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"Current Pharmaceutical Design is a necessity for scientists working in the multidisciplinary fields encompassing the areas of drug design and discovery."

Annette M. Doherty
Pfizer Global R&D France

Forthcoming Special Issues

An Approach to the Theoretical and Experimental Design of Fused Compounds in the Treatment of Mental and Motor Dysfunctions


Guest Editor(s): Eduardo Sobarzo-Sánchez
Tentative Publication Date: October, 2018
Submit Abstract via Email Download Description
Special Issues - In-Press

Recent advances towards the treatment of depressive disorders


Guest Editor(s): Kefeng Li, Xu Wang
Download Description
Published Special Issues

Managing strategies for diverse diseases: Challenges from bench to bedside in successful drug discovery and development


Current Pharmaceutical Design, Volume 23, Number 11
Guest Editor(s): Mohammad Amjad Kamal, Nigel H. Greig

Authors' Comments
Thank you for the high quality of your services and it was such a pleasure and learning experience working with you.

Menglin Li
(School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 100029, China)


Current Pharmaceutical Design

,

Volume 24

-

Number 26



Editorial   Open Access



Review Article



Review Article

Computer-aided Drug Design and Drug Pharmacokinetic Prediction: A Mini-review

, 24(26): 3014 - 3019

Jamshid Tabeshpour, Amirhossein Sahebkar*, Mohammad Reza Zirak , Majid Zeinali , Mahmoud Hashemzaei, Sajed Rakhshani and Saleh Rakhshani *


DOI: 10.2174/1381612824666180903123423


Review Article



Review Article

Metabolomics in Vitamin Status Assessment

, 24(26): 3028 - 3033

Yurgita R. Varaeva*, Elena N. Livantsova, Igor V. Ukrainets, Svetlana D. Kosyura and Antonina V. Starodubova


DOI: 10.2174/1381612824666180912142743


Review Article



Review Article

Mitochondria and the Pathophysiological Mechanism of Atrial Fibrillation

, 24(26): 3055 - 3061

Xinye Li, Xinyu Yang, Yanda Li, Mengchen Yuan, Chao Tian, Yihan Yang, Xiaoyu Zhang, Chao Liu, Yonghong Gao, Nian Liu, Hongcai Shang* and Yanwei Xing*


DOI: 10.2174/1381612824666180903125300


Review Article

Mechanisms and Treatments of Oxidative Stress in Atrial Fibrillation

, 24(26): 3062 - 3071

Xiaomeng Ren, Xiaofeng Wang, Mengchen Yuan, Chao Tian, Huilong Li, Xinyu Yang, Xinye Li, Yanda Li, Yihan Yang, Nian Liu, Hongcai Shang, Yonghong Gao* and Yanwei Xing*


DOI: 10.2174/1381612824666180903144042


Articles Ahead of Print

Computational Advances in the Label-free Quantification of Cancer Proteomics Data


Jing Tang, Yang Zhang, Jianbo Fu, Yuxia Wang, Yi Li, Qingxia Yang, Lixia Yao, Weiwei Xue* and Feng Zhu*


View Abstract View on PubMed



The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer


Ashfaq UR Rehman , Mueed UR Rehman , K M Tahir , Shah Saud, Hao Liu, Dong Song, Pinky Sultana, Abdul Wadood and Hai-Feng Chen*


View Abstract View on PubMed


In vitro -In vivo- In silico Simulation of Experimental Design Based Optimized Curcumin Loaded Multiparticulates System


Sima Singh*, Afzal Hussain, Uma Ranjan Lal, Nisar Sayyad, Rajshekhar Karpoormath and Manimbulu Nlooto


View Abstract View on PubMed



Phytochemistry, Traditional Uses and Pharmacological Profile of Rose Hip: A Review


Zahra Ayati, Mohammad Sadegh Amiri , Mahin Ramezani , Elahe Delshad, Amirhossein Sahebkar* and Seyed Ahmad Emami


View Abstract View on PubMed


β-caryophyllene Delivery Systems: Enhancing the Oral Pharmacokinetic and Stability


Pauline S. Santos*, Thaisa C. Oliveira, Luis Mário R. Júnior, Ana Figueiras and Lívio C.C. Nunes


View Abstract View on PubMed


Genetic Polymorphisms and Zinc Status: Implications for Supplementation in Metabolic Diseases


Fabio Virgili, Roberto Ambra, Jacqueline McCormack, Elizabeth Ellen Simpson, Donatella Ciarapica, Lorenzo Barnaba, Elena Azzini and Angela Polito*


View Abstract View on PubMed


Influence of Hormones on Sjögren’s Syndrome


Liu Yang, Wei Wei, Xi He, Yu Xie, Mohammad Amjad Kamal and Jiang Li*


View Abstract


From Molecular Mechanism to the Etiology of Sjogren Syndrome


Wei Wei, Syed Sayeed Ahmad, Shuang Chi, Yu Xie, Mohammad Amjad Kamal and Jiang Li*


View Abstract View on PubMed


Abstracts Ahead of Print


Nanotechnology as an emerging pathway for cancer therapy and diagnosis


Albeena Mahmood, Kavindra Kumar Kesari, Ismat Fatima, Mohd. Haris Siddiqui*, Qazi Mohammad Sajid Jamal, Salman Akhtar, Mohd. Kalim Ahmad Khan, Mohammad Amjad Kamal and Jamal M. Arif


View Abstract



Polyphenols: plant sources and food industry applications.


