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Protein & Peptide Letters

Volume 28, 12 Issues, 2021
ISSN: 1875-5305 (Online)
ISSN: 0929-8665 (Print)
This journal supports open access

Aims & Scope

Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations.

Protein & Peptide Letters focuses on:

  • Structure Studies
  • Advances in Recombinant Expression
  • Drug Design
  • Chemical Synthesis
  • Function
  • Pharmacology
  • Enzymology
  • Conformational Analysis
  • Immunology
  • Biotechnology
  • Protein Engineering
  • Protein Folding
  • Sequencing
  • Molecular Recognition
  • Purification and Analysis

Protein & Peptide Letters


Volume 28


Number 6

Review Article (Mini-Review)

Evolution and Structure of API5 and Its Roles in Anti-Apoptosis

, 28(6): 612 - 622

Meishan Chen, Weiwei Wu, Dongwu Liu, Yanhua Lv, Hongkuan Deng, Sijia Gao, Yaqi Gu, Mujie Huang, Xiao Guo, Baohua Liu, Bosheng Zhao and Qiuxiang Pang*

DOI: 10.2174/0929866527999201211195551

Review Article

Research Article

N-Terminally Added Tag Selectively Enhances Heterologous Expression of VacA Cytotoxin Variants from Helicobacter pylori

, 28(6): 643 - 650

Aung Khine Linn, Nitchakan Samainukul, Somsri Sakdee, Chonthicha Butnampetch, Hui-Chun Li, Chanan Angsuthanasombat* and Gerd Katzenmeier

DOI: 10.2174/0929866527666201112122831

Research Article

Evaluation of the In Vivo Acute Toxicity and In Vitro Hemolytic and Immunomodulatory Activities of the Moringa oleifera Flower Trypsin Inhibitor (MoFTI)

, 28(6): 665 - 674

Leydianne Leite de Siqueira Patriota, Dayane Kelly Dias do Nascimento Santos, Bárbara Rafaela da Silva Barros, Lethícia Maria de Souza Aguiar, Yasmym Araújo Silva, Angela Caroline Lima Amorim dos Santos, Mariana Gama e Silva, Luana Cassandra Breitenbach Barroso Coelho, Patrícia Maria Guedes Paiva, Emmanuel Viana Pontual, Cristiane Moutinho Lagos de Melo, Rosemairy Luciane Mendes and Thiago Henrique Napoleáo*

DOI: 10.2174/0929866527999201113105858

Research Article

Protein & Peptide Letters, Volume 28 (2021) - Number 7

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Database Study on the Expression and Purification of Membrane Proteins

Chen-Yan china Zhang *, Shi-Qi Zhao , Shi-Long Zhang , Li-Heng Luo, Ding-Chang Liu, Wei-Hang Ding, Dong-Jie Fu, Xu-Dong Deng and Da-Chuan Yin

DOI: 10.2174/0929866528666210415120234
View Abstract View on PubMed

Strategy for the Enrichment of Protein Biomarkers from Diverse Bacterial Select Agents

Sasikumar Sabna, Dev Vrat Kamboj, Ravi Bhushan Kumar, Prabhakar Babele, Sakshi Rajoria, Mahendra Kumar Gupta and Syed Imteyaz Alam*

DOI: 10.2174/0929866528666210405160131
View Abstract View on PubMed

Genome-Wide Association Study for Major Biofuel Traits in Sorghum Using Minicore Collection

Laavanya Rayaprolu, Sivasubramani Selvanayagam, D. Manohar Rao, Rajeev Gupta, Roma Rani Das, Abhishek Rathore, Prasad Gandham, Usha Kiranmayee KNS, Santosh P. Deshpande* and Ashok Kumar Are*

DOI: 10.2174/0929866528666210215141243
View Abstract View on PubMed

Potential Application of CRISPR/Cas9 System to Engineer Abiotic Stress Tolerance in Plants

Temoor Ahmed, Muhammad Shahid*, Muhammad Noman, Sher Muhammad, Muhammad Tahir ul Qamar, Md. Arshad Ali, Awais Maqsood, Rahila Hafeez, Solabomi Olaitan Ogunyemi and Bin Li

DOI: 10.2174/0929866528666210218220138
View Abstract View on PubMed

Abstracts Ahead of Print

Lactococcus lactis Administration Modulates IgE and IL-4 Production and Promotes Enterobacteria Growth in the Gut from Ethanol-Intake Mice

