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Current Pharmaceutical Design

Volume 28, 46 Issues, 2022
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Design publishes timely in-depth reviews/mini reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field.

Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Current Pharmaceutical Design

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Volume 28

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Number 11





Review Article




Review Article

Treatment of Adult Spinal Muscular Atrophy: Overview and Recent Developments

, 28(11): 892 - 898

Svenja Brakemeier, Benjamin Stolte, Christoph Kleinschnitz and Tim Hagenacker*


DOI: 10.2174/1381612828666220329115433



General Review Article



General Review Article



Current Pharmaceutical Design, Volume 28 (2022) - Number 14


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 28 (2022) - Number 13


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Design, Volume 28 (2022) - Number 12


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Application of Heterocycles as an Alternative for the Discovery of New Anti-ulcer Compounds: A Mini-Review


Lucas Linhares de Lócio*, Agnis Pâmela Simões do Nascimento, Mirelly Barbosa Santos, Joilly Nilce Santana Gomes, Yvnni Maria Sales de Medeiros e Silva, Sonaly Lima Albino, Vanda Lúcia dos Santos and Ricardo Olímpio de Moura


DOI: 10.2174/1381612828666220512095559
View Abstract View on PubMed


Application of Artificial Intelligence in Drug Discovery


Hitesh Chopra, Atif Amin Baig, Rupesh K. Gautam* and Mohammad Amjad Kamal*


DOI: 10.2174/1381612828666220608141049
View Abstract View on PubMed



Utility of Indian Fruits in Cancer Prevention and Treatment: Time to Undertake Translational and Bedside Studies


Pankaj Prabhakar, Giriyapura Srikantachar Pavankumar, Shamprasad Varija Raghu, Suresh Rao, Krishna Prasad, Thomas george and Manjeshwar Shrinath Baliga*


DOI: 10.2174/1381612828666220601151931
View Abstract View on PubMed


Antimicrobial Benefits of Flavonoids and their Nanoformulations


Sara Salatin*, Ahad Bazmani, Shahriar Shahi*, Behrooz Naghili, Mohammad Yousef Memar and Solmaz Maleki Dizaj


DOI: 10.2174/1381612828666220509151407
View Abstract View on PubMed


Natural and Synthetic Micelles for the Delivery of Small Molecule Drugs, Imaging Agents and Nucleic Acids


Anwarul Azim Akib, Ragib Shakil, Md. Mahamudul Hasan Rumon, Chanchal Kumar Roy, Ezharul Hoque Chowdhury* and Al-Nakib Chowdhury*


DOI: 10.2174/1381612828666220506135301
View Abstract View on PubMed


Recent Advances in Acid-sensitive Ion Channels in Central Nervous System Diseases


Yueqin Zhu, Xiaojie Hu, Lili Wang, Jin Zhang, Xuesheng Pan, Yangyang Li, Rui Cao, Bowen Li, Huimin Lin, Yanan Wang, Longquan Zuo and Yan Huang*


DOI: 10.2174/1381612828666220422084159
View Abstract View on PubMed



Managing Apoptosis in Lung Diseases Using Nano-Assisted Drug Delivery System


Monu Kumar Shukla, Amit Dubey, Sadanand Pandey, Sachin K Singh, Gaurav Gupta, Parteek Prasher, Dinesh Kumar Chellappan, Brian G Oliver, Deepak Kumar* and Kamal Dua*


DOI: 10.2174/1381612828666220413103831
View Abstract View on PubMed


Hippo: A New Hub for Atherosclerotic Disease


Xi-Yan Liu, Kun Zhou, Kai-Jiang Tian, Bin-Jie Yan, Zhong Ren, Zhi-Xiang Zhou, Wen-Hao Xiong and Zhi-Sheng Jiang*


DOI: 10.2174/1381612828666220428090540
View Abstract


Abstracts Ahead of Print


Luliconazole topical dermal drug delivery for superficial fungal infections: Penetration hurdles and role of functional nanomaterials


Chanti Katta Babu, Shubhra, Shaik Mahammad Ghouse, Pankaj Kumar Singh, Dharmendra Kumar Khatri, Srinivas Nanduri, Shashi Bala Singh and Jitender Madan*


DOI: 10.2174/1381612828666220623095743
View Abstract


Atypical antipsychotic drugs in dual disorders: current evidence and clinical guidelines


