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Current Medicinal Chemistry

Volume 28, 42 Issues, 2021
ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)
This journal supports open access

Aims & Scope

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth/mini reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Current Medicinal Chemistry

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Volume 28

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Number 32











Review Article

Machine Learning Approaches in Parkinson’s Disease

, 28(32): 6548 - 6568

Annamaria Landolfi*, Carlo Ricciardi, Leandro Donisi, Giuseppe Cesarelli, Jacopo Troisi, Carmine Vitale, Paolo Barone and Marianna Amboni


DOI: 10.2174/0929867328999210111211420


Review Article (Mini-Review)

Artificial Intelligence as a Business Partner in Cardiovascular Precision Medicine: An Emerging Approach for Disease Detection and Treatment Optimization

, 28(32): 6569 - 6590

Valeria Visco, Germano Junior Ferruzzi, Federico Nicastro, Nicola Virtuoso, Albino Carrizzo, Gennaro Galasso, Carmine Vecchione and Michele Ciccarelli*


DOI: 10.2174/0929867328666201218122633


Review Article (Mini-Review)

Artificial Intelligence: the “Trait D’Union” in Different Analysis Approaches of Autism Spectrum Disorder Studies

, 28(32): 6591 - 6618

Francesca Marciano*, Giorgia Venutolo, Carminia Marina Ingenito, Antonella Verbeni, Concetta Terracciano, Elizabeth Plunk, Francesco Garaci, Armando Cavallo and Alessio Fasano


DOI: 10.2174/0929867328666210203205221




Articles Ahead of Print

Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies


Adel Hajj Ali, Nour Younis, Rola Abdallah, Farah Shaer, Ali Dakroub, Mohammed Ayoub, Rabah Iratni, Hadi Mohamad Yassine, Kazem Zibara, Alexander Orekhov, Ahmed Fawzy El-Yazbi and Ali Eid *


DOI: 10.2174/0929867328666210222092628
View Abstract View on PubMed




Structure-based Design of Anti-cancer Vaccines: The Significance of Antigen Presentation to Boost the Immune Response


Alicia Asín, Fayna García-Martín, Jesús Hector Busto, Alberto Avenoza, Jesús Manuel Peregrina* and Francisco Corzana*


DOI: 10.2174/0929867328666210810152917
View Abstract View on PubMed


Targeting Chikungunya Virus Entry: Alternatives for New Inhibitors in Drug Discovery


Leandro Rocha Silva, Érica Erlanny da Silva Rodrigues, Jamile Taniele-Silva, Letícia Anderson, João Xavier de Araújo-Júnior, Ênio José Bassi and Edeildo F. da Silva-Júnior*


DOI: 10.2174/0929867328666210623165005
View Abstract View on PubMed




Recent Insights into the Nutritional Antioxidant Therapy in Prevention and Treatment of Diabetic Vascular Complications: A Comprehensive Review


Narasimha M. Beeraka, Irina K. Tomilova, Galina A. Batrak, Maria V. Zhaburina, Vladimir N. Nikolenko, Mikhail Y. Sinelnikov* and Liudmila M. Mikhaleva


DOI: 10.2174/0929867328666210810142527
View Abstract View on PubMed




Abstracts Ahead of Print


The Syntheses and Medicinal Attributes of Phenanthrenes as Anticancer Agents: A Quinquennial Update


Sarthak Jhingran, Kritika Laxmikeshav, Sayali Mone, Venkata Rao K and Nagula Shankaraiah*


DOI: 10.2174/0929867328666211018110223
View Abstract




Multicomponent reactions in the synthesis of antiviral compounds


Lorenzo Botta, Silvia Cesarini, Claudio Zippilli, Bruno Mattia Bizzarri, Angelica Fanelli and Raffaele Saladino*


DOI: 10.2174/0929867328666211007121837
View Abstract


Molecular Link between Circadian Rhythmicity and Mood Disorders


Frank Faltraco, Denise Palm, Andrew Coogan, Frederick Simon, Oliver Tucha and Johannes Thome*


DOI: 10.2174/0929867328666211007113725
View Abstract


The Development of Machine Learning Methods in discriminating Secretory Proteins of Malaria Parasite


