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Medicinal Chemistry

Volume 17, 10 Issues, 2021
ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)
This journal supports open access

Aims & Scope

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Medicinal Chemistry

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Volume 17

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Number 6







Research Article



Research Article

2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Anti-glioma Activities in C6 and GL261 Cells

, 17(6): 601 - 610

Alana de Vasconcelos, Ana Júlia Zulian Boeira, Bruna Bento Drawanz, Nathalia Stark Pedra, Natália Pontes Bona, Francieli Moro Stefanello and Wilson Cunico*


DOI: 10.2174/1573406416666200403075826


Research Article

A Comprehension into Target Binding and Spatial Fingerprints of Noscapinoid Analogues as Inhibitors of Tubulin

, 17(6): 611 - 622

Seema Mandavi, Sant Kumar Verma, Laxmi Banjare, Amit Dubey, Renu Bhatt*, Suresh Thareja* and Akhlesh Kumar Jain*


DOI: 10.2174/1573406416666200117120348




Research Article

Synthesis, Antitrypanosomal and Antimycobacterial Activities of Coumarin N-acylhydrazonic Derivatives

, 17(6): 630 - 637

Camila Capelini, Vitória R.F. Câmara, José D. Figueroa Villar, Juliana M.C. Barbosa, Kelly Salomão, Solange L. de Castro, Policarpo A.S. Junior, Silvane M.F. Murta, Thais B. Couto, Maria C.S. Lourenço, James L. Wardell, John N. Low, Edson F. da Silva and Samir A. Carvalho*


DOI: 10.2174/1573406416666200121105215


Research Article



Medicinal Chemistry, Volume 17 (2021) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Medicinal Chemistry, Volume 17 (2021) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print



From Anti-infective Agents to Cancer Therapy: A Drug Repositioning Study Revealed a New Use for Nitrofuran Derivatives


Gabriella Ortore*, Giulio Poli, Adriano Martinelli, Tiziano Tuccinardi, Flavio Rizzolio and Isabella Caligiuri


DOI: 10.2174/1573406417666210511001241
View Abstract View on PubMed



Novel Dipeptides Bearing Sulfonamide as Antimalarial and Antitrypanosomal Agents: Synthesis and Molecular Docking


Ogechi Chinelo Ekoh*, Uchechukwu Okoro, David Ugwu, Rafat Ali, Sunday Okafor, Daniel Ugwuja and Solomon Attah


DOI: 10.2174/1573406417666210604101201
View Abstract View on PubMed



Synthesis, Antileishmanial Activity and in silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes


Thiago M. de Aquino*, Paulo H. B. França, Érica E. E. S. Rodrigues, Igor J. S. Nascimento, Paulo F. S. Santos-Júnior, Pedro G. V. Aquino, Mariana S. Santos, Aline C. Queiroz, Morgana V. Araújo, Magna S. Alexandre-Moreira, Raiza R. L. Rodrigues, Klinger A. F. Rodrigues, Johnnatan D. Freitas, Jacques Bricard, Mario R. Meneghetti, Jean-Jacques Bourguignon, Martine Schmitt, Edeildo F. da Silva-Júnior* and João X. de Araújo-Júnior


DOI: 10.2174/1573406417666210216154428
View Abstract View on PubMed



In vitro, in vivo and in silico Antihyperglycemic Activity of Some Semi-synthetic Phytol Derivatives


Harish C. Upadhyay, Akansha Mishra, Jyotsana Pandey, Pooja Sharma, Akhilesh K. Tamrakar, Arvind K. Srivastava, Feroz Khan and Santosh K. Srivastava*


DOI: 10.2174/1573406417666201216124018
View Abstract View on PubMed



Abstracts Ahead of Print

Synthesis, molecular docking and mosquitocidal efficacy of lawsone and its derivatives against the dengue vector Aedes aegypti L. (Diptera: Culicidae)


Antony Stalin*, Paul Dhivya, Ding Lin, Yue Feng, Antony Cruz Asharaja, Munusamy Rajiv Gandhi, Balakrishnan Senthamarai Kannan, Subramani Kandhasamy, Appadurai Daniel Reegan* and Yuan Chen*


DOI: 10.2174/1573406417666210727121654
View Abstract



Computational and synthetic biology approaches for the biosynthesis of antiviral and anticancer terpenoids from Bacillus subtilis.


