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Current Pharmaceutical Design

Volume 25, 46 Issues, 2019
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

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  • 148th of 267 in

    Pharmacology & Pharmacy

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Aims & Scope

Current Pharmaceutical Design publishes timely in-depth/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

,

Volume 25

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Number 36



Editorial   Open Access



Review Article



Review Article

An Update on the Immunological, Metabolic and Genetic Mechanisms in Drug Hypersensitivity Reactions

, 25(36): 3813 - 3828

Cristobalina Mayorga*, Maria I. Montañez, Raquel Jurado-Escobar, Violeta Gil-Ocaña and Jose A. Cornejo-García


DOI: 10.2174/1381612825666191105122414


Review Article

Early Biomarkers for Severe Drug Hypersensitivity Reactions

, 25(36): 3829 - 3839

Adriana Ariza, Maria J. Torres*, Carmen Moreno-Aguilar, Rubén Fernández-Santamaría and Tahia D. Fernández


DOI: 10.2174/1381612825666191107105440


Review Article

Clinical Phenotypes of Severe Cutaneous Drug Hypersensitivity Reactions

, 25(36): 3840 - 3854

Hakan Guvenir, Tugba Arikoglu, Emine Vezir and Emine Dibek Misirlioglu*


DOI: 10.2174/1381612825666191107162921


Review Article

Drug-Induced liver Injury Associated with Severe Cutaneous Hypersensitivity Reactions: A Complex Entity in Need of a Multidisciplinary Approach

, 25(36): 3855 - 3871

Judith Sanabria-Cabrera, Inmaculada Medina-Cáliz, Simona Stankevičiūtė, Antonio Rodríguez-Nicolás, Marina Almarza-Torres, M. Isabel Lucena* and Raúl J. Andrade


DOI: 10.2174/1381612825666191107161912


Review Article



Review Article



Articles Ahead of Print

Neurophysiology and Treatment of Disorders of Consciousness Induced by Traumatic Brain Injury: Orexin Signaling as a Potential Therapeutic Target


Huiling Tang, Qiumei Zhu, Wei Li, Siru Qin, Yinan Gong, Hong Wang, Seiji Shioda, Shanshan Li, Jin Huang, Baohu Liu, Yuxin Fang, Yangyang Liu, Shenjun Wang, Yongming Guo, Qing Xia, Yi Guo and Zhifang Xu*


DOI: 10.2174/1381612825666191029101830
View Abstract View on PubMed


Wnt-β-catenin Signaling Pathway, the Achilles' Heels of Cancer Multidrug Resistance


Morteza Ghandadi*, Reza Valadan, Hamidreza Mohammadi, Javad Akhtari, Shaban Ali Khodashenas and Sorour Ashari


DOI: 10.2174/1381612825666191112142943
View Abstract View on PubMed


Melatonin: Implications for Ocular Disease and Therapeutic Potential


Luca Scuderi, Sergio Davinelli, Clemente Maria Iodice, Silvia Bartollino, Giovanni Scapagnini, Ciro Costagliola and Gianluca Scuderi*


DOI: 10.2174/1381612825666191113110225
View Abstract View on PubMed


Aging Methotrexate and Vasculoprotection: Mechanistic Insights and Potential Therapeutic Applications in Old Age


Arduino A Mangoni*, Sara Tommasi, Angelo Zinellu, Salvatore Sotgia, Stefania Bassu, Matteo Piga, Gian Luca Erre and Ciriaco Carru


DOI: 10.2174/1381612825666191112091700
View Abstract View on PubMed


Aging and Neuroinflammatory Disorders: New Biomarkers and Therapeutic Targets


Caterina Maria Gambino, Bruna Lo Sasso, Giulia Bivona, Luisa Agnello and Marcello Ciaccio*


DOI: 10.2174/1381612825666191112093034
View Abstract View on PubMed


Triggering of Toll-like Receptors in Old Individuals. Relevance for Vaccination


Nahid Zareian, Stefano Aprile, Laura Cristaldi, Mattia Emanuela Ligotti, Sonya Vasto and Farzin Farzaneh*


DOI: 10.2174/1381612825666191111155800
View Abstract View on PubMed



Circulating miRNAs in Successful and Unsuccessful Aging. A Mini-review


Giuseppe Cammarata, Giovanni Duro*, Tiziana Di Chiara, Alessia Lo Curto, Simona Taverna and Giuseppina Candore


DOI: 10.2174/1381612825666191119091644
View Abstract View on PubMed


Individual DNA Methylation Profile Is Correlated with Age and Can Be Targeted to Modulate Healthy Aging and Longevity


Francesco Guarasci, Patrizia D’ Aquila, Alberto Montesanto, Andrea Corsonello, Dina Bellizzi and Giuseppe Passarino*


DOI: 10.2174/1381612825666191112095655
View Abstract View on PubMed


Genetic Signatures of Centenarians: Implications for Achieving Successful Aging


Calogero Caruso, Anna Aiello, Giulia Accardi, Elena Ciaglia, Monica Cattaneo and Annibale Puca*


DOI: 10.2174/1381612825666191112094544
View Abstract View on PubMed


Abstracts Ahead of Print

Long-Term Effects Of Hypoxia-Reoxygenation On Thioredoxins In Rat Central Nervous System


Otero-Losada M*, Canepa L, Udovin L, Kobiec T, Toro-Urrego N, Kolliker Frers RA and Capani F


DOI: 10.2174/1381612825666191211111926
View Abstract


Traditional Risk Factors are Causally Related to Carotid Intima-Media Thickness Progression: Inferences from Observational Cohort Studies and Interventional Trials.


Beatrice Frigerio, José P. Werba, Mauro Amato, Alessio Ravani, Daniela Sansaro, Daniela Coggi, Lorenzo Vigo, Elena Tremoli and Damiano Baldassarre*


DOI: 10.2174/1381612825666191213120339
View Abstract


Characteristics of Blood Lipid Profiles of Professional Athletes: Literature Review


Yurgita Ruslanovna Varaeva , Elena Nikolaevna Livantsova, Natalia Valer’evna Polenova, Svetlana Dmitrievna Kosyura, Dmitriy Borisovich Nikitjuk and Antonina Vladimirovna Starodubova*


DOI: 10.2174/1381612825666191213115232
View Abstract


Anthocyanins Prevent and Inhibit Colorectal Cancer through PI3K/AKT/survivin Signaling Pathway


Xin Zhao*, Panfeng Feng, Wenqian He, Xing Du, Chao Chen, Lianhuan Suo, Min Liang, Na Zhang and Yan Zhang


DOI: 10.2174/1381612825666191212105145
View Abstract



Methods for reducing contrast use and avoiding acute kidney injury during endovascular procedures


Chrysovalantis Vergadis*, Georgios Festas, Eleni Spathi, Paris Pappas and Stavros Spiliopoulos


DOI: 10.2174/1381612825666191211112800
View Abstract




“Energy-sensing pathways in ischemia: The counterbalance between AMPK and mTORC”.


Angel Cespedes, Mario Villa, Irene Benito-Cuesta, Maria Jose Perez-Alvarez , Lara Ordoñez and Francisco Wandosell*


DOI: 10.2174/1381612825666191210152156
View Abstract


Epicardial fat: a new therapeutic target in psoriasis


Preetha Kamath, Gabrielle Benesh, Paolo Romanelli and Gianluca Iacobellis *


DOI: 10.2174/1381612825666191206091105
View Abstract


Published Contents

Editor's Choice

Early Biomarkers for Severe Drug Hypersensitivity Reactions

, 2019; 25(36): 3829 - 3839

Adriana Ariza, Maria J. Torres*, Carmen Moreno-Aguilar, Rubén Fernández-Santamaría and Tahia D. Fernández


DOI: 10.2174/1381612825666191107105440




Application of Three-dimensional (3D) Tumor Cell Culture Systems and Mechanism of Drug Resistance

, 2019; 25(34): 3599 - 3607

Adeeb Shehzad, Vijaya Ravinayagam, Hamad AlRumaih, Meneerah Aljafary, Dana Almohazey, Sarah Almofty, Noor A. Al-Rashid and Ebtesam A. Al-Suhaimi*


DOI: 10.2174/1381612825666191014163923






TREX1 As a Potential Therapeutic Target for Autoimmune and Inflammatory Diseases

, 2019; 25(30): 3239 - 3247

Sha-Sha Tao*, Guo-Cui Wu, Qin Zhang, Tian-Ping Zhang, Rui-Xue Leng, Hai-Feng Pan and Dong-Qing Ye


DOI: 10.2174/1381612825666190902113218



A Mitochondrial Approach to Cardiovascular Risk and Disease

, 2019; 25(29): 3175 - 3194

Caroline D. Veloso, Getachew D. Belew, Luciana L. Ferreira, Luís F. Grilo, John G. Jones, Piero Portincasa, Vilma A. Sardão and Paulo J. Oliveira*


DOI: 10.2174/1389203720666190830163735




Hyperferritinaemia: An Iron Sword of Autoimmunity

, 2019; 25(27): 2909 - 2918

Joanna Giemza-Stokłosa, Md. Asiful Islam and Przemysław J. Kotyla*


DOI: 10.2174/1381612825666190709202804



Open Access Articles

Nanomedicines to Treat Skin Pathologies with Natural Molecules

, 2019; 25(21): 2323 - 2337

Elisabetta Esposito*, Claudio Nastruzzi, Maddalena Sguizzato and Rita Cortesi




The Role of Autophagy and Death Pathways in Dose-dependent Isoproterenolinduced Cardiotoxicity

, 2019; 25(19): 2192 - 2198

Alexandra Gyongyosi, Rita Zilinyi, Andras Czegledi, Agnes Tosaki, Arpad Tosaki and Istvan Lekli*






Effects of As2O3 and Resveratrol on the Proliferation and Apoptosis of Colon Cancer Cells and the hERG-mediated Potential Mechanisms

, 2019; 25(12): 1385 - 1391

Caichuan Yan*, Fengmei Li*, Yuhao Zhang, Yang Li, Mingzhu Li, Fang Wang, Guocui Zhang, Yuexin Li, Baoxin Li and Xin Zhao





Probucol-induced hERG Channel Reduction can be Rescued by Matrine and Oxymatrine in vitro

, 2019; 25: 1 - 7 (E-Pub Ahead of Print)

Yuan-qi Shi, Pan Fan, Guo-cui Zhang, Yu-hao Zhang, Ming-zhu Li, Fang Wang and Bao-xin Li*




Emerging Therapeutic Targets in Oncologic Photodynamic Therapy

, 2018; 24(44): 5268 - 5295

Gina Manda*, Mihail E. Hinescu, Ionela V. Neagoe, Luis F.V. Ferreira, Rica Boscencu, Paul Vasos, Selma H. Basaga and Antonio Cuadrado






Small Molecules as PD-1/PD-L1 Pathway Modulators for Cancer Immunotherapy

, 2018; 24(41): 4911 - 4920

Peifu Jiao, Qiaohong Geng*, Peng Jin, Gaoxing Su, Houyun Teng, Jinlong Dong and Bing Yan*





Novel Data on the Prevalence, Identification, Scouting, and Treatment of Familial Hypercholesterolaemia

, 2018; 24(31): 3597 - 3598

Michael Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos and Vasilios G. Athyros





Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis

, 2018; 24(26): 3143 - 3151

Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky





Most Cited Articles

Research Article

PNitro-Tyr-PseAAC: Predict nitrotyrosine sites in proteins by incorporating five features into Chou’s general PseAAC

, 2018; 24(34): 4034-4043.

Ahmad W. Ghauri, Yaser D. Khan, Nouman Rasool, Sher A. Khan* and Kuo-Chen Chou


DOI: 10.2174/1381612825666181127101039



Review Article

Rapid-acting antidepressants

, 2018; 24(22): 2556-2563.

Jeffrey M. Witkin*, Daniel E. Knutson, Gabriel J. Rodriguez and Samuel Shi


DOI: 10.2174/1381612824666180730104707


Review Article

Antibacterial metal oxide nanoparticles: Challenges in interpreting the literature

, 2018; 24(8): 896-903.

Usha Kadiyala, Nicholas A. Kotov and J. Scott VanEpps*


DOI: 10.2174/1381612824666180219130659


Review Article

Polyphenols: Potential use in the prevention and treatment of cardiovascular diseases

, 1 January 2018; 24(2): 239-258.

Rosaria Vincenza Giglio, Angelo Maria Patti, Arrigo F.G. Cicero, Giuseppe Lippi, Manfredi Rizzo*, Peter P. Toth and Maciej Banach


DOI: 10.2174/1381612824666180130112652


Review Article

Signaling pathways in inflammation and anti-inflammatory therapies

, 2018; 24(14): 1449-1484.

Yiu To Yeung, Faisal Aziz, Angelica Guerrero-Castilla and Sandro Arguelles*


DOI: 10.2174/1381612824666180327165604


Review Article

Curcumin: A natural pan-HDAC inhibitor in cancer

, 1 January 2018; 24(2): 123-129.

Sara Saffar Soflaei, Amir Abbas Momtazi-Borojeni, Muhammed Majeed, Giuseppe Derosa, Pamela Maffioli and Amirhossein Sahebkar*


DOI: 10.2174/1381612823666171114165051


Review Article

Colchicine pharmacokinetics and mechanism of action

, 2018; 24(6): 659-663.

Christos Angelidis*, Zoi Kotsialou, Charalampos Kossyvakis, Agathi-Rosa Vrettou, Achilleas Zacharoulis, Fotios Kolokathis, Vasilios Kekeris and Georgios Giannopoulos


DOI: 10.2174/1381612824666180123110042


Review Article

Recent findings in molecular basis of inflammation and anti-inflammatory plants

, 2018; 24(14): 1551-1562.

Sedigheh Kazemi, Hedayatollah Shirzad and Mahmoud Rafieian-Kopaei*


DOI: 10.2174/1381612824666180403122003


Review Article

Curcumin as an adjunct therapy and microRNA modulator in breast cancer

, 1 January 2018; 24(2): 171-177.

Saeed Norouzi, Muhammed Majeed, Matteo Pirro, Daniele Generali and Amirhossein Sahebkar*


DOI: 10.2174/1381612824666171129203506


Review Article

Antibacterial coatings based on chitosan for pharmaceutical and biomedical applications

, 2018; 24(8): 866-885.

Juliana Miguel Vaz, Daniele Pezzoli, Pascale Chevallier, Clayton Souza Campelo, Gabriele Candiani and Diego Mantovani*


DOI: 10.2174/1381612824666180219143900


Review Article

Placental exosomes during gestation: Liquid biopsies carrying signals for the regulation of human parturition

, 2018; 24(9): 974-982.

Carlos Salomon*, Zarin Nuzhat, Christopher L. Dixon and Ramkumar Menon*


DOI: 10.2174/1381612824666180125164429


Review Article

Cytoprotective polyphenols against chronological skin aging and cutaneous photodamage

, 1 January 2018; 24(2): 99-105.

Sergio Davinelli*, Juan Carlos Bertoglio, Ascanio Polimeni and Giovanni Scapagnini


DOI: 10.2174/1381612823666171109102426


Review Article

Diet and brain health: Which role for polyphenols?

, 1 January 2018; 24(2): 227-238.

Vanessa Castelli, Davide Grassi, Raffaella Bocale, Michele d'Angelo, Andrea Antonosante, Annamaria Cimini, Claudio Ferri and Giovambattista Desideri*


DOI: 10.2174/1381612824666171213100449


Review Article

Simulated protein thermal detection (SPTD) for enzyme thermostability study and an application example for pullulanase from bacillus deramificans

, 2018; 24(34): 4023-4033.

Jian-Xiu Li, Shu-Qing Wang, Qi-Shi Du*, Hang Wei, Xiao-Ming Li, Jian-Zong Meng, Qing-Yan Wang, Neng-Zhong Xie*, Ri-Bo Huang* and Kuo-Chen Chou


DOI: 10.2174/1381612824666181113120948



Most Accessed Articles

Recent Advances in Cancer Therapy: An Overview

, 2010; 16(1): 3-10.

A. Urruticoechea, R. Alemany, J. Balart, A. Villanueva, F. Vinals and G. Capella


DOI: 10.2174/138161210789941847





The Microbial Quality Aspects and Decontamination Approaches for the Herbal Medicinal Plants and Products: An in-Depth Review

, 2016; 22(27): 4264-4287.

Daniela Dal Molim Ghisleni, Marina de Souza Braga, Irene Satiko Kikuchi, Mirela Braşoveanu, Monica R. Nemţanu, Kamal Dua and Terezinha de Jesus Andreoli Pinto


DOI: 10.2174/1381612822666160623070829


The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

, 2017; 23(40): 6206-6214.

Junichi Matsumoto, Tessandra Stewart, William A. Banks and Jing Zhang*


DOI: 10.2174/1381612823666170913164738


Inhibition of Heat Shock Protein 90 as a Novel Platform for the Treatment of Cancer

, 2019; 25(8): 849-855.

Chang Gao, Ya-Nan Peng, Hai-Zhou Wang, Shi-Lin Fang, Meng Zhang, Qiu Zhao and Jing Liu*


DOI: 10.2174/1381612825666190503145944



JAK Inhibition: The Most Promising Agents in the IBD Pipeline?

, 2019; 25(1): 32-40.

Agnès Fernández-Clotet, Jesús Castro-Poceiro and Julián Panés*


DOI: 10.2174/1381612825666190405141410




Editor-in-Chief

William A. Banks
(29546 citations)
Seattle VA Puget Sound Health Care System
Room 810C, Building 1
1660 S. Columbian Way
Seattle, WA 98108
USA

Biography View Full Editorial Board

Journal History

Current Pharmaceutical Design was introduced in 1995 with the assistance of Dr. William A. Banks, who is the current Editor-in-Chief serving since 1995.
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Scopus CiteScore Metrics: 1.94

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