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Current Topics in Medicinal Chemistry

Volume 19, 32 Issues, 2019
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Ranking and Category

  • 20th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 19

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Number 12



Editorial   Open Access



Review Article



Review Article



Review Article



Review Article



Review Article

Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers

, 19(12): 1051 - 1058

Ting Wang, Zhuyu Xu, Yongping Lu, Jianyou Shi, Wenbo Liu, Chengchen Zhang, Zhongliang Jiang, Baowen Qi* and Lan Bai*


DOI: 10.2174/1568026619666190510103416


Review Article

Pharmaceutical Inhibition of Neddylation as Promising Treatments for Various Cancers

, 19(12): 1059 - 1069

Lina Yin, Yuanyuan Xue, Qiannan Shang, Haichao Zhu, Meihua Liu, Yingxiang Liu and Qingzhong Hu*


DOI: 10.2174/1568026619666190311110646


Articles Ahead of Print

Untangling the Metabolic Reprogramming in Brain Cancer: Discovering Key Molecular Players Using Mass Spectrometry


Anatoly Sorokin*, Vsevolod Shurkhay, Stanislav Pekov, Evgeny Zhvansky, Daniil Ivanov, Eugene E. Kulikov, Igor Popov, Alexander Potapov and Eugene Nikolaev


DOI: 10.2174/1568026619666190729154543
View Abstract View on PubMed





Chemical Intuition in Drug Design and Discovery


Julia Galvez B. Pedreira, Lucas S. Franco and Eliezer J. Barreiro*


DOI: 10.2174/1568026619666190620144142
View Abstract View on PubMed







Abstracts Ahead of Print

Virtual Screening Techniques in Drug Discovery: Review and Recent Applications


Sheisi Fonseca Leite da Silva Rocha*, Carolina Gurski Olanda, Harold Hilarion Fokoue and Carlos Mauricio R. Sant`Anna


DOI: 10.2174/1568026619666190816101948
View Abstract


Bothrops alternatus snake venom induces cytokine expression and oxidative stress on renal function


Francisco Assis Nogueira Júnior, Antonio Rafael Coelho Jorge, Aline Diogo Marinho, João Alison de Moraes Silveira, Natacha Teresa Queiroz Alves, Pedro Henrique Sá Costa, Paula Letícia Braga e Silva, Adriano José Maia Chaves-Filho, Dânya Bandeira Lima, Tiago Lima Sampaio, Glayciane Bezerra de Morais, Janaina Serra Azul Monteiro Evangelista, Alice Maria Costa Martins, Rui Seabra Ferreira Jr., Danielle Silveira Macedo, Roberta Jeane Bezerra Jorge* and Helena Serra Azul Monteiro


DOI: 10.2174/1568026619666190809100319
View Abstract



Pharmacology of ivabradine and the effect on chronic heart failure


Yue Zhou, Jian Wang, Zhuo Meng, Shuang Zhou, Jiayu Peng, Sun Chen, Qingjie Wang* and Kun Sun*


DOI: 10.2174/1568026619666190809093144
View Abstract



Homologation: A versatile molecular modification strategy to drug discovery


Lídia Moreira Lima*, Marina Amaral Alves and Daniel Nascimento do Amaral


DOI: 10.2174/1568026619666190808145235
View Abstract



Antitumoral Potential of Lansbermin-I, a Novel Disintegrin from Porthidium lansbergii lansbergii Venom on Breast Cancer Cells


Leonel Montealegre-Sánchez*, Sarah N. C. Gimenes, Daiana S. Lopes, Samuel C. Teixeira, Luis Solano-Redondo, Veridiana de M. Rodrigues and Eliécer Jiménez-Charris*


DOI: 10.2174/1568026619666190806151401
View Abstract


Differences in kynurenine metabolism during depressive, manic, and euthymic phases of bipolar affective disorder


Alexander Maget, Martina Platzer*, Susanne A. Bengesser, Frederike T. Fellendorf, Armin Birner, Robert Queissner, Carlo Hamm, Bernd Reininghaus, Andrzej Hecker, Lukas Tomberger, Renè Pilz, Nina Dalkner, Natalie Moll, Gregor Schütze, Markus Schwarz, Hans P. Kapfhammer and Eva Z. Reininghaus


DOI: 10.2174/1568026619666190802145128
View Abstract



Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19: 1 - 19 (E-Pub Ahead of Print)

Chenyi Liao, Mathilde Poujol de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May and Jianing Li*






Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley








Most Cited Articles

Review Article

Bis-coumarin derivatives and their biological activities

, 2018; 18(2): 101-113.