Letícia Antunes Athayde, Sarah Leão Fiorini de Aguiar, Mariana Camila Gonçalves Miranda, Ronize Viviane Jorge Brito, Ana Maria Caetano de Faria, Sergio Avelino Mota Nobre and Mariléia Chaves Andrade*

DOI: 10.2174/0929866528666210727102019
View Abstract

pH-sensitive polymer-based carriers as a useful approach for oral delivery of therapeutic protein: A review

Maryam Shamseddini lori, Mandana Ohadi, Mohammad Amin Raeisi Estabragh, Sepehr Afsharipour, Ibrahim M Banat and Gholamreza Dehghannoudeh*

DOI: 10.2174/0929866528666210720142841
View Abstract

Encapsulation of Purified Pediocin of Pediococcus Pentosaceus into Liposome Based Nanovesicles and its Antilisterial Effect

Vaithiyanathan Suganthi, Selvarajan Ethiraj, Nivetha Anbalagan, Jannatul Firdous Siddique and Mohanasrinivasan Vaithilingam*

DOI: 10.2174/2666255814666210617145058
View Abstract

Serum HSP90-Alpha and Oral Squamous Cell Carcinoma : A Prospective Biomarker

Muhammad Usman, Amber Ilyas, Basir Syed, Zehra Hashim, Aftab Ahmed and Shamshad Zarina*

DOI: 10.2174/0929866528666210616112539
View Abstract

Published Contents

Editor's Choice

Plant Bioactive Peptides: Current Status and Prospects Towards Use on Human Health

, 2021; 28(6): 623 - 642

Tsun-Thai Chai*, Kah-Yaw Ee, D. Thirumal Kumar, Fazilah Abd Manan and Fai-Chu Wong

DOI: 10.2174/0929866527999201211195936

Phosphorylated and O-GlcNAc Modified IRS-1 (Ser1101) and -2 (Ser1149) Contribute to Human Diabetes Type II

, 2021; 28(3): 333 - 339

Afshan Kaleem*, Sabahat Javed, Nayab Rehman, Roheena Abdullah, Mehwish Iqtedar, Mohammad Nauman Aftab, Daniel C. Hoessli and Ikram-Ul Haq

DOI: 10.2174/0929866527666200813210407

Expression, Solubilization, Refolding and Final Purification of Recombinant Proteins as Expressed in the form of “Classical Inclusion Bodies” in E. coli

, 2021; 28(2): 122 - 130

Mohammad Sadegh Hashemzadeh*, Mozafar Mohammadi, Hadi Esmaeili Gouvarchin Ghaleh, Mojtaba Sharti, Ali Choopani and Amulya Kumar Panda

DOI: 10.2174/0929866527999200729182831

Establishment of Method for the Determination of Aggregated α-Synuclein in DLB Patient Using RT-QuIC Assay

, 2021; 28(1): 115 - 120

Seok-Joo Park, Yun-Jung Lee, Jeong-Ho Park, Hyoung-Tae Jin, Myoung-Ju Choi, Cha-Gyun Jung, Hiroyasu Akatsu, Eun-Kyoung Choi and Yong-Sun Kim*

DOI: 10.2174/0929866527666200420105352

Adipokines: A Rainbow of Proteins with Metabolic and Endocrine Functions

, 2020; 27(12): 1204 - 1230

Sara Parrettini, Massimiliano Cavallo, Francesco Gaggia, Riccardo Calafiore and Giovanni Luca*

DOI: 10.2174/0929866527666200505214555

Development of Cell Penetrating Peptides for Effective Delivery of Recombinant Factors into Target Cells

, 2020; 27(11): 1092 - 1101

Ubashini Vijakumaran, Fazlina Nordin*, Zariyantey Abdul Hamid, Maha Abdullah and Tye Gee Jun

DOI: 10.2174/0929866527666200525164135

Open Access Articles

Expression, Purification and Characterization of Recombinant Human Coagulation Factor XIIIa in Pichia Pastoris

, 2021; 28(1): 55 - 62

Linyan Cheng, Ting Zhang, Yuchang Fei, Hao Shen, Hui Huang, Jin Chen, Bin Xu* and Jian Xu*

Why Do We Need New Markers for Male Hypogonadism and How Seminal Proteomics Might Solve the Problem?