Vibha Shukla, Ashish Runthala, Vikrant Singh Rajput, Potla Durthi Chandrasai, Anurag Tripathi and Suresh Chandra Phulara*


DOI: 10.2174/1573406417666210712211557
View Abstract



Synthesis and Evaluation of Chiral Rhodanine Derivatives Bearing Quinoxalinyl Imidazole Moiety as ALK5 Inhibitors


Li-Min Zhao, Fang Yan Guo, Hui Min Wang, Tong Dou, Jun Da Qi, Wen Bo Xu, Lianxun Piao, Xuejun Jin, Fen-Er Chen, Hu-Ri Piao, Chang Ji Zheng* and Cheng Hua Jin*


DOI: 10.2174/1573406417666210628144849
View Abstract


Potential Biological Targets Prediction, ADME Profiling, & Molecular Docking studies of Novel Steroidal Products from Cunninghamella Blakesleana


Maria Yousuf*, Sidra Rafi, Urooj Ishrat, Alekberzadeh Shafiga, Gulnara Dashdamirova , Vazirova Leyla and Heydarov Iqbal


DOI: 10.2174/1573406417666210608143128
View Abstract



Functionalized Homologues and Positional Isomers of Rabbit 15-Lipoxygenase RS75091 Inhibitor


Alexander Zhuravlev, Alexey Golovanov, Valery Toporkov, Hartmut Kuhn and Igor Ivanov*


DOI: 10.2174/1573406417666210604112009
View Abstract


Efficient Synthesis and Biological Evaluation of 6-Trifluoroethoxy Functionalized Pteridine Derivatives as EGFR Inhibitors


Jin Lin, Zemin Zhang, Xiongqiang Lin, Zhendong Chen, Tian Luc, Daijun Zha, Jian Wang, Xiuzhi Xu and Zhulai Li*


DOI: 10.2174/1573406417666210604105923
View Abstract



Published Contents

Open Access Articles


Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy

, 2021; 17(2): 97 - 120

Shabana Bibi, Yuan-Bing Wang, De-Xiang Tang, Mohammad Amjad Kamal and Hong Yu*




Synthesis, Cytotoxicity, Anti-migration and Anti-Invasion Activity of Diphyllin Heterocyclic Derivatives

, 2021; 17: 1 - 8 (E-Pub Ahead of Print)

Weidong Shen, Haijiao Chen, Miaomiao Wu, Ting Zhang, Li Zhu and Yu Zhao*





Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies

, 2021; 17: 1 - 9 (E-Pub Ahead of Print)

Thaise Martins, Vera L.M. Silva, Artur M.S. Silva, José L.F.C. Lima, Eduarda Fernandes* and Daniela Ribeiro*





Pyrazoles and Fused Pyrimidines: Synthesis, Structure Elucidation, Antitubercular Activity and Molecular Docking Study

, 2021; 17: 1 - 18 (E-Pub Ahead of Print)

Amerah M. Al-Soliemy, Rehab Sabour and Thoraya A. Farghaly*




Anti-Mycobacterial Peroxides: A New Class of Agents for Development Against Tuberculosis

, 2020; 16(3): 392 - 402

Christiaan W. van der Westhuyzen, Richard K. Haynes, Jenny-Lee Panayides, Ian Wiid and Christopher J. Parkinson*




Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity

, 2019; 15(6): 602 - 623

Ahmed M. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K.C. Basnet, Benjamin Noll, Peng Li, Laychiluh B. Mekonnen, Jingfeng Lu, Hugo Albrecht, Robert W. Milne, Cobus Gerber, Mingfeng Yu * and Shudong Wang*




The Evaluation of Metal Co-ordinating Bis-Thiosemicarbazones as Potential Anti-malarial Agents

, 2019; 15(1): 51 - 58

Fady N. Akladios, Scott D. Andrew, Samantha J. Boog, Carmen de Kock, Richard K. Haynes and Christopher J. Parkinson*




Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun






Most Cited Articles



Research Article

Synthesis and structural elucidation of novel benzothiazole derivatives as anti-tubercular agents: In-silico screening for possible target identification

, 2019; 15(3): 311-326.

