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"Letters in Drug Design & Discovery should be available in every library in the pharmaceutical industry and in universities."

R. F. Borne, Associate Director
Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, USA

Forthcoming Special Issues

Opportunities and challenges in anticandidal drug discovery and development


Guest Editor(s): Mohammad Abid
Tentative Publication Date: September, 2018
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Published Special Issues

NEW INSIGHTS ON CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF NATURAL PRODUCTS


Letters in Drug Design & Discovery, Volume 15, Number 03
Guest Editor(s): Gokhan Zengin, Marcello Locatelli

Authors' Comments
I would like to thank Bentham Science Publishers for their peerless effort to keep up scientists and students updated with the latest science and research work. Actually, Bentham assists researchers to achieve their goals to spread their reputation worldwide. I have experienced sincere, efficient and effective communication while dealing with Bentham team members. I intend to submit my work to Bentham and try to pick up journals that match my research profile. I have submitted a recent work to Medicinal Chemistry and nowadays I am drafting a manuscript targeting Current Pharmaceutical Design. Honestly, no words neither sentences would express my gratefulness and admiration. Bentham has offered my institution three months trial to access their journal lists and surf on its Board. This free access trial fulfills my literature review and broadens my horizon to absorb the recent research in pharmaceutical sciences and medicinal chemistry. Finally, I wish Bentham more success and achievement!

Dima Sabbah
(Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan)


Letters in Drug Design & Discovery

,

Volume 15

-

Number 12



Biography   Open Access



Research Article



Research Article

Synthesis and Antioxidant Activities of Ferrocenyl-containing Curcumin Analogues

, 15(12): 1252 - 1258

Xianjiao Meng, Shengling Li, Wenbing Ma*, Jianlong Wang, Zhiyong Hu and Duanlin Cao*


DOI: 10.2174/1570180815666180219161110




Research Article

New 1,3-oxazolylphosphonium Salts as Potential Biocides: QSAR Study, Synthesis, Antibacterial Activity and Toxicity Evaluation

, 15(12): 1259 - 1267

Maria M. Trush*, Vasyl Kovalishyn, Alla D. Ocheretniuk, Larisa E. Kalashnikova, Volodymyr M. Prokopenko, Oleksandr V. Holovchenko, Oleksandr L. Kobzar, Volodymyr S. Brovarets and Larisa O. Metelytsia


DOI: 10.2174/1570180815666180219164334




Research Article

Synthesis and Anticancer Properties of Methyl N1-(thien-4-yl)amidrazone- 3-carboxylates

, 15(12): 1268 - 1275

Ali M. Almansour, Jalal A. Zahra*, Salim S. Sabri, Mustafa M. El-Abadelah, Malik A. Zihlif and Mutasem O. Taha


DOI: 10.2174/1570180815666180306152143




Research Article

Synthesis, Characterization and Antimicrobial Activity of Thiamine Complexes

, 15(12): 1276 - 1287

Sumaira Khurshid*, Shazia Shah, Qurrat-ul-Ain, Arshia, Zahida T. Maqsood, Saima Tauseef and Khalid Mohammed Khan*


DOI: 10.2174/1570180815666180321155734




Research Article

Arylsulfonylhydrazone Induced Apoptosis in MDA-MB-231 Breast Cancer Cells

, 15(12): 1288 - 1298

Thais Batista Fernandes, Ricardo Alexandre de Azevedo, Rosania Yang, Sarah Fernandes Teixeira, Gustavo Henrique Goulart Trossini, Jose Alexandre Marzagao Barbuto, Adilson Kleber Ferreira and Roberto Parise-Filho*


DOI: 10.2174/1570180815666180321161513




Research Article



Articles Ahead of Print


Synthesis, Anti-inflammatory, Antimicrobial Potential and Molecular Docking Studies of 4,5-Disubstituted-1,2,4-Triazole Thioacetate Derivatives


Muhammad Nouman Arif, Humaira Nadeem*, Rehan Zafar Paracha, Arifullah Khan, Imran Khanzada and Fawad Ali


View Abstract



Synthesis, Anti-proliferative Evaluation, and Molecular Docking Studies of 3-(alkylthio)-5,6-diaryl-1,2,4-triazines as Tubulin Polymerization Inhibitors