Giovanni Martinotti, Stefania Chiappini, Alessio Mosca, Andrea Miuli, Maria Chiara Santovito, Mauro Pettorruso*, Valentin Skryabin, Stefano L. Sensi and Massimo Di Giannantonio


DOI: 10.2174/1381612828666220623092853
View Abstract




Hypothyroidism and Risk of Cardiovascular Disease


Zoran M Gluvic*, Sonja S Zafirovic, Milan M Obradovic, Emina M Sudar-Milovanovic, Manfredi Rizzo and Esma R Isenovic


DOI: 10.2174/1381612828666220620160516
View Abstract


Down-regulated ALKBH5 Expression Could Affect the Function of T Cells in Systemic Lupus Erythematosus Patients.


Li-Jun Deng, Xin-Yu Fang, Jun Wu, Qing-Ru Li, Yan-Mei Mao, Rui-Xue Leng, Yin-Guang Fan* and Dong-Qing Ye*


DOI: 10.2174/1381612828666220617154204
View Abstract



Identification of Neural Progenitor Cell-Associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma


Yongchang Yang, Xing Xu, Yang Xie, Yancheng Liu, Chunlan Ning, Yiding Ai, Chao Lv, Haotian Wei, Xianglian Ge, Tailong Yi, Yongjun Piao, Xiaoguang Wang and Xun Jin*


DOI: 10.2174/1381612828666220617085508
View Abstract


Aberrant connection formation and glia involvement in the progression of pharmacoresistant mesial temporal lobe epilepsy


Vega-García Angélica, Guevara-Guzmán Rosalinda, García-Gómez Omar, Feria-Romero Iris, Fernández-Valverde Francisca, Alonso-Vanegas Mario and Orozco-Suárez Sandra*


DOI: 10.2174/1381612828666220616162739
View Abstract


Published Contents

Editor's Choice





Outer Membrane Vesicles of Bordetella pertussis Encapsulated into Sodium Alginate Nanoparticles as Novel Vaccine Delivery System

, 2021; 27(42): 4341 - 4354

Abbas Rami, Fatemeh Kazemi-Lomedasht, Ali Mirjalili, Mojtaba Noofeli, Fereshteh Shahcheraghi* and Naser M. Dounighi*


DOI: 10.2174/1381612827666210907154715



Anticholinergic Exposure in Elderly Complex Chronic Patients: A Cross-Sectional Study

, 2021; 27(40): 4186 - 4194

Ángela Tristancho-Pérez, Ángela Villalba-Moreno, María D. Santos-Rubio, María D. López-Malo, Bernardo Santos-Ramos and Susana Sánchez-Fidalgo*


DOI: 10.2174/1381612827666210830164054






Hypertension in Pregnancy: Unanswered Questions

, 2021; 27(36): 3795 - 3803

Vasilios Papademetriou *, Konstantinos Stavropoulos , Dimitrios Patoulias, Christodoulos Papadopoulos, Kerpiniotis Georgios, Maria Toumpourleka and Alexandros Sachinidis


DOI: 10.2174/1381612827666210830091652



Open Access Articles

The Pathogenic Subpopulation of Th17 Cells in Obesity

, 2021; 27(37): 3924 - 3938

Natalia Todosenko, Maria Vulf*, Kristina Yurova, Daria Skuratovskaia, Olga Khaziakhmatova, Natalia Gazatova, Olga Melashchenko, Olga Urazova and Larisa Litvinova





Exosome Limitations in the Treatment of Inflammatory Diseases

, 2021; 27(28): 3105 - 3121

Daria Skuratovskaia*, Maria Vulf, Olga Khaziakhmatova, Vladimir Malashchenko, Aleksandra Komar, Egor Shunkin, Natalia Gazatova and Larisa Litvinova




Marine Bioactive Peptides in Supplements and Functional Foods - A Commercial Perspective

, 2021; 27(11): 1353 - 1364

Ragnhild Dragøy Whitaker*, Themis Altintzoglou, Kjersti Lian and Estefania Noriega Fernandez








A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats

, 2020; 26(31): 3884 - 3894

Branka Petković*, Srđan Kesić, Slavica Ristić, Željko Pavković, Jelena Podgorac, Gordana Stojadinović and Vesna Pešić





γ-Aminobutyric Acid and Derivatives Reduce the Incidence of Acute Pain after Herpes Zoster - A Systematic Review and Meta-analysis

