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Current Pharmaceutical Biotechnology

Volume 23, 15 Issues, 2022
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology

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Volume 23

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Number 10





Review Article

Bacterial Proteomics and its Application in Pathogenesis Studies

, 23(10): 1245 - 1256

Mahdi Asghari Ozma, Ehsaneh Khodadadi, Mohammad Ahangarzadeh Rezaee, Mohammad Asgharzadeh, Mohammad Aghazadeh, Elham Zeinalzadeh, Khudaverdi Ganbarov and Hossein Samadi Kafil*


DOI: 10.2174/1389201022666210908153234


Review Article

Escherichia coli and Colorectal Cancer: Unfolding the Enigmatic Relationship

, 23(10): 1257 - 1268

Roghayeh Nouri, Alka Hasani, Kourosh Masnadi Shirazi, Mohammad Reza Alivand, Bita Sepehri, Simin Sotoodeh, Fatemeh Hemmati and Mohammad Ahangarzadeh Rezaee*


DOI: 10.2174/1389201022666210910094827


Review Article

Herbal Medicine for the Management of Laxative Activity

, 23(10): 1269 - 1283

Muhammad Akram, Muthu Thiruvengadam*, Rida Zainab, Muhammad Daniyal, Marc Moboladji Bankole, Maksim Rebezov, Mohammad Ali Shariati* and Eleonora Okuskhanova


DOI: 10.2174/1389201022666210812121328



Articles Ahead of Print

Nanoengineered Therapeutic Scaffolds for Burn Wound Management


Ziauddin, Tanveer Hussain, Ahsan Nazir, Urwa Mahmood, Misbah Hameed, Seeram Ramakrishna and Sharjeel Abid*


DOI: 10.2174/1389201023666220329162910
View Abstract View on PubMed





The Possible Protective Effect of Hepatitis B Vaccine Against Lymphomas: A Systematic Review


Lorenza Lia, Daniela Grima, Francesca Amici, Linda Manzi, Alessandro Monaci and Giuseppe La Torre*


DOI: 10.2174/1389201023666220113111946
View Abstract View on PubMed


Antisense Agents against Antibiotic-Resistant Bacteria


Javad Nezhadi*, Sepehr Taghizadeh, Ehsaneh Khodadadi, Mehdi Yousefi, Khudaverdi Ganbarov, Bahman Yousefi, Hamed Ebrahimzadeh Leylabadlo, Mohammad Asgharzadeh, Asghar Tanomand, Fahimeh Kazeminava and Hossein Samadi Kafil


DOI: 10.2174/1389201023666220114160216
View Abstract View on PubMed



Capecitabine as a Second-line Treatment for Older Patients with Pancreatic Cancer


Giandomenico Roviello*, Giuseppe Aprile, Martina Catalano, Monica Ramello, Raffaele Conca and Roberto Petrioli


DOI: 10.2174/1389201023666220307090450
View on PubMed




Abstracts Ahead of Print

Medicinal plants with anti-dengue and immunomodulatory activity


Bandt-Pulido Juan-Pablo, Pedroza-Escobar David*, Salas-Rojas Mónica, Sharma Ashutosh, Nuñez-Avellaneda Daniel, Delgadillo-Guzmán Dealmy, García-Garza Rubén, Velázquez-Gauna Sergio-Everardo, Ramirez-Moreno Agustina, Vega-Menchaca María-Del-Carmen, Hernández-Herrera Alejandro-David and Castillo-Maldonado Irais*


DOI: 10.2174/1389201023666220520110204
View Abstract


Nucleic Acid Nanotechnology: Trends, Opportunities and Challenges


Raghvendra Pratap Singh*, Atul K. Srivastava, Ying-Jie Yang, Geetanjali Manchanda*, Ajay Kumar, Sachin T. Yerpude, Alok R. Rai and RC Dubey*


DOI: 10.2174/1389201023666220520103325
View Abstract



Distribution of Nicotinamide Mononucleotide After Intravenous Injection in Normal and Ischemic Stroke Mice


Si-Li Zheng, Dong-Sheng Wang, Xin Dong, Yun-Feng Guan, Qi Qi, Wen-Jun Hu, Chen Hong, Chuan Zhang and Chao-Yu Miao*


DOI: 10.2174/1389201023666220518113219
View Abstract



Purification and characterization of a novel D-Galactose binding lectin from seeds of Meizotropis buteiformis.