Ting Liu, Jiamao Chen, Qian Zhang, Kyle Hippe, Cassandra Hunt, Thu Le, Renzhi Cao and Hua Tang*


DOI: 10.2174/0929867328666211005140625
View Abstract


Celecoxib and dimethylcelecoxib block oxidative phosphorylation, epithelial-mesenchymal transition and invasiveness in breast cancer stem cells


Juan Carlos Gallardo-Pérez, Alhelí Adán-Ladrón de Guevara, Marco Antonio García-Amezcua, Diana Xochiquetzal Robledo-Cadena, Silvia Cecilia Pacheco-Velázquez, Javier Alejandro Belmont-Díaz, Jorge Luis Vargas-Navarro, Rafael Moreno-Sánchez and Sara Rodríguez-Enríquez*


DOI: 10.2174/0929867328666211005124015
View Abstract


The Role of Kallikrein 7 in Tumorigenesis


Fengyi Xiang, Yueqing Wang, Chunyu Cao, Qingyun Li, Hao Deng, Jun Zheng, Xiaowen Liu* and Xiao Tan*


DOI: 10.2174/0929867328666210915104537
View Abstract


Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury


Lucas Alexandre Santos Marzano, Fabyolla Lúcia Macedo de Castro, Caroline Amaral Machado, João Luís Vieira Monteiro de Barros, Thiago Macedo e Cordeiro, Ana Cristina Simões e Silva, Antônio Lúcio Teixeira and Aline Silva de Miranda*


DOI: 10.2174/0929867328666210923143713
View Abstract


Published Contents

Open Access Articles

Micro Composite Palmitoylethanolamide/Rutin Reduces Vascular Injury through Modulation of the Nrf2/HO−1 and NF-kB Pathways

, 2021; 28(30): 6287 - 6302

Roberta Fusco, Rosalba Siracusa, Enrico Gugliandolo, Alessio Filippo Peritore, Ramona D’Amico, Marika Cordaro, Rosalia Crupi, Daniela Impellizzeri, Chiara Gomiero, Salvatore Cuzzocrea* and Rosanna Di Paola*




Design and Synthesis of Novel Aminoalkanamides Targeting Neurodegeneration and Symptoms of Alzheimer’s Disease

, 2021; 28(29): 6082 - 6094

Agnieszka Jankowska, Grzegorz Satała, Gniewomir Latacz, Anna Partyka, Annamaria Lubelska, Krzysztof Pociecha, Artur Świerczek, Natalia Wilczyńska, Barbara Mordyl, Andrzej J. Bojarski, Elżbieta Wyska and Grażyna Chłoń-Rzepa*




Deep Learning in the Quest for Compound Nomination for Fighting COVID-19

, 2021; 28(28): 5699 - 5732

Maria Mernea, Eliza C. Martin, Andrei-José Petrescu* and Speranta Avram*




Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors

, 2021; 28(26): 5431 - 5446

Chih-Shiang Chang, Vathan Kumar, Der-Yen Lee, Yeh Chen, Yu-Chieh Wu, Jing-Yan Gao and Po-Chen Chu*





Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors

, 2021; 28(24): 4995 - 5003

Zhao Dang, Lei Zhu, Lan Xie, Kuo-Hsiung Lee, Faisal Malik, Zhijun Li, Li Huang* and Chin-Ho Chen*




A Novel Dicationic Boron Dipyrromethene-based Photosensitizer for Antimicrobial Photodynamic Therapy against Methicillin-Resistant Staphylococcus aureus

, 2021; 28(21): 4283 - 4294

Priyanga Dharmaratne, Ligang Yu, Roy Chi-Hang Wong, Ben Chun-Lap Chan, Kit-Man Lau, Baiyan Wang, Clara Bik San Lau, Kwok-Pui Fung, Dennis Kee-Pui Ng and Margaret Ip*






Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance

, 2021; 28(6): 1126 - 1142

Wei Li, Kun Liu, Yi Chen, Mingyue Zhu* and Mengsen Li*




miR-30e-5p Regulates Autophagy and Apoptosis by Targeting Beclin1 Involved in Contrast-induced Acute Kidney Injury

