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Medicinal Chemistry

Volume 17, 10 Issues, 2021
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry


Volume 17


Number 3

Review Article

Features, Pharmacological Chemistry, Molecular Mechanism and Health Benefits of Lemon

, 17(3): 187 - 202

Nitika Singh, Nagendra Sastry Yarla, Nikhat Jamal Siddiqi, Maria de Lourdes Pereira and Bechan Sharma*

DOI: 10.2174/1573406416666200909104050

Research Article

Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study

, 17(3): 216 - 229

Uma Krithika, Prabhakaran Prabitha, Subhankar P. Mandal, Sivamani Yuvaraj, Durai Priya, Ashish D. Wadhwani and Bommenahally Ravanappa Prashantha Kumar*

DOI: 10.2174/1573406416666200610191002

Research Article

Structure-Activity Relationship Study of an Alkynylphosphonate and Vynilphosphonate Analogues of Calcitriol

, 17(3): 230 - 246

Silvina M. Grioli, Eliana N. Alonso, Evangelina Mascaró, Santiago A. Stabile, María J. Ferronato, Mario A. Quevedo, Gabriel Radivoy, María M. Facchinetti, Cristian A. Vitale and Alejandro C. Curino*

DOI: 10.2174/1573406416999200818145115

Research Article

Novel Coumarin Containing Dithiocarbamate Derivatives as Potent α-Glucosidase Inhibitors for Management of Type 2 Diabetes

, 17(3): 264 - 272

Marjan Mollazadeh, Maryam Mohammadi-Khanaposhtani, Yousef Valizadeh, Afsaneh Zonouzi, Mohammad A. Faramarzi, Mitra Kiani, Mahmood Biglar, Bagher Larijani, Haleh Hamedifar , Mohammad Mahdavi * and Mir Hamed Hajimiri*

DOI: 10.2174/1573406416666200826101205

Research Article

Molecular Docking Studies Reveal Rhein from rhubarb (Rheum rhabarbarum) as a Putative Inhibitor of ATP-binding Cassette Super-family G member 2

, 17(3): 273 - 288

Muhammad Saad Khan, Bareera Mehmood, Qudsia Yousafi, Shabana Bibi, Sahar Fazal, Shahzad Saleem, Muhammad Wasim Sajid, Awais Ihsan, Muhammad Azhar* and Mohammad Amjad Kamal*

DOI: 10.2174/1573406416666191219143232

Research Article

New Oxazolidines Inhibit the Secretion of IFN-γ and IL-17 by PBMCS from Moderate to Severe Asthmatic Patients

, 17(3): 289 - 297

Renata Virgínia Cavalcanti Santos, Eudes Gustavo Constantino Cunha, Gabriela Souto Vieira de Mello, José Ângelo Rizzo, Jamerson Ferreira de Oliveira, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta and Moacyr Jesus Barreto de Melo Rêgo*

DOI: 10.2174/1573406416666200910151950

Medicinal Chemistry, Volume 17 (2021) - Number 7

This issue is in progress but contains articles that are final and fully citable.

Medicinal Chemistry, Volume 17 (2021) - Number 6

This issue is in progress but contains articles that are final and fully citable.

Medicinal Chemistry, Volume 17 (2021) - Number 5

This issue is in progress but contains articles that are final and fully citable.

Medicinal Chemistry, Volume 17 (2021) - Number 4

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies

Thaise Martins, Vera L.M. Silva, Artur M.S. Silva, José L.F.C. Lima, Eduarda Fernandes* and Daniela Ribeiro*

DOI: 10.2174/1573406417666201230093207
View Abstract View on PubMed

Synthesis and Biological Evaluation of 4-Aminoantipyrine Analogues

Houwei Ren, Premnath Dhanaraj, Israel V M V Enoch*, Mosae Selvakumar Paulraj and Indiraleka M

DOI: 10.2174/1573406416666201106105303
View Abstract View on PubMed

Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives

Digamber S. Pawar, Vasant V. Chabukswar*, Savita R. Tapase, Kisan M. Kodam, Anurudhha Chabukswar, Pravin B. Adhav, Balasaheb B. Diwate, Sunita Salunke Gawali, Sabrina Dallavalle and Swati C. Jagdale