Katharigatta N. Venugopala*, Sandeep Chandrashekharappa, Melendhran Pillay, Subhrajyoti Bhandary, Mahmoud Kandeel, Fawzi M. Mahomoodally , Mohamed A. Morsy, Deepak Chopra , Bandar E. Aldhubiab, Mahesh Attimarad, Osama I. Alwassil , Sree Harsha, Koleka Mlisana and Bharti Odhav


DOI: 10.2174/1573406414666180703121815


Research Article

Helminthicidal and larvicidal potentials of biogenic silver nanoparticles synthesized from medicinal plant momordica charantia

, 2019; 15(7): 781-789.

Amruta Shelar, Jaiprakash Sangshetti, Shampa Chakraborti*, Ajay Vikram Singh*, Rajendra Patil* and Suresh Gosavi*


DOI: 10.2174/1573406415666190430142637


Research Article

ZnO nanoparticles catalyst in the synthesis of bioactive fused pyrimidines as anti-breast cancer agents targeting VEGFR-2

, 2019; 15(3): 277-286.

Dina H. Dawood, Eman M.H. Abbas, Thoraya A. Farghaly*, Mamdouh M. Ali and Mohammed F. Ibrahim


DOI: 10.2174/1573406414666180912113226


Research Article

New hybrid scaffolds based on hydrazinyl thiazole substituted coumarin; as novel leads of dual potential; In Vitro α-amylase inhibitory and antioxidant (DPPH and ABTS radical scavenging) activities

, 2019; 15(1): 87-101.

Uzma Salar, Khalid M. Khan*, Sridevi Chigurupati, Shazia Syed, Shantini Vijayabalan, Abdul Wadood, Muhammad Riaz, Mehreen Ghufran and Shahnaz Perveen


DOI: 10.2174/1573406414666180903162243


Review Article

Thiazole compounds as antiviral agents: An update

, 2020; 16(1): 4-23.

Inder P. Singh*, Shiv Gupta and Sanjay Kumar


DOI: 10.2174/1573406415666190614101253



Research Article

Synthesis, molecular modelling and biological studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one derivatives as HIV-1 integrase inhibitors

, 2019; 15(7): 755-770.

Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian


DOI: 10.2174/1573406415666181219113225


Research Article

iATP: A sequence based method for identifying anti-tubercular peptides

, 2020; 16(5): 620-625.

Wei Chen*, Pengmian Feng and Fulei Nie


DOI: 10.2174/1573406415666191002152441


Research Article

Rational design of colchicine derivatives as anti-HIV agents via QSAR and molecular docking

, 2019; 15(4): 328-340.

Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul


DOI: 10.2174/1573406414666180924163756



Research Article

The assessment of interleukin-18 on the risk of coronary heart disease

, 2020; 16(5): 626-634.

Weiju Sun, Ying Han, Shuo Yang, He Zhuang, Jingwen Zhang, Liang Cheng* and Lu Fu*


DOI: 10.2174/1573406415666191004115128


Research Article

The inhibition of polysialyltranseferase ST8SiaIV through heparin binding to polysialyltransferase domain (pstd)

, 2019; 15(5): 486-495.

Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*


DOI: 10.2174/1573406415666181218101623


Research Article

Pyrano[3,2-c]quinoline derivatives as new class of α-glucosidase inhibitors to treat type 2 diabetes: Synthesis, in vitro biological evaluation and kinetic study

, 2019; 15(1): 8-16.

Zahra Heydari, Maryam Mohammadi-Khanaposhtani, Somaye Imanparast, Mohammad A. Faramarzi, Mohammad Mahdavi *, Parviz R. Ranjbar* and Bagher Larijani


DOI: 10.2174/1573406414666180528110104



Most Accessed Articles

Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer

, 2021; 17(8): 866-874.

