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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 25, 14 Issues, 2022
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 25

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Number 8









Research Article

Effects of Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Fructose and Potassium Oxonate

, 25(8): 1294 - 1303

Yu-Zhi Wang, Cong Zhou, Li-Jie Zhu, Xing-Li-Shang He, Lin-Zi Li, Xiang Zheng, Wan-Feng Xu, Ying-Jie Dong, Bo Li, Qiao-Xian Yu*, Gui-Yuan Lv* and Su-Hong Chen*


DOI: 10.2174/1386207324666210528114345


Research Article

3 CpG Methylation Biomarkers for the Diagnosis of Polycystic Ovary Syndrome (PCOS) in Blood Samples

, 25(8): 1304 - 1313

Linling Xie, Xiaotao Jiang, Yi Chen, Cihui Huang, Yanfen Chen, Guantong Liu, Wenxi Sun, Lei Zeng* and Ruling Lu*


DOI: 10.2174/1386207321666210602170054


Combinatorial Chemistry & High Throughput Screening, Volume 25 (2022) - Number 9


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

A Case Report of Burkholderia mallei Infection Leading to Pneumonia


Guanfeng He, Yu Zeng, Qizhong He, Tuxuan Liu, Nanhong Li, Hui Lin, Muhong Zeng, Yonglong Li, Min Peng*, Junfen Cheng*, Wang Liu* and Weimin Yao*


DOI: 10.2174/1386207325666220509152221
View Abstract View on PubMed


SIX1: A Prognostic Biomarker in Uterine Corpus Endometrial Carcinoma


Quangang Zhao, Guohua Chen*, Xin Yang, Taiyong Wang, Shuhong Yuan and Qi Meng


DOI: 10.2174/1386207325666220404121856
View Abstract View on PubMed




Favipiravir in SARS-CoV-2 Infection: Is it Worth it?


Gaber El-Saber Batiha*, Mohamed Moubarak, Hazem M. Shaheen, Ali Muhammad Zakariya, Ibe Michael Usman, Abdur Rauf, Achyut Adhikari, Abhijit Dey, Athanasios Alexiou*, Helal F. Hetta, Ali I. Al-Gareeb and Hayder M. Al-kuraishy


DOI: 10.2174/1386207325666220414111840
View Abstract View on PubMed


Effects of Long Noncoding RNA AK093407 on the Biological Behavior of Colon Cancer Cells and the Underlying Mechanism


Zhao Xuerong, Sun Ao, Wang Jianping, Zheng Xin, Tian Duoduo, Wang Mingjuan, Xiao Lijun*, Zhao Enhong and Zheng-Guo Cui


DOI: 10.2174/1386207325666220408092028
View Abstract View on PubMed




Pharmacology and Ethnomedicinal Potential of Selected Plants Species from Apiaceae (Umbelliferae)


Gitishree Das, Subrata Das, Anupam Das Talukdar, Chidambaram Kulandaisamy Venil, Sankhadip Bose, Sabyasachi Banerjee, Han-Seung Shin, Erick P. Gutiérrez-Grijalva, J. Basilio Heredia and Jayanta Kumar Patra*


DOI: 10.2174/1386207325666220406110404
View Abstract View on PubMed



Abstracts Ahead of Print





Neoadjuvant Endocrine Therapy: A Potential Way to Make Cold Hormone Receptor-Rich Breast Cancer Hot


Yinan Wu, Xiaonan Gong, Kaiyue Wang, Chengcheng Yu, Jili Qiu, Suzhan Zhang*, Yue Hu and Kaimin Hu


DOI: 10.2174/1386207325666220617145448
View Abstract


miRNA-633 and KAI1 as potential biomarkers of malignant melanoma with gastric cancer


Zheng-xiang Wang*, Guang-jing Zhang, Xiu-fang Yang, Shi-jun Feng, Shan-shan Ji and Ya-bin Qi


DOI: 10.2174/1386207325666220616125608
View Abstract





Construction of a Competitive Endogenous RNA Network Related to Exosomes in Diabetic Retinopathy


Tong Wang, Mao-yuan Cheng, Meng-ya Shan, Cui-yao Tang, Nai-jia Pan, Zi-hui Xu* and Xian-lun Tang


DOI: 10.2174/1386207325666220610122114
View Abstract


Published Contents

Editor's Choice


A Potential MRI Agent and an Anticancer Drug Encapsulated within CPMV Virus-Like Particles

, 2021; 24(10): 1557 - 1571

Alaa A.A. Aljabali*, Lorca Alzoubi, Yassmen Hamzat, Alaa Alqudah, Mohammad A. Obeid, Mazhar S. Al Zoubi, Raed M. Ennab, Walhan Alshaer, Khaled Albatayneh, Bahaa Al-Trad, Dana A. Alqudah, Dinesh Kumar Chellappan, Gaurav Gupta, Murtaza M. Tambuwala, Dua Kamal and David J. Evans


DOI: 10.2174/1386207323666200914110012








Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques

, 2021; 24(5): 605 - 623

Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht* and Faezeh Ghasemi*


DOI: 10.2174/1386207323666200901101955





Open Access Articles



Elucidation of the Mechanisms and Molecular Targets of Qishen Yiqi Formula for the Treatment of Pulmonary Arterial Hypertension using a Bioinformatics/Network Topology-based Strategy

, 2021; 24(5): 701 - 715

Peiliang Wu, Xiaona Xie, Mayun Chen, Junwei Sun, Luqiong Cai, Jinqiu Wei, Lin Yang, Xiaoying Huang* and Liangxing Wang*





Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy

, 2020; 23(4): 334 - 344

Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*





Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*





Most Cited Articles


Research Article

Drug target group prediction with multiple drug networks

, 2020; 23(4): 274-284.

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927



Review Article

Progress in molecularly imprinted polymers for biomedical applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526


Research Article

Identification of the active constituents and significant pathways of guizhi-shaoyao-zhimu decoction for the treatment of diabetes mellitus based on molecular docking and network pharmacology

, 2019; 22(9): 584-598.

Qing Zhang, Ruolan Li, Wei Peng, Mengmeng Zhang, Jia Liu, Shujun Wei, Jiaolong Wang, Chunjie Wu, Yongxiang Gao* and Xufeng Pu*


DOI: 10.2174/1386207322666191022101613




General Research Article

Lead finding from selected flavonoids with antiviral (Sars-cov-2) potentials against covid-19: An in-silico evaluation

, 2021; 24(6): 879-890.

Uma Sankar Gorla*, Koteswara Rao, Uma Sankar Kulandaivelu, Rajasekhar Reddy Alavala and Siva Prasad Panda


DOI: 10.2174/1386207323999200818162706


General Research Article

Discovery of potent sars-cov-2 inhibitors from approved antiviral drugs via docking and virtual screening

, 2021; 24(3): 441-454.

Samir Chtita *, Assia Belhassan, Adnane Aouidate, Salah Belaidi, Mohammed Bouachrine and Tahar Lakhlifi


DOI: 10.2174/1386207323999200730205447






Research Article

Green route for the removal of pb from aquatic environment

, 2020; 23(7): 587-598.

Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim


DOI: 10.2174/1386207323666200127123349




Most Accessed Articles

Lead Finding from Selected Flavonoids with Antiviral (SARS-CoV-2) Potentials Against COVID-19: An In-silico Evaluation

, 2021; 24(6): 879-890.

Gorla, Uma Sankar; Rao, Gsn Koteswara; Kulandaivelu, Uma Sankar; Alavala, Rajasekhar Reddy; Panda, Siva Prasad


DOI: 10.2174/1386207323999200818162706


Discovery of Potent SARS-CoV-2 Inhibitors from Approved Antiviral Drugs via Docking and Virtual Screening

, 2021; 24(3): 441-454.

Chtita, Samir; Belhassan, Assia; Aouidate, Adnane; Belaidi, Salah; Bouachrine, Mohammed; Lakhlifi, Tahar


DOI: 10.2174/1386207323999200730205447




Diagnosis of Alzheimer's Disease Based on Deeply-Fused Nets

, 2021; 24(6): 781-789.

Chen, Chang Zu; Wu, Qi; Li, Zuo Yong; Xiao, Lei; Hu, Zhong Yi


DOI: 10.2174/1386207323666200825092649



Molecular Mechanisms of Thymoquinone as Anticancer Agent

, 2021; 24(10): 1573-1582.

Alhmied, Fatma; Alammar, Ali; Alsultan, Bayan; Alshehri, Muruj; Pottoo, Faheem Hyder


DOI: 10.2174/1386207323999201110192942


Herbal Medicine: Clinical Perspective & Regulatory Status

, 2021; 24(1): 139-147.

Barkat, Md Abul; Goyal, Anjali; Barkat, Harshita A.; Salauddin, Mohammad; Pottoo, Faheem H.; Anwer, Esra T.


DOI: 10.2174/1386207323666200712145041



Curcumin-containing Silver Nanoparticles Prevent Carbon Tetrachlo-ride-induced Hepatotoxicity in Mice

, 2021; 24(7): 1055-1068.

Ebaid, Hossam; Habila, Mohamed; Hassan, Iftekhar; Al-Tamimi, Jameel; Omar, Mohamed S.; Rady, Ahmed; Alhazza, Ibrahim M.


DOI: 10.2174/1386207323999200824115536



Potential Leads from Liquorice Against SARS-CoV-2 Main Protease using Molecular Docking Simulation Studies

, 2021; 24(2): 195-212.

Sinha, Saurabh K.; Prasad, Satyendra K.; Islam, Md Ataul; Chaudhary, Sushil K.; Singh, Shashikant; Shakya, Anshul


DOI: 10.2174/1386207323666200605150024


A Systems Biology Approach for miRNA-mRNA Expression Patterns Analysis in Rheumatoid Arthritis

, 2021; 24(2): 294-305.

Tavasolian, Fataneh; Hosseini, Ahmad Zavaran; Soudi, Sara; Naderi, Mahmood; Sahebkar, Amirhossein


DOI: 10.2174/1386207323666200806164635




Editor-in-Chief

graphic
Gerald H. Lushington
LiS Consulting
Lawrence, KS
(USA)
Biography
View Full Editorial Board

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