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Medicinal Chemistry

Volume 16, 8 Issues, 2020
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access
Order Your Article Before PrintSubscribe to this Journal

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

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Volume 16

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Number 6



Research Article



Research Article

Synthesis, In vitro α-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives

, 16(6): 724 - 734

Hayat Ullah, Fazal Rahim, Muhammad Taha*, Raffaqat Hussain, Abdul Wadood, Mohsan Nawaz, Zainul Wahab, Kanwal and Khalid M. Khan


DOI: 10.2174/1573406415666190612150447


Research Article



Research Article



Research Article



Research Article

Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

, 16(6): 774 - 783

Mayara S.S. do Nascimento, Vitória R.F. Câmara, Juliana S. da Costa, Juliana M.C. Barbosa, Alessandra S.M. Lins, Kelly Salomão, Solange L. de Castro, Samir A. Carvalho, Edson F. da Silva and Carlos A.M. Fraga*


DOI: 10.2174/1573406415666190627103013


Research Article



Research Article



Medicinal Chemistry, Volume 16 (2020) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines


Délis Galvão Guimarães, Arlan de Assis Gonsalves, Larissa Araújo Rolim, Edigênia Cavalcante Araújo, Victória Laysna dos Anjos Santos, Maria Francilene Souza Silva, Fátima de Cássia Evangelista de Oliveira, Marcília Pinheiro da Costa, Claudia Pessoa, Marília Oliveira Fonseca Goulart, Thaissa Lucio Silva, Danyelle Cândido Santos and Cleônia Roberta Melo Araújo*


DOI: 10.2174/1573406416666200817164308
View Abstract View on PubMed


New oxazolidines inhibit the secretion of IFN-γ and IL-17 by PBMCS from moderate to severe asthmatic patients


Renata Virgínia Cavalcanti Santos*, Eudes Gustavo Constantino Cunha, Gabriela Souto Vieira de Mello, José Ângelo Rizzo, Jamerson Ferreira de Oliveira, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta and Moacyr Jesus Barreto de Melo Rêgo


DOI: 10.2174/1573406416666200910151950
View Abstract




Features, Pharmacological chemistry, molecular mechanism and health benefits of Lemon


Nitika Singh, Nagesndra Sastry Yarla, Nikhat Jamal Siddiqi, Maria de Lourdes Pereira and Bechan Sharma*


DOI: 10.2174/1573406416666200909104050
View Abstract


Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents


Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou* and Hiroyuki Osada


DOI: 10.2174/1573406416666200817160708
View Abstract View on PubMed


Evaluation of ligustrazine based synthetic compounds for mechanism based antiproliferative effects


Syed Nasir Abbas Bukhari*, Nasser Hadal Alotaibi, Waqas Ahmad, Khalid Saad Alharbi, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Muhammad Masood Ahmad, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja and Muhammad Ajaz Hussain


DOI: 10.2174/1573406416666200905125038
View Abstract


Oreganum Vulgare: In-vitro assessment of cytotoxicity, Molecular docking studies, Antioxidant, and evaluation of anti-inflammatory activity in LPS stimulated RAW 264.7 cells


Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi and Mubashir Hussain Masoodi*


DOI: 10.2174/1573406416666200904110828
View Abstract


Indane-1,3-diones: as potential and selective α-glucosidase inhibitors, their synthesis, in vitro and in silico studies.


Asma Mukhtar, Shazia Shah, Kanwal, Shehryar Hameed, Khalid Mohammed Khan*, Shahid Ullah Khan, Sumera Zaib, Jamshed Iqbal and Shahnaz Parveen


DOI: 10.2174/1573406416666200826102051
View Abstract


Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Open Access Articles

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy

, 2020; 16: 1 - 24 (E-Pub Ahead of Print)

Shabana Bibi, Yuan-Bing Wang, De-Xiang Tang, Mohammad Amjad Kamal and Hong Yu*




Synthesis, Antimicrobial Evaluation and Docking Study of Novel 3,5- Disubstituted-2-Isoxazoline and 1,3,5-Trisubstituted-2-Pyrazoline Derivatives

, 2019; 15: 1 - 12 (E-Pub Ahead of Print)

Ahmed Hussein Ismail, Ahmed Mutanabbi Abdula, Ivan H.R. Tomi, Ali Hussein R. Al-Daraji and Younis Baqi*




Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles



Research Article

Synthesis and structural elucidation of novel benzothiazole derivatives as anti-tubercular agents: In-silico screening for possible target identification

, 2019; 15(3): 311-326.

Katharigatta N. Venugopala*, Sandeep Chandrashekharappa, Melendhran Pillay, Subhrajyoti Bhandary, Mahmoud Kandeel, Fawzi M. Mahomoodally , Mohamed A. Morsy, Deepak Chopra , Bandar E. Aldhubiab, Mahesh Attimarad, Osama I. Alwassil , Sree Harsha, Koleka Mlisana and Bharti Odhav


DOI: 10.2174/1573406414666180703121815


Research Article

ZnO nanoparticles catalyst in the synthesis of bioactive fused pyrimidines as anti-breast cancer agents targeting VEGFR-2

, 2019; 15(3): 277-286.