Jamshed Iqbal*, Ayesha Basharat, Sehrish Bano, Syed Mobasher Ali Abid, Julie Pelletier and Jean Sévigny


DOI: 10.2174/1573406416666200925141703





Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4- Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro

, 2021; 17(8): 820-833.

Lucas da Silva Santos, Matheus Fillipe Langanke de Carvalho, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Julio César Dias Lopes, Fernando de Pilla Varotti, Rossimiriam Pereira de Freitas and Rosemeire Brondi Alves*


DOI: 10.2174/1573406416666200602161047



Indane-1,3-diones: As Potential and Selective α-glucosidase Inhibitors, their Synthesis, in vitro and in silico Studies

, 2021; 17(8): 887-902.

Asma Mukhtar, Shazia Shah, Kanwal, Shehryar Hameed, Khalid. Mohammed Khan*, Shahid Ullah Khan, Sumera Zaib, Jamshed Iqbal* and Shahnaz Perveen


DOI: 10.2174/1573406416666200826102051


Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies

, 2021; 17(8): 903-912.

Mahboob Ali, Momin Khan*, Khair Zaman, Abdul Wadood, Maryam Iqbal, Aftab Alam, Sana Shah, Ashfaq Ur Rehman, Muhammad Yousaf, Rafaila Rafique and Khalid Mohammed Khan


DOI: 10.2174/1573406416666200611103039


Synthesis and Anticancer Activity of Thiadiazole Containing Thiourea, Benzothiazole and Imidazo[2,1-b][1,3,4]thiadiazole Scaffolds

, 2021; 17(7): 750-765.

Stephen Paul Avvaru, Malleshappa N. Noolvi*, Uttam A More, Sudipta Chakraborty, Ashutosh Dash, Tejraj M. Aminabhavi, Kumar P. Narayan and Vishnu Sutariya


DOI: 10.2174/1573406416666200519085626



Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation

, 2021; 17(7): 732-749.

Tran Khac Vu*, Nguyen Thi Thanh, Nguyen Van Minh, Nguyen Huong Linh, Nguyen Thi Phương Thao, Trương Thuc Bao Nguyen, Doan Thi Hien, Luu Van Chinh, Ta Hong Duc, Lai Duc Anh and Pham-The Hai


DOI: 10.2174/1573406416666200420081540



Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives

, 2021; 17(8): 926-936.

Digamber S. Pawar, Vasant V. Chabukswar*, Savita R. Tapase, Kisan M. Kodam, Anurudhha Chabukswar, Pravin B. Adhav, Balasaheb B. Diwate, Sunita Salunke Gawali, Sabrina Dallavalle and Swati C. Jagdale


DOI: 10.2174/1573406416666200817155056


Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies

, 2021; 17(8): 834-843.

Taibi Ben Hadda*, Fatma Sezer Senol Deniz, Ilkay Erdogan Orhan, Hsaine Zgou, Abdur Rauf, Yahia Nasser Mabkhot*, Brahim Bennani, Dalia R. Emam, Nabila Abdelshafy Kheder, Abdulrhman Asayari, Abdullatif Bin Muhsinah and Aneela Maalik*


DOI: 10.2174/1573406416666200610185654


Pyrazole Derivatives of Medically Relevant Phenolic Acids: Insight into Antioxidative and Anti-LOX Activity

, 2021; 17(8): 807-819.

Vesna Milovanović, Zorica D. Petrović*, Slađana Novaković, Goran A. Bogdanović, Dušica Simijonović, Milan Mladenović, Jovica Branković and Vladimir P. Petrović


DOI: 10.2174/1573406416666200602152643




Editor-in-Chief

graphic
Dimitra Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy
Aristotle University of Thessaloniki
Thessaloniki
(Greece)
Biography
View Full Editorial Board

Nobel Laureate on Editorial Board

graphic
Prof. Ferid Murad
(USA)

COPE Compliant

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Journal History

Medicinal Chemistry Journal was launched in 2005. Dr. Dimitra Hadjipavlou-Litina serves as the Editor-in-Chief of the journal.

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