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CNS & Neurological Disorders - Drug Targets

Formerly: Current Drug Targets - CNS & Neurological Disorders

Volume 19, 10 Issues, 2020
ISSN: 1996-3181 (Online)
ISSN: 1871-5273 (Print)
This journal supports open access
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Ranking and Category

  • 150th of 267 in

    Neurosciences

  • 119th of 267 in

    Pharmacology & Pharmacy

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

CNS & Neurological Disorders - Drug Targets

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Volume 19

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Number 4



Biography   Open Access



Review Article



Review Article (Mini-Review)



Letter Article   Open Access

When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

, 19(4): 257 - 263

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore


DOI: 10.2174/1871527319666200611130804


Research Article



Research Article



Research Article

Lisdexamfetamine Alters BOLD-fMRI Activations Induced by Odor Cues in Impulsive Children

, 19(4): 290 - 305

Silvia S. Hidalgo Tobón, Pilar Dies Suárez, Eduardo Barragán Pérez, Javier M. Hernández López, Julio García and Benito de Celis Alonso*


DOI: 10.2174/1871527319666200613222502


Research Article

Metabolic Adjustments by LncRNAs in Peripheral Neutrophils Partly Account for the Complete Compensation of Asymptomatic MMD Patients

, 19(4): 306 - 317

Ziping Han, Lingzhi Li, Ping Liu, Yuyou Huang, Sijia Zhang, Guangwen Li, Fangfang Li, Haiping Zhao, Zhen Tao, Rongliang Wang, Qingfeng Ma* and Yumin Luo*


DOI: 10.2174/1871527319666200618150827


CNS & Neurological Disorders - Drug Targets , Volume 19 (2020) - Number 8


This issue is in progress but contains articles that are final and fully citable.

CNS & Neurological Disorders - Drug Targets , Volume 19 (2020) - Number 7


This issue is in progress but contains articles that are final and fully citable.

CNS & Neurological Disorders - Drug Targets , Volume 19 (2020) - Number 6


This issue is in progress but contains articles that are final and fully citable.

CNS & Neurological Disorders - Drug Targets , Volume 19 (2020) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


MCC950 Reduces Neuronal Apoptosis in Spinal Cord Injury in Mice


Ning He, Xiaohe Zheng, Teng He, Gerong Shen, Kunyu Wang, Jue Hu, Mingzhi Zheng, Yueming Ding, Xinghui Song, Jinjie Zhong, Ying-ying Chen, Lin-lin Wang* and Yueliang Shen


DOI: 10.2174/1871527319666201005170659
View Abstract View on PubMed




Exploring the various aspects of Brain Derived Neurotropic Factor (BDNF) in Diabetes Mellitus


Eshita Sharma, Tapan Behl*, Vineet Mehta, Arun Kumar, Dhruv Setia, Md. Sahab Uddin, Gokhan Zengin and Sandeep Arora


DOI: 10.2174/1871527319666201014125642
View Abstract



Herbal Drug Interaction: Mechanistic Details Through the Pharmacokinetic Portfolio


Salman Ahmed, Haroon Khan*, Hamed Mirzaei, Muhammad Mohtasheemul Hasan, Mohamed Eddouks and Maria Daglia


DOI: 10.2174/1871527319666201008151710
View Abstract View on PubMed



Melatonin alleviates pyroptosis of retinal neurons following acute intraocular hypertension


Zhang Yu*, Huang Yanxia, Guo Limin, Zhang Yun, Zhao Mingxuan, Xue Fuyao, Tan Cheng, Huang Jufang and Chen Dan


DOI: 10.2174/1871527319666201012125149
View Abstract



Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice


Interlink Between Insulin Resistance and Neurodegeneration with an Update on Current Therapeutic Approaches

, 2020; 19(3): 174 - 183

Subrat Kumar Bhattamisra*, Lee Yuen Shin, Hanis Izzati Binti Mohd Saad, Vikram Rao, Mayuren Candasamy, Manisha Pandey and Hira Choudhury


DOI: 10.2174/1871527319666200518102130





Pharmacotherapy of Down’s Syndrome: When and Which?