, 2020; 27(12): 1186 - 1191

Giuseppe Grande*, Domenico Milardi, Silvia Baroni, Andrea Urbani and Alfredo Pontecorvi

The Renin-Angiotensin System and the Cerebrovascular Diseases: Experimental and Clinical Evidence

, 2020; 27(6): 463 - 475

Lucas M. Kangussu, Lucas Alexandre Santos Marzano, Cássio Ferraz Souza, Carolina Couy Dantas, Aline Silva Miranda and Ana Cristina Simões e Silva*

miR-146a-5p Regulated Cell Proliferation and Apoptosis by Targeting SMAD3 and SMAD4

, 2020; 27(5): 411 - 418

Meiyu Qiu, Tao Li, Binhu Wang, Hongbin Gong and Tao Huang*

NMAAP1 Maintains M1 Phenotype in Macrophages Through Binding to IP3R and Activating Calcium-related Signaling Pathways

, 2019; 26(10): 751 - 757

Qihui Liu, Pei Zhu, Shanshan Liu, Mengyan Tang, Yuanxin Wang, Yuan Tian, Zheng Jin, Dong Li and Dongmei Yan*

Differential S-acylation of Enveloped Viruses

, 2019; 26(8): 588 - 600

Larisa V. Kordyukova*, Marina V. Serebryakova, Vladislav V. Khrustalev and Michael Veit

Little Antimicrobial Peptides with Big Therapeutic Roles

, 2019; 26(8): 564 - 578

Dan Zhang, Yu He, Yang Ye, Yanni Ma, Peng Zhang, Hongxia Zhu, Ningzhi Xu and Shufang Liang*

Dimerization of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity

, 2019; 26(2): 98 - 107

Esteban N. Lorenzon, Julia P. Piccoli, Norival A. Santos-Filho and Eduardo M. Cilli*

Most Cited Articles

Review Article (Mini-Review)

Mini review on antimicrobial peptides, sources, mechanism and recent applications

, 2020; 27(1): 4-16.

Jaspreet Kaur Boparai and Pushpender Kumar Sharma*

DOI: 10.2174/0929866526666190822165812

Review Article

Clinical applications of antimicrobial peptides (AMPs): Where do we stand now?

, 2020; 27(2): 120-134.

Mithoor Divyashree, Madhu K. Mani, Dhanasekhar Reddy, Ranjith Kumavath*, Preetam Ghosh, Vasco Azevedo and Debmalya Barh*

DOI: 10.2174/0929866526666190925152957

Review Article

Leucine rich repeat proteins: Sequences, mutations, structures and diseases

, 2019; 26(2): 108-131.

Norio Matsushima*, Shintaro Takatsuka, Hiroki Miyashita and Robert H. Kretsinger

DOI: 10.2174/0929866526666181208170027

Research Article

Characterizing the binding of angiotensin converting enzyme i inhibitory peptide to human hemoglobin: Influence of electromagnetic fields

, 2020; 27(10): 1007-1021.

Farzaneh Sadeghzadeh, Amir Arsalan Entezari, Kiana Behzadian, Kimia Habibi, Zeinab Amiri-Tehranizadeh*, Ahmad Asoodeh, Mohammad Reza Saberi and Jamshidkhan Chamani*

DOI: 10.2174/1871530320666200425203636

Research Article

Lytic polysaccharide monooxygenase from aspergillus fumigatus can improve enzymatic cocktail activity during sugarcane bagasse hydrolysis

, 2019; 26(5): 377-385.

Paula Fagundes de Gouvêa, Luis Eduardo Gerolamo, Aline Vianna Bernardi, Lucas Matheus Soares Pereira, Sergio Akira Uyemura and Taisa Magnani Dinamarco*

DOI: 10.2174/0929866526666190228163629

Review Article

Dimerization of antimicrobial peptides: A promising strategy to enhance antimicrobial peptide activity

, 2019; 26(2): 98-107.

Esteban N. Lorenzon, Julia P. Piccoli, Norival A. Santos-Filho and Eduardo M. Cilli*

DOI: 10.2174/0929866526666190102125304

Review Article

The renin-angiotensin system and the cerebrovascular diseases: Experimental and clinical evidence

, 2020; 27(6): 463-475.

Lucas M. Kangussu, Lucas Alexandre Santos Marzano, Cássio Ferraz Souza, Carolina Couy Dantas, Aline Silva Miranda and Ana Cristina Simões e Silva*

DOI: 10.2174/0929866527666191218091823

Research Article

Applicability of instability index for in vitro protein stability prediction

, 2019; 26(5): 339-347.

Dilani G. Gamage, Ajith Gunaratne, Gopal R. Periyannan* and Timothy G. Russell

DOI: 10.2174/0929866526666190228144219

Research Article

Influence of calcium ions on the thermal characteristics of α-amylase from thermophilic anoxybacillus sp. gxs-bl

, 2019; 26(2): 148-157.

