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Current Medicinal Chemistry

Volume 29, 42 Issues, 2022
ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)
This journal supports open access

Aims & Scope

Current Medicinal Chemistry covers all the latest and outstanding developments in the field of medicinal chemistry. It also includes topics related to quantitative structure-function relationships, drug absorption, drug distribution, drug metabolism, new and emerging drug targets, pharmacogenomics, drug discovery toxicology, high-throughput screening, combinatorial chemistry, structural characterization and organic syntheses of naturally occurring compounds, as well as chemical and analytical techniques used in rational drug design. Each issue incorporates a series of timely in-depth/mini-reviews and guest-edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents.

Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be informed and up-to-date with the latest and most important developments relevant to their field.

Current Medicinal Chemistry


Volume 29


Number 19

Review Article

Review Article

Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury

, 29(19): 3392 - 3419

Lucas Alexandre Santos Marzano, Fabyolla Lúcia Macedo de Castro, Caroline Amaral Machado, João Luís Vieira Monteiro de Barros, Thiago Macedo e Cordeiro, Ana Cristina Simões e Silva, Antônio Lúcio Teixeira and Aline Silva de Miranda*

DOI: 10.2174/0929867328666210923143713

Review Article

Review Article

An Updated Review on the Therapeutic, Diagnostic, and Prognostic Value of Long Non-Coding RNAs in Gastric Cancer

, 29(19): 3471 - 3482

Alemeh Mohammadzadeh, Narges Dastmalchi, Bashdar Mahmud Hussen, Mahdi Abdoli Shadbad and Reza Safaralizadeh*

DOI: 10.2174/0929867328666211115121019

Research Article

Alamandine Induces Neuroprotection in Ischemic Stroke Models

, 29(19): 3483 - 3498

Sthéfanie C.A. Gonçalves, Beatriz L.T. Bassi, Lucas M. Kangussu, Daniele T. Alves, Lorena K.S. Ramos, Lorena F. Fernandes, Marco T.R. Alves, Ruben Sinisterra, Gisele E. Bruch, Robson A.S. Santos, André R. Massensini* and Maria J. Campagnole-Santos

DOI: 10.2174/0929867329666220204145730

Current Medicinal Chemistry, Volume 29 (2022) - Number 24

This issue is in progress but contains articles that are final and fully citable.

Current Medicinal Chemistry, Volume 29 (2022) - Number 23

This issue is in progress but contains articles that are final and fully citable.

Current Medicinal Chemistry, Volume 29 (2022) - Number 22

This issue is in progress but contains articles that are final and fully citable.

Current Medicinal Chemistry, Volume 29 (2022) - Number 21

This issue is in progress but contains articles that are final and fully citable.

Current Medicinal Chemistry, Volume 29 (2022) - Number 20

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Anti-inflammatory Drug Combination Therapy for Atherosclerosis: Colchicine and Fenofibrate

Michael Spartalis*, Ioanna Tzima, Artemis Anastasiou, Eleftherios Spartalis, Dimitrios C. Iliopoulos and Gerasimos Siasos

DOI: 10.2174/0929867329666220407095216
View on PubMed

Design, Synthesis, and Biological Activity of a Novel Series of 2-Ureidonicotinamide Derivatives Against Influenza A Virus

Chao Zhang, Jun-Jie Xiang, Jing Zhao, Yan-Li Meng, Fu-Rong Zhang, Zhe Jin, Pang-Chui Shaw, Xiao-Ping Liu* and Chun Hu

DOI: 10.2174/0929867329666220224114627
View Abstract View on PubMed

The Role of Mass Spectrometry in the Discovery of Antibiotics and Bacterial Resistance Mechanisms: Proteomics and Metabolomics Approaches

Miguel Cuevas-Cruz, Ulises Hernández-Guzmán, Poulette Carolina Álvarez-Rosales, Meike Schnabel, Saúl Gómez-Manzo and Roberto Arreguín-Espinosa*

DOI: 10.2174/0929867329666220329090822
View Abstract View on PubMed

Essential Principles and Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging

Monica Viviano, Elisabetta Barresi, Fabrice G. Siméon, Barbara Costa, Sabrina Taliani, Federico Da Settimo, Victor W. Pike and Sabrina Castellano*

DOI: 10.2174/0929867329666220329204054
View Abstract View on PubMed

The Emerging Role of EMT-related lncRNAs in Therapy Resistance and their Applications as Biomarkers

Zahra Abedi kichi, Mona Soltani, Mina Rezaei, Zeinab Shirvani-Farsani* and Mahbubeh Rojhannezhad

