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University of Sydney, Australia

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Thank you for your mail. I am very delighted to be the author of this article in your esteemed journal (Medicinal Chemistry, Bentham science publishers ). Glad to say that the quality of your service is very nice. I will surely contribute new research publication to this esteemed journal soon.

Sreekanth Thota
(National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, Brazil)


Medicinal Chemistry

,

Volume 14

-

Number 8



Biography   Open Access



Research Article

Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 Å Resolution

, 14(8): 754 - 763

Malik S. Ahmad*, Saima Rasheed, Sven Falke, Binish Khaliq, Markus Perbandt, Muhammad I. Choudhary, Wojciech T. Markiewicz, Jan Barciszewski and Christian Betzel*


DOI: 10.2174/1573406414666180524095946




Research Article

Synthesis and Biological Evaluation of 12N-substituted Tricyclic Matrinic Derivatives as a Novel Family of Anti-Influenza Agents

, 14(8): 764 - 772

Sheng Tang, Yu-Huan Li , Xin-Yue Cheng, Jin-Qiu Yin , Ying-Hong Li , Dan-Qing Song , Yan-Xiang Wang * and Zhan-Dong Liu*


DOI: 10.2174/1573406414666180222093033




Research Article



Research Article

Antimicrobial Evaluation of Erythrinan Alkaloids from Erythrina cristagalli L.

, 14(8): 784 - 790

Janaína M. de Ávila, Ionara I. Dalcol*, Alessandra O. Pereira, Eveline W. Santos, Adriano Ferraz, Maura Z. Santos, Marco A. Mostardeiro and Ademir F. Morel


DOI: 10.2174/1573406414666180524081650




Research Article

Synthesis of Nucleosides and Non-nucleosides Based 4,6-disubstituted-2- oxo-dihydropyridine-3-carbonitriles as Antiviral Agents

, 14(8): 791 - 808

Tarek S. Ibrahim, Hassan A. El-Sayed, Maan T. Khayat, Amany M.M. AL-Mahmoudy, Ahmed H. Moustafa*, Ayat K.S. El-Deen, Sherif A.F. Rostom and Siva S. Panda*


DOI: 10.2174/1573406414666180522123524




Research Article

Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies

, 14(8): 809 - 817

Jamshed Iqbal *, Muhammad S.A. Abbasi, Sumera Zaib , Saifullah Afridi, Norbert Furtmann, Jürgen Bajorath and Peter Langer


DOI: 10.2174/1573406414666180222091833




Research Article

2-Oxo-1,2,3,4-tetrahydropyrimidines Ethyl Esters as Potent β- Glucuronidase Inhibitors: One-pot Synthesis, In vitro and In silico Studies

, 14(8): 818 - 830

Sarosh Iqbal*, Nimra N. Shaikh, Khalid M. Khan*, Sehrish Naz, Zaheer Ul-Haq, Shahnaz Perveen and Muhammad I. Choudhary*


DOI: 10.2174/1573406414666180525105325




Medicinal Chemistry, Volume 15 (2019) - Number 1


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions


Mauricio M. Victor*, Ravir R. Farias, Danielle L. da Silva, Paulo Henrique Fonseca do Carmo, Maria A. de Resende-Stoianoff, Claudio Viegas, Patricia F. Espurie and Marcos J. Marquese


View Abstract View on PubMed


Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents


Samar Said Fatahala*, Shahira Nofal, Eman Mahmoud and Rania Helmy Abd El-hameed


View Abstract View on PubMed


Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles


Wei-yuan Yuan, Xue Chen, Ning-ning Liu, Yi-ning Wen, Bei Yang, Graciela Andrei, Robert Snoeck, Yu-hong Xiang, Yong-wei Wu, Zhen Jiang, Dominique Schols, Zhuo-yong Zhang and Qin-pei Wu*


View Abstract View on PubMed




Design, Synthesis and Anticancer Evaluation of Novel Series of Indibulin Analogues


Ebrahim Saeedian Moghadam, Farhad Saravani, Seyednasser Ostad, Shohreh Tavajohi, Morteza Pirali Hamedani and Mohsen Amini*


View Abstract View on PubMed


Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents


Monika Gensicka-Kowalewska, Mirosława Cichorek, Anna Ronowska, Milena Deptuła, Ilona Klejbor and Krystyna Dzierzbicka*


View Abstract View on PubMed


Evaluation of Antiplasmodial Potential of C-2 and C-8 Modified Quinolines: in vitro and in silico Study