, 2019; 18(10): 750 - 757

Seyed K. Tayebati*, Alessandro Cecchi, Ilenia Martinelli, Elisa Carboni and Francesco Amenta


DOI: 10.2174/1871527318666191114092924




Cordycepin Exerts Neuroprotective Effects via an Anti-Apoptotic Mechanism based on the Mitochondrial Pathway in a Rotenone-Induced Parkinsonism Rat Model

, 2019; 18(8): 609 - 620

Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge* and Xiao-Ling Zhang*


DOI: 10.2174/1871527318666190905152138



Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations

, 2019; 18(7): 530 - 554

Maria Lia Lunardelli, Rosalia Crupi, Rosalba Siracusa, Giorgio Cocuzza, Marika Cordaro, Emilio Martini, Daniela Impellizzeri, Rosanna Di Paola and Salvatore Cuzzocrea*


DOI: 10.2174/1871527318666190617162041



The Effect of Vitamin D3 Supplementation on Serum BDNF, Dopamine, and Serotonin in Children with Attention-Deficit/Hyperactivity Disorder

, 2019; 18(6): 496 - 501

Marzieh Seyedi, Fatemeh Gholami, Mahsa Samadi, Mahmoud Djalali, Mohammad Effatpanah*, Mir Saeed Yekaninejad, Rezvan Hashemi, Mina Abdolahi, Maryam Chamari and Niyaz Mohammadzadeh Honarvar


DOI: 10.2174/1871527318666190703103709




Open Access Articles

Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

, 2020; 19(8): 611 - 617

Deborah Amstutz, Steffen Paschen, Martin Lenard Lachenmayer, Marie Elise Maradan-Gachet, Günther Deuschl, Paul Krack and Ines Debove*




When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient

, 2020; 19(4): 257 - 263

Alessandra Costanza*, Andrea Amerio, Andrea Aguglia, Andrea Escelsior, Gianluca Serafini, Isabella Berardelli, Maurizio Pompili and Mario Amore





Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

, 2019; 18(3): 245 - 255

Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou* and Yan Li*




Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer’s Disease Model Rats by Maintaining Synaptic Plasticity

, 2018; 17(5): 389 - 399

Kai Wang, Weiming Sun, Linlin Zhang, Wei Guo, Jiachun Xu, Shuang Liu, Zhen Zhou and Yulian Zhang*




Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve

, 2018; 17(3): 184 - 192

Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman




Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate

, 2017; 16(6): 714 - 723

Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*




Nanomaterials for Neurology: State-of-the-Art

, 2016; 15(10): 1306 - 1324

María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas




The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

, 2016; 15(5): 564 - 577

Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka





The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

, 2016; 15(3): 337 - 343

Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins




Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid

, 2015; 14(10): 1343 - 1349

Evgeny E. Akkuratov, Jian Wu, David Sowa, Zahoor A. Shah and Lijun Liu






The Role of Neuroimaging in Our Understanding of the Suicidal Brain

, 2013; 12(7): 921 - 929

Stefanie Desmyter, Stijn Bijttebier and Kees van Heeringen





Most Cited Articles

Review Article

Nf-κb as a key mediator of brain inflammation in Alzheimer’s disease

, 2019; 18(1): 3-10.

Chul Ju Hwang, Dong-Young Choi, Mi Hee Park and Jin Tae Hong*


DOI: 10.2174/1871527316666170807130011



Review Article

Epigenetics in neurodegenerative diseases: The role of histone deacetylases

, 2019; 18(1): 11-18.

Sorabh Sharma, K.C. Sarathlal and Rajeev Taliyan*


DOI: 10.2174/1871527317666181004155136


Research Article

Ethyl acetohydroxamate incorporated chalcones: Unveiling a novel class of chalcones for multitarget monoamine oxidase-b inhibitors against alzheimer’s disease

, 2019; 18(8): 643-654.

Reeta, Seung Cheol Baek, Jae Pil Lee, T.M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim* and Bijo Mathew*


DOI: 10.2174/1871527318666190906101326


Review Article

Perspective design of chalcones for the management of cns disorders: A mini-review

, 2019; 18(6): 432-445.

Bijo Mathew*, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, Md. Sahab Uddin, Jerad Suresh, Githa Elizabeth Mathew, Monu Joy, Akash Marathakam and Sheeba Varghese Gupta


DOI: 10.2174/1871527318666190610111246


Research Article

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway

, 2019; 18(2): 115-123.