Farhad Saravani, Ebrahim Saeedian Moghadam, Hafezeh Salehabadi, Sayednaser Ostad, Morteza Pirali Hamedani, Massod Amanlou, Mohammad Faramarzi and Mohsen Amini*


View Abstract


3D-QSAR Studies of S-DABO Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors


Yueping Wang, Jie Chang, Jiangyuan Wang, Peng Zhong, Yufang Zhang, Christopher Cong Lai and Yanping He*


View Abstract



Evaluation of the in vitro Antitumor Activity of Nanostructured Cyclotides in Polymers of Eudragit® L 100-55 and RS 30 D


Osmar N. Silva*, Michelle F. S. Pinto, Juliane F. C. Viana, Camila G. Freitas, Isabel C.M. Fensterseifer, David J. Craik and Octavio L. Franco


View Abstract


Genoprotective Effect of New Triazine Derivatives in Endosulfan Mediated Toxicity, an in vivo and in vitro Study


Nima Naderi, Seyed Mostafa Ghasemi Najarkolaee, Mona Modanlookordi, Mohammad Shokrzadeh and Hamid Irannejad*


View Abstract


Design and Synthesis of Benzopyranopyrimidinyl Phosphonates as Cytotoxic and Antioxidant Agents


Sarva Santhisudha, Tenkayala Sobha Rani, Peddaiahgari Vasu Govardhana Reddy and Cirandur Suresh Reddy


View Abstract


Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study


Xing-Hai Liu*, Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Bao-Ju Li


View Abstract


Abstracts Ahead of Print

Challenges in the discovery and optimization of mGlu2/4 heterodimer positive allosteric modulators


Mark G. Fulton, Matthew T. Loch, Caroline A. Cuoco, Alice L. Rodriguez, Emily Days, Paige N. Vinson, Krystian A. Kozek, C David Weaver, Anna L. Blobaum, Jeff Conn, Colleen M. Niswender and Craig W. Lindsley*


View Abstract


Progress in Synthesis and Bioactivity Evaluation of Pyrazoloquinazolines


Hui Zhao, Xiaoxia Hu, Yue Zhang, Chunlei Tang* and Bainian Feng*


View Abstract


An Environment-Friendly Synthesis of Piperonal Chalcones and Their Cytotoxic and Antioxidant Evaluation


Sanal Dev, Della Grace Thomas Parambi, Benncy Baby, Githa Elizabeth Mathew, Hendawy OM, Monu Joy, Shine Sudev and Bijo Mathew*


View Abstract


Potential of nanoparticles in combating Candida infections


Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani


View Abstract





Synthesis of Pyridinyl-benzo[d]imidazole/Pyridinyl-benzo[d]thiazole Derivatives and their Yeast Glucose uptake Activity In Vitro


Momin Khan*, Riaz Ahmad, Gauhar Rehman, Naeem Gul, Uzma Salar, Khalid M. Khan, Shahnaz Perveen and Sana Shah


View Abstract


Design and synthesis of novel thiosemicarbazones as potent anti-breast cancer agents


Mashooq Ahmad Bhat, M. Al-Tahhan, Mohamed Al-Omar and Ahmed M. Naglah


View Abstract



Editor's Choice

Preparation and Characterization of GLUT1-mediated Novel Brain Targeting Magnetic Nanoparticles

, 2018; 15(12): 1308 - 1313

Li Zhang, Yi Zhao, Qiming Yue, Qiuyi Fu, Li Hai, Li Guo, Qiantao Wang* and Yong Wu*


DOI: 10.2174/1570180815666180322113934



Synthesis and Mosquiticidal Activity of Novel Hydrazone Containing Pyrimidine Derivatives against Aedes aegypti

, 2018; 15(9): 951 - 956

Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep, David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*


DOI: 10.2174/1570180815666180102141640



Inhibitory Effects of 1,4-disubstituted Thiosemicarbazide Derivatives on Streptococcus mutans and Streptococcus sanguinis Mono-species Biofilms

, 2018; 15(8): 843 - 850

Malgorzata Miazga-Karska, Maciej Wos, Agnieszka A. Kaczor, Anna Pachuta-Stec, Grazyna Ginalska and Monika Pitucha*