Rakesh Kumar, Ritika Sharma, Inder Kumar, Pooja Upadhyay, Ankit Kumar Dhiman, Rohit Kumar, Rakesh Kumar, Rituraj Purohit*, Dinkar Sahal* and Upendra Sharma*


View Abstract View on PubMed



Synthesis and Biological Evaluation of 3-cyano-4H-chromene Derivatives Bearing Carbamate Functionality


Fatma Boukattaya, Amal Daoud, Fabien Boeda, Morwenna S. M. Pearson-Long, Neji Gharsallah, Adel Kadri, Philippe Bertus* and Houcine Ammar


View Abstract View on PubMed


Abstracts Ahead of Print

New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity


Sahar M. Abou-Seri, AlShaimaa M. Taha, Mona A. Mohamed* and Nour M. Abdelkader


View Abstract


Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation


Tiago O. Brito, Lethícia O. Abreu, Karen M. Gomes, Maria C. S. Lourenço, Patricia M. L. Pereira, Sueli F. Yamada-Ogatta, Ângelo de Fàtima, Cesar A. Tisher, Fernando Macedo and Marcelle L. F. Bispo*


View Abstract


Evaluation of Cytotoxic Potentials of Some Isoindole-1,3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines


Ayse Tan, Ayse Sahin Yaglioglu, Nurhan Horasan Kishali*, Ertan Sahin and Yunus Kara*


View Abstract



The Substantial Improvement of Amphotericin B Selective Toxicity upon Modification of Mycosamine with Bulky Substituents


Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Marcin Serocki, Izabela Chabowska, Maria J. Milewska, Dominik Ziętkowski and Sławomir Milewski*


View Abstract


Efficacy of novel Schiff base derivatives as antifungal compounds in combination with approved drugs against Candida albicans


Manzoor Ahmad Malik, Shabir Ahmad Lone, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Aijaz Ahmad* and Athar Adil Hashmi*


View Abstract


Synthesis and biological studies of new multifunctional curcumin platforms for anticancer drug delivery


Andrii Bazylevich , Helena Tuchinsky, Eti Zigman-Hoffman, Ran Weissman , Ofer Shpilberg , Oshrat Hershkovitz-Rokah, Leonid Patsenker and Gary Gellerman*


View Abstract


Design, synthesis and anxiolytic activity evaluation of N-acyl-tryptophanyl-containing dipeptides, potential TSPO ligands


T. A. Gudasheva, O. A. Deeva, G. V. Mokrov, A. S. Dyabina, M. A. Yarkova and S. B. Seredenin


View Abstract


Spirocyclohexadienones as an Uncommon Scaffold for Acetylcholinesterase Inhibitory Activity


Ralph C. Gomes, Renata P. Sakata*, Wanda P. Almeida* and Fernando Coelho*


View Abstract


Design, synthesis and in vitro evaluation of novel anti-HIV 3-pyrazol-3-yl-pyridin-2-one analogs


Sanjay Kumar, Shiv Gupta, Shraddha Gaikwad, Leila Fotooh Abadi, Late Kamlesh Kumar Bhutani, Smita Kulkarni* and Inder Pal Singh*


View Abstract


Open Access Articles

Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies

, 2018; 14(8): 809 - 817

Jamshed Iqbal *, Muhammad S.A. Abbasi, Sumera Zaib , Saifullah Afridi, Norbert Furtmann, Jürgen Bajorath and Peter Langer




Diclofenac 1,3,4-Oxadiazole Derivatives; Biology-Oriented Drug Synthesis (BIODS) in Search of Better Non-Steroidal, Non-Acid Antiinflammatory Agents

, 2018; 14(7): 674 - 687

Shazia Shah, Arshia, Nida Siraj Kazmi, Almas Jabeen, Aisha Faheem, Nida Dastagir, Tariq Ahmed, Khalid Mohammed Khan*, Shakil Ahmed, Abeer Raza and Shahnaz Perveen




Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

, 2018; 14(3): 225 - 229

Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino




IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages

, 2017; 13(8): 727 - 733

Alfonso Lopez-Vazquez, Jesus J. Garcia-Banuelos*, Angelica S. Gonzalez-Garibay, Pedro E. Urzua-Lozano, Susana Del Toro-Arreola, Miriam R. Bueno-Topete, Sergio Sanchez-Enriquez, Jose F. Munoz-Valle, Luis F. Jave-Suarez, Juan Armendariz-Borunda and Blanca E. Bastidas-Ramirez*




Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert

, 2015; 11(4): 391 - 399

Christian Celia, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Renato. C Barbacane, Massimo Fresta, Luisa Di Marzio and Donatella Paolino




Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes

, 2015; 11(4): 383 - 390

Huizhen Cai, Fukang Liu, Pingguo Zuo, Guiling Huang, Zhixiu Song, Tingting Wang, Huixia Lu, Fei Guo, Chao Han and Guiju Sun





Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

, 2015; 11(1): 50 - 59

Bhimanna Kuppast, Katerina Spyridaki, Christophina Lynch, Yueshan Hu, George Liapakis, Gareth E. Davies and Hesham Fahmy





Most Cited Articles




miRNAs as Circulating Biomarkers for Alzheimer’s Disease and Parkinson’s Disease

, 2016; 12(3): 217-225.