Rana Kamei, Oinam Sangita Devi, Sorokhaibam Jibankumar Singh, Wayenbam Sobhachandra Singh and Senjam Sunil Singh*


DOI: 10.2174/1389201023666220517145338
View Abstract



Anti-Cancer Virotherapy in Russia: Lessons from the Past, Current Challenges and Prospects for the Future


Nadezhda M. Kolyasnikova, Nikolay B. Pestov*, Jeanne M. Sanchez-Pimentel, Nikolay A. Barlev and Aidar A. Ishmukhametov


DOI: 10.2174/1389201023666220516121813
View Abstract


Current synopsis on siRNA therapeutics as a novel anti-cancer and antiviral strategy: Progress and challenges


Sanjay Sharma, Rupesh K. Gautam, Abhishek Kanugo*, Dinesh Kumar Mishra and Mohammad Amjad Kamal*


DOI: 10.2174/1389201023666220516120432
View Abstract


Time for a change! A spotlight on the many neglected facets of sponge microbial biotechnology


Bruno Francesco Rodrigues de Oliveira, Jéssyca Freitas-Silva, Anna Luiza Bauer Canellas, Wellington Felipe Costa and Marinella Silva Laport*


DOI: 10.2174/1389201023666220516103715
View Abstract


Published Contents

Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice




Green Synthesis and Applications of Nanomaterials

, 2021; 22(13): 1705 - 1747

N.B. Singh*, Preeti Jain, Anindita De and Richa Tomar


DOI: 10.2174/1389201022666210412142734



Recent Advances in Clinical Utility of Probiotics in Gastrointestinal Tract Disorders

, 2021; 22(12): 1559 - 1573

Prativa Biswasroy, Deepak Pradhan, Dipak K. Sahu, Amita Sahu, Goutam Ghosh and Goutam Rath*


DOI: 10.2174/1389201021666201029154239




Is Biotechnological Next-Generation Therapeutics Promising Enough in Clinical Development to Treat Advanced Colon Cancer?

, 2021; 22(10): 1287 - 1301

Sarubala Malayaperumal, Sushmitha Sriramulu, Antara Banerjee, M.K. Makalakshmi and Surajit Pathak*


DOI: 10.2174/1389201021666201126142716



Targeted Delivery of CRISPR/Cas13 as a Promising Therapeutic Approach to Treat SARS-CoV-2

, 2021; 22(9): 1149 - 1155

Kazem Abbaszadeh-Goudarzi, Mohammad H. Nematollahi, Hashem Khanbabaei, Hossein H. Nave, Hamid R. Mirzaei, Hossein Pourghadamyari* and Amirhossein Sahebkar *


DOI: 10.2174/1389201021666201009154517



Growing Preferences towards Analog-based Drug Discovery

, 2021; 22(8): 1030 - 1045

Mehak Dangi, Alka Khichi, Ritu Jakhar and Anil K. Chhillar*


DOI: 10.2174/1389201021666200908121409



Recent Advances in the Scaffold Engineering of Protein Binders

, 2021; 22(7): 878 - 891

Mohammad K.B. Ahmadi, Seyed A. Mohammadi, Manoochehr Makvandi, Morteza Mamouei, Mohammad Rahmati*, Hesam Dehghani and David W. Wood


DOI: 10.2174/1389201021999200824101035



Open Access Articles

<i>Scutellaria baicalensis</i> Extract-phospholipid Complex: Preparation and Initial Pharmacodynamics Research in Rats

, 2022; 23(6): 847 - 860

Shibin Chen*, Qiujie Xie, Ming Yang, Yajun Shi, Junhui Shi and Xiaobin Zeng*




miR-199b-5p-AKAP1-DRP1 Pathway Plays a Key Role in ox-LDL-induced Mitochondrial Fission and Endothelial Apoptosis

