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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 20, 10 Issues, 2021
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

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Volume 20

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Number 9





Review Article (Mini-Review)

Cellular Senescence and ApoE4: Their Repercussions in Alzheimer’s Disease

, 20(9): 778 - 785

Angeles C. Tecalco-Cruz*, Jesús Zepeda-Cervantes, Lilia López-Canovas, Josué Oriando Ramírez-Jarquín, José Pedraza-Chaverrí and Alfredo Briones-Herrera


DOI: 10.2174/1871527320666210628102721




Review Article



Review Article

The Link between Exercise and Homocysteine in the Alzheimer’s Disease: A Bioinformatic Network Model

, 20(9): 814 - 821

Luana Lemos Leão, Laís Francielle Francisca Felício, Knut Engedal, Gro Gujord Tangen, Kari Midtbø Kristiansen, Sérgio Henrique Sousa Santos, Alfredo Maurício Batista de Paula and Renato Sobral Monteiro-Junior*


DOI: 10.2174/1871527320666210706122618








Articles Ahead of Print




Pharmacotherapeutic Potential of Garlic in Age-Related Neurological Disorders


Ramin Ahangar-Sirous, Mohadeseh Poudineh, Arina Ansari, Ali Nili, Seyyed Mohammad Matin Alavi Dana, Zahra Nasiri, Zahra Sadat Hosseini, Dariush Karami, Melika Mokhtari and Niloofar Deravi*


DOI: 10.2174/1871527320666210927101257
View Abstract View on PubMed



Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure


Amit Raj Sharma, Gitika Batra , Lokesh Saini, Saurabh Sharma, Abhishek Mishra, Rubal Singla, Ashutosh Singh , Rahul Soloman Singh, Ashish Jain , Seema Bansal, Manish Modi and Bikash Medhi*


DOI: 10.2174/1871527320666210806165430
View Abstract View on PubMed


Benzodiazepines and Sleep Architecture: A Systematic Review


Felipe Maraucci Ribeiro de Mendonça, Giulia Paulo Rossi Ribeiro de Mendonça, Laura Costa Souza, Lucas Pequeno Galvão, Henrique Soares Paiva, Cintia de Azevedo Marques Périco, Julio Torales, Antonio Ventriglio, João Maurício Castaldelli-Maia and Anderson Sousa Martins Silva*


DOI: 10.2174/1871527320666210618103344
View Abstract View on PubMed


Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation


Viktor S. Kokhan, Sofia Mariasina, Vladimir A. Pikalov, Denis A. Abaimov, Siva G. Somasundaram , Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1871527320666210122092330
View Abstract View on PubMed



Effective Connectivity Between the Orbitofrontal Cortex and the Precuneus Differentiates Major Psychiatric Disorders: Results from a Transdiagnostic Spectral DCM Study


Sevdalina Kandilarova, Drozdstoy Stoyanov*, Katrin Aryutova, Rossitsa Paunova, Mladen Mantarkov, Ivo Mitrev, Anna Todeva-Radneva and Karsten Specht


DOI: 10.2174/1871527320666210917142815
View Abstract View on PubMed


Abstracts Ahead of Print

An Overview of Acute Flaccid Myelitis


Aseem Setia, Jasween Bhatia and Sankha Bhattacharya*


DOI: 10.2174/1871527320666211125101424
View Abstract



Role of Vitamins in Neurodegenerative Diseases: A Review


Ravi Ranjan Kumar, Lovekesh Singh, Amandeep Thakur, Shamsher Singh and Bhupinder Kumar*


DOI: 10.2174/1871527320666211119122150
View Abstract


Dipsacoside B Exerts a Beneficial Effect on Brain Injury in the Ischemic Stroke Rat through Inhibition of Mitochondrial E3 Ubiquitin Ligase 1


Kai-Di Ren, Zi-Mei Peng, Jing Tian, Ya-Wei Peng, Yi-Yue Zhang, Xiao-Jie Zhang, Zhong-Yang Hu, Xiu-Ju Luo* and Jun Peng*


DOI: 10.2174/1871527320666211118143554
View Abstract


Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia


Tapan Behl*, Arpita Arora, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau and Ebrahim Mostafavi*


DOI: 10.2174/1871527320666211110115257
View Abstract





Comparing the efficacy and safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for sedation in colonoscopy patients: A double-blinded randomized clinical trial


Reza Aminnejad, Ahmad Hormati*, Hamed Shafiee, Faezeh Alemi, Maryam Hormati, Mohammad Saeidi, Sajjad Ahmadpour, Seyed Mahdi Sabouri and Mohammad Aghaali


DOI: 10.2174/1871527320666211006141406
View Abstract



Published Contents

Editor's Choice

Cellular Senescence and ApoE4: Their Repercussions in Alzheimer’s Disease

, 2021; 20(9): 778 - 785

Angeles C. Tecalco-Cruz*, Jesús Zepeda-Cervantes, Lilia López-Canovas, Josué Oriando Ramírez-Jarquín, José Pedraza-Chaverrí and Alfredo Briones-Herrera


