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Medicinal Chemistry

Volume 17, 10 Issues, 2021
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

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Volume 17

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Number 3



Review Article

Features, Pharmacological Chemistry, Molecular Mechanism and Health Benefits of Lemon

, 17(3): 187 - 202

Nitika Singh, Nagendra Sastry Yarla, Nikhat Jamal Siddiqi, Maria de Lourdes Pereira and Bechan Sharma*


DOI: 10.2174/1573406416666200909104050




Research Article

Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study

, 17(3): 216 - 229

Uma Krithika, Prabhakaran Prabitha, Subhankar P. Mandal, Sivamani Yuvaraj, Durai Priya, Ashish D. Wadhwani and Bommenahally Ravanappa Prashantha Kumar*


DOI: 10.2174/1573406416666200610191002


Research Article

Structure-Activity Relationship Study of an Alkynylphosphonate and Vynilphosphonate Analogues of Calcitriol

, 17(3): 230 - 246

Silvina M. Grioli, Eliana N. Alonso, Evangelina Mascaró, Santiago A. Stabile, María J. Ferronato, Mario A. Quevedo, Gabriel Radivoy, María M. Facchinetti, Cristian A. Vitale and Alejandro C. Curino*


DOI: 10.2174/1573406416999200818145115




Research Article

Novel Coumarin Containing Dithiocarbamate Derivatives as Potent α-Glucosidase Inhibitors for Management of Type 2 Diabetes

, 17(3): 264 - 272

Marjan Mollazadeh, Maryam Mohammadi-Khanaposhtani, Yousef Valizadeh, Afsaneh Zonouzi, Mohammad A. Faramarzi, Mitra Kiani, Mahmood Biglar, Bagher Larijani, Haleh Hamedifar , Mohammad Mahdavi * and Mir Hamed Hajimiri*


DOI: 10.2174/1573406416666200826101205


Research Article

Molecular Docking Studies Reveal Rhein from rhubarb (Rheum rhabarbarum) as a Putative Inhibitor of ATP-binding Cassette Super-family G member 2

, 17(3): 273 - 288

Muhammad Saad Khan, Bareera Mehmood, Qudsia Yousafi, Shabana Bibi, Sahar Fazal, Shahzad Saleem, Muhammad Wasim Sajid, Awais Ihsan, Muhammad Azhar* and Mohammad Amjad Kamal*


DOI: 10.2174/1573406416666191219143232


Research Article

New Oxazolidines Inhibit the Secretion of IFN-γ and IL-17 by PBMCS from Moderate to Severe Asthmatic Patients

, 17(3): 289 - 297

Renata Virgínia Cavalcanti Santos, Eudes Gustavo Constantino Cunha, Gabriela Souto Vieira de Mello, José Ângelo Rizzo, Jamerson Ferreira de Oliveira, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta and Moacyr Jesus Barreto de Melo Rêgo*


DOI: 10.2174/1573406416666200910151950


Medicinal Chemistry, Volume 17 (2021) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Medicinal Chemistry, Volume 17 (2021) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Medicinal Chemistry, Volume 17 (2021) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Medicinal Chemistry, Volume 17 (2021) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies


Thaise Martins, Vera L.M. Silva, Artur M.S. Silva, José L.F.C. Lima, Eduarda Fernandes* and Daniela Ribeiro*


DOI: 10.2174/1573406417666201230093207
View Abstract View on PubMed




Synthesis and Biological Evaluation of 4-Aminoantipyrine Analogues


Houwei Ren, Premnath Dhanaraj, Israel V M V Enoch*, Mosae Selvakumar Paulraj and Indiraleka M


DOI: 10.2174/1573406416666201106105303
View Abstract View on PubMed



Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives


Digamber S. Pawar, Vasant V. Chabukswar*, Savita R. Tapase, Kisan M. Kodam, Anurudhha Chabukswar, Pravin B. Adhav, Balasaheb B. Diwate, Sunita Salunke Gawali, Sabrina Dallavalle and Swati C. Jagdale