DOI: 10.2174/1573406416666200817155056
View Abstract View on PubMed

Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc

Raül Agut, Eva Falomir*, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Fernando Díaz, Fernando Josa-Prado and J. Alberto Marco

DOI: 10.2174/1573406416666201120103913
View Abstract View on PubMed

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Vitor F. Ferreira, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G. S. Lima and Fernando de C. da Silva*

DOI: 10.2174/1573406416666201106104756
View Abstract View on PubMed

Abstracts Ahead of Print

Synthesis, Antileishmanial Activity and in silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes

Thiago M. de Aquino*, Paulo H. B. França, Érica E. E. S. Rodrigues, Igor J. S. Nascimento, Paulo F. S. Santos-Júnior, Pedro G. V. Aquino, Mariana S. Santos, Aline C. Queiroz, Morgana V. Araújo, Magna S. Alexandre-Moreira, Raiza R. L. Rodrigues, Klinger A. F. Rodrigues, Johnnatan D. Freitas, Jacques Bricard, Mario R. Meneghetti, Jean-Jacques Bourguignon, Martine Schmitt, Edeildo F. da Silva-Júnior* and João X. de Araújo-Júnior

DOI: 10.2174/1573406417666210216154428
View Abstract

In vitro, in vivo and in silico Antihyperglycemic Activity of Some Semi-synthetic Phytol Derivatives.

Harish C. Upadhyay, Akansha Mishra, Jyotsana Pandey, Pooja Sharma, Akhilesh K. Tamrakar, Arvind K. Srivastava, Feroz Khan and Santosh K. Srivastava*

DOI: 10.2174/1573406417666201216124018
View Abstract

Published Contents

Open Access Articles

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy

, 2021; 17(2): 97 - 120

Shabana Bibi, Yuan-Bing Wang, De-Xiang Tang, Mohammad Amjad Kamal and Hong Yu*

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino

IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*

Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino

Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun

Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy

Most Cited Articles

Research Article

iATP: A sequence based method for identifying anti-tubercular peptides

, 2020; 16(5): 620-625.

Wei Chen*, Pengmian Feng and Fulei Nie

DOI: 10.2174/1573406415666191002152441

Review Article

Thiazole compounds as antiviral agents: An update

, 2020; 16(1): 4-23.

Inder P. Singh*, Shiv Gupta and Sanjay Kumar

DOI: 10.2174/1573406415666190614101253

Research Article

The assessment of interleukin-18 on the risk of coronary heart disease

, 2020; 16(5): 626-634.

Weiju Sun, Ying Han, Shuo Yang, He Zhuang, Jingwen Zhang, Liang Cheng* and Lu Fu*

DOI: 10.2174/1573406415666191004115128

Review Article

An increasing role of polyphenols as novel therapeutics for alzheimer’s: A review

, 2020; 16(8): 1007-1021.

Nasiara Karim, Haroon Khan*, Imran Khan, Ouyang Guo, Eduardo Sobarzo-Sánchez, Luca Rastrelli and Mohammad A. Kamal

DOI: 10.2174/1573406415666191105154407

Research Article

The introduction of hydrazone, hydrazide, or azepane moieties to the triterpenoid core enhances an activity against m. Tuberculosis

, 2021; 17(2): 134-145.

Oxana B. Kazakova*, Natalya I. Medvedeva, Irina E. Smirnova, Tatyana V. Lopatina and Alexander V. Veselovsky

DOI: 10.2174/1573406416666200115161700

Research Article

Antiglycation activity of triazole schiff’s bases against fructose-mediated glycation: In vitro and in silico study

, 2020; 16(4): 575-591.

Muniza Shaikh, Salman Siddiqui, Humaira Zafar, Uzma Naqeeb, Fakiha Subzwari, Rehan Imad, Khalid M. Khan and Muhammad I. Choudhary*

DOI: 10.2174/1573406415666190212105718

Research Article

Curcumin-based antioxidant and glycohydrolase inhibitor compounds: Synthesis and in vitro appraisal of the dual activity against diabetes

, 2021; 17(7): 677-698.