Gohar Mushtaq, Nigel H. Greig, Firoz Anwar, Mazin A. Zamzami, Hani Choudhry, Munvar M. Shaik, Ian A. Tamargo and Mohammad A. Kamal


DOI: 10.2174/1573406411666151030112140


Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor

, 2016; 12(3): 204-210.

Ricardo Cabezas, Marco Avila-Rodriguez, Nelson E. Vega-Vela, Valentina Echeverria, Janneth González, Oscar A. Hidalgo, Altair B. Santos, Gjumrakch Aliev and George E. Barreto


DOI: 10.2174/1573406411666151019120444


Recent Updates on the Association Between Alzheimer’s Disease and Vascular Dementia

, 2016; 12(3): 226-237.

Ghulam M. Ashraf, Sandesh Chibber, Mohammad, Syed K. Zaidi, Shams Tabrez, Ausaf Ahmad, Shazi Shakil, Gohar Mushtaq, Saleh S. Baeesa and Mohammad A. Kamal


DOI: 10.2174/1573406411666151030111820


Discovery of Flexible Naphthyltriazolylmethane-based Thioacetic Acids as Highly Active Uric Acid Transporter 1 (URAT1) Inhibitors for the Treatment of Hyperuricemia of Gout

, 2017; 13(3): 260-281.

Xiansheng Zhang, Jingwei Wu, Wei Liu, Yuqiang Liu, Yafei Xie, Qian Shang, Zhixing Zhou, Weiren Xu, Lida Tang, Jianwu Wang and Guilong Zhao*


DOI: 10.2174/1573406412666160915163002



New N,N,N’,N’-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities

, 2016; 12(1): 83-89.

Farid Abrigach, Btissam Bouchal, Olivier Riant, Yohan Mace, Abdelilah Takfaoui, Smaail Radi, Abdelouahad Oussaid, Mohammed Bellaoui and Rachid Touzani


DOI: 10.2174/1573406411666150519111800



Most Accessed Articles

USP7: Target Validation and Drug Discovery for Cancer Therapy

, 2018; 14(1): 3-18.

Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*


DOI: 10.2174/1573406413666171020115539



New Perspectives of Alzheimer Disease Diagnosis – the Most Popular and Future Methods

, 2018; 14(1): 34-43.

Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*


DOI: 10.2174/1573406413666171002120847



Drug Design, Synthesis and In Vitro Evaluation of Substituted Benzofurans as Hsp90 Inhibitors

, 2018; 14(1): 44-52.

Sundeep Kadasi, Thadeu E.M.M. Costa, Neha Arukala, Mallika Toshakani, Chaitanya Duggineti, Sreekanth Thota, Sayan D. Gupta, Shiva Raj, Carmen Penido, Maria G. Henriques and Nulgumnalli M. Raghavendra*


DOI: 10.2174/1573406413666170623085534


Synthesis and Antibacterial Activity Against MRSA of Pleuromutilin Derivatives Possessing a Mercaptoethylamine Linker

, 2018; 14(6): 585-594.

Zhao-Sheng Zhang, Yun-Zhen Huang, Jian Luo, Bing-Feng Wang, Zhen Jin, Ya-Hong Liu and You-Zhi Tang*


DOI: 10.2174/1573406414666180416131737


Antibacterial Assessment of Heteroaryl, Vinyl, Benzyl, and Alkyl Tetrazole Compounds

, 2018; 14(6): 550-555.

Joshua Dudley, Liana Feinn, Heather DeFrancesco, Erica Lindsay, Adiel Coca* and Elizabeth Lewis Roberts


DOI: 10.2174/1573406413666171120162420



A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs

, 2018; 14(4): 387-393.

Maria Arkel, Patrizia Garbati, Annalisa Salis, Gianluca Damonte, Nara Liessi, Enrico Adriano, Umberto Benatti, Maurizio Balestrino and Enrico Millo*


DOI: 10.2174/1573406413666171120164702



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