Fangfang Li , Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*


DOI: 10.2174/1871527317666181114140340


Clinical Trial

Ultramicronized palmitoylethanolamide (Um-PEA) as add-on treatment in fibromyalgia syndrome (FMS): Retrospective observational study on 407 patients

, 2019; 18(4): 326-333.

Vittorio Schweiger*, Alvise Martini, Paola Bellamoli, Katia Donadello, Carlo Schievano, Giovanna D. Balzo, Piercarlo Sarzi-Puttini, Massimo Parolini and Enrico Polati


DOI: 10.2174/1871527318666190227205359



Research Article

Cordycepin exerts neuroprotective effects via an anti-apoptotic mechanism based on the mitochondrial pathway in a rotenone-induced parkinsonism rat model

, 2019; 18(8): 609-620.

Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge* and Xiao-Ling Zhang*


DOI: 10.2174/1871527318666190905152138



Research Article

Motor recovery after chronic spinal cord transection in rats: A proof-of-concept study evaluating a combined strategy

, 2019; 18(1): 52-62.

Antonio Ibarra*, Erika Mendieta-Arbesú, Paola Suarez-Meade, Elisa García-Vences, Susana Martiñón, Roxana Rodriguez-Barrera, Joel Lomelí, Adrian Flores-Romero, Raúl Silva-García, Vinnitsa Buzoianu-Anguiano, Cesar V. Borlongan and Tamara D. Frydman


DOI: 10.2174/1871527317666181105101756



Systemic Review Article

Efficacy of celecoxib adjunct treatment on bipolar disorder: Systematic review and meta-analysis

, 2019; 18(1): 19-28.

Daniela V. Bavaresco, Tamy Colonetti, Antônio J. Grande, Francesc Colom, Samira S. Valvassori, João Quevedo and Maria I. da Rosa*


DOI: 10.2174/1871527317666181105162347


Research Article

Exosomal miR-214-5p released from glioblastoma cells modulates inflammatory response of microglia after lipopolysaccharide stimulation through targeting CXCR5

, 2019; 18(1): 78-87.

Jian-kai Yang*, Hong-jiang Liu, Yuanyu Wang, Chen Li, Ji-peng Yang, Liang Yang, Xue-jiao Qi, Yin-long Zhao, Xue-fang Shi, Jing-chen Li, Guo-zhu Sun and Bao-hua Jiao


DOI: 10.2174/1871527317666181105112009


Review Article

A pharmacological appraisal of neuroprotective and neurorestorative flavonoids against neurodegenerative diseases

, 2019; 18(2): 103-114.

Jia Zhao*, Mengxia Zhu, Mukesh Kumar, Fung Yin Ngo, Yinghui Li, Lixing Lao and Jianhui Rong


DOI: 10.2174/1871527317666181105093834



Most Accessed Articles






TRP Channels: New Potential Therapeutic Approaches in CNS Neuropathies

, 2013; 12(2): 274-293.

Maria Beatrice Morelli, Consuelo Amantini, Sonia Liberati, Matteo Santoni and Massimo Nabissi


DOI: 10.2174/18715273113129990056




The locus of Action of CGRPergic Monoclonal Antibodies Against Migraine: Peripheral Over Central Mechanisms

, 2020; 19(5): 344-359.

Abimael González-Hernández, Bruno A. Marichal-Cancino, Enrique García-Boll and Carlos M. Villalón*


DOI: 10.2174/1871527319666200618144637


Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities

, 2013; 12(5): 698-714.

Ramon Rodrigo, Rodrigo Fernandez-Gajardo, Rodrigo Gutierrez, Jose Manuel Matamala, Rodrigo Carrasco, Andres Miranda-Merchak and Walter Feuerhake


DOI: 10.2174/1871527311312050015



Editor-in-Chief

Edoardo Spina
Department of Clinical and Experimental Medicine
University of Messina
Policlinico Universitario
Via Consolare Valeria
Messina
(Italy)
Biography
View Full Editorial Board

COPE Compliant

Journal History

Current Drug Targets - CNS & Neurological Disorders was launched in 2002 and later renamed in 2006 as CNS & Neurological Disorders - Drug Targets.
Scopus CiteScore Metrics: 2.72

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