrea , Di Maro Antimo, Cafaro Valeria , Di Donato Alberto, Notomista Eugenio and Pizzo Elio*


DOI: 10.2174/1568026620666200327173815
View Abstract


Application of Polymeric Nano-Materials in Management of Inflammatory Bowel Disease


Minakshi Prasad*, Rajesh Kumar , Mayukh Ghosh, Basanti Brar, Manju Barnela and Preeti Lakhani


DOI: 10.2174/1568026620666200320113322
View Abstract




Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles

Telomere- Related Markers for Cancer

, 2020; 20(6): 410 - 432

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*





Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*






Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*





Most Cited Articles

Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen


DOI: 10.2174/1568026619666190122144217



Review Article

Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

, 2019; 19(5): 337-355.

Anil Kumar Saxena* and Anamika Singh


DOI: 10.2174/1568026619666190219105722


Review Article

Zinc-depend ent deacetylase (HDAC) inhibitors with different zinc binding groups

, 2019; 19(3): 223-241.

Yan Li, Fang Wang, Xiaoxue Chen, Jie Wang, Yonglong Zhao, Yongjun Li and Bin He*


DOI: 10.2174/1568026619666190122144949


Review Article

Nanoparticle therapy for prostate cancer: Overview and perspectives

, 2019; 19(1): 57-73.

Junfu Zhang, Liying Wang, Xinru You, Tuzeng Xian, Jun Wu* and Jun Pang*


DOI: 10.2174/1568026619666190125145836


Perspectives in Medicinal Chemistry

Targeting histone lysine demethylase LSD1/KDM1A as a new avenue for cancer therapy

, 2019; 19(11): 889-891.

Yuan Fang, Guochao Liao* and Bin Yu*


DOI: 10.2174/156802661911190725094910


Review Article

Prediction of drug-drug interactions related to inhibition or induction of drug-metabolizing enzymes

, 2019; 19(5): 319-336.

Alexander V. Dmitriev*, Alexey A. Lagunin, Dmitry А. Karasev, Anastasia V. Rudik, Pavel V. Pogodin, Dmitry A. Filimonov and Vladimir V. Poroikov


DOI: 10.2174/1568026619666190123160406



Perspectives in Medicinal Chemistry

Functional inhibition of VEGF and EGFR suppressors in cancer treatment

, 2019; 19(3): 178-179.

Sanjeev Kumar Singh and Anuraj Nayarisseri


DOI: 10.2174/156802661903190328155731



Review Article

STAT3: A potential drug target for tumor and inflammation

, 2019; 19(15): 1305-1317.

Yang Sheng Hu, Xu Han and Xin Hua Liu*


DOI: 10.2174/1568026619666190620145052


Review Article

Small molecule natural products and Alzheimer’s disease

, 2019; 19(3): 187-204.

Xiaoai Wu, Huawei Cai, Lili Pan, Gang Cui, Feng Qin, YunChun Li and Zhengxin Cai*


DOI: 10.2174/1568026619666190201153257



Review Article

Unfolded protein response as a therapeutic target in cardiovascular disease

, 2019; 19(21): 1902-1917.

Guangyu Zhang, Xiaoding Wang, Thomas G. Gillette, Yingfeng Deng and Zhao V. Wang*


DOI: 10.2174/1568026619666190521093049


Review Article

Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases

, 2019; 19(19): 1694-1711.

Viktoriya Ivasiv, Claudia Albertini, Ana E. Gonçalves, Michele Rossi and Maria L. Bolognesi*


DOI: 10.2174/1568026619666190619115735



Most Accessed Articles

The Present and Future of Novel Protein Degradation Technology

, 2019; 19(20): 1784-1788.

Liwen Xia, Wei Liu, Yinsen Song, Hailiang Zhu* and Yongtao Duan*


DOI: 10.2174/1568026619666191011162955










Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*


DOI: 10.2174/1568026619666190712204603




Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.

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