, 2020; 26(25): 3026 - 3038

Wuttapon Sadaeng, Katalin Márta, Péter Mátrai, Péter Hegyi, Barbara Tóth, Balázs Németh, László M. Czumbel, Thanyaporn Sang-Ngoen, Zoltán Gyöngyi, Gábor Varga*, Péter Révész, István Szanyi, Kázmér Karádi and Gábor Gerber




Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis

, 2020; 26(25): 3015 - 3025

Beáta Kerémi, Katalin Márta, Kornélia Farkas, László M. Czumbel, Barbara Tóth, Zsolt Szakács, Dezső Csupor, József Czimmer, Zoltán Rumbus, Péter Révész, Adrienn Németh, Gábor Gerber, Péter Hegyi and Gábor Varga*






Circulating MicroRNAs and Blood-Brain-Barrier Function in Breast Cancer Metastasis

, 2020; 26(13): 1417 - 1427

Carolin J. Curtaz, Constanze Schmitt, Kinga G. Blecharz-Lang, Norbert Roewer, Achim Wöckel and Malgorzata Burek*





Most Cited Articles

Review Article

Pollution, toxicity and carcinogenicity of organic dyes and their catalytic bio-remediation

, 2019; 25(34): 3645-3663.

Muhammad Ismail, Kalsoom Akhtar, M.I. Khan, Tahseen Kamal, Murad A. Khan, Abdullah M. Asiri, Jongchul Seo and Sher B. Khan*


DOI: 10.2174/1381612825666191021142026


General Review Article

Long non-coding RNAs as epigenetic regulators in cancer

, 2019; 25(33): 3563-3577.

Asma Vafadar, Zahra Shabaninejad, Ahmad Movahedpour, Soheila Mohammadi, Sima Fathullahzadeh, Hamid R. Mirzaei, Afshin Namdar, Amir Savardashtaki* and Hamed Mirzaei*


DOI: 10.2174/1381612825666190830161528


Review Article

Synthesis of silver nanoparticles and their biomedical applications a comprehensive review

, 2019; 25(24): 2650-2660.

Rajasree Shanmuganathan, Indira Karuppusamy, Muthupandian Saravanan, Harshiny Muthukumar, Kumar Ponnuchamy, Vijayan Sri Ramkumar and Arivalagan Pugazhendhi*


DOI: 10.2174/1381612825666190708185506


Review Article

Cholinesterase inhibitors for Alzheimer's disease: Multitargeting strategy based on anti-Alzheimer's drugs repositioning

, 2019; 25(33): 3519-3535.

Md. Tanvir Kabir, Md. Sahab Uddin*, Mst. Marium Begum, Shanmugam Thangapandiyan, Md. Sohanur Rahman, Lotfi Aleya, Bijo Mathew, Muniruddin Ahmed, George E. Barreto and Ghulam Md. Ashraf


DOI: 10.2174/1381612825666191008103141


Review Article

NMDA receptor antagonists: Repositioning of memantine as a multitargeting agent for Alzheimer's therapy

, 2019; 25(33): 3506-3518.

Md. Tanvir Kabir, Mohammad A. Sufian, Md. Sahab Uddin*, Mst. Marium Begum, Shammi Akhter, Ariful Islam, Bijo Mathew, Md. Siddiqul Islam, Md. Shah Amran and Ghulam Md. Ashraf*


DOI: 10.2174/1381612825666191011102444


Review Article

Alginate nanoparticles for drug delivery and targeting

, 2019; 25(11): 1312-1334.

Patricia Severino, Classius F. da Silva, Luciana N. Andrade, Daniele de Lima Oliveira, Joana Campos and Eliana B. Souto*


DOI: 10.2174/1381612825666190425163424



Review Article

Emerging potential of naturally occurring autophagy modulators against neurodegeneration

, 2020; 26(7): 772-779.

Md. Ataur Rahman*, Md Rezanur Rahman, Toyfiquz Zaman, Md. Sahab Uddin, Rokibul Islam, Mohamed M. Abdel-Daim and Hyewhon Rhim*


DOI: 10.2174/1381612826666200107142541


Review Article

Composition and potential health benefits of pomegranate: A review

, 2019; 25(16): 1817-1827.

Vesna Vučić*, Milkica Grabež, Armen Trchounian and Aleksandra Arsić


DOI: 10.2174/1381612825666190708183941


Review Article

Metal/metal oxide nanoparticles: Toxicity, applications, and future prospects

, 2019; 25(37): 4013-4029.