, 2022; 23: 1 - 11 (E-Pub Ahead of Print)

Xiaolei Cui, Yingping Tian, Yapei Zhao, Hengbo Gao, Dongqi Yao, Liang Liu and Yongjun Li*





Investigation on the Antibacterial Activity of Electronic Cigarette Liquids (ECLs): A Proof of Concept Study

, 2021; 22(7): 983 - 994

Virginia Fuochi, Massimo Caruso , Rosalia Emma, Aldo Stivala, Riccardo Polosa, Alfio Distefano and Pio M. Furneri *




Analysis of the Differences in the Expression of mRNAs and miRNAs Associated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin

, 2021; 22(4): 541 - 548

Piotr Januszyk*, Krzysztof Januszyk, Magdalena Wierzbik-Strońska, Dariusz Boroń and Beniamin Grabarek




Leaf and Fruit Methanolic Extracts of <i>Azadirachta indica</i> Exhibit Antifertility Activity on Rats’ Sperm Quality and Testicular Histology

, 2021; 22(3): 400 - 407

Castillo-Maldonado Irais, Borjón-Ríos Claudia, Pedroza-Escobar David*, Sharma Ashutosh, García-Garza Rubén, Ramírez-Moreno Agustina, Vega-Menchaca M. del Carmen, Rivera-Guillén Mario-Alberto and Serrano-Gallardo Luis-Benjamín*




Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer

, 2021; 22(2): 317 - 326

Karol Talkowski*, Kamil Kiełbasiński, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń and Marcin Oplawski






Cisplatin Changes Expression of SEMA3B in Endometrial Cancer

, 2020; 21(13): 1368 - 1376

Wojciech Peszek*, Piotr Kras, Beniamin O. Grabarek, Dariusz Boroń and Marcin Oplawski




Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line

, 2020; 21(12): 1269 - 1277

Kamil Kiełbasiński*, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń, Magdalena Wierzbik-Strońska and Marcin Oplawski





Differences in the Expression Pattern of mRNA Protein SEMA3F in Endometrial Cancer <i>in vitro</i> under Cisplatin Treatment

, 2020; 21(11): 1119 - 1128

Przemysław Kieszkowski*, Dariusz Dąbruś, Beniamin O. Grabarek and Dariusz Boroń




Analysis of the Clinical Diagnostic Value of GMFB in Cerebral Infarction

, 2020; 21(10): 955 - 963

Zhaohu Yuan*, Zhiwu Yu, Yiyu Zhang and Huikuan Yang




Plant Phenolics as Pathogen-Carrier Immunogenicity Modulator Haptens

, 2020; 21(10): 897 - 905

Castillo-Maldonado Irais, Sevilla-González María-de-la-Luz, Delgadillo-Guzmán Dealmy, Ramírez-Moreno Agustina, Cabral-Hipólito Nidia, Rivera-Guillén Mario-Alberto, Serrano-Gallardo Luis-Benjamín*, Vega-Menchaca María-del-Carmen and Pedroza-Escobar David*





Most Cited Articles


Review Article

Current prospects of nutraceuticals: A review

, 2020; 21(10): 884-896.

Vedant Sachdeva, Arpita Roy and Navneeta Bharadvaja*


DOI: 10.2174/1389201021666200130113441





Research Article

Healthcare-associated infections due to multidrug-resistant organisms: A surveillance study on extra hospital stay and direct costs

, 2019; 20(8): 643-652.

Guglielmo Giraldi, Marzietta Montesano, Christian Napoli, Paola Frati, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti and Giovanni B. Orsi*


DOI: 10.2174/1389201020666190408095811



Review Article

Ginger: A novel strategy to battle cancer through modulating cell signalling pathways: A review

, 2019; 20(1): 5-16.

Ahmad Almatroudi, Mohammed A. Alsahli, Faris Alrumaihi, Khaled S. Allemailem and Arshad H. Rahmani*


DOI: 10.2174/1389201020666190119142331


Research Article

Advanced loss eventuality assessment and technical estimates: An integrated approach for management of healthcare-associated infections

, 2019; 20(8): 625-634.