, 2021; 28: 1 - 11 (E-Pub Ahead of Print)

Xiaoqin Liu, Qingzhao Li , Lixin Sun, Limei Chen, Yue Li, Beibei Huang, Yunshuang Liu and Chunyang Jiang *





Feruloyl Sucrose Esters: Potent and Selective Inhibitors of α-glucosidase and α-amylase

, 2021; 28: 1 - 16 (E-Pub Ahead of Print)

Surabhi Devaraj, Yew Mun Yip, Parthasarathi Panda, Li Lin Ong, Pooi Wen Kathy Wong, Dawei Zhang, Yusuf Ali* and Zaher Judeh*




Tumor in 3D: In Vitro Complex Cellular Models to Improve Nanodrugs Cancer Therapy

, 2020; 27(42): 7234 - 7255

Soraia Fernandes*, Marco Cassani, Stefania Pagliari, Petr Filipensky, Francesca Cavalieri and Giancarlo Forte*






Most Cited Articles


Review Article

Role of ox-LDL and LOX-1 in atherogenesis

, 2019; 26(9): 1693-1700.

Ajoe John Kattoor, Sri Harsha Kanuri and Jawahar L. Mehta*


DOI: 10.2174/0929867325666180508100950


Review Article

Targeting cxcl12/cxcr4 axis in tumor immunotherapy

, 2019; 26(17): 3026-3041.

Weiqiang Zhou, Shanchun Guo*, Mingli Liu, Matthew E. Burow and Guangdi Wang*


DOI: 10.2174/0929867324666170830111531



Review Article

Plant-derived products as antibacterial and antifungal agents in human health care

, 2019; 26(29): 5501-5541.

Ladislav Kokoska*, Pavel Kloucek , Olga Leuner* and Pavel Novy


DOI: 10.2174/0929867325666180831144344


Review Article

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases

, 2019; 26(18): 3225-3241.

Miguel D. Ferrer, Carla Busquets-Cortés, Xavier Capó, Silvia Tejada, Josep A. Tur, Antoni Pons and Antoni Sureda*


DOI: 10.2174/0929867325666180514112124


Review Article

Role of autophagy in Parkinson’s disease

, 2019; 26(20): 3702-3718.

Silvia Cerri and Fabio Blandini*


DOI: 10.2174/0929867325666180226094351


Review Article

Immune checkpoint inhibitors: Basics and challenges

, 2019; 26(17): 3009-3025.

Bin Li*, Ho Lam Chan and Pingping Chen*


DOI: 10.2174/0929867324666170804143706


General Review Article

Homocysteine and hyperhomocysteinaemia

, 2019; 26(16): 2948-2961.

Bozidarka L. Zaric*, Milan Obradovic, Vladan Bajic , Mohamed A. Haidara , Milos Jovanovic and Esma R. Isenovic*


DOI: 10.2174/0929867325666180313105949


Review Article

ABC transporters: Regulation and association with multidrug resistance in hepatocellular carcinoma and colorectal carcinoma

, 2019; 26(7): 1224-1250.

María Paula Ceballos, Juan Pablo Rigalli, Lucila Inés Ceré, Mariana Semeniuk, Viviana Alicia Catania and María Laura Ruiz*


DOI: 10.2174/0929867325666180105103637



Review Article

Medical applications of collagen and collagen-based materials

, 2019; 26(3): 506-516.

Anatoly B. Shekhter, Alexey L. Fayzullin*, Marina N. Vukolova, Tatyana G. Rudenko, Varvara D. Osipycheva and Petr F. Litvitsky


DOI: 10.2174/0929867325666171205170339


Review Article

Osteoporosis: Current and emerging therapies targeted to immunological checkpoints

, 2020; 27(37): 6356-6372.

Massimo De Martinis, Maria Maddalena Sirufo and Lia Ginaldi*


DOI: 10.2174/0929867326666190730113123


General Review Article

Aptamer-based targeted drug delivery systems: Current potential and challenges

, 2020; 27(13): 2189-2219.

Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu* and Yanfei Liu*


DOI: 10.2174/0929867325666181008142831


Review Article

Applications of cellulose-based materials in sustained drug delivery systems

, 2019; 26(14): 2485-2501.

Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi* and Yonghao Ni


DOI: 10.2174/0929867324666170705143308



Most Accessed Articles


The Therapeutic use of the Zonulin Inhibitor AT-1001 (Larazotide) for a Variety of Acute and Chronic Inflammatory Diseases

, 2021; 28(28): 5788-5807.

Jacopo Troisi*, Giorgia Venutolo, Concetta Terracciano, Matteo Delli Carri, Simone Di Micco, Annamaria Landolfi and Alessio Fasano


DOI: 10.2174/0929867328666210104110053



Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors

, 2021; 28(24): 4995-5003.

Zhao Dang, Lei Zhu, Lan Xie, Kuo-Hsiung Lee, Faisal Malik, Zhijun Li, Li Huang* and Chin-Ho Chen*


DOI: 10.2174/0929867328666201229121802



Targeting the Nucleotide Metabolism Proteins of the NUDIX Family and SAMHD1 in Cancer

, 2021; 28(21): 4088-4116.

Prescillia Forey, Emeline Cros-Perrial, Charles Dumontet and Lars Petter Jordheim*


DOI: 10.2174/0929867328666201125120422



Convolutional Neural Network-based Virtual Screening

, 2021; 28(10): 2033-2047.

Wenying Shan, Xuanyi Li, Hequan Yao and Kejiang Lin*


DOI: 10.2174/0929867327666200526142958


Machine Learning Approaches in Parkinson’s Disease

, 2021; 28(32): 6548-6568.

Annamaria Landolfi*, Carlo Ricciardi, Leandro Donisi, Giuseppe Cesarelli, Jacopo Troisi, Carmine Vitale, Paolo Barone and Marianna Amboni


DOI: 10.2174/0929867328999210111211420


Advances in Sickle Cell Disease Treatments

, 2021; 28(10): 2008-2032.

Aline Renata Pavan and Jean Leandro dos Santos*


DOI: 10.2174/0929867327666200610175400


The Correlation between Lipid Metabolism Disorders and Prostate Cancer

, 2021; 28(10): 2048-2061.

Justyna Dłubek, Jacek Rysz, Zbigniew Jabłonowski, Anna Gluba-Brzózka* and Beata Franczyk


DOI: 10.2174/0929867327666200806103744


Astroglial Connexins in Neurological and Neuropsychological Disorders and Radiation Exposure

, 2021; 28(10): 1970-1986.

Yuan Duo Liu, Ge Tang, Feng Qian, Lian Liu*, Jiang Rong Huang* and Feng Ru Tang*


DOI: 10.2174/0929867327666200610175037


New Perspectives in the Pharmacological Potential of Naringin in Medicine

, 2021; 28(10): 1987-2007.

María Angélica Rivoira, Valeria Rodriguez, Germán Talamoni and Nori Tolosa de Talamoni*


DOI: 10.2174/0929867327666200604171351


New Perspectives on Machine Learning in Drug Discovery

, 2021; 28(32): 6704-6728.

Simona Musella, Giulio Verna, Alessio Fasano and Simone Di Micco*


DOI: 10.2174/0929867327666201111144048


Alport Syndrome: A Comprehensive Review on Genetics, Pathophysiology, Histology, Clinical and Therapeutic Perspectives

, 2021; 28(27): 5602-5624.

Ana Luisa Pedrosa, Letícia Bitencourt, Rafaela Moreira Paranhos, Cristiana Afonso Leitáo, Guilherme Costa Ferreira and Ana Cristina Simões e Silva*


DOI: 10.2174/0929867328666210108113500




Editor-in-Chief

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Atta-ur-Rahman, FRS
(32052 citations)
Kings College
University of Cambridge
Cambridge
(UK)
Biography
View Full Editorial Board

Nobel Laureates on Editorial Board

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Prof. John Gurdon
(UK)

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Prof. Jean-Marie Lehn
(France)

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Prof. Ferid Murad
(USA)

COPE Compliant

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Journal History

Current Medicinal Chemistry was introduced in 1994 with the assistance of Dr. Atta-ur-Rahman, who is the current Editor-in-Chief serving since 1994.

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