Marina Marranzano*, Rosa La Rosa, Mariano Malaguarnera, Rosa Palmeri, Matilde Tessitori and Antonio C Barbera


View Abstract


Simulated protein thermal detection (SPTD) for enzyme thermostability study and an application example for pullulanase from Bacillus deramificans


Jian-Xiu Li, Shu-Qing Wang, Qi-Shi Du*, Hang Wei, Xiao-Ming Li, Jian-Zong Meng, Qing-Yan Wang, Neng-Zhong Xie*, Ri-Bo Huang* and Kuo-Chen Chou


View Abstract


Small molecules as PD-1/PD-L1 pathway modulators for cancer immunotherapy


Peifu Jiao, Qiaohong Geng*, Peng Jin, Gaoxing Su, Houyun Teng, Jinlong Dong and Bing Yan*


View Abstract



Advances in antidiabetic drugs targeting Insulin Secretion


Yanting Ding, Yilian Li, Qin Chen* and Bing Niu*


View Abstract



The effects of coenzyme Q10 supplementation on metabolic profiles of patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials


Marzieh Bakhshayeshkaram, Kamran B Lankarani, Naghmeh Mirhosseini, Reza Tabrizi, Maryam Akbari, Mohammad Hossein Dabbaghmanesh and Zatollah Asemi*


View Abstract


Editor's Choice


Microvascular (dys)Function in Stable Coronary Artery Disease: Cross Talk with Epicardial Segments

, 2018; 24(25): 2900 - 2905

Lucian Calmac, Vlad Bataila, Bogdan Dragoescu, Cosmin Mihai, Alexandru Scafa-Udriste and Maria Dorobantu*


DOI: 10.2174/1381612824666180702113448



The Mechanism of Exosomes Function in Neurological Diseases: A Progressive Review

, 2018; 24(24): 2855 - 2861

Mengchen Yuan, Nan Liu, Xiaofeng Wang, Chao Tian, Xiaomeng Ren, Hanlai Zhang, Xinyu Yang, Xinye Li, Haiyan Zhu, Lingqun Zhu, Hongcai Shang, Yanwei Xing* and Yonghong Gao*


DOI: 10.2174/1381612824666180903113136



Targeted Liposomes for siRNA Delivery to Cancer

, 2018; 24(23): 2664 - 2672

Josimar O. Eloy, Raquel Petrilli, Giovanni Loureiro Raspantini and Robert J. Lee*


DOI: 10.2174/1381612824666180807121935



The Role of Neuroimaging in the Diagnosis and Treatment of Depressive Disorder: A Recent Review

, 2018; 24(22): 2515 - 2523

Tianbin Song, Xiaowei Han, Lei Du, Jing Che, Jing Liu, Sumin Shi, Chao Fu, Wenwen Gao, Jie Lu* and Guolin Ma*


DOI: 10.2174/1381612824666180727111142



Phase Behavior of Polymorphic Fats in Drug Delivery Systems - A Review of the State of Art

, 2018; 24(21): 2508 - 2512

Joana R. Campos, Ana R. Fernandes, Patricia Severino, Maria L. Gracia, Selma B. Souto and Eliana B. Souto*


DOI: 10.2174/1381612824666180522092740



Parkinson’s Disease: Alpha Synuclein, Heme Oxygenase and Biotherapeutic Countermeasures

, 2018; 24(20): 2317 - 2321

David D. Haines*, Maxim V. Trushin, Stephen Rose, Iloki Assanga Simon Bernard and Fadia F. Mahmoud


DOI: 10.2174/1381612824666180717161338






Open Access Articles

Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis

, 2018; 24(26): 3143 - 3151

Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky




Next-generation Metabolomics in the Development of New Antidepressants: Using Albiflorin as an Example

, 2018; 24(22): 2530 - 2540

Jian Han, Yonghong Xia, Lejun Lin, Zuoguang Zhang, Hui Tian and Kefeng Li*





Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production

, 2018; 24(18): 2012 - 2022

Robert Racz, Akos Nagy, Zoltan Rakonczay , Erika Katalin Dunavari, Gabor Gerber and Gabor Varga*




Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach

, 2018; 24(13): 1366 - 1376

Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*




Development of Peptide Vaccines in Dengue

, 2018; 24(11): 1157 - 1173

Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*





Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity

, 2018; 24(5): 576 - 594

Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo







IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development

, 2017; 23(38): 5964 - 5970

Ann Hellstrom*, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard




A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension

, 2017; 23(34): 5191 - 5199

Louise M. Sorensen, Markus Wehland, Marcus Kruger, Ulf Simonsen, Mohamed Z. Nassef, Manfred Infanger and Daniela Grimm*




A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure

, 2017; 23(34): 5115 - 5124

Yong Wang*, Qiyan Wang, Chun Li, Linghui Lu, Qian Zhang, Ruixin Zhu* and Wei Wang*






Most Cited Articles

Autism: Pathophysiology and Promising Herbal Remedies

, 2016; 22(3): 277-285.

Mahmoud Bahmani, Amir Sarrafchi, Hedayatollah Shirzad and Mahmoud Rafieian-Kopaei


DOI: 10.2174/1381612822666151112151529


Air Pollution Exposure and Blood Pressure: An Updated Review of the Literature

, 2016; 22(1): 28-51.

Paolo Giorgini, Paolo Di Giosia, Davide Grassi, Melvyn Rubenfire, Robert D. Brook and Claudio Ferri


DOI: 10.2174/1381612822666151109111712



Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers

, 2016; 22(34): 5257-5269.

Hamid Reza Mirzaei, Amirhossein Sahebkar, Mohsen Mohammadi, Reza Yari, Hossein Salehi, Mohammad Hasan Jafari, Afshin Namdar, Ehsan Khabazian, Mahmoud Reza Jaafari and Hamed Mirzaei


DOI: 10.2174/1381612822666160303110838


The potential for circulating microRNAs in the diagnosis of myocardial infarction: a novel approach to disease diagnosis and treatment

, 2016; 22(3): 397-403.

Sharareh Gholamin, Alireza Pasdar, Mohammad Sadegh Khorrami, Hamed Mirzaei, Hamid Reza Mirzaei, Rasoul Salehi, Gordon A. Ferns, Majid Ghayour-Mobarhan and Amir Avan


DOI: 10.2174/1381612822666151112151924


Computer Aided Drug Design: Success and Limitations

, 2016; 22(5): 572-581.

Mohammad Hassan Baig, Khurshid Ahmad, Sudeep Roy, Jalaluddin Mohammad Ashraf, Mohd Adil, Mohammad Haris Siddiqui, Saif Khan, Mohammad Amjad Kamal, Ivo Provazník and Inho Choi


DOI: 10.2174/1381612822666151125000550


Herba Epimedii: An Ancient Chinese Herbal Medicine in the Prevention and Treatment of Osteoporosis

, 2016; 22(3): 328-349.

Lili Wang, Yu Li, Yubo Guo, Rufeng Ma, Min Fu, Jianzhao Niu, Sihua Gao and Dongwei Zhang


DOI: 10.2174/1381612822666151112145907


From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

, 2016; 22(34): 5270-5293.

Andreas H. Laustsen, Mikael Engmark, Christina Milbo, Jónas Johannesen, Bruno Lomonte, José María Gutiérrez and Brian Lohse


DOI: 10.2174/1381612822666160623073438




Most Accessed Articles

Recent Advances in Cancer Therapy: An Overview

, 2010; 16(1): 3-10.

A. Urruticoechea, R. Alemany, J. Balart, A. Villanueva, F. Vinals and G. Capella


DOI: 10.2174/138161210789941847



Signaling Pathways in Inflammation and Anti-inflammatory Therapies

, 2018; 24(14): 1449-1484.

Yiu To Yeung, Faisal Aziz, Angelica Guerrero-Castilla and Sandro Arguelles*


DOI: 10.2174/1381612824666180327165604



Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon Monoxide Therapeutics?

, 2018; 24(20): 2264-2282.

Christopher P. Hopper, Lorenz Meinel, Christoph Steiger* and Leo E. Otterbein*


DOI: 10.2174/1381612824666180723161811


A Critical Review of the Antipsychotic Effects of Cannabidiol: 30 Years of a Translational Investigation

, 2012; 18(32): 5131-5140.

Antonio Waldo Zuardi, Jose Alexandre S. Crippa, Jaime E.C. Hallak, Sagnik Bhattacharyya, Zerrin Atakan, Rocio Martin-Santos, Philip K. McGuire and Francisco Silveira Guimaraes


DOI: 10.2174/138161212802884681


Role of Melatonin in the Inflammatory Process and its Therapeutic Potential

, 2018; 24(14): 1563-1588.

Livia Carrascal, Pedro Nunez-Abades, Antonio Ayala and Mercedes Cano*


DOI: 10.2174/1381612824666180426112832





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