Vittorio Gatto, Matteo Scopetti, Raffaele La Russa*, Alessandro Santurro, Luigi Cipolloni, Rocco V. Viola, Mariantonia Di Sanzo, Paola Frati and Vittorio Fineschi


DOI: 10.2174/1389201020666190408095050


Research Article

New rules on patient’s safety and professional liability for the Italian health service

, 2019; 20(8): 615-624.

Sara Albolino, Tommaso Bellandi, Simone Cappelletti, Marco Di Paolo, Vittorio Fineschi*, Paola Frati, Caterina Offidani, Michela Tanzini, Riccardo Tartaglia and Emanuela Turillazzi


DOI: 10.2174/1389201020666190408094016


Review Article

Functional biomolecule delivery systems and bioengineering in cartilage regeneration

, 2019; 20(1): 32-46.

Marta A. Szychlinska, Ugo D'Amora, Silvia Ravalli, Luigi Ambrosio, Michelino Di Rosa and Giuseppe Musumeci*


DOI: 10.2174/1389201020666190206202048




Review Article

Potential pharmaceutical and food applications of postbiotics: A review

, 2020; 21(15): 1576-1587.

Aziz H. Rad, Amin Abbasi*, Hossein S. Kafil* and Khudaverdi Ganbarov


DOI: 10.2174/1389201021666200516154833


Review Article

Blood brain barrier permeability prediction using machine learning techniques: An update

, 2019; 20(14): 1163-1171.

Deeksha Saxena, Anju Sharma, Mohammed H. Siddiqui and Rajnish Kumar*


DOI: 10.2174/1389201020666190821145346



Most Accessed Articles


Novel Therapeutic Approaches and Targets for Treatment of Psoriasis

, 2021; 22(1): 7-31.

Radi, Giulia; Campanati, Anna; Diotallevi, Federico; Bianchelli, Tommaso; Offidani, Annamaria


DOI: 10.2174/1389201021666200629150231




Targeted Delivery of CRISPR/Cas13 as a Promising Therapeutic Approach to Treat SARS-CoV-2

, 2021; 22(9): 1149-1155.

Abbaszadeh-Goudarzi, Kazem; Nematollahi, Mohammad H.; Khanbabaei, Hashem; Nave, Hossein H.; Mirzaei, Hamid R.; Pourghadamyari, Hossein; Sahebkar, Amirhossein


DOI: 10.2174/1389201021666201009154517


The Research Progress of Taxol in Taxus

, 2021; 22(3): 360-366.

Shao, Fenjuan; Wilson, Iain W.; Qiu, Deyou


DOI: 10.2174/1389201021666200621163333


Novel Therapeutic Approaches and Targets for the Treatment of Hidradenitis Suppurativa

, 2021; 22(1): 59-72.

Giuffrida, Roberta; Cannavo, Serafinella Patrizia; Coppola, Marialorena; Guarneri, Claudio


DOI: 10.2174/1389201021666200505100556





Enhanced Intracellular Delivery of Curcumin by Chitosan-Lipoic Acid as Reduction-Responsive Nanoparticles

, 2021; 22(5): 614-627.

Rezaei, Somayeh; Kashanian, Soheila; Bahrami, Yadollah; Zhaleh, Hossein; Cruz, Luis J.


DOI: 10.2174/1389201021999200727153513



Usnic Acid Inhibits Proliferation and Migration through ATM Mediated DNA Damage Response in RKO Colorectal Cancer Cell

, 2021; 22(8): 1129-1138.

Wu, Wenbing; Gou, Hui; Dong, Jingying; Yang, Xiaolong; Zhao, Yanan; Peng, Heng; Chen, Dan; Geng, Ruiman; Chen, Lihong; Liu, Ji


DOI: 10.2174/1389201021666201002155955






Editor-in-Chief

graphic
Nikolaos Labrou
School of Food, Biotechnology and Development
Department of Biotechnology
Agricultural University of Athens
Athens
(Greece)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Pharmaceutical Biotechnology was launched in 2000. Dr. Nikolaos Labrou serves as the Editor-in-Chief of the journal.

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