Si-Ming Liao , Ge Liang , Jing Zhu , Bo Lu , Li-Xin Peng , Qing-Yan Wang, Yu-Tuo Wei , Guo-Ping Zhou* and Ri-Bo Huang *

DOI: 10.2174/0929866526666190116162958

Most Accessed Articles

Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma

, 2021; 28(7): 735-749.

Guilherme Machado Xavier, André Luiz Sena Guimarães*, Carlos Alberto de Carvalho Fraga*, Talita Antunes Guimarães, Marcela Gonçalves de Souza, Kimberly Marie Jones and Lucyana Conceição Farias

DOI: 10.2174/0929866527999201209221012

Lactococcus lactis and Resveratrol Decrease Body Weight and Increase Benefic Gastrointestinal Microbiota in Mice

, 2021; 28(7): 761-768.

Keila Lopes Mendes, Deborah de Farias Lelis, Letícia Antunes Athayde Souza, Ronize Viviane Jorge Brito, Mariléia Chaves Andrade, Sérgio Avelino Mota Nobre, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Juliana Pinto de Lima, Aline M. Hilzendeger and Sérgio Henrique Sousa Santos*

DOI: 10.2174/0929866527999201209214850

Site-Selective, Chemical Modification of Protein at Aromatic Side Chain and Their Emergent Applications

, 2021; 28(7): 788-808.

Arnab Chowdhury, Saurav Chatterjee, Akumlong Pongen, Dhanjit Sarania, Nitesh Mani Tripathi and Anupam Bandyopadhyay*

DOI: 10.2174/0929866528666210129152535

Plant Terpenes on Treating Cardiovascular and Metabolic Disease: A Review

, 2021; 28(7): 750-760.

Janaína Ribeiro Oliveira, Guilherme Henrique Mendes Ribeiro, Luiz Fernando Rezende and Rodrigo Araújo Fraga-Silva*

DOI: 10.2174/0929866528999210128210145

Hepatotoxic Effect of Lafoensia pacari A. St. Hil. (Lythraceae) on a Diet-Induced Obese Mice Model

, 2021; 28(7): 781-787.

Natália Gonçalves Ribeiro, Fabio Ribeiro dos Santos, Janaína Ribeiro Oliveira, Amanda Souto Machado, Deborah de Faria Lelis, Alfredo Maurício Batista de Paula, André Luis Sena Guimarães, Lucyana Conceição Farias and Sérgio Henrique Sousa Santos*

DOI: 10.2174/0929866528666210127151803

Hydroalcoholic Extract of Solanum lycocarpum A. St. Hil. (Solanaceae) Leaves Improves Alloxan-Induced Diabetes Complications in Mice

, 2021; 28(7): 769-780.

Victor Hugo Dantas Guimarães, Jéssica Nayara Basilio Silva, Daniela Fernanda de Freitas, Otávio Cardoso Filho, Luiz Henrique da Silveira, Barbhara Mota Marinho, Alfredo Maurício Batista de Paula, Geraldo Aclécio Melo and Sérgio Henrique Sousa Santos*

DOI: 10.2174/0929866528999210128205817

Allergen Homologues, Pathogenesis-Related 1, Polygalacturonase, and Pectin Methyl Esterase from a Japanese Hop

, 2021; 28(4): 362-371.

Seok Woo Jang, Kyoung Yong Jeong*, Ji Eun Yuk, Jongsun Lee, Kyung Hee Park and Jung-Won Park

DOI: 10.2174/0929866527666200813201924

CRISPR-Cas9, A Promising Therapeutic Tool for Cancer Therapy: A Review

, 2020; 27(10): 931-944.

Fatima Akram*, Ikram ul Haq, Zeeshan Ahmed, Hamza Khan and Muhammad Shrafat Ali

DOI: 10.2174/0929866527666200407112432

Evolution and Structure of API5 and Its Roles in Anti-Apoptosis

, 2021; 28(6): 612-622.

Meishan Chen, Weiwei Wu, Dongwu Liu, Yanhua Lv, Hongkuan Deng, Sijia Gao, Yaqi Gu, Mujie Huang, Xiao Guo, Baohua Liu, Bosheng Zhao and Qiuxiang Pang*

DOI: 10.2174/0929866527999201211195551


Prof. Ben M. Dunn
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
Gainesville, FL
Email: bdunn@ufl.eduBiography
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Journal History

Protein & Peptide Letters was introduced in 2001 with the assistance of Dr. Ben M. Dunn, who is the current Editor-in-Chief serving since 2001.
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