DOI: 10.2174/0929867329666220329203032
View Abstract View on PubMed

Metallic Nanoparticles: A New Frontier in the Fight Against Leishmaniasis

Rhanoica Oliveira Guerra, José Rodrigues do Carmo Neto, Tarcísio de Albuquerque Martins, Thaís Soares Farnesi-de-Assunção, Virmondes Rodrigues Junior, Carlo José Freire de Oliveira, Anielle Christine Almeida Silva and Marcos Vinicius da Silva*

DOI: 10.2174/0929867329666220225111052
View Abstract View on PubMed

Abstracts Ahead of Print

Electrochemical aptasensing for lifestyle and chronic disease management

Sayali Upasham, Madhavi Pali, Badrinath Jagannath, Kai-Chun Lin and Shalini Prasad*

DOI: 10.2174/0929867329666220520111715
View Abstract

Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review

Hossein Javid, Mehdi Karimi-Shahri, Malihe khorramdel, Alireza Sharbaf mashhad, Ayda Tadayyon Tabrizi, Thozhukat Sathyapalan, Amir-R Afshari* and Amirhossein Sahebkar*

DOI: 10.2174/0929867329666220511185745
View Abstract

Published Contents

Open Access Articles

Dual Targeting Strategies on Histone Deacetylase 6 (HDAC6) and Heat Shock Protein 90 (Hsp90)

, 2022; 29(9): 1474 - 1502

Davide Bonanni, Andrea Citarella, Davide Moi, Luca Pinzi, Elisa Bergamini and Giulio Rastelli*

Deep Learning in the Quest for Compound Nomination for Fighting COVID-19

, 2021; 28(28): 5699 - 5732

Maria Mernea, Eliza C. Martin, Andrei-José Petrescu* and Speranta Avram*

Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling

, 2021; 28(18): 3476 - 3489

Nazarius S. Lamango*, Augustine T. Nkembo, Elizabeth Ntantie and Nada Tawfeeq

Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance

, 2021; 28(6): 1126 - 1142

Wei Li, Kun Liu, Yi Chen, Mingyue Zhu* and Mengsen Li*

Tumor in 3D: <i>In Vitro</i> Complex Cellular Models to Improve Nanodrugs Cancer Therapy

, 2020; 27(42): 7234 - 7255

Soraia Fernandes*, Marco Cassani, Stefania Pagliari, Petr Filipensky, Francesca Cavalieri and Giancarlo Forte*

Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints

, 2020; 27(37): 6356 - 6372

Massimo De Martinis, Maria Maddalena Sirufo and Lia Ginaldi*

Most Cited Articles

Review Article

Role of ox-LDL and LOX-1 in atherogenesis

, 2019; 26(9): 1693-1700.

Ajoe John Kattoor, Sri Harsha Kanuri and Jawahar L. Mehta*

DOI: 10.2174/0929867325666180508100950

Review Article

Targeting cxcl12/cxcr4 axis in tumor immunotherapy

, 2019; 26(17): 3026-3041.

Weiqiang Zhou, Shanchun Guo*, Mingli Liu, Matthew E. Burow and Guangdi Wang*

DOI: 10.2174/0929867324666170830111531

Review Article

Immune checkpoint inhibitors: Basics and challenges

, 2019; 26(17): 3009-3025.

Bin Li*, Ho Lam Chan and Pingping Chen*

DOI: 10.2174/0929867324666170804143706

Review Article

Plant-derived products as antibacterial and antifungal agents in human health care

, 2019; 26(29): 5501-5541.

Ladislav Kokoska*, Pavel Kloucek , Olga Leuner* and Pavel Novy

DOI: 10.2174/0929867325666180831144344

Review Article

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases

, 2019; 26(18): 3225-3241.

Miguel D. Ferrer, Carla Busquets-Cortés, Xavier Capó, Silvia Tejada, Josep A. Tur, Antoni Pons and Antoni Sureda*

DOI: 10.2174/0929867325666180514112124

Review Article

Role of autophagy in Parkinson’s disease

, 2019; 26(20): 3702-3718.

Silvia Cerri and Fabio Blandini*

DOI: 10.2174/0929867325666180226094351

General Review Article

Metal–organic framework (MoF)-based nanomaterials for biomedical applications

, 2019; 26(18): 3341-3369.

Zhidong Luo, Shuran Fan, Chuying Gu, Weicong Liu, Jinxiang Chen, Baohong Li* and Jianqiang Liu*

DOI: 10.2174/0929867325666180214123500

General Review Article

Homocysteine and hyperhomocysteinaemia

, 2019; 26(16): 2948-2961.

Bozidarka L. Zaric*, Milan Obradovic, Vladan Bajic , Mohamed A. Haidara , Milos Jovanovic and Esma R. Isenovic*

DOI: 10.2174/0929867325666180313105949

Review Article

Metal-organic framework (Mof)-based drug delivery

, 2020; 27(35): 5949-5969.

