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Letters in Drug Design & Discovery

Volume 17, 12 Issues, 2020
ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
This journal supports open access

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  • 57th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of the latest Internet technology for both the submission and review of manuscripts. The journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.

Letters in Drug Design & Discovery

,

Volume 17

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Number 2



Biography   Open Access



Review Article



Research Article



Research Article



Research Article

An Environment-friendly Synthesis of Piperonal Chalcones and Their Cytotoxic and Antioxidant Evaluation

, 17(2): 138 - 144

Sanal Dev, Della Grace Thomas Parambi, Bency Baby, Githa Elizabeth Mathew, Hendawy Omnia Magdy, Monu Joy, Shine Sudev and Bijo Mathew*


DOI: 10.2174/1570180815666181016155934


Research Article

Synthesis, Antiproliferative, and Antioxidant Activities of Substituted N-[(1,3,4-Oxadiazol-2-yl) Methyl] Benzamines

, 17(2): 145 - 154

Mohamed Jawed Ahsan*, Lakshya Bhandari, Shally Makkar, Rajan Singh, Mohd. Zaheen Hassan, Mohammed H. Geesi, Mohamed Afroz Bakht, Surender Singh Jadav, Tuniki Balaraju, Yassine Riadi , Sandhya Rani, Habibullah Khalilullah, Vasubabu Gorantla and Afzal Hussain


DOI: 10.2174/1570180816666181113110033


Research Article



Research Article



Letters in Drug Design & Discovery, Volume 17 (2020) - Number 3


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Molecular Docking of 4-ehoxychalcones on Oxidoreductase/Pirin Inhibitors and Cytotoxic Evaluation on Breast/Skin Cancer Cell Lines


Kishori Ramachandra Harshitha, Balladka Kunhanna Sarojini*, Badiadka Narayana, Anupam Glorious Lobo and Bhuvanesh Sukhlal Kalal


DOI: 10.2174/1570180817666200129143803
View Abstract




Synthesis, Molecular Docking and α-Glucosidase Inhibitory Activity Study of 2,4,6-triaryl pyrimidine Derivatives


Mohammed Hussen Bule , Roghaieh Esfandyari, Tadesse Bekele Tafesse, Mohsen Amini*, Mohammad Ali Faramarzi and Mohammad Abdollahi


DOI: 10.2174/1570180817666200103130536
View Abstract





Synthesis and Evaluation of α-Asaronol Esters with LDH and GABAA Receptor Modulation as Anticonvulsant Agents


Yajun Bai, Bin Li, Jing Xie, Xufei Chen, Shu Cheng, Yujun Bai, Ying Sun, Fanggang Qin, Jing Liang, Yanrui Ding and Xiaohui Zheng*


DOI: 10.2174/1570180816666191204104127
View Abstract



Abstracts Ahead of Print







Anticholinesterase activity of cinnamic acids derivatives: in-vitro, in-vivo biological evaluation and docking study


Shahrzad Ghafary, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, Tahmineh Akbarzadeh, Mohammad Sharifzadeh, Najmeh Edraki, Farshad Homayouni Moghadam and Mohsen Amini*


DOI: 10.2174/1570180817666191224094049
View Abstract


Published Contents

Editor's Choice

Progress in Synthesis and Bioactivity Evaluation of Pyrazoloquinazolines

, 2020; 17(2): 104 - 113

Hui Zhao, Xiaoxia Hu, Yue Zhang, Chunlei Tang* and Bainian Feng*


DOI: 10.2174/1570180815666181017120100



Targeting Inflammation with Conjugated Cinnamic Amides, Ethers and Esters

, 2020; 17(1): 3 - 11

Ioannis Fotopoulos, Eleni Pontiki and Dimitra Hadjipavlou Litina*


DOI: 10.2174/1570180816666181129125511




Molecular Modeling of an Orphan GPR18 Receptor

, 2019; 16(10): 1167 - 1174

Kamil J. Kuder, Tadeusz Karcz, Maria Kaleta and Katarzyna Kiec-Kononowicz*


DOI: 10.2174/1570180815666180810114847



The Structure of MT189-Tubulin Complex Provides Insights into Drug Design

, 2019; 16(9): 1069 - 1073

Zhongping Li, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen


DOI: 10.2174/1570180816666181122122655



Paclitaxel-tyroserleutide Conjugates Self-assembly into Nanocarrier for Drug Delivery

