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Current Medicinal Chemistry

Volume 29, 42 Issues, 2022
ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)
This journal supports open access

Aims & Scope

Current Medicinal Chemistry covers all the latest and outstanding developments in the field of medicinal chemistry. It also includes topics related to quantitative structure-function relationships, drug absorption, drug distribution, drug metabolism, new and emerging drug targets, pharmacogenomics, drug discovery toxicology, high-throughput screening, combinatorial chemistry, structural characterization and organic syntheses of naturally occurring compounds, as well as chemical and analytical techniques used in rational drug design. Each issue incorporates a series of timely in-depth/mini-reviews and guest-edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents.

Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be informed and up-to-date with the latest and most important developments relevant to their field.

Current Medicinal Chemistry


Volume 29


Number 31


Target Mutