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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 21, 18 Issues, 2021
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry

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Volume 21

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Number 14



Biography   Open Access











Research Article

Anti-Tumor Activity and Underlying Mechanism of Phomoxanthone B in MCF7 Cells

, 21(14): 1825 - 1834

Chuan Chen, Ziyue Zhao, Qian Dong, XueHui Gao, Huibin Xu, Runlei Yang, JianChun Qin* and Duqiang Luo*


DOI: 10.2174/1871520620999201124215511


Research Article

FOXM1-Dependent Transcriptional Regulation of EZH2 Induces Proliferation and Progression in Prostate Cancer

, 21(14): 1835 - 1841

Juan-Hua Tian, Li-Jun Mu, Mei-Yu Wang, Jin Zeng, Qing-Zhi Long, Bin-Guan, Wen Wang, Yu-Mei Jiang, Xiao-Jing Bai and Yue-Feng Du*


DOI: 10.2174/1871520620666200731161810


Research Article



Articles Ahead of Print


Radioprotective Potential of Nutraceuticals and their Underlying Mechanism of Action


Shabnoor Iqbal, Muhammad Ajmal Shah*, Azhar Rasul, Malik Saadullah, Sobia Tabassum, Shujat Ali, Muhammad Zafar, Haji Muhammad, Md Sahab Uddin, Gaber El-Saber Batiha and Celia Vargas-De-La-Cruz


DOI: 10.2174/1871520621666210223101246
View Abstract View on PubMed


Inhibition of Growth of Esophageal Cancer by Alantolactone via Wnt/β- Catenin Signaling


Zijie Wang, Qing Hu, Huan Chen, Lei Shi, Min He, Hui Liu, Ting Li, Muhan Lü, Mingming Deng* and Gang Luo*


DOI: 10.2174/1871520621666210112124546
View Abstract View on PubMed



The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis


Jia Huo, Yuan Wang, Yanfei Zhang, Wei Wang, Peiwen Yang, Wenwei Zhao, Miaomiao Zhang, Lu Cui and Dingwei Zhang*


DOI: 10.2174/1871520621666210322092906
View Abstract


A Review of Anti-Cancer and Related Properties of Lichen-Extracts and Metabolites


Ankita H. Tripathi, Nidhi Negi, Rekha Gahtori, Amrita Kumari, Penny Joshi, Lalit M. Tewari, Yogesh Joshi, Rajesh Bajpai, Dalip K. Upreti and Santosh K. Upadhyay*


DOI: 10.2174/1871520621666210322094647
View Abstract


Traditionally Used Natural Products in Preventing Ionizing Radiation-Induced Dermatitis: First Review on the Clinical Studies


Faizan Kalekhan, Avinash K. Kudva, Shamprasad V. Raghu, Suresh Rao, Sanath K. Hegde, Paul Simon and Manjeshwar S. Baliga*


DOI: 10.2174/1871520621666210405093236
View Abstract View on PubMed


Diagnostic and Therapeutic Applications of Exosome Nanovesicles in Lung Cancer: State-of-The-Art


Rezvan Mohammadi, Seyede A. Hosseini, Somaye Noruzi, Ailin Ebrahimzadeh and Amirhossein Sahebkar*


DOI: 10.2174/1871520621666210301085318
View Abstract View on PubMed


Zebrafish Avatar to Develop Precision Breast Cancer Therapies


Debora Corsinovi, Alice Usai, Miriam De Sarlo, Martina Giannaccini and Michela Ori*


DOI: 10.2174/1871520621666210402111634
View Abstract View on PubMed



Abstracts Ahead of Print

New C2- and N3-Modified Thieno[2,3-d]Pyrimidine Conjugates with Cytotoxicity in the Nanomolar Range


Anelia Ts. Mavrova*, Stefan Dimov, Denitsa Yancheva*, Miroslav Rangelov, Diana Wesselinova and Emilia Naydenova


DOI: 10.2174/1871520621666210727130227
View Abstract





Imidazolidine Derivatives in Cancer Research: What is known?