DOI: 10.2174/1573406416666200817155056
View Abstract View on PubMed




Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc


Raül Agut, Eva Falomir*, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Fernando Díaz, Fernando Josa-Prado and J. Alberto Marco


DOI: 10.2174/1573406416666201120103913
View Abstract View on PubMed


Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry


Vitor F. Ferreira, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G. S. Lima and Fernando de C. da Silva*


DOI: 10.2174/1573406416666201106104756
View Abstract View on PubMed


Abstracts Ahead of Print




Synthesis, Antileishmanial Activity and in silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes


Thiago M. de Aquino*, Paulo H. B. França, Érica E. E. S. Rodrigues, Igor J. S. Nascimento, Paulo F. S. Santos-Júnior, Pedro G. V. Aquino, Mariana S. Santos, Aline C. Queiroz, Morgana V. Araújo, Magna S. Alexandre-Moreira, Raiza R. L. Rodrigues, Klinger A. F. Rodrigues, Johnnatan D. Freitas, Jacques Bricard, Mario R. Meneghetti, Jean-Jacques Bourguignon, Martine Schmitt, Edeildo F. da Silva-Júnior* and João X. de Araújo-Júnior


DOI: 10.2174/1573406417666210216154428
View Abstract






In vitro, in vivo and in silico Antihyperglycemic Activity of Some Semi-synthetic Phytol Derivatives.


Harish C. Upadhyay, Akansha Mishra, Jyotsana Pandey, Pooja Sharma, Akhilesh K. Tamrakar, Arvind K. Srivastava, Feroz Khan and Santosh K. Srivastava*


DOI: 10.2174/1573406417666201216124018
View Abstract



Published Contents

Open Access Articles


Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy

, 2021; 17(2): 97 - 120

Shabana Bibi, Yuan-Bing Wang, De-Xiang Tang, Mohammad Amjad Kamal and Hong Yu*





Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles

Research Article

iATP: A sequence based method for identifying anti-tubercular peptides

, 2020; 16(5): 620-625.

Wei Chen*, Pengmian Feng and Fulei Nie


DOI: 10.2174/1573406415666191002152441


Review Article

Thiazole compounds as antiviral agents: An update

, 2020; 16(1): 4-23.

Inder P. Singh*, Shiv Gupta and Sanjay Kumar


DOI: 10.2174/1573406415666190614101253


Research Article

The assessment of interleukin-18 on the risk of coronary heart disease

, 2020; 16(5): 626-634.

Weiju Sun, Ying Han, Shuo Yang, He Zhuang, Jingwen Zhang, Liang Cheng* and Lu Fu*


DOI: 10.2174/1573406415666191004115128



Review Article

An increasing role of polyphenols as novel therapeutics for alzheimer’s: A review

, 2020; 16(8): 1007-1021.

Nasiara Karim, Haroon Khan*, Imran Khan, Ouyang Guo, Eduardo Sobarzo-Sánchez, Luca Rastrelli and Mohammad A. Kamal


DOI: 10.2174/1573406415666191105154407


Research Article

The introduction of hydrazone, hydrazide, or azepane moieties to the triterpenoid core enhances an activity against m. Tuberculosis

, 2021; 17(2): 134-145.

Oxana B. Kazakova*, Natalya I. Medvedeva, Irina E. Smirnova, Tatyana V. Lopatina and Alexander V. Veselovsky


DOI: 10.2174/1573406416666200115161700




Research Article

Antiglycation activity of triazole schiff’s bases against fructose-mediated glycation: In vitro and in silico study

, 2020; 16(4): 575-591.

Muniza Shaikh, Salman Siddiqui, Humaira Zafar, Uzma Naqeeb, Fakiha Subzwari, Rehan Imad, Khalid M. Khan and Muhammad I. Choudhary*


DOI: 10.2174/1573406415666190212105718


Research Article

Curcumin-based antioxidant and glycohydrolase inhibitor compounds: Synthesis and in vitro appraisal of the dual activity against diabetes

, 2021; 17(7): 677-698.

