Bentham Science Logo

Current Topics in Medicinal Chemistry

Volume 19, 32 Issues, 2019
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Ranking and Category

  • 20th of 61 in

    Chemistry, Medicinal

Order Your Article Before Print

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

,

Volume 19

-

Number 10



Editorial   Open Access



Review Article



Review Article



Review Article



Review Article



Review Article



Research Article

Comparative Drug Resistance Reversal Potential of Natural Glycosides: Potential of Synergy Niaziridin & Niazirin

, 19(10): 847 - 860

Gaurav R. Dwivedi, Anupam Maurya, Dharmendra K. Yadav, Feroz Khan, Mahendra K. Gupta, Prashant Gupta, Mahendra P. Darokar* and Santosh K. Srivastava*


DOI: 10.2174/1568026619666190412120008


Review Article

Molecular Targets for Malarial Chemotherapy: A Review

, 19(10): 861 - 873

Dharmendra K. Yadav*, Surendra Kumar, Mahesh K. Teli, Ravikant Yadav and Sandeep Chaudhary


DOI: 10.2174/1568026619666190603080000


Articles Ahead of Print

Recent Study of Dual HDAC/PARP Inhibitor for the Treatment of Tumor


Haiying Lu, Lan Bai, Yanping Zhou, Yongping Lu, Zhongliang Jiang* and Jianyou Shi*


DOI: 10.2174/1568026619666190603092407
View Abstract View on PubMed




PET Imaging of Adenosine Receptors in Diseases


Jindian Li, Xingfang Hong, Guoquan Li, Peter S. Conti, Xianzhong Zhang* and Kai Chen


DOI: 10.2174/1568026619666190708163407
View Abstract View on PubMed


Antihyperalgesic Activity of Quillaic Acid Obtained from Quillaja Saponaria Mol.


Sylvia Arrau, Maité Rodríguez-Díaz, Bruce K. Cassels, Gabriela Valenzuela-Barra, Carla Delporte*, Andrés Barriga and Hugo F. Miranda*


DOI: 10.2174/1568026619666190509115741
View Abstract View on PubMed


A Computer - Aided Drug Designing for Pharmacological Inhibition of Mutant ALK for the Treatment of Non-small Cell Lung Cancer


Saphy Sharda, Ravina Khandelwal, Ritu Adhikary, Diksha Sharma, Manisha Majhi, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666190521084941
View Abstract View on PubMed


Targeting the PAC1 Receptor for Neurological and Metabolic Disorders


Chenyi Liao, Mathilde Poujol de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May and Jianing Li*


DOI: 10.2174/1568026619666190709092647
View Abstract View on PubMed





Abstracts Ahead of Print




The Use of Conformational Restriction in Medicinal Chemistry


Pedro de Sena M. Pinheiro, Daniel A. Rodrigues, Rodolfo do Couto Maia, Sreekanth Thota and Carlos A. M. Fraga*


DOI: 10.2174/1568026619666190712205025
View Abstract



Recent Progress in the Development of HIV-1 Entry Inhibitors: From Small Molecules to Potent Anti-HIV Agents


Khomson Suttisintong*, Narongpol Kaewchangwat, Eknarin Thanayupong, Chakkrapan Nerungsi, Onsiri Srikun and Pornpan Pungpo


DOI: 10.2174/1568026619666190712204050
View Abstract



Chemical Intuition in Drug Design and Discovery


Julia Galvez B. Pedreira, Lucas S. Franco and Eliezer J. Barreiro*


DOI: 10.2174/1568026619666190620144142
View Abstract



Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases


Viktoriya Ivasiv, Claudia Albertini, Ana Elisa Goncalves, Michele Rossi and Maria Laura Bolognesi*


DOI: 10.2174/1568026619666190619115735
View Abstract


Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles



Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley









Most Cited Articles

Review Article

Bis-coumarin derivatives and their biological activities

, 2018; 18(2): 101-113.

Qing-Cheng Ren, Chuan Gao , Zhi Xu , Lian-Shun Feng, Ming-liang Liu*, Xiang Wu* and Feng Zhao*


DOI: 10.2174/1568026618666180221114515


Review Article

Coumarin compounds in medicinal chemistry: Some important examples from the last years

, 2018; 18(2): 124-148.

Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*


DOI: 10.2174/1568026618666180329115523



Review Article

Recent development of small molecule glutaminase inhibitors

, 2018; 18(6): 432-443.