Jian Cao, Xuejiao Li and Hongqi Tian*

DOI: 10.2174/0929867326666190618152518

Review Article

Applications of cellulose-based materials in sustained drug delivery systems

, 2019; 26(14): 2485-2501.

Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi* and Yonghao Ni

DOI: 10.2174/0929867324666170705143308

General Review Article

Aptamer-based targeted drug delivery systems: Current potential and challenges

, 2020; 27(13): 2189-2219.

Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu* and Yanfei Liu*

DOI: 10.2174/0929867325666181008142831

Review Article

Medical applications of collagen and collagen-based materials

, 2019; 26(3): 506-516.

Anatoly B. Shekhter, Alexey L. Fayzullin*, Marina N. Vukolova, Tatyana G. Rudenko, Varvara D. Osipycheva and Petr F. Litvitsky

DOI: 10.2174/0929867325666171205170339

Most Accessed Articles

Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications

, 2021; 28(2): 308-328.

Amiri, Atefeh; Pourhanifeh, Mohammad Hossein; Mirzaei, Hamid Reza; Nahand, Javid Sadri; Moghoofei, Mohsen; Sahebnasagh, Roxana; Mirzaei, Hamed; Hamblin, Michael R.

DOI: 10.2174/0929867327666200204141952

Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder

, 2021; 28(2): 360-376.

Amiri, Atefeh; Mahjoubin-Tehran, Maryam; Asemi, Zatollah; Shafiee, Alimohammad; Hajighadimi, Sarah; Moradizarmehri, Sanaz; Mirzaei, Hamid Reza; Mirzaei, Hamed

DOI: 10.2174/0929867326666191212102407

Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy

, 2021; 28(2): 329-345.

Zhu, Shunqin; Yu, Qin; Huo, Chunsong; Li, Yuanpeng; He, Linshen; Ran, Botian; Chen, Ji; Li, Yonghao; Liu, Wanhong

DOI: 10.2174/0929867327666200121124404

Nanoparticles in Combating Cancer: Opportunities and Limitations: A Brief Review

, 2021; 28(2): 346-359.

Pedziwiatr-Werbicka, Elzbieta; Horodecka, Katarzyna; Shcharbin, Dzmitry; Bryszewska, Maria

DOI: 10.2174/0929867327666200130101605

Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids

, 2021; 28(2): 238-252.

Gomez-Zorita, Saioa; Milton-Laskibar, Inaki; Aguirre, Leixuri; Fernandez-Quintela, Alfredo; Xiao, Jianbo; Portillo, Maria P.

DOI: 10.2174/0929867326666191029112626

New Perspectives in the Pharmacological Potential of Naringin in Medicine

, 2021; 28(10): 1987-2007.

Angelica Rivoira, Maria; Rodriguez, Valeria; Talamoni, German; Tolosa de Talamoni, Nori

DOI: 10.2174/0929867327666200604171351

Current Scenario and Future Prospect in the Management of COVID-19

, 2021; 28(2): 284-307.

Borah, Pobitra; Deb, Pran Kishore; Deka, Satyendra; Venugopala, Katharigatta N.; Singh, Vinayak; Mailavaram, Raghu Prasad; Kalia, Kiran; Tekade, Rakesh Kumar

DOI: 10.2174/0929867327666200908113642

Protective Role of Natural Products in Glioblastoma Multiforme: A Focus on Nitric Oxide Pathway

, 2021; 28(2): 377-400.

Afshari, Amir R.; Mollazadeh, Hamid; Mohtashami, Elmira; Soltani, Arash; Soukhtanloo, Mohammad; Hosseini, Azar; Jalili-Nik, Mohammad; Vahedi, Mohammad Mahdi; Roshan, Mostafa Karimi; Sahebkar, Amirhossein

DOI: 10.2174/0929867327666200130104757

Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data

, 2021; 28(2): 213-237.

Mastinu, Andrea; Ribaudo, Giovanni; Ongaro, Alberto; Bonini, Sara Anna; Memo, Maurizio; Gianoncelli, Alessandra

DOI: 10.2174/0929867327666200210144847

Deep Learning in Drug Target Interaction Prediction: Current and Future Perspectives

, 2021; 28(11): 2100-2113.

Abbasi, Karim; Razzaghi, Parvin; Poso, Antti; Ghanbari-Ara, Saber; Masoudi-Nejad, Ali

DOI: 10.2174/0929867327666200907141016


Atta-ur-Rahman, FRS
(32052 citations)
Kings College
University of Cambridge
View Full Editorial Board

Nobel Laureates on Editorial Board

Prof. John Gurdon

Prof. Jean-Marie Lehn

Prof. Ferid Murad

COPE Compliant

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Journal History

Current Medicinal Chemistry was introduced in 1994 with the assistance of Dr. Atta-ur-Rahman, who is the current Editor-in-Chief serving since 1994.



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