Auvani Antunes da Silva Júnior, Marina Galdino da Rocha Pitta, Mardonny Bruno de Oliveira Chagas, Moacyr Jesus Barreto de Melo Rêgo, Michelle Melgarejo da Rosa and Maira Galdino da Rocha Pitta*


DOI: 10.2174/1871520621666210727113639
View Abstract


Pembrolizumab for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer: Analysis of Prognostic Factors of Outcomes


Carmelo Tibaldi*, Francesca Mazzoni, Vieri Scotti, Enrico Vasile, Daniele Pozzessere, Irene Stasi, Andrea Camerini, Francesca Federici, Giulia Meoni, Chiara Caparello, Marianna Turrini, Virginia Rossi , Lucia Pia Ciccone, Irene Pecora, Beatrice Fantechi, Lorenzo Antonuzzo, Diana Giannarelli and Editta Baldini


DOI: 10.2174/1871520621666210727112212
View Abstract



An Insight into Anticancer Bioactives from Punica granatum (Pomegranate)


Kanika Sharma, Payal Kesharwani, Shiv Kumar Prajapati, Ankit Jain*, Dolly Jain, Nishi Mody and Swapnil Sharma


DOI: 10.2174/1871520621666210726143553
View Abstract



Efficacy of Neoadjuvant Therapy in Improving Long-Term Survival of Patients with Resectable Rectal Cancer: A Meta-Analysis


Xinlong Li, Xiangyuan Li, Rongrong Fu, Derry Ng, Tong Yang, Yu Zhang, Mengting Zhang, Yetan Shi, Yixuan Gu, Chenhui Lv and Gang Chen *


DOI: 10.2174/1871520621666210726134809
View Abstract


Published Contents

Editor's Choice

Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple- Negative Breast Cancer Cell Migration

, 2021; 21(14): 1901 - 1910

Wanessa F. Altei, Bianca C. Pachane, Lucimara J. Martins, Ralph C. Gomes, Ricardo N. Santos, Daniara C. Fernandes, Heloisa S. Selistre-de-Araújo, Fernando Coelho * and Adriano D. Andricopulo*


DOI: 10.2174/1871520621666201207092836






Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti-Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents

, 2021; 21(10): 1228 - 1239

Paul Awolade, Nosipho Cele, Oluwakemi Ebenezer, Nagaraju Kerru, Lalitha Gummidi, Liang Gu, Gabriella Palma, Mandeep Kaur and Parvesh Singh*


DOI: 10.2174/1871520620666200929153138



On the Cytotoxicity of Chiral Ruthenium Complexes Containing Sulfur Amino Acids against Breast Tumor Cells (MDA-231 and MCF-7)

, 2021; 21(9): 1172 - 1182

Celisnolia M. Leite*, João Honorato de Araujo-Neto, Rodrigo S. Corrêa, Legna Colina-Vegas, Diego Martínez-Otero, Paulo R. Martins, Cristiane G. Silva and Alzir A. Batista*


DOI: 10.2174/1871520620666200824114816



Synthesis and Evaluation of Cytotoxic Activity of Certain Benzo[h]chromene Derivatives

, 2021; 21(8): 963 - 986

Samir M. Awad, Mosaad S. Mohamed, Marwa Abd El-Fattah Khodair and Rania H. Abd El-Hameed*


DOI: 10.2174/1871520620666200925103742




Novel Dihydropyrimidinone-Derived Selenoesters as Potential Cytotoxic Agents to Human Hepatocellular Carcinoma: Molecular Docking and DNA Fragmentation

, 2021; 21(6): 703 - 715

Jean C. Benassi, Flavio A.R. Barbosa, Valdelúcia M.A.S. Grinevicius, Fabiana Ourique, Daniela Coelho, Karina B. Felipe, Antônio L. Braga, Danilo W. Filho and Rozangela C. Pedrosa*


DOI: 10.2174/1871520620666200728124640



Anticancer Active Heterocyclic Chalcones: Recent Developments

, 2021; 21(5): 558 - 566

Prasad Dandawate, Khursheed Ahmed, Subhash Padhye, Aamir Ahmad* and Bernhard Biersack*


DOI: 10.2174/1871520620666200705215722



Open Access Articles



The Killing of Human Neuroblastoma Cells by the Small Molecule JQ1 Occurs in a p53-Dependent Manner

, 2020; 20(13): 1613 - 1625

Joseph Mazar*, Caleb Gordon, Varun Naga and Tamarah J. Westmoreland




Cytotoxic Sesquiterpenes from Sonchus oleraceus

, 2020; 20(6): 709 - 714

Hongying Zhang, Yiding Wang, Shaojiu Wang, Qian Wang, Tianjing Wang, Jie Zhu* and Bing Liu




Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug- Resistant Cells

, 2020; 20(6): 687 - 699

Gongshen Jin*, Kangwei Wang, Yonghong Liu, Xianhu Liu, Xiaojing Zhang and Hao Zhang




Deglucohellebrin: A Potent Agent for Glioblastoma Treatment

, 2020; 20(1): 103 - 110

Evrysthenis Vartholomatos, George A. Alexiou*, Georgios S. Markopoulos, Diamanto Lazari, Olga Tsiftsoglou, Ieremias Chousidis, Ioannis Leonardos and Athanasios P. Kyritsis





Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis

, 2019; 19(10): 1253 - 1261

Naipeng Cui, Dan-Dan Lin, Yang Shen, Jian-Guo Shi, Bing Wang, Ming-Zhi Zhao, Lishuang Zheng, Hua Chen* and Jian-Hong Shi*





New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang




Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau




Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*





Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante




Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi





Most Cited Articles



Review Article

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention

, 2019; 19(1): 38-47.

Alessandro Colapietro, Andrea Mancini, Anna Maria D'Alessandro and Claudio Festuccia*


DOI: 10.2174/1871520619666181231112453


Research Article

Synthesis and biological evaluation of novel heterocyclic imines linked coumarin- thiazole hybrids as anticancer agents

, 2019; 19(4): 557-566.

Nerella S. Goud, Mahammad S. Ghouse, Jatoth Vishnu, Jakkula Pranay, Ravi Alvala, Venu Talla, Insaf A. Qureshi and Mallika Alvala*


DOI: 10.2174/1871520619666190207140120



Review Article

Phytochemicals in anticancer drug development

, 2019; 19(2): 172-183.

Rohit Dutt, Vandana Garg, Naveen Khatri and Anil K. Madan*


DOI: 10.2174/1871520618666181106115802



Research Article

Novel inhibitors of DNA repair enzyme TDP1 combining monoterpenoid and adamantane fragments

, 2019; 19(4): 463-472.

Evgenii S. Mozhaitsev, Alexandra L. Zakharenko, Evgeniy V. Suslov*, Dina V. Korchagina, Olga D. Zakharova, Inna A. Vasil'eva, Arina A. Chepanova, Ellena Black, Jinal Patel, Raina Chand, Jóhannes Reynisson, Ivanhoe K.H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov and Olga I. Lavrik


DOI: 10.2174/1871520619666181207094243


Review Article

Garlic and its active compounds: A potential candidate in the prevention of cancer by modulating various cell signalling pathways

, 2019; 19(11): 1314-1324.

Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi and Arshad H. Rahmani*


DOI: 10.2174/1871520619666190409100955



Research Article

Let-7a could serve as a biomarker for chemo-responsiveness to docetaxel in gastric cancer

, 2019; 19(3): 304-309.

Najibeh Shekari, Faezeh Asghari, Navideh Haghnavaz, Dariush Shanehbandi, Vahid Khaze, Behzad Baradaran and Tohid Kazemi*


DOI: 10.2174/1871520619666181213110258


Review Article

Nitrogen-containing heterocycles as anticancer agents: An overview

, 2020; 20(18): 2150-2168.

Damanpreet K. Lang, Rajwinder Kaur*, Rashmi Arora, Balraj Saini and Sandeep Arora


DOI: 10.2174/1871520620666200705214917




Research Article

Hydroxytyrosol and oleuropein inhibit migration and invasion of MDA-MB-231 triple-negative breast cancer cell via induction of autophagy

, 2019; 19(16): 1983-1990.

Hui-Yuan Lu*, Jian-Sheng Zhu, Zhan Zhang, Wei-Jian Shen, Shan Jiang, Yun-Feng Long, Bin Wu, Tao Ding, Fei Huan and Shou-Lin Wang


DOI: 10.2174/1871520619666190722101207



Most Accessed Articles

Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple- Negative Breast Cancer Cell Migration

, 2021; 21(14): 1901-1910.