DOI: 10.2174/1871527320666210628102721




Cellular and Molecular Mechanisms of Dementia: Decoding the Causal link of Diabetes Mellitus in Alzheimer’s Disease

, 2021; 20(7): 602 - 612

Mahmood Rasool*, Arif Malik, Sulayman Waquar, Ahmad Zaheer, Muhammad Asif, Zafar Iqbal, Kalamegam Gauthaman*, Mohammad Amjad Kamal and Peter Natesan Pushparaj*


DOI: 10.2174/1871527320666210212114116




Neurological Manifestations of COVID-19 and the Importance of Magnetic Resonance Imaging

, 2021; 20(5): 390 - 391

Rubens J. Gagliardi*, Renan Domingues, Cristine Cukier, Maria F. Mendes, Vivian D.B. Gagliardi and Francisco T.M. de Oliveira


DOI: 10.2174/1871527320666210122093458




The Role of Statins in the Management of Delirium: Recent Advances

, 2021; 20(3): 203 - 215

Junhui Chen, Yuhai Wang, Ximin Hu, Mingchang Li, Kun Xiong, Zhaocai Zhang* and Qianxue Chen*


DOI: 10.2174/1871527319666200720111318




Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update

, 2020; 19(9): 648 - 662

Manisha Pandey*, Hira Choudhury*, Rohit Kumar Verma, Viney Chawla, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja and Muhammad Wahab Amjad


DOI: 10.2174/1871527319999200819095620




Open Access Articles

Restless Leg Syndrome in Patients with Liver Cirrhosis! Its Frequency, Severity, and Correlation

, 2021; 20(5): 465 - 472

Iftikhar Haider Naqvi*, Jawad Ahmed, Maliha Salim, Muhammad Ubaid, Farheen Malik, Razna Afzal, Muhammad Moinuddin Ashrafi and Muhammad Arbaz Arshad Khan




Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment

, 2021; 20(4): 378 - 384

Ovidiu Băjenaru, Gabriel Prada, Florina Antochi, Cătălin Jianu, Cătălina Tudose, Adina Cuciureanu, Any A. Docu, Valérie Perrot, Madalina Avram and Cristina Tiu*




Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

, 2020; 19(8): 611 - 617

Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack and Ines Debove*




Low Serum Levels of Fibroblast Growth Factor 2 in Gunn Rats: A Hyperbilirubinemia Animal Model of Schizophrenic Symptoms

, 2020; 19(7): 503 - 508

Maiko Hayashida*, Sadayuki Hashioka*, Kenji Hayashida, Shoko Miura, Keiko Tsuchie, Tomoko Araki, Muneto Izuhara, Misako Kanayama, Koji Otsuki, Michiharu Nagahama, Muhammad Alim Jaya, Ryosuke Arauchi, Rei Wake, Arata Oh-Nishi, Jun Horiguchi, Tsuyoshi Miyaoka, Masatoshi Inagaki and Eishin Morita




When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

, 2020; 19(4): 257 - 263

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore





Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

, 2019; 18(3): 245 - 255

Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou* and Yan Li*




Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins




Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid

, 2015; 14(10): 1343 - 1349

Evgeny E. Akkuratov, Jian Wu, David Sowa, Zahoor A. Shah and Lijun Liu





Most Cited Articles

Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*


DOI: 10.2174/1871527316666170807130011


Research Article

Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer’s disease

, 2019; 18(8): 643-654.

Reeta, Seung Cheol Baek, Jae Pil Lee, T.M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim* and Bijo Mathew*


DOI: 10.2174/1871527318666190906101326



Review Article

Epigenetics in neurodegenerative diseases: The role of histone deacetylases

, 2019; 18(1): 11-18.

Sorabh Sharma, K.C. Sarathlal and Rajeev Taliyan*


DOI: 10.2174/1871527317666181004155136


Review Article

Perspective design of chalcones for the management of cns disorders: A mini-review

, 2019; 18(6): 432-445.

Bijo Mathew*, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, Md. Sahab Uddin, Jerad Suresh, Githa Elizabeth Mathew, Monu Joy, Akash Marathakam and Sheeba Varghese Gupta


DOI: 10.2174/1871527318666190610111246


Letter Article

When sick brain and hopelessness meet: Some aspects of suicidality in the neurological patient

, 2020; 19(4): 257-263.

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore


DOI: 10.2174/1871527319666200611130804



Research Article

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway

, 2019; 18(2): 115-123.

Fangfang Li , Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340


Research Article

The role of annexin A1 and formyl peptide receptor 2/3 signaling in chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory

, 2020; 19(1): 27-43.

Alessio Filippo Peritore, Rosalia Crupi, Maria Scuto, Enrico Gugliandolo, Rosalba Siracusa, Daniela Impellizzeri, Marika Cordaro, Ramona D’amico, Roberta Fusco, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527319666200107094732


Review Article

Neuro-psychiatric alterations in patients with diabetic foot syndrome

, 2019; 18(8): 598-608.