Dina H. Dawood, Eman M.H. Abbas, Thoraya A. Farghaly*, Mamdouh M. Ali and Mohammed F. Ibrahim


DOI: 10.2174/1573406414666180912113226


Research Article

Helminthicidal and larvicidal potentials of biogenic silver nanoparticles synthesized from medicinal plant momordica charantia

, 2019; 15(7): 781-789.

Amruta Shelar, Jaiprakash Sangshetti, Shampa Chakraborti*, Ajay Vikram Singh*, Rajendra Patil* and Suresh Gosavi*


DOI: 10.2174/1573406415666190430142637



Research Article

New hybrid scaffolds based on hydrazinyl thiazole substituted coumarin; as novel leads of dual potential; In Vitro α-amylase inhibitory and antioxidant (DPPH and ABTS radical scavenging) activities

, 2019; 15(1): 87-101.

Uzma Salar, Khalid M. Khan*, Sridevi Chigurupati, Shazia Syed, Shantini Vijayabalan, Abdul Wadood, Muhammad Riaz, Mehreen Ghufran and Shahnaz Perveen


DOI: 10.2174/1573406414666180903162243


Research Article

The inhibition of polysialyltranseferase ST8SiaIV through heparin binding to polysialyltransferase domain (pstd)

, 2019; 15(5): 486-495.

Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*


DOI: 10.2174/1573406415666181218101623


Review Article

Thiazole compounds as antiviral agents: An update

, 2020; 16(1): 4-23.

Inder P. Singh*, Shiv Gupta and Sanjay Kumar


DOI: 10.2174/1573406415666190614101253


Research Article

Synthesis, molecular modelling and biological studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one derivatives as HIV-1 integrase inhibitors

, 2019; 15(7): 755-770.

Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian


DOI: 10.2174/1573406415666181219113225


Research Article

The assessment of interleukin-18 on the risk of coronary heart disease

, 2020; 16(5): 626-634.

Weiju Sun, Ying Han, Shuo Yang, He Zhuang, Jingwen Zhang, Liang Cheng* and Lu Fu*


DOI: 10.2174/1573406415666191004115128


Research Article

Inhibition of α-amylase activity by Zn<sup>2+</sup>: Insights from spectroscopy and molecular dynamics simulations

, 2019; 15(5): 510-520.

Si-Ming Liao, Nai-Kun Shen, Ge Liang, Bo Lu, Zhi-Long Lu, Li-Xin Peng, Feng Zhou, Li-Qin Du, Yu-Tuo Wei, Guo-Ping Zhou* and Ri-Bo Huang*


DOI: 10.2174/1573406415666181217114101



Research Article

Discovery of n-phenyl-4-(1h-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent mnk2 inhibitors: Design, synthesis, sar analysis, and evaluation of in vitro anti-leukaemic activity

, 2019; 15(6): 602-623.

Ahmed M. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K.C. Basnet, Benjamin Noll, Peng Li, Laychiluh B. Mekonnen, Jingfeng Lu, Hugo Albrecht, Robert W. Milne, Cobus Gerber, Mingfeng Yu * and Shudong Wang*


DOI: 10.2174/1573406415666181219111511




Most Accessed Articles


Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU

, 2016; 12(1): 30-36.

Yuqi Jiang, Xiaoguang Li, Xiaoyang Li, Jinning Hou, Yongzheng Ding, Jian Zhang, Wenfang Xu and Yingjie Zhang


DOI: 10.2174/1573406411666150714111045


Synthesis, Anticancer Evaluation and Docking Study of 3- Benzyloxyhydantoin Derivatives

, 2016; 12(1): 37-47.

Jun Liu, Kai Zhang, Xi Mai, Jinjin Wei, Yijing Liao, Ying Zhong, Yang Liu, Lihua Feng and Chao Liu


DOI: 10.2174/1573406411666150708111631


Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives

, 2020; 16(4): 487-494.

Natália N. Santiago, Giulianna P. de Alcântara, Juliana S. da Costa, Samir A. Carvalho, Juliana M.C. Barbosa, Kelly Salomão, Solange L. de Castro, Henrique M.G. Pereira and Edson F. da Silva*


DOI: 10.2174/1573406415666190712115237


Cystic Fibrosis Revisited – a Review Study

, 2017; 13(2): 102-109.

Blanka Klimova, Kamil Kuca, Michal Novotny and Petra Maresova


DOI: 10.2174/1573406412666160608113235


Synthesis, Antimycobacterial, Antiviral, Antimicrobial Activity and QSAR Studies of N2-acyl isonicotinic Acid Hydrazide Derivatives

, 2013; 9(1): 53-76.

Vikramjeet Judge, Balasubramanian Narasimhan, Munish Ahuja, Dharmarajan Sriram, Perumal Yogeeswari, Erik De Clercq, Christophe Pannecouque and Jan Balzarini


DOI: 10.2174/1573406411309010053




Editor-in-Chief

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
(Greece)
Biography
View Full Editorial Board

Nobel Laureate on Editorial Board

Prof. Ferid Murad
(USA)

Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.85

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