DOI: 10.2174/1570180814666171012164241



Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

, 2018; 15(7): 787 - 795

Pegah Khosravian, Mehdi Khoobi, Mehdi Shafiee Ardestani, Mohammad Porgham Daryasari, Malihe Hassanzadeh, Payam Ghasemi-Dehkordi, Massoud Amanlou and Hamid Akbari Javar*


DOI: 10.2174/1570180815666180117155818



Synthesis and Mosquitocidal Activity of a Series of Hydrazone Derivatives against Aedes aegypti

, 2018; 15(6): 671 - 677

Mehlika Dilek Altintop*, Nurhayat Tabanca, James J. Becnel, Jeffrey R. Bloomquist, Zafer Asim Kaplancikli and Ahmet Ozdemir


DOI: 10.2174/1570180814666171002155548





Antimicrobial, Gastroprotective and Healing Effect of the Hydroalcoholic Extract of Astronium fraxinifolium

, 2018; 15(3): 325 - 334

Anita Oliveira Brito Pereira Bezerra Martins, Ana Luiza Albuquerque Siebra, Cicera Datiane de Morais Oliveira, Gerlania Oliveira Leite, Henrique Douglas Melo Coutinho, Margareth Linde Athayde, Aline Augusti Bolignon, Jacqueline Cosmo Andrade, Larissa Rolim Oliveira, Marta Regina Kerntopf, Roseli Barbosa, Francisco Rafael Alves Santana Cesario, Thales Silva Coutinho, Lucindo Jose Quintans-Junior and Irwin Rose Alencar de Menezes*


DOI: 10.2174/1570180814666170213160114





Open Access Articles

A Study on the Synthesis of Risedronic Acid; The Role of an Ionic Liquid Additive

, 2018; 15: 1 - 7 (E-Pub Ahead of Print)

David Illes Nagy, Alajos Grun, Julia Sinkovicz, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*




Synthesis and Biological Evaluation of some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors

, 2018; 15: 1 - 9 (E-Pub Ahead of Print)

Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*




Synthesis and Anti-Oxidant Evaluation of Some Novel Sulfa Drugs

, 2017; 14(12): 1425 - 1432

Moustafa A. Gouda* and Belal H.M. Hussein




L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis

, 2017; 14(6): 737 - 742

Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*




Synthesis of Novel 4-(Dimethylaminoalkyl)piperazine-1-carbodithioa t e Derivatives as Cholinesterase Inhibitors

, 2017; 14(5): 528 - 539

Ulviye Acar Cevik, Serkan Levent, Begum Nurpelin Saglık, Yusuf Ozkay* and Zafer Asım Kaplancıklı




In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR

, 2017; 14(2): 125 - 134

Wolfgang Walther, Oyinlola Dada, Cillian O’Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke




Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475 - 478

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich






4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls

, 2015; 12(2): 131 - 139

Maria Antonietta Dettori, Davide Fabbri, Marina Pisano, Carla Rozzo, Giuseppe Palmieri, Alessandro Dessi, Roberto Dallocchio and Giovanna Delogu




Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking

, 2014; 11(3): 331 - 338

Muhammad Yar, Marek Bajda, Rana Atif Mehmood, Lala Rukh Sidra, Nisar Ullah, Lubna Shahzadi, Muhammad Ashraf, Tayaba Ismail, Sohail Anjum Shahzad, Zulfiqar Ali Khan, Syed Ali Raza Naqvi and Nasir Mahmood




Optimized Synthesis of Etidronate

, 2013; 10(8): 733 - 737

Rita Kovacs, David Illes Nagy, Alajos Grün, Gyorgy Tibor Balogh, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich






Selective Androgen Receptor Modulators Antagonize Apolipoprotein E4-Induced Cognitive Impairments

, 2008; 5(4): 271 - 276

Summer Acevedo, Luis Gardell, Stefania Risso Bradley, Fabrice Piu and Jacob Raber





Most Cited Articles

Microwave Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-triazolo[4,3-a] pyridine Moiety

, 2016; 13(6): 521-525.

Zhi-Wen Zhai, Yan-Xia Shi, Ming-Yan Yang, Wen Zhao, Zhao-Hui Sun, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, Bao-Ju Li and Yong-Gang Zhang


DOI: 10.2174/157018081306160618181757








Synthesis of Novel C3-Linked β-Carboline-Pyridine Derivatives Employing Khronke Reaction: DNA-binding Ability and Molecular Modeling Studies

, 2016; 13(4): 335-342.