Ratiram G. Chaudhary*, Ganesh S. Bhusari, Ashish D. Tiple, Alok R. Rai, Subhash R. Somkuvar, Ajay K. Potbhare, Trimurti L. Lambat, Prashant P. Ingle and Ahmed A. Abdala*


DOI: 10.2174/1381612825666191111091326



General Review Article

Ethnobotany, phytochemistry and traditional uses of curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): A Review

, 2019; 25(8): 871-935.

Zahra Ayati, Mahin Ramezani , Mohammad Sadegh Amiri, Ali Tafazoli Moghadam, Hoda Rahimi, Aref Abdollahzade, Amirhossein Sahebkar * and Seyed Ahmad Emami *


DOI: 10.2174/1381612825666190402163940


Review Article

Extracellular vesicles as drug delivery systems - Methods of production and potential therapeutic applications

, 2019; 25(2): 132-154.

Magdalena Surman, Anna Drożdż, Ewa Stępień and Małgorzata Przybyło*


DOI: 10.2174/1381612825666190306153318





Most Accessed Articles

Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections

, 2021; 27(13): 1588-1596.

Gasparotto Junior, Arquimedes; Lima Tolouei, Sara Emilia; dos Reis Livero, Francislaine Aparecida; Gasparotto, Francielli; Boeing, Thaise; de Souza, Priscila


DOI: 10.2174/1381612827666210114150607


Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-kappa B to Halt Alzheimer's Disease

, 2021; 27(3): 402-414.

Uddin, Md Sahab; Hasana, Sharifa; Ahmad, Jamil; Hossain, Md Farhad; Rahman, Md Mosiqur; Behl, Tapan; Rauf, Abdur; Ahmad, Ausaf; Hafeez, Abdul; Perveen, Asma; Ashraf, Ghulam Md


DOI: 10.2174/1381612826666201118092422



Hepatoprotective Effects of Resveratrol in Non-Alcoholic Fatty Live Disease

, 2021; 27(22): 2558-2570.

Tejada, Silvia; Capo, Xavier; Mascaro, Catalina M.; Monserrat-Mesquida, Margalida; Quetglas-Llabres, M. Magdalena; Pons, Antoni; Tur, Josep A.; Sureda, Antoni


DOI: 10.2174/1381612826666200417165801


Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease

, 2021; 27(3): 357-366.

Uddin, Md Sahab; Kabir, Md Tanvir; Al Mamun, Abdullah; Behl, Tapan; Mansouri, Rasha A.; Aloqbi, Akram Ahmed; Perveen, Asma; Hafeez, Abdul; Ashraf, Ghulam Md


DOI: 10.2174/1381612826666200531151004



Phytosterols: Targeting Neuroinflammation in Neurodegeneration

, 2021; 27(3): 383-401.

Dash, Raju; Mitra, Sarmistha; Ali, Md Chayan; Oktaviani, Diyah Fatimah; Hannan, Md Abdul; Choi, Sung Min; Moon, Il Soo


DOI: 10.2174/1381612826666200628022812





Repurposing Drugs for the Management of Patients with Confirmed Coronavirus Disease 2019 (COVID-19)

, 2021; 27(1): 115-126.

Wietzikoski Lovato, Evellyn Claudia; Barboza, Lorena Neris; Wietzikoski, Samantha; Vasques de Souza, Amanda Nascimento; Auth, Pablo Alvarez; Gasparotto Junior, Arquimedes; dos Reis Livero, Francislaine Aparecida


DOI: 10.2174/1381612826666200707121636


miRNAs in SARS-CoV 2: A Spoke in the Wheel of Pathogenesis

, 2021; 27(13): 1628-1641.

Satyam, Rohit; Bhardwaj, Tulika; Goel, Sachin; Jha, Niraj Kumar; Jha, Saurabh Kumar; Nand, Parma; Ruokolainen, Janne; Kamal, Mohammad Amjad; Kesari, Kavindra Kumar


DOI: 10.2174/1381612826999201001200529







Editor-in-Chief

graphic
Alessandro Antonelli
(14789 citations)
Department of Clinical and Experimental Medicine
Laboratory of Primary Human Cells
University of Pisa
Pisa
(Italy)
Biography
View Full Editorial Board

Nobel Laureates on Editorial Board

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Andrew V. Schally
(USA)

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