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Current Topics in Medicinal Chemistry

Volume 19, 32 Issues, 2019
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

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  • 20th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 19

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Number 26



Biography   Open Access



Biography   Open Access



Perspectives in Medicinal Chemistry   Open Access



Editorial   Open Access



Review Article



Review Article



Review Article   Open Access



Current Topics in Medicinal Chemistry, Volume 19 (2019) - Number 29


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 19 (2019) - Number 28


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 19 (2019) - Number 27


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Feasibility of Targeting Glioblastoma Stem Cells: From Concept to Clinical Trials


Vadim V. Tarasov, Andrey A. Svistunov, Vladimir N. Chubarev, Tamara A. Zatsepilova, Nina G. Preferanskaya, Olga I. Stepanova, Alexander V. Sokolov, Samira A. Dostdar, Nina N. Minyaeva, Margarita E. Neganova, Sergey G. Klochkov, Lyudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568026619666191112140939
View Abstract View on PubMed






Mechanism and Development of Modern General Anesthetics


Xiaoxuan Yang, Anita Luethy, Honghai Zhang, Yan Luo, Qingsheng Xue, Buwei Yu and Han Lu*


DOI: 10.2174/1568026619666191114101425
View Abstract View on PubMed


The Use of Fibrin-based Tissue Adhesives for Breast in Reconstructive and Plastic Surgery


Kuo Chen*, Mikhail Y. Sinelnikov, Vladimir N. Nikolenko, Igor V. Reshetov, Yu Cao, Zhi Li, Ekaterina V. Kochurova, Svetlana N. Nikolenko, Marco Avila-Rodríguez, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev


DOI: 10.2174/1568026619666191112101448
View Abstract View on PubMed


The Posterior Perforated Substance: A Brain Mystery Wrapped in an Enigma


Vladimir N. Nikolenko, Leonid A. Gridin, Marine V. Oganesyan, Negoriya A. Rizaeva, Yury S. Podolskiy, Valentina A. Kudryashova, Ekaterina V. Kochurova, Roman K. Kostin, Ekaterina E. Tyagunova, Lyudmila M. Mikhaleva, Marco Avila-Rodriguez, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568026619666191127122452
View Abstract View on PubMed



Progress in the Mechanism and Clinical Application of Cilostazol


Huilei Zheng, Hua Yang, Danping Gong, Lanxian Mai, Xiaoling Qiu, Lidai Chen, Xiaozhou Su, Ruoqi Wei and Zhiyu Zeng*


DOI: 10.2174/1568026619666191122123855
View Abstract View on PubMed


Abstracts Ahead of Print


Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene-1,4-dione)


Juliana S. Novais, Aline C. Rosandiski, Carolina M. de Carvalho, Letícia S. de Saules Silva, Lais C. dos S. Velasco de Souza, Marcos V. Santana, Nathalia R. C. Martins, Helena C. Castro, Vitor F. Ferreira, Daniel T. G. Gonzaga, Gabriel O. de Resende and Fernando de C. da Silva*


DOI: 10.2174/1568026619666191210160342
View Abstract


In Silico Studies For Bacterystic Evaluation Against Staphylococcus Aureus Of 2-Naftomic Acid Analogues


Alex France Messias Monteiro, Marcus Tullius Scotti *, Alejandro Speck-Planche, Renata Priscila Costa Barros and Luciana Scotti


DOI: 10.2174/1568026619666191206111742
View Abstract


Machine Learning as proposal for a better application of food nanotechnology regulation in European Union


Ricardo Santana *, Enrique Onieva, Robin Zuluaga, Aliuska Duardo-Sánchez and Piedad Gañán


DOI: 10.2174/1568026619666191205152538
View Abstract


Progress in Target Drug Molecules for Alzheimer's Disease


Jiayang Xie, Ruirui Liang, Yajiang Wang, Junyi Huang, Xin Cao* and Bing Niu*


DOI: 10.2174/1568026619666191203113745
View Abstract


A comprehensive review of the genus Pyrola herbs in traditional uses, phytochemistry and pharmacological activities.


Xiliang Yang*, Jianglian She, Jinping Liu, Tao Yang, Gege An, Qingru Chen, Cheng Fan, Shuangjun Li, Qian Liu, Chunguo Qian, Ying Liu, Yajie zhou and Jingyi Zhao


DOI: 10.2174/1568026619666191203112412
View Abstract


Antioxidant and antibacterial activity of sulfonamides derived from carvacrol: a structure-activity relationship study


Aldo S. de Oliveira*, Luiz F. S. de Souza, Ricardo J. Nunes, Susana Johann, David L. Palomino-Salcedo, Leonardo L. G. Ferreira and Adriano D. Andricopulo


DOI: 10.2174/1568026619666191127144336
View Abstract


Antibacterial Activity of Cissus incisa Extracts against Multidrug-Resistant Bacteria


Deyani Nocedo-Mena, Elvira Garza-González, Mauricio González-Ferrara and María del Rayo Camacho-Corona*


DOI: 10.2174/1568026619666191121123926
View Abstract


The Association of Sleep Disorders, Obesity, and Sleep-Related Hypoxia with Cancer


Anna Brzecka, Karolina Sarul, Tomasz Dyła, Marco Avila-Rodriguez, Ricardo Cabezas-Perez, Vladimir N. Chubarev, Nina N. Minyaeva, Sergey G. Klochkov, Margarita E. Neganova, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland, Vadim V. Tarasov and Gjumrakch Aliev*


DOI: 10.2174/1568026619666191118110155
View Abstract


Updated Understanding of the Degenerative Disc Diseases - Causes versus Effects - Treatments, Studies and Hypothesis


Cristian Muresanu, Siva G. Somasundaram, Margarita E. Neganova, Elena V. Bovina, Sergey V. Vissarionov, Okom N. F. C. Ofodile, Vladimir P. Fisenko, Valentin Bragin, Nina N. Minyaeva, Vladimir N. Chubarev, Sergey G. Klochkov, Vadim V. Tarasov, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568026619666191114113048
View Abstract


Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles


Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*






Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley





Most Cited Articles

Review Article

Coumarin compounds in medicinal chemistry: Some important examples from the last years

, 2018; 18(2): 124-148.

Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*


DOI: 10.2174/1568026618666180329115523


Perspectives in Medicinal Chemistry

Perspectives in medicinal chemistry

, 2018; 18(23): 2000-2001.

Dorina Lauritano


DOI: 10.2174/156802661823190110112258



Review Article

Bis-coumarin derivatives and their biological activities

, 2018; 18(2): 101-113.

Qing-Cheng Ren, Chuan Gao , Zhi Xu , Lian-Shun Feng, Ming-liang Liu*, Xiang Wu* and Feng Zhao*


DOI: 10.2174/1568026618666180221114515


Review Article

Recent development of small molecule glutaminase inhibitors

, 2018; 18(6): 432-443.

Minsoo Song*, Soong-Hyun Kim, Chun Young Im and Hee-Jong Hwang


DOI: 10.2174/1568026618666180525100830



Review Article

Recent development of coumarin derivatives as potential antiplasmodial and antimalarial agents

, 2018; 18(2): 114-123.

Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*


DOI: 10.2174/1568026618666171215101158


Review Article

Applications of machine learning methods in drug toxicity prediction

, 2018; 18(12): 987-997.

Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao and Hongsheng Liu*


DOI: 10.2174/1568026618666180727152557


Review Article

Ubiquitin proteasome system as a potential drug target for malaria

, 2018; 18(5): 315-320.

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R. S. Garcia*


DOI: 10.2174/1568026618666180427145308


Review Article

Epigenetic targets and their inhibitors in cancer therapy

, 2018; 18(28): 2395-2419.

Le Zhao, Yong-Tao Duan, Ping Lu, Zhi-Juan Zhang, Xiao-Ke Zheng, Jun-Lei Wang* and Wei-Sheng Feng*


DOI: 10.2174/1568026619666181224095449


Research Article

Structure-based virtual screening for the identification of high affinity compounds as potent VEGFR2 inhibitors for the treatment of renal cell carcinoma

, 2018; 18(25): 2174-2185.

Khushboo Sharma, Khushboo Patidar, Meer Asif Ali, Pravin Patil, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666181130142237


Review Article

Backbone-cyclized peptides: A critical review

, 2018; 18(7): 526-555.

Samuel J.S. Rubin and Nir Qvit*


DOI: 10.2174/1568026618666180518092333




Research Article

New benzothiazole-based thiazolidinones as potent antimicrobial agents. Design, synthesis and biological evaluation

, 2018; 18(1): 75-87.

Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric


DOI: 10.2174/1568026618666180206101814



Most Accessed Articles


The Present and Future of Novel Protein Degradation Technology

, 2019; 19(20): 1784-1788.

Liwen Xia, Wei Liu, Yinsen Song, Hailiang Zhu* and Yongtao Duan*


DOI: 10.2174/1568026619666191011162955






Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399-1417.

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*


DOI: 10.2174/1568026619666190709092647


An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis

, 2019; 19(9): 646-661.

Matteo Mori, José Camilla Sammartino, Luca Costantino, Arianna Gelain, Fiorella Meneghetti, Stefania Villa and Laurent Roberto Chiarelli*


DOI: 10.2174/1568026619666190227182701


Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*


DOI: 10.2174/1568026619666190712204603


3D-QSAR in Drug Design - A Review

, 2010; 10(1): 95-115.

Jitender Verma, Vijay M. Khedkar and Evans C. Coutinho


DOI: 10.2174/156802610790232260




Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.
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Scopus CiteScore Metrics: 2.42


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