Nagula Shankaraiah, Pankaj Sharma, Srinivas Pedapati, Shalini Nekkanti, Vunnam Srinivasulu, Niggula Praveen Kumar and Ahmed Kamal


DOI: 10.2174/157018081304160303180050



Prediction of Caco-2 Cell Permeability Using Bilinear Indices and Multiple Linear Regression

, 2016; 13(2): 161-169.

Huong Le-Thi-Thu, Yudith Canizares-Carmenate, Yovani Marrero-Ponce, Francisco Torrens and Juan A. Castillo-Garit


DOI: 10.2174/1570180812666150630183511


Synthesis and Antimicrobial Evaluation of Amphipathic Peptide Models

, 2016; 13(7): 715-724.

Marianna Sakka, Alexandra Balliou, Asimina Marianou, Dimitris Krikorian, Margarita Tsirogianni, Artemis Tsiligianni, Katerina Vartzeli, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou- Pomonis


DOI: 10.2174/1570180813666160616122410


Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475-478.

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich


DOI: 10.2174/1570180812666151022221805


Design, Synthesis and Mode of Action of Some New 2-(4'-aminophenyl) benzothiazole Derivatives as Potent Antimicrobial Agents

, 2016; 13(5): 429-437.

Meenakshi Singh, Sudhir Kumar Singh, Mayank Gangwar, Satheeshkumar Sellamuthu, Gopal Nath and Sushil K. Singh


DOI: 10.2174/1570180812666150821003220



Design and Synthesis of Novel Spiro-Piperidinyl Pyrazolone Derivatives and Their Potential Antiviral Activity

, 2016; 13(2): 149-160.

Rajagopalan Srinivasan, Badiadka Narayana, Balladka Kunhanna Sarojini, Veerakyathappa Bhanuprakash, Chenna Govindaraju Darshan Raj and Prakash S. Nayak


DOI: 10.2174/1570180812666150630182740



Most Accessed Articles

Synthesis and Cytotoxicity Evaluation of Novel Tricyclic Dihydropyrazolo [4,3-f][1,2,3]triazolo Diazepines

, 2018; 15(10): 1020-1025.

Chiranjeevi Bingi, Ashok Kale, Yedla Poornachandra, Chityal Ganesh Kumar and Krishnaiah Atmakur*


DOI: 10.2174/1570180815666180222143229


Synthesis of New Thiazolyl-Pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects

, 2018; 15(7): 744-756.

Belgin Sever, Mehlika Dilek Altıntop, Hulya Karaca Gencer, Handan Acelya Kapkac, Ozlem Atli, Merve Baysal and Ahmet Ozdemir*


DOI: 10.2174/1570180814666170925152902



2-Indolinone Derivatives as Potent Urease Inhibitors

, 2018; 15(8): 814-821.

Momin Khan*, Muhammad Yousaf, Abdul Wadood, Zahid Hussain, Muhammad Naeem, Khair Zaman, Sana Shah, Khalid Mohammed Khan and Shahnaz Perveen


DOI: 10.2174/1570180814666171116154110


Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

, 2016; 13(6): 475-478.

Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich


DOI: 10.2174/1570180812666151022221805


Antimicrobial Activities of Synthetic Arylidine Nicotinic and Isonicotinic Hydrazones

, 2018; 15(10): 1057-1067.

Muhammad Hayat, Khalid Mohammed Khan*, Sumayya Saeed, Uzma Salar, Momin Khan, Taimoor Baig, Aqeel Ahmad, Shahnaz Parveen and Muhammad Taha


DOI: 10.2174/1570180814666170914120337


Synthesis and Antibacterial/Antitubercular/Antioxidant Activities of Compounds Containing Fluoroquinolone Ring Linked to a 4-thiazolidinone Moiety

, 2018; 15(10): 1087-1094.

Tejeswara Rao Allaka, Naresh Kumar Katari, Venkanna Banothu, Srinubabu Maddela, Manojit Pal* and Jaya Shree Anireddy*


DOI: 10.2174/1570180815666171229150032


L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis

, 2017; 14(6): 737-742.

Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*


DOI: 10.2174/1570180814666170216102632



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