Wanessa F. Altei, Bianca C. Pachane, Lucimara J. Martins, Ralph C. Gomes, Ricardo N. Santos, Daniara C. Fernandes, Heloisa S. Selistre-de-Araújo, Fernando Coelho * and Adriano D. Andricopulo*


DOI: 10.2174/1871520621666201207092836


Anti-MDR Effects of Quercetin and its Nanoemulsion in Multidrug-Resistant Human Leukemia Cells

, 2021; 21(14): 1911-1920.

Maiara B. Marques, Ayane P. Machado, Priscila A. Santos, Michele Carrett-Dias, Gabriela S. Araújo, Barbara da Silva Alves, Bárbara Santos de Oliveira, Flavio M.R. da Silva Júnior, Cristiana L. Dora, Andrés D. Cañedo, Daza M.V.B. Filgueira, Estela Fernandes e Silva* and Ana Paula de Souza Votto


DOI: 10.2174/1871520621999210104200722



Anti-Tumor Activity and Underlying Mechanism of Phomoxanthone B in MCF7 Cells

, 2021; 21(14): 1825-1834.

Chuan Chen, Ziyue Zhao, Qian Dong, XueHui Gao, Huibin Xu, Runlei Yang, JianChun Qin* and Duqiang Luo*


DOI: 10.2174/1871520620999201124215511


The Efficacy and Safety of Additional Anti-HER2-Targeting Drugs in the Treatment of HER2-Positive Advanced Breast Cancer: A Meta-Analysis

, 2021; 21(14): 1931-1940.

Nannan Du, Bangsheng Chen, Zefeng Shen, Bin Zhou, Xiaojun Fu, Danyi Mao, Feiyan Mao, Derry M. Ng, Parikshit A. Khadaroo and Lei Yang*


DOI: 10.2174/1871520621666201231142841



FOXM1-Dependent Transcriptional Regulation of EZH2 Induces Proliferation and Progression in Prostate Cancer

, 2021; 21(14): 1835-1841.

Juan-Hua Tian, Li-Jun Mu, Mei-Yu Wang, Jin Zeng, Qing-Zhi Long, Bin-Guan, Wen Wang, Yu-Mei Jiang, Xiao-Jing Bai and Yue-Feng Du*


DOI: 10.2174/1871520620666200731161810


99mTechnetium- or Cy7-Labeled Fab(Tocilizumab) as Potential Multiple Myeloma Imaging Agents

, 2021; 21(14): 1883-1893.

Ximena Camacho*, Carolina Perroni, Camila L. Machado, Camila de Godoi Carneiro, Mara de Souza Junqueira, Daniele Faria, María F. García, Marcelo Fernández, Natalia Oddone, Juan Benech, Carlos A. Buchpiguel, Hugo Cerecetto, Roger Chammas, Eloisa Riva, Pablo Cabral and Juan P. Gambini


DOI: 10.2174/1871520621999210104181238


Anticancer Potential of Doxorubicin in Combination with Green-Synthesized Silver Nanoparticle and its Cytotoxicity Effects on Cardio-Myoblast Normal Cells

, 2021; 21(14): 1842-1849.

Jafar Saeidi, Samaneh Dolatabadi, Mahbubeh B. Esfahani, Masood Saeidi, Mahnaz Mohtashami*, Kiana Mokhtari and Ahmad Ghasemi*


DOI: 10.2174/1871520621666201207093913



Evaluation of Anti-Tumor Potential of Lactobacillus acidophilus ATCC4356 Culture Supernatants in MCF-7 Breast Cancer

, 2021; 21(14): 1861-1870.

Ramazan Behzadi, Ahmad Hormati, Karim Eivaziatashbeik, Sajjad Ahmadpour*, Fatemeh Khodadust, Fatemeh Zaboli, Esmail Fattahi, Rana Jahanban-­Esfahlan and Khaled Seidi


DOI: 10.2174/1871520621666201207085239





Chalcone Scaffolds as Anticancer Drugs: A Review on Molecular Insight in Action of Mechanisms and Anticancer Properties

, 2021; 21(13): 1650-1670.

Shefali Shukla, Anantpreet K. Sood, Kartika Goyal, Ambika Singh, Vaidehi Sharma, Neha Guliya, Shikha Gulati and Sanjay Kumar*


DOI: 10.2174/1871520620999201124212840




Editor-in-Chief

graphic
Simone Carradori
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
Chieti
(Italy)
Biography
View Full Editorial Board

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Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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