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Authors' Comments
My experience of working with Bentham Science has been positive. I think the review was completed timely and handled in a very professional manner, which is very important.

Dr. Pollen K. Yeung
(Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, Faculties of Health Professions and Medicine, Dalhousie University, Halifax, NS, )


Drug Metabolism Letters

,

Volume 12

-

Number 2



Biography   Open Access



Research Article



Research Article



Research Article



Research Article



Research Article



Research Article



Research Article

Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line

, 12(2): 138 - 144

Sandra R. Lepri , Daniele Sartori , Simone C. Semprebon*, Adrivanio Baranoski , Giuliana C. Coatti and Mario S. Mantovani


DOI: 10.2174/1872312812666180709150440




Abstracts Ahead of Print

“Branched tail” oxyquinoline inhibitors of HIF prolyl hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip


Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Yu. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan


View Abstract



Editor's Choice










Open Access Articles



The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells

, 2016; 10(4): 295 - 305

Tetsuo Sasabe*, Shinichiro Maeda, Kenichi Kishida, Mariko Yamano, Yoshihiro Miwa and Toshihiro Sugiyama




Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

, 2016; 10(2): 91 - 100

Peter W. Fan, Jacob Z. Chen, M. Allan Jaochico, Hank La, Ning Liu, Teresa Mulder, Robert T. Cass, Matthew Durk, Kirsten Messick, Nicole Valle, Shannon Liu, Wendy Lee, James J. Crawford, Joachim Rudolf, Lesley J. Murray, S. Cyrus Khojasteh and Matthew Wright




Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83 - 90

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam





Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation

, 2016; 10(2): 144 - 150

Julius L. Apuy, Cathie Xiang, Sarah Franc, Sayee G. Hegde, Robert Hubbard, Jingjing Zhao and Mehran F. Moghaddam





Influence of ABCB1 Gene Polymorphisms and P-Glycoprotein Activity on Cyclosporine Pharmacokinetics in Peripheral Blood Mononuclear Cells in Healthy Volunteers

, 2008; 2(2): 76 - 82

Nicolas Ansermot, Michela Rebsamen, Jocelyne Chabert, Marc Fathi, Marianne Gex-Fabry, Youssef Daali, Marie Besson, Michel Rossier, Serge Rudaz, Denis Hochstrasser, Pierre Dayer and Jules Desmeules




Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats

, 2008; 2(2): 138 - 145

Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen and Rolf K. Berge





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Clinical Confirmation that the Selective JAK1 Inhibitor Filgotinib (GLPG0634) has a Low Liability for Drug-drug Interactions

, 2016; 10(1): 38-48.

Florence Namour*, Julie Desrivot, Annegret Van der Aa, Pille Harrison, Chantal Tasset and Gerben van`t Klooster


DOI: 10.2174/1872312810666151223103353


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Ben-Quan Shen, Daniela Bumbaca, Qin Yue, Ola Saad, Jay Tibbitts, S. Cyrus Khojasteh and Sandhya Girish


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DOI: 10.2174/1872312809666150119110200


Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

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DOI: 10.2174/1872312810666160223121836




Elucidating the Mechanism of Tofacitinib Oxidative Decyanation

, 2016; 10(2): 136-143.

Hoa Le, Peter W. Fan, Susan Wong, Shuguang Ma, James P. Driscoll, Cornelis E.C.A. Hop and S. Cyrus Khojasteh


DOI: 10.2174/1872312810666160427104954




Most Accessed Articles

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions

, 2018; 12(1): 3-13.

Susan Wong, Utkarsh Doshi, Peter Vuong, Ning Liu, Suzanne Tay, Hoa Le, Mika Kosaka, Jane R. Kenny, Albert P. Li and Zhengyin Yan*


DOI: 10.2174/1872312812666171213114422






Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83-90.

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam


DOI: 10.2174/1872312810666160223121836



Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat

, 2017; 11(2): 102-110.

Jennifer L. Dumouchel*, Upendra A. Argikar, Jaimie Spear, Ann Brown, Christine E. Dunne, Valerie M. Kramlinger, Amanda L. Cirello and Mithat Gunduz


DOI: 10.2174/1872312811666170911122919





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