Sajjad Esmaeili, Nazanin Ghobadi, Donya Nazari, Alireza Pourhossein, Hassan Rasouli, Hadi Adibi* and Reza Khodarahmi*


DOI: 10.2174/1573406416666200506083718



Review Article

Denouement of chemicals on amyotrophic lateral sclerosis: Is green chemistry the answer

, 2020; 16(8): 1058-1068.

Faizana Fayaz, Faheem H. Pottoo, Sadat Shafi, Mushtaq A. Wani, Sharad Wakode* and Anjali Sharma


DOI: 10.2174/1573406416666200413111330


Review Article

Therapeutic effects of ziziphus jujuba mill. Fruit in traditional and modern medicine: A review

, 2020; 16(8): 1069-1088.

Zahra Sobhani , Sara Nikoofal-Sahlabadi, Mohammad S. Amiri, Mahin Ramezani, Seyed A. Emami* and Amirhossein Sahebkar*


DOI: 10.2174/1573406415666191031143553


Review Article

Current insights of inhibitors of p38 mitogen-activated protein kinase in inflammation

, 2021; 17(6): 555-575.

Archana Awasthi, Mantripragada Bhagavan Raju and Md. Azizur Rahman*


DOI: 10.2174/1573406416666200227122849


Research Article

The antioxidant, anticarcinogenic and antimicrobial properties of verbascum thapsus l.

, 2020; 16(7): 991-995.

Saman Mahdavi*, Morteza Amiradalat, Marzieh Babashpour, Hosein Sheikhlooei and Mohammad Miransari


DOI: 10.2174/1573406415666190828155951



Most Accessed Articles


Methoxychalcones: Effect of Methoxyl Group on the Antifungal, Antibacterial and Antiproliferative Activities

, 2020; 16(7): 881-891.

Beatriz C. Marques, Mariana B. Santos, Daiane B. Anselmo, Diego A. Monteiro, Eleni Gomes, Marilia F.C. Saiki, Paula Rahal, Pedro L. Rosalen, Janaina C.O. Sardi and Luis O. Regasini*


DOI: 10.2174/1573406415666190724145158


Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

, 2020; 16(6): 774-783.

Mayara S.S. do Nascimento, Vitória R.F. Câmara, Juliana S. da Costa, Juliana M.C. Barbosa, Alessandra S.M. Lins, Kelly Salomão, Solange L. de Castro, Samir A. Carvalho, Edson F. da Silva and Carlos A.M. Fraga*


DOI: 10.2174/1573406415666190627103013




Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study

, 2021; 17(3): 216-229.

Uma Krithika, Prabhakaran Prabitha, Subhankar P. Mandal, Sivamani Yuvaraj, Durai Priya, Ashish D. Wadhwani and Bommenahally Ravanappa Prashantha Kumar*


DOI: 10.2174/1573406416666200610191002



2-Mercapto Benzothiazole Derivatives: As Potential Leads for the Diabetic Management

, 2020; 16(6): 826-840.

Saeed Ullah, Salma Mirza, Uzma Salar, Shafqat Hussain, Kulsoom Javaid, Khalid M. Khan*, Ruqaiya Khalil, Atia-tul-Wahab, Zaheer Ul-Haq, Shahnaz Perveen and Muhammad I. Choudhary


DOI: 10.2174/1573406415666190612153150


New Insights Towards 1,4-Benzodiazepines from Curcumin. Design, Synthesis and Antimicrobial Activities

, 2020; 16(8): 1112-1123.

Othman Hamed*, Oswa Fares, Shaima Taleeb, Ghaleb Adwan, Haythem Saadeh, Shehdeh Jodeh and Manuel Algarra


DOI: 10.2174/1573406415666190826160251



Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

, 2020; 16(6): 784-795.

Krisnna M.A. Alves, Fábio José Bonfim Cardoso, Kathia M. Honorio and Fábio A. de Molfetta*


DOI: 10.2174/1573406415666190712111139





Foreword

, 2021; 17(1): 1-1.

Dimitra Hadjipavlou-Litina


DOI: 10.2174/157340641701201204091649




Editor-in-Chief

graphic
Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
(Greece)
Biography
View Full Editorial Board

Nobel Laureate on Editorial Board

graphic
Prof. Ferid Murad
(USA)

COPE Compliant

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Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.

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