Qing-Cheng Ren, Chuan Gao , Zhi Xu , Lian-Shun Feng, Ming-liang Liu*, Xiang Wu* and Feng Zhao*


DOI: 10.2174/1568026618666180221114515


Review Article

Coumarin compounds in medicinal chemistry: Some important examples from the last years

, 2018; 18(2): 124-148.

Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*


DOI: 10.2174/1568026618666180329115523


Review Article

Recent development of small molecule glutaminase inhibitors

, 2018; 18(6): 432-443.

Minsoo Song*, Soong-Hyun Kim, Chun Young Im and Hee-Jong Hwang


DOI: 10.2174/1568026618666180525100830


Review Article

Recent development of coumarin derivatives as potential antiplasmodial and antimalarial agents

, 2018; 18(2): 114-123.

Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*


DOI: 10.2174/1568026618666171215101158



Review Article

Prediction and targeting of interaction interfaces in G-protein coupled receptor oligomers

, 2018; 18(8): 714-746.

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610


Review Article

Learning from nature: Bioinspired strategies towards antimicrobial nanostructured systems

, 2018; 18(1): 22-41.

Giuseppe Vitiello, Brigida Silvestri and Giuseppina Luciani*


DOI: 10.2174/1568026618666180206101129


Research Article

Structure-based virtual screening for the identification of high affinity compounds as potent VEGFR2 inhibitors for the treatment of renal cell carcinoma

, 2018; 18(25): 2174-2185.

Khushboo Sharma, Khushboo Patidar, Meer Asif Ali, Pravin Patil, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666181130142237


Review Article

Targeting sugar uptake and metabolism for cancer identification and therapy: An overview

, 2018; 18(6): 467-483.

Marina Tanasova*, Vagarshak V. Begoyan and Lukasz J. Weselinski


DOI: 10.2174/1568026618666180523110837






Review Article

Applications of machine learning methods in drug toxicity prediction

, 2018; 18(12): 987-997.

Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao and Hongsheng Liu*


DOI: 10.2174/1568026618666180727152557


Review Article

An update on MDMX and dual MDM2/X inhibitors

, 2018; 18(8): 647-660.

Margarida Espadinha, Valentina Barcherini, Elizabeth A. Lopes and Maria M.M. Santos*


DOI: 10.2174/1568026618666180604080119



Most Accessed Articles





Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment

, 2018; 18(15): 1333-1348.

C.P. Taborda*, R. Buccheri, G. Benard, A.N. Duarte-Neto, J.D. Nosanchuk and L.R. Travassos


DOI: 10.2174/1568026618666181002112231


3D-QSAR in Drug Design - A Review

, 2010; 10(1): 95-115.

Jitender Verma, Vijay M. Khedkar and Evans C. Coutinho


DOI: 10.2174/156802610790232260


Leishmaniasis and Chagas Disease – Neglected Tropical Diseases: Treatment Updates

, 2019; 19(3): 174-177.

Leandro Stefano Sangenito, Vanessa da Silva Santos, Claudia Masini d'Avila-Levy, Marta Helena Branquinha, André Luis Souza dos Santos* and Simone S.C. de Oliveira


DOI: 10.2174/156802661903190328155136


Recent Advances in Prostate-Specific Membrane Antigen-Based Radiopharmaceuticals

, 2019; 19(1): 33-56.

Wei Diao, Huawei Cai, Lihong Chen, Xi Jin, Xinyang Liao and Zhiyun Jia*


DOI: 10.2174/1568026619666190201100739


Protein/ Hormone Based Nanoparticles as Carriers for Drugs Targeting Protein-Protein Interactions

, 2019; 19(6): 444-456.

Ebtesam Al-Suhaimi*, Vijaya Ravinayagam, B. Rabindran Jermy, Tarhini Mohamad and Abdelhamid Elaissari


DOI: 10.2174/1568026619666190304152320


In Vitro, In Silico and Ex Vivo Studies of Dihydroartemisinin Derivatives as Antitubercular Agents

, 2019; 19(8): 633-644.

Komal Kalani, Sarfaraz Alam, Vinita Chaturvedi, Shyam Singh, Feroz Khan and Santosh Kumar Srivastava*


DOI: 10.2174/1568026619666190305131425




Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.
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Scopus CiteScore Metrics: 1.44


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