, 2019; 16(8): 882 - 891

Yongjia Liu, Leilei Shi, Bangshang Zhu*, Yue Su, Hui Li* and Xinyuan Zhu


DOI: 10.2174/1570180815666180803124625





Potential of Nanoparticles in Combating Candida Infections

, 2019; 16(5): 478 - 491

Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


DOI: 10.2174/1570180815666181015145224




Open Access Articles

A Series of Furan-Based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity

, 2020; 17(3): 312 - 322

Mehlika Dilek Altıntop*, Belgin Sever, Özlem Atlı Eklioğlu, Merve Baysal, Rasime Demirel and Ahmet Özdemir




Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

, 2019; 16(12): 1387 - 1394

Mark Gallant Fulton, Matthew Thomas Loch, Caroline Anne Cuoco, Alice Lambert Rodriguez, Emily Days, Paige Newton Vinson, Krystian Andrezej Kozek, Charles David Weaver, Anna Louise Blobaum, Peter Jeffrey Conn, Colleen Marie Niswender* and Craig William Lindsley*




Antitumor Activity of Cyclodextrin-based Supramolecular Platinum Prodrug In vitro and In vivo

, 2019; 16(11): 1296 - 1301

Yu-Hui Zhang, Jie Wang, Siqintana Xin, Li-Juan Wang and Xianliang Sheng*




Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions

, 2019; 16(11): 1248 - 1257

Hedvig Bölcskei*, Andrea Német-Hanzelik, Zsófia Dubrovay, Viktor Háda and György Keglevich





Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, Anticancer, Antimicrobial and In Silico Studies

, 2019; 16(9): 994 - 1005

Naveen Kumar, Swamy Sreenivasa*, Bhuvanesh Sukhlal Kalal, Vasantha Kumar, Bantwal Shivarama Holla, Vinitha Ramanath Pai, Nadigar Revansiddappa Mohan and Shivaraj Govindaiah




The Structure of MT189-Tubulin Complex Provides Insights into Drug Design

, 2019; 16(9): 1069 - 1073

Zhongping Li, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen






In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration

, 2019; 16(8): 948 - 960

Sara Melisa Arciniegas Ruiz, María Josefa Bernad Bernad, Raquel Lopez Arellano, Roberto Diaz Torres, Sara Del Carmen Caballero Chacón and Dinorah Vargas Estrada*





Design and Synthesis of Novel Thiosemicarbazones as Potent Anti-breast Cancer Agents

, 2019; 16(4): 446 - 452

Mashooq Ahmad Bhat*, M. Al-Tahhan, Mohamed A. Al-Omar, Ahmed M. Naglah and Abdullah Al-Dhfyan




A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive

, 2019; 16(3): 238 - 244

Dávid Illés Nagy, Alajos Grün, Júlia Sinkovicz, Sándor Garadnay, István Greiner and György Keglevich*




Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 2019; 16(2): 102 - 110

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*




Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid

, 2018; 15(7): 713 - 720

David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*





Most Cited Articles

Research Article

Novel trifluoromethylpyrazole acyl thiourea derivatives: Synthesis, antifungal activity and docking study

, 2019; 16(7): 785-791.

Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*


DOI: 10.2174/1570180815666180704103047



Research Article

Evaluation of the in vitro antitumor activity of nanostructured cyclotides in polymers of Eudragit<sup>®</sup> L 100-55 and RS 30 D

, 2019; 16(4): 437-445.