Emmanuel Navarro-Flores, Pilar Pérez-Ros, Francisco Miguel Martínez-Arnau, Iván Julían-Rochina and Omar Cauli*


DOI: 10.2174/1871527318666191002094406


Research Article

Cordycepin exerts neuroprotective effects via an anti-apoptotic mechanism based on the mitochondrial pathway in a rotenone-induced parkinsonism rat model

, 2019; 18(8): 609-620.

Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge* and Xiao-Ling Zhang*


DOI: 10.2174/1871527318666190905152138


Clinical Trial

Ultramicronized palmitoylethanolamide (Um-PEA) as add-on treatment in fibromyalgia syndrome (FMS): Retrospective observational study on 407 patients

, 2019; 18(4): 326-333.

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati


DOI: 10.2174/1871527318666190227205359



Research Article

Exosomal miR-214-5p released from glioblastoma cells modulates inflammatory response of microglia after lipopolysaccharide stimulation through targeting CXCR5

, 2019; 18(1): 78-87.

Jian-kai Yang*, Hong-jiang Liu, Yuanyu Wang, Chen Li, Ji-peng Yang, Liang Yang, Xue-jiao Qi, Yin-long Zhao, Xue-fang Shi, Jing-chen Li, Guo-zhu Sun and Bao-hua Jiao


DOI: 10.2174/1871527317666181105112009


General Research Article

Neuroprotection of rotenone-induced parkinsonism by ursolic acid in pd mouse model

, 2020; 19(7): 527-540.

Walia Zahra, Sachchida Nand Rai, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Chetan Keswani, Rakesh K. Singh and Surya Pratap Singh*


DOI: 10.2174/1871527319666200812224457



Most Accessed Articles




Herbal Drug Interaction: Mechanistic Details through Pharmacokinetic Portfolio

, 2021; 20(8): 677-686.

Salman Ahmed, Haroon Khan*, Hamed Mirzaei, Muhammad Mohtasheemul Hasan, Mohamed Eddouks and Maria Daglia*


DOI: 10.2174/1871527319666201008151710



Autophagic Dysfunction in Dementia: Scope for Development of Potential Remedies

, 2021; 20(8): 704-722.

Bhumika Kumar, Mukesh Pandey, Ashwini Kumar Mishra, Anjali Sharma, Faizana Fayaz and Faheem Hyder Pottoo*


DOI: 10.2174/1871527319666201209112256



Immunotherapies for Parkinson’s Disease: Progression of Clinical Development

, 2021; 20(9): 802-813.

Jet Shee Teng, Yin Yin Ooi, Soi Moi Chye, Anna Pick Kiong Ling and Rhun Yian Koh*


DOI: 10.2174/1871527320666210526160926


Melatonin and Sleep Disturbances in Alzheimer’s Disease

, 2021; 20(8): 736-754.

A.H.M. Safayet Ullah Prodhan , Cinzia Cavestro, Mohammad Amjad Kamal and Mohammad Asiful Islam*


DOI: 10.2174/1871527320666210804155617



The Link between Exercise and Homocysteine in the Alzheimer’s Disease: A Bioinformatic Network Model

, 2021; 20(9): 814-821.

Luana Lemos Leão, Laís Francielle Francisca Felício, Knut Engedal, Gro Gujord Tangen, Kari Midtbø Kristiansen, Sérgio Henrique Sousa Santos, Alfredo Maurício Batista de Paula and Renato Sobral Monteiro-Junior*


DOI: 10.2174/1871527320666210706122618



GluN2B/N-methyl-D-aspartate Receptor Antagonists: Advances in Design, Synthesis, and Pharmacological Evaluation Studies

, 2021; 20(9): 822-862.

Vinod Ugale*, Ashish Dhote, Rushikesh Narwade, Saurabh Khadse, P. Narayana Reddy and Atul Shirkhedkar


DOI: 10.2174/1871527320666210309141627


Cellular Senescence and ApoE4: Their Repercussions in Alzheimer’s Disease

, 2021; 20(9): 778-785.

Angeles C. Tecalco-Cruz*, Jesús Zepeda-Cervantes, Lilia López-Canovas, Josué Oriando Ramírez-Jarquín, José Pedraza-Chaverrí and Alfredo Briones-Herrera


DOI: 10.2174/1871527320666210628102721


Modifiable Risk Factors Associated with Alzheimer’s Disease with Special Reference to Sleep Disturbance

, 2021; 20(7): 594-601.

Pallavi Singh Chauhan, Meerambika Mishra, Bhupendra Koul, Mayank Sharma and Dhananjay Yadav*


DOI: 10.2174/1871527320666210319111852




Editor-in-Chief

graphic
Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria
Messina
(Italy)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Targets - CNS & Neurological Disorders was launched in 2002 and later renamed in 2006 as CNS & Neurological Disorders - Drug Targets.

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