Minsoo Song*, Soong-Hyun Kim, Chun Young Im and Hee-Jong Hwang


DOI: 10.2174/1568026618666180525100830


Review Article

Recent development of coumarin derivatives as potential antiplasmodial and antimalarial agents

, 2018; 18(2): 114-123.

Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*


DOI: 10.2174/1568026618666171215101158


Review Article

Prediction and targeting of interaction interfaces in G-protein coupled receptor oligomers

, 2018; 18(8): 714-746.

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610


Review Article

Learning from nature: Bioinspired strategies towards antimicrobial nanostructured systems

, 2018; 18(1): 22-41.

Giuseppe Vitiello, Brigida Silvestri and Giuseppina Luciani*


DOI: 10.2174/1568026618666180206101129


Research Article

Structure-based virtual screening for the identification of high affinity compounds as potent VEGFR2 inhibitors for the treatment of renal cell carcinoma

, 2018; 18(25): 2174-2185.

Khushboo Sharma, Khushboo Patidar, Meer Asif Ali, Pravin Patil, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666181130142237


Review Article

Targeting sugar uptake and metabolism for cancer identification and therapy: An overview

, 2018; 18(6): 467-483.

Marina Tanasova*, Vagarshak V. Begoyan and Lukasz J. Weselinski


DOI: 10.2174/1568026618666180523110837



Review Article

Applications of machine learning methods in drug toxicity prediction

, 2018; 18(12): 987-997.

Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao and Hongsheng Liu*


DOI: 10.2174/1568026618666180727152557


Review Article

Current status and future prospects of small–molecule protein–protein interaction (PPI) inhibitors of tumor necrosis factor (TNF) and receptor activator of NF-κB ligand (RANKL)

, 2018; 18(8): 661-673.

Georgia Melagraki, Georgios Leonis, Evangelos Ntougkos, Vagelis Rinotas, Christos Papaneophytou, Thomas Mavromoustakos, George Kontopidis, Eleni Douni, George Kollias* and Antreas Afantitis*


DOI: 10.2174/1568026618666180607084430


Review Article

Cyclic peptides that govern signal transduction pathways: From prokaryotes to multi-cellular organisms

, 2018; 18(7): 625-644.

Ryan W. Mull , Anthony Harrington, Lucia A. Sanchez and Yftah Tal-Gan*


DOI: 10.2174/1568026618666180518090705



Research Article

New benzothiazole-based thiazolidinones as potent antimicrobial agents. Design, synthesis and biological evaluation

, 2018; 18(1): 75-87.

Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric


DOI: 10.2174/1568026618666180206101814



Most Accessed Articles





Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment

, 2018; 18(15): 1333-1348.

C.P. Taborda*, R. Buccheri, G. Benard, A.N. Duarte-Neto, J.D. Nosanchuk and L.R. Travassos


DOI: 10.2174/1568026618666181002112231


3D-QSAR in Drug Design - A Review

, 2010; 10(1): 95-115.

Jitender Verma, Vijay M. Khedkar and Evans C. Coutinho


DOI: 10.2174/156802610790232260


Genetic Mechanisms of Antibiotic Resistance and the Role of Antibiotic Adjuvants

, 2018; 18(1): 42-74.

Daniela Santos Pontes, Rodrigo Santos Aquino de Araujo, Natalina Dantas, Luciana Scotti , Marcus Tullius Scotti, Ricardo Olimpio de Moura and Francisco Jaime Bezerra Mendonca-Junior *


DOI: 10.2174/1568026618666180206095224


Recent Advances in Prostate-Specific Membrane Antigen-Based Radiopharmaceuticals

, 2019; 19(1): 33-56.

Wei Diao, Huawei Cai, Lihong Chen, Xi Jin, Xinyang Liao and Zhiyun Jia*


DOI: 10.2174/1568026619666190201100739


Leishmaniasis and Chagas Disease – Neglected Tropical Diseases: Treatment Updates

, 2019; 19(3): 174-177.

Leandro Stefano Sangenito, Vanessa da Silva Santos, Claudia Masini d'Avila-Levy, Marta Helena Branquinha, André Luis Souza dos Santos* and Simone S.C. de Oliveira


DOI: 10.2174/156802661903190328155136





Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.
Track Your Manuscript:


Scopus CiteScore Metrics: 1.44


Related Journals

Related eBooks

eBooks Catalog