Osmar N. Silva, Michelle F.S. Pinto, Juliane F.C. Viana, Camila G. Freitas, Isabel C.M. Fensterseifer, David J. Craik and Octavio L. Franco*


DOI: 10.2174/1570180815666180801115526


Research Article

Novel 1,3,4-oxadiazole fused thiadiazole derivatives: Synthesis and study of anticancer activities

, 2019; 16(6): 656-662.

Zanjam Spandana, Reddymasu Sreenivasulu, Tadigiri MalathiRekha and Mandava Venkata Basaveswara Rao*


DOI: 10.2174/1570180816666181031125946


Research Article

Synthesis, anti-proliferative evaluation, and molecular docking studies of 3-(Alkylthio)-5,6-diaryl-1,2,4-triazines as tubulin polymerization inhibitors

, 2019; 16(11): 1194-1201.

Farhad Saravani, Ebrahim Saeedian Moghadam, Hafezeh Salehabadi, Seyednasser Ostad, Morteza Pirali Hamedani, Massoud Amanlou, Mohammad Ali Faramarzi and Mohsen Amini*


DOI: 10.2174/1570180815666180727114216


Research Article

A study on the synthesis of risedronic acid: The role of an ionic liquid additive

, 2019; 16(3): 238-244.

Dávid Illés Nagy, Alajos Grün, Júlia Sinkovicz, Sándor Garadnay, István Greiner and György Keglevich*


DOI: 10.2174/1570180815666180626122630


Letter

One-pot synthesis of betulin triterpenoid quaternized pyridine derivatives and their antimicrobial activity

, 2020; 17(1): 79-84.

Elvira Rifovna Shakurova, Darina Alexandrovna Pozdnyakova, Elena Valeryevna Tretyakova and Lyudmila Vyacheslavovna Parfenova*


DOI: 10.2174/1570180816666181217123629


Research Article

Identifying the structural features of diphenyl ether analogues for inha inhibition: A 2D and 3D QSAR based study

, 2020; 17(1): 31-47.

Ashutosh Prasad Tiwari, Varadaraj Bhat Giliyar*, Gurypur Gautham Shenoy and Vandana Kalwaja Eshwara


DOI: 10.2174/1570180816666190611153933


Research Article

Scoring ligand efficiency: Potency, ligand efficiency and product ligand efficiency within big data landscape

, 2019; 16(11): 1258-1263.

Jaroslaw Polanski*, Anna Pedrys, Roksana Duszkiewicz and Johann Gasteiger


DOI: 10.2174/1570180816666190112154505


Research Article

Melatonin ameliorates radiation-induced sciatic nerve injury

, 2020; 17(1): 21-30.

Dheyauldeen Shabeeb*, Ahmed Eleojo Musa, Mansoor Keshavarz, Gholamreza Hassanzadeh, Mohammed Reza Hadian, Azin Nowrouzi, Alireza Shirazi* and Masoud Najafi


DOI: 10.2174/1570180816666190617160434



Research Article

Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, anticancer, antimicrobial and in silico studies

, 2019; 16(9): 994-1005.

Naveen Kumar, Swamy Sreenivasa*, Bhuvanesh Sukhlal Kalalc, Vasantha Kumar, Bantwal Shivarama Holla, Vinitha Ramanath Pai, Nadigar Revansiddappa Mohand and Shivaraj Govindaiah


DOI: 10.2174/1570180816666181220123924



General Research Article

The development of tyrosyl-DNA phosphodyesterase 1 (TDP1) inhibitors based on the amines combining aromatic/heteroaromatic and monoterpenoid moieties

, 2019; 16(5): 597-605.

Evgenii Mozhaitsev, Evgenii Suslov*, Yuliya Demidova, Dina Korchagina, Konstantin Volcho, Alexandra Zakharenko, Inna Vasil'eva, Maksim Kupryushkin, Arina Chepanova, Daniel Moscoh Ayine-Tora, Jóhannes Reynisson, Nariman Salakhutdinov and Olga Lavrik


DOI: 10.2174/1570180816666181220121042


Research Article

Design, synthesis and cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids as potent anti-breast cancer agents

, 2019; 16(7): 818-824.

Maryam Mohammadi-Khanaposhtani, Kiana Fahimi, Elahe Karimpour-Razkenari, Maliheh Safavi, Mohammad Mahdavi, Mina Saeedi and Tahmineh Akbarzadeh*


DOI: 10.2174/1570180815666180627121006



Most Accessed Articles

Design, Synthesis and Anti Colon Cancer Activity Evaluation of Phosphorylated Derivatives of Lamivudine (3TC)

, 2011; 8(1): 59-64.

Valasani Koteswara Rao, Sanapalli S. Reddy, Balam S. Krishna, Cirandur S. Reddy, Nimmanapalli P. Reddy, Tamatam C.M. Reddy, Chamarthi N. Raju and S. K. Ghosh


DOI: 10.2174/157018011793663921


Synthesis and Antimicrobial Activity of Adamantyl Substituted Pyridoxine Derivatives

, 2019; 16(12): 1360-1369.

Rail Khaziev, Nikita Shtyrlin, Roman Pavelyev, Raushan Nigmatullin, Raylya Gabbasova, Denis Grishaev, Anna Shtro, Anastasia Galochkina , Yulia Nikolaeva , Tatiana Vinogradova , Olga Manicheva, Marine Dogonadze, Oleg Gnezdilov , Evgenii Sokolovich, Petr Yablonskiy, Konstantin Balakin and Yurii Shtyrlin*


DOI: 10.2174/1570180816666190911150705


Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions

, 2019; 16(11): 1248-1257.

Hedvig Bölcskei*, Andrea Német-Hanzelik, Zsófia Dubrovay, Viktor Háda and György Keglevich


DOI: 10.2174/1570180816666181106123809


Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, Anticancer, Antimicrobial and In Silico Studies

, 2019; 16(9): 994-1005.

Naveen Kumar, Swamy Sreenivasa*, Bhuvanesh Sukhlal Kalal, Vasantha Kumar, Bantwal Shivarama Holla, Vinitha Ramanath Pai, Nadigar Revansiddappa Mohan and Shivaraj Govindaiah


DOI: 10.2174/1570180816666181220123924


Design, Synthesis and Biological Evaluation of Camptothecin Conjugated with NSAIDs as Novel Dual-actin Antitumor Agents

, 2019; 16(12): 1378-1386.

Xingchen Cai, Weiwei Huang, Yi Huang, Lihua Xia, Miao Liu, Mengke Wang, Wenchao Wang and Qingyong Li*


DOI: 10.2174/1570180816666190221103257


Design, Synthesis and Pharmacological Evaluation of Novel Antiinflammatory and Analgesic O-Benzyloxime Compounds Derived From Natural Eugenol

, 2019; 16(10): 1157-1166.

Rodrigo César da Silva, Fabiano Veiga, Fabiana Cardoso Vilela, André Victor Pereira, Thayssa Tavares da Silva Cunha, Roberta Tesch, Claudio Viegas Jr., Danielle Ferreira Dias, Alexandre Giusti-Paiva, Marcia Paranho Veloso and Carlos Alberto Manssour Fraga*


DOI: 10.2174/1570180815666180620145609


Synthesis and Biological Activity of N-(arylsulfonyl) Valine Hydrazones and Assistance of NMR Spectroscopy for Definitive 3D Structure

, 2019; 16(9): 974-983.

Sevil Şenkardeş, Esra Tatar, Ridvan Nepravishta*, Dorisa Cela, Maurizio Paci, Özlem Bingöl Özakpınar, Turgut Şekerler, Erik De Clercq, Christophe Pannecouque, Ş. Güniz Küçükgüzel* and İlkay Küçükgüzel


DOI: 10.2174/1570180815666180810120609






Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

Biography View Full Editorial Board

Journal History

Letters in Drug Design & Discovery was introduced in 2004. Dr. Kamil Kuca serves as the Editor-in-Chief of the journal.
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Scopus CiteScore Metrics: 1.05

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