Sajjad Esmaeili, Nazanin Ghobadi, Donya Nazari, Alireza Pourhossein, Hassan Rasouli, Hadi Adibi* and Reza Khodarahmi*

DOI: 10.2174/1573406416666200506083718

Review Article

Denouement of chemicals on amyotrophic lateral sclerosis: Is green chemistry the answer

, 2020; 16(8): 1058-1068.

Faizana Fayaz, Faheem H. Pottoo, Sadat Shafi, Mushtaq A. Wani, Sharad Wakode* and Anjali Sharma

DOI: 10.2174/1573406416666200413111330

Review Article

Therapeutic effects of ziziphus jujuba mill. Fruit in traditional and modern medicine: A review

, 2020; 16(8): 1069-1088.

Zahra Sobhani , Sara Nikoofal-Sahlabadi, Mohammad S. Amiri, Mahin Ramezani, Seyed A. Emami* and Amirhossein Sahebkar*

DOI: 10.2174/1573406415666191031143553

Review Article

Current insights of inhibitors of p38 mitogen-activated protein kinase in inflammation

, 2021; 17(6): 555-575.

Archana Awasthi, Mantripragada Bhagavan Raju and Md. Azizur Rahman*

DOI: 10.2174/1573406416666200227122849

Research Article

The antioxidant, anticarcinogenic and antimicrobial properties of verbascum thapsus l.

, 2020; 16(7): 991-995.

Saman Mahdavi*, Morteza Amiradalat, Marzieh Babashpour, Hosein Sheikhlooei and Mohammad Miransari

DOI: 10.2174/1573406415666190828155951

Most Accessed Articles

Methoxychalcones: Effect of Methoxyl Group on the Antifungal, Antibacterial and Antiproliferative Activities

, 2020; 16(7): 881-891.

Beatriz C. Marques, Mariana B. Santos, Daiane B. Anselmo, Diego A. Monteiro, Eleni Gomes, Marilia F.C. Saiki, Paula Rahal, Pedro L. Rosalen, Janaina C.O. Sardi and Luis O. Regasini*

DOI: 10.2174/1573406415666190724145158

Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

, 2020; 16(6): 774-783.

Mayara S.S. do Nascimento, Vitória R.F. Câmara, Juliana S. da Costa, Juliana M.C. Barbosa, Alessandra S.M. Lins, Kelly Salomão, Solange L. de Castro, Samir A. Carvalho, Edson F. da Silva and Carlos A.M. Fraga*

DOI: 10.2174/1573406415666190627103013

Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study

, 2021; 17(3): 216-229.

Uma Krithika, Prabhakaran Prabitha, Subhankar P. Mandal, Sivamani Yuvaraj, Durai Priya, Ashish D. Wadhwani and Bommenahally Ravanappa Prashantha Kumar*

DOI: 10.2174/1573406416666200610191002

2-Mercapto Benzothiazole Derivatives: As Potential Leads for the Diabetic Management

, 2020; 16(6): 826-840.

Saeed Ullah, Salma Mirza, Uzma Salar, Shafqat Hussain, Kulsoom Javaid, Khalid M. Khan*, Ruqaiya Khalil, Atia-tul-Wahab, Zaheer Ul-Haq, Shahnaz Perveen and Muhammad I. Choudhary

DOI: 10.2174/1573406415666190612153150

New Insights Towards 1,4-Benzodiazepines from Curcumin. Design, Synthesis and Antimicrobial Activities

, 2020; 16(8): 1112-1123.

Othman Hamed*, Oswa Fares, Shaima Taleeb, Ghaleb Adwan, Haythem Saadeh, Shehdeh Jodeh and Manuel Algarra

DOI: 10.2174/1573406415666190826160251

Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

, 2020; 16(6): 784-795.

Krisnna M.A. Alves, Fábio José Bonfim Cardoso, Kathia M. Honorio and Fábio A. de Molfetta*

DOI: 10.2174/1573406415666190712111139


, 2021; 17(1): 1-1.

Dimitra Hadjipavlou-Litina

DOI: 10.2174/157340641701201204091649


Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
View Full Editorial Board

Nobel Laureate on Editorial Board

Prof. Ferid Murad

COPE Compliant

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Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.

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