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Current Topics in Medicinal Chemistry

Volume 22, 32 Issues, 2022
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 21

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Number 32











Current Topics in Medicinal Chemistry, Volume 22 (2022) - Number 1


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


DNA Nanodevices: From Mechanical Motions to Biomedical Applications


Yiming Wang, Zhaoran Wang, Xiaohui Wu, Shaoli Liu, Fengsong Liu, Qiao Jiang* and Baoquan Ding*


DOI: 10.2174/1568026621666211105100240
View Abstract View on PubMed






Formulating the Structural Aspects of Various Benzimidazole Cognates


Prayaga Rajappan Krishnendu, Vishal Payyalot Koyiparambath, Vaishnav Bhaskar, Babu Arjun and Subin Mary Zachariah*


DOI: 10.2174/1568026621666211201122752
View Abstract View on PubMed




Garlic (Allium sativum L.): Its Chemistry, Nutritional Composition, Toxicity, and Anticancer Properties


Abdur Rauf, Tareq Abu-Izneid, Muthu Thiruvengadam*, Muhammad Imran, Ahmed Olatunde, Mohammad Ali Shariati, Saud Bawazeer, Saima Naz, Samira Shirooie, Ana Sanches-Silva, Umar Farooq and Galiya Kazhybayeva


DOI: 10.2174/1568026621666211105094939
View Abstract View on PubMed


Abstracts Ahead of Print

Recent Development of Flavonoids with Various Activities


Zhi-Gang Sun, Zhi-Na Li, Jin-Mai Zhang, Xiao-Yan Hou, Stacy Mary Yeh and Xin Ming*


DOI: 10.2174/1568026622666220117111858
View Abstract


Natural Products as Sources of Multitarget Compounds: Advances in the Development of Ferulic Acid as Multitarget Therapeutic


Rajwinder Kaur, Ankita Sood, Damanpreet Kaur Lang, Rashmi Arora, Neeraj Kumar, Vishal Diwan and Balraj Saini*


DOI: 10.2174/1568026622666220117105740
View Abstract






Contribution of Transcriptome to Elucidate the Biology of Plasmodium spp


Kleber Simônio Parreira, Pedro Scarpelli, Wânia Rezende Lima and R. S Garcia*


DOI: 10.2174/1568026622666220111140803
View Abstract


Published Contents

Editor's Choice


Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Open Access Articles

Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review

, 2021; 21(1): 28 - 47

Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga and Martin O. Onani*




Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward

, 2020; 20(32): 2959 - 2969

Danny Feijtel, Marion de Jong and Julie Nonnekens*




Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening

, 2020; 20(18): 1582 - 1592

Carlos Garcia-Hernandez, Alberto Fernández* and Francesc Serratosa




Telomere-related Markers for Cancer

, 2020; 20(6): 410 - 432

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*




Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*





Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley




LncRNA as a Therapeutic Target for Angiogenesis

, 2017; 17(15): 1750 - 1757

Mohan M. Kumar and Ravi Goyal*






Most Cited Articles

Review Article

Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases

, 2019; 19(19): 1694-1711.

Viktoriya Ivasiv, Claudia Albertini, Ana E. Gonçalves, Michele Rossi and Maria L. Bolognesi*


DOI: 10.2174/1568026619666190619115735





Review Article

Biological signatures of alzheimer’s disease

, 2020; 20(9): 770-781.

Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode* and Faheem H. Pottoo


DOI: 10.2174/1568026620666200228095553


Review Article

Discovery and development of anti-HIV therapeutic agents: Progress towards improved HIV medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*


DOI: 10.2174/1568026619666190712204603


Review Article

STAT3: A potential drug target for tumor and inflammation

, 2019; 19(15): 1305-1317.

Yang Sheng Hu, Xu Han and Xin Hua Liu*


DOI: 10.2174/1568026619666190620145052


Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen


DOI: 10.2174/1568026619666190122144217



Review Article

Virtual screening techniques in drug discovery: Review and recent applications

, 2019; 19(19): 1751-1767.

Sheisi F.L. da Silva Rocha, Carolina G. Olanda, Harold H. Fokoue and Carlos M.R. Sant'Anna*


DOI: 10.2174/1568026619666190816101948



Review Article

Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

, 2019; 19(5): 337-355.

Anil Kumar Saxena* and Anamika Singh


DOI: 10.2174/1568026619666190219105722


Review Article

Zinc-depend ent deacetylase (HDAC) inhibitors with different zinc binding groups

, 2019; 19(3): 223-241.

Yan Li, Fang Wang, Xiaoxue Chen, Jie Wang, Yonglong Zhao, Yongjun Li and Bin He*


DOI: 10.2174/1568026619666190122144949





Most Accessed Articles


Thiazolidinedione: A Privileged Scaffold for the Development of Anticancer Agents

, 2021; 21(28): 2529-2545.

Juan Sun, Yue-Hu Chen, Han-Yu Liu, Emmerson Hondo, Yang Zhou* and Yuan-Feng Wu*


DOI: 10.2174/1568026621666210521143550





Euglena Species: Bioactive Compounds and their Varied Applications

, 2021; 21(29): 2620-2633.

Swati Prabha Gupta, Khushboo, Vivek Kumar Gupta, Ujla Minhas, Rakesh Kumar and Bechan Sharma*


DOI: 10.2174/1568026621666210813111424



Sterol 14α-Demethylase from Trypanosomatidae Parasites as a Promising Target for Designing New Antiparasitic Agents

, 2021; 21(21): 1900-1921.

Paulo Fernando da Silva Santos-Júnior, Martine Schmitt, João Xavier de Araújo-Júnior and Edeildo Ferreira da Silva-Júnior*


DOI: 10.2174/1568026621666210303144448





Chemical Composition, Acetylcholine Esterase and Anti-bacterial Activities of Essential Oils of Elaeosilenum thapsioides (Desf.) Maire from Algeria

, 2021; 21(29): 2610-2619.

Zakaria Barbeche, Hocine Laouer, Ramazan Erenler, Mohamed Hajji, Guido Flamini, Ylenia Pieracci, Latifa Khattabi, Chawki Bensouici and Salah Akkal*


DOI: 10.2174/1568026621666210813110847



Transition Metal-mediated Uncaging Chemistry in Prodrug Design

, 2021; 21(24): 2205-2212.

Hai Yang Shu, Ren De Zhu, Jing Wu, Xin Hua Liu and Jing Bo Shi*


DOI: 10.2174/1568026621666210624113313





Editor-in-Chief

graphic
Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)
Biography
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COPE Compliant

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Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who served as the editor-in-chief from 2001 to 2020. Currently, Dr. Jia Zhou is the Editor-in-Chief of the journal.

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