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"Letters in Drug Design & Discovery should be available in every library in the pharmaceutical industry and in universities."

R. F. Borne, Associate Director
Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, USA

Forthcoming Special Issues

Opportunities and challenges in anticandidal drug discovery and development

Guest Editor(s): Mohammad Abid
Tentative Publication Date: April, 2018
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Published Special Issues


Letters in Drug Design & Discovery, Volume 15, Number 03
Guest Editor(s): Gokhan Zengin, Marcello Locatelli

Authors' Comments
I would like to thank Bentham Science Publishers for their peerless effort to keep up scientists and students updated with the latest science and research work. Actually, Bentham assists researchers to achieve their goals to spread their reputation worldwide. I have experienced sincere, efficient and effective communication while dealing with Bentham team members. I intend to submit my work to Bentham and try to pick up journals that match my research profile. I have submitted a recent work to Medicinal Chemistry and nowadays I am drafting a manuscript targeting Current Pharmaceutical Design. Honestly, no words neither sentences would express my gratefulness and admiration. Bentham has offered my institution three months trial to access their journal lists and surf on its Board. This free access trial fulfills my literature review and broadens my horizon to absorb the recent research in pharmaceutical sciences and medicinal chemistry. Finally, I wish Bentham more success and achievement!

Dima Sabbah
(Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan)

Letters in Drug Design & Discovery


Volume 15


Number 5

Research Article

Research Article

Research Article

Research Article

Computational Approach to the Discovery of Phytochemical Molecules with Therapeutic Potential Targets to the PKCZ protein

, 15(5): 488 - 499

Poliany G. Freitas*, Thiago C. Elias, Icaro A. Pinto, Luciano T. Costa, Paulo V.S.D. de Carvalho, Daniel de Q. Omote, Ihosvany Camps, Tati Ishikawa, Helen A. Arcuri, Susana Vinga, Arlindo L. Oliveira, Walter F.A. Junior and Nelson J.F. da Silveira

DOI: 10.2174/1570180814666170810120150

Research Article

In Silico Bioactivity Prediction of Methoxime-3,4-dephostatin Derivatives on Human PTP1B: Search for Novel Antidiabetic Leads

, 15(5): 500 - 507

Sabina B. Choudhury, Anupam D. Talukdar*, Manabendra D. Choudhury, Monjur A. Laskar and Abhishek Chowdhury

DOI: 10.2174/1570180814666170907162934


Antimicrobial Activity and Molecular Docking of Tannins from Pimenta dioica

, 15(5): 508 - 515

Reham Al-Harbi, Mona Shaaban*, Razan Al-wegaisi, Fatma Moharram, Ola Abd El-Rahman and Shahenda El-Messery

DOI: 10.2174/1570180814666170810113850

Review Article

Synthesis and Cytotoxicity Evaluation of Novel Tricyclic Dihydropyrazolo [4,3-f][1,2,3]triazolo Diazepines

Chiranjeevi Bingi, Ashok Kale, Y Poornachandra, C Ganesh Kumar and Krishnaiah Atmakur*

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Molecular Docking and 3D-QSAR Studies on 7-azaindole Derivatives as Inhibitors of Trk A: A Strategic Design in Novel Anticancer Agents

Adnane Aouidate*, Adib Ghaleb, Mounir Ghamali, Samir Chtita, Abdellah Ousaa, M`barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine and Tahar Lakhlifi

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Plant Antioxidants and Mechanisms of Action

Weslley Felix de Oliveira, Priscila Marcelino dos Santos Silva, Luana Cassandra Breitenbach Barroso Coelho and Maria Tereza dos Santos Correia *

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Synthesis and Cytotoxic Activity of 2,6-Diarylidenecyclohexanones and their 6-Amino-1,3-dimethyluracil Monoadducts

Erika Madeleyne Ramos-Rivera , Cuauhtemoc Alvarado, Jose D. Solano, Luis Roa de la Fuente, Angeles Dominguez-Rivera, Miguel Angel Vilchis-Reyes* and Miguel Angel Martinez-Urbina

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Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

Pegah Khosravian, Mehdi Khoobi, Mehdi Shafiee Ardestani, Mohammad Porgham Daryasari, Malihe Hassanzadeh, Payam Ghasemi-Dehkordi, Massoud Amanlou and Hamid Akbari Javar*

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Synthesis and Antibacterial/Antitubercular/Antioxidant Activities of Compounds Containing Fluoroquinolone Ring Linked to a 4-thiazolidinone Moiety

Tejeswara Rao Allaka, Naresh Kumar Katari, Venkanna Banothu, Srinubabu Maddela, Jaya Shree Anireddy and Manojit Pal *

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Unveiling the Accuracy of Homology Modeling to Elucidate the Structure of GPCRs-HIV Co-receptor-CCR5 as a Case Study

Vadivelu Aanand , Rajendran Anitha , Somarathinam Kanagasabai , Gunalan Seshan , Changdev G Gadhe and Gugan Kothandan *

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Preparation and Characterization of GLUT1-mediated Novel Brain Targeting Magnetic Nanoparticles

Li Zhang, Yi Zhao, Qiming Yue, Qiuyi Fu, Li Hai, Li Guo, Qiantao Wang and Yong Wu*

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Synthesis, Characterization and Evaluation of Gemfibrozil-Stilbene Hybrid as Antioxidant Agent

Rosa Amoroso, Lidia Leporini, Ivana Cacciatore, Lisa Marinelli, Alessandra Ammazzalorso, Isabella Bruno, Barbara De Filippis, Marialuigia Fantacuzzi, Cristina Maccallini, Luigi Menghini, Antonio Di Stefano and Letizia Giampietro*

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Arylsulfonylhydrazone induced apoptosis in MDA-MB-231 breast cancer cells

Thais Batista Fernandes, Ricardo Alexandre de Azevedo, Rosania Yang, Sarah Fernandes Teixeira, Gustavo Henrique Goulart Trossini, Jose Alexandre Marzagao Barbuto, Adilson Kleber Ferreira and Roberto Parise Filho*

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Synthesis, Characterization and Antimicrobial Activity of Thiamine Complexes

Sumaira Khurshid, Shazia Shah, Qurat-ul-Ain, Arshia, Zahida T. Maqsood, Saima Tauseef and Khalid Muhammad Khan

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Synthesis and Antifungal Activity of Some 6-tert-butyl-8-chloro-2, 3-dimethylquinolin-4-ol Derivatives against Pyricularia oryae

Yue-Ming Fang, Rui-Rui Zhang, Zhong-Hua Shen, Cheng-Xia Tan, Jian-Quan Weng, Tian-Ming Xu, Xing-Hai Liu*, Hong-Ying Huang and Hong-Ke Wu

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Synthesis and Anticancer Properties of Methyl N1-(thien-4-yl)amidrazone-3-carboxylates

Ali M. Almansour, Jalal A. Zahra*, Salim S. Sabri, Mustafa M. El-Abadelah, Malik A. Zihlif and Mutasem O. Taha

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Synthesis, Biological Evaluation and Docking studies of 1,3,4-Oxadiazole Fused Benzothiazole Derivatives for Anticancer Drugs

Madala Subramanyam, Reddymasu Sreenivasulu, M. V. Basaveswara Rao, Rambabu Gundla and Koya Prabhakara Rao *

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