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Current Drug Metabolism

Volume 20, 14 Issues, 2019
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Ranking and Category

  • 200th of 298 in

    Biochemistry & Molecular Biology

  • 158th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 20

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Number 5



Biography   Open Access



Review Article



Review Article

Effects of Radiation on Drug Metabolism: A Review

, 20(5): 350 - 360

Xiangyang Li*, Jianxin Yang, Yijie Qiao, Yabin Duan, Yuanyao Xin, Yongqiong Nian, Lin Zhu and Guiqin Liu


DOI: 10.2174/1389200220666190405171303


Review Article

Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato


DOI: 10.2174/1389200220666190402143125


Review Article



Review Article

Vitamin D in Inflammatory Bowel Disease: Biological, Clinical and Therapeutic Aspects

, 20(5): 390 - 398

Raúl Vicente Olmedo-Martín, Inmaculada González-Molero, Gabriel Olveira, Víctor Amo-Trillo and Miguel Jiménez-Pérez*


DOI: 10.2174/1389200220666190520112003


Research Article

Interethnic Variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population

, 20(5): 399 - 410

Sara Abudahab*, Nancy Hakooz, Yazun Jarrar, Mohammad Al Shhab, Ahmad Saleh, Malek Zihlif and Rana Dajani


DOI: 10.2174/1389200220666190528085151


Letters to the editor   Open Access



Current Drug Metabolism, Volume 20 (2019) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Abstracts Ahead of Print

Association of genetic variants in CYP3A4, CYP3A5, CYP2C8, and CYP2C19 with tacrolimus pharmacokinetics in renal transplant recipients


Zijie Wang, Ming Zheng*, Haiwei Yang*, Zhijian Han, Jun Tao, Hao Chen, Li Sun, Miao Guo, Libin Wang, Ruoyun Tan, Ji-Fu Wei and Min Gu


View Abstract


Nanogels for Skin Cancer Therapy via Transdermal Delivery: Current Designs


Phuong H.L. Tran, Wei Duan, Beom-Jin Lee and Thao T.D. Tran*


View Abstract


Published Contents

Editor's Choice

Interethnic Variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population

, 2019; 20(5): 399 - 410

Sara Abudahab*, Nancy Hakooz, Yazun Jarrar, Mohammad Al Shahhab, Ahmad Saleh, Malek Zihlif and Rana Dajani


DOI: 10.2174/1389200220666190528085151



Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*


DOI: 10.2174/1389200220666190111114146







Sodium Oxybate Therapy for Alcohol Withdrawal Syndrome and Keeping of Alcohol Abstinence

, 2018; 19(13): 1056 - 1064

Carmen Mannucci, Simona Pichini, Elvira Ventura Spagnolo, Fabrizio Calapai, Sebastiano Gangemi, Michele Navarra and Gioacchino Calapai*


DOI: 10.2174/1389200219666171207122227






Open Access Articles

Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum




A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics?

, 2014; 15(6): 581 - 598

Lorena Baietto, Silvia Corcione, Giovanni Pacini, Giovanni Di Perri, Antonio D’Avolio and Francesco Giuseppe De Rosa




Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

, 2014; 15(2): 209 - 217

Kelly E. Caudle, Teri E. Klein, James M. Hoffman, Daniel J. Muller, Michelle Whirl-Carrillo, Li Gong, Ellen M. McDonagh, Katrin Sangkuhl, Caroline F. Thorn, Matthias Schwab, Jose A.G. Agundez, Robert R. Freimuth, Vojtech Huser, Ming Ta Michael Lee, Otito F. Iwuchukwu, Kristine R. Crews, Stuart A. Scott, Mia Wadelius, Jesse J. Swen, Rachel F. Tyndale, C. Michael Stein, Dan Roden, Mary V. Relling, Marc S. Williams and Samuel G. Johnson





Most Cited Articles

Review Article

Medicinal and therapeutic potential of herbs and plant metabolites/extracts countering viral pathogens-current knowledge and future prospects

, 2018; 19(3): 236-263.

Kuldeep Dhama*, Kumaragurubaran Karthik, Rekha Khandia, Ashok Munjal, Ruchi Tiwari, Rajneesh Rana, Sandip Kumar Khurana, Sana Ullah, Rifat Ullah Khan, Mahmoud Alagawany, Mayada Ragab Farag, Maryam Dadar and Sunil Kumar Joshi


DOI: 10.2174/1389200219666180129145252


Review Article

Long circulating polymeric nanoparticles for gene/drug delivery

, 2018; 19(9): 723-738.

Jiaming Hu, Yan Sheng*, Junfeng Shi, Bohao Yu, Zhiqiang Yu and Guochao Liao*


DOI: 10.2174/1389200219666171207120643


Review Article

Herbal immunomodulators - A remedial panacea for designing and developing effective drugs and medicines: Current scenario and future prospects

, 2018; 19(3): 264-301.

Ruchi Tiwari*, Shyma K. Latheef, Ishtiaq Ahmed, Hafiz M.N. Iqbal, Mohammed Hussen Bule, Kuldeep Dhama, Hari Abdul Samad, Kumaragurubaran Karthik, Mahmoud Alagawany, Mohamed Ezzat Abd El-Hack, Mohd. Iqbal Yatoo and Mayada Ragab Farag


DOI: 10.2174/1389200219666180129125436



Review Article

Role of mitochondrial mechanism in chemotherapy-induced peripheral neuropathy

, 1 January 2018; 19(1): 47-54.

Mohammad Waseem, Pooja Kaushik, Heena Tabassum* and Suhel Parvez


DOI: 10.2174/1389200219666171207121313


Review Article

An insight into the therapeutic potential of major coffee components

, 2018; 19(6): 544-556.

Muhammad Torequl Islam*, Shams Tabrez*, Nasimudeen R. Jabir, Murtaza Ali, Mohammad Amjad Kamal, Lidiane da Silva Araujo, Jose Victor De Oliveira Santos, Ana Maria Oliveira Ferreira Da Mata, Rai Pablo Sousa De Aguiar and Ana Amelia de Carvalho Melo Cavalcante


DOI: 10.2174/1389200219666180302154551


Review Article

Adverse events of proton pump inhibitors: Potential mechanisms

, 2018; 19(2): 142-154.

Andrea Corsonello*, Fabrizia Lattanzio, Silvia Bustacchini, Sabrina Garasto, Annalisa Cozza, Roberto Schepisi, Federica Lenci, Filippo Luciani, Marcello Giuseppe Maggio, Andrea Ticinesi, Valeria Butto, Sara Tagliaferri and Francesco Corica


DOI: 10.2174/1389200219666171207125351


Review Article

Replacing GHB with GBL in recreational settings: A new trend in chemsex

, 2018; 19(13): 1080-1085.

Francesco Paolo Busardò*, Massimo Gottardi, Anastasio Tini, Adele Minutillo, Ascanio Sirignano, Enrico Marinelli and Simona Zaami


DOI: 10.2174/1389200219666180925090834


General Review Article

Anti-cancer effects of metformin: Recent evidences for its role in prevention and treatment of cancer

, 2018; 19(9): 793-797.

Masoumeh Kheirandish, Hamidreza Mahboobi*, Maryam Yazdanparast, Warda Kamal and Mohammad Amjad Kamal


DOI: 10.2174/1389200219666180416161846


Review Article

Plant-derived polyphenols in human health: Biological activity, metabolites and putative molecular targets

, 2018; 19(4): 351-369.

Marilo Olivares-Vicente, Enrique Barrajon-Catalan*, Maria Herranz-Lopez, Antonio Segura-Carretero, Jorge Joven, Jose Antonio Encinar and Vicente Micol


DOI: 10.2174/1389200219666180220095236


Review Article

Current state of in vitro cell-based renal models

, 2018; 19(4): 310-326.

Elnaz Gozalpour* and Katherine S. Fenner


DOI: 10.2174/1389200219666180119115133


Review Article

Current therapeutic approaches for targeting inflammation in depression and cardiovascular disease

, 2018; 19(8): 674-687.

Pedro Zuzarte, Angela Duong, Maria L. Figueira, Atilio Costa-Vitali and Gustavo Scola*


DOI: 10.2174/1389200219666180305143501


Review Article

Pharmacogenetics of metabolic genes of anthracyclines in acute myeloid leukemia

, 1 January 2018; 19(1): 55-74.

Juan Eduardo Megias-Vericat*, David Martinez-Cuadron, Maria Jose Herrero, Salvador F. Alino, Jose Luis Poveda , Miguel Angel Sanz and Pau Montesinos


DOI: 10.2174/1389200218666171101124931


General Review Article

Essential oils: Extraction techniques, pharmaceutical and therapeutic potential - A review

, 2018; 19(13): 1100-1110.

Zarith Asyikin Abdul Aziz, Akil Ahmad, Siti Hamidah Mohd Setapar*, Alptug Karakucuk, Muhammad Mohsin Azim, David Lokhat, Mohd. Rafatullah, Magdah Ganash, Mohammad A. Kamal and Ghulam Md Ashraf*


DOI: 10.2174/1389200219666180723144850


Review Article

Drug-induced cholestasis: Mechanisms, models, and markers

, 2018; 19(10): 808-818.

Sagnik Chatterjee* and Pieter Annaert


DOI: 10.2174/1389200219666180427165035



Most Accessed Articles



Cannabinoids and Cytochrome P450 Interactions

, 2016; 17(3): 206-226.

Ondřej Zendulka, Gabriela Dovrtělová, Kristýna Nosková, Miroslav Turjap, Alexandra Šulcová, Lumír Hanuš and Jan Juřica


DOI: 10.2174/1389200217666151210142051



Bile Acids in Physiology, Pathology and Pharmacology

, 2016; 17(1): 4-29.

Jose J.G. Marin, Rocio I.R. Macias, Oscar Briz, Jesus M. Banales and Maria J. Monte


DOI: 10.2174/1389200216666151103115454









Editor-in-Chief

Michael Sinz
Bristol Myers Squibb
Princeton, NJ
USA

Biography View Full Editorial Board

Journal History

Current Drug Metabolism was launched in 2000. Dr. Michael Sinz serves as the Editor-in-Chief of the journal.
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Scopus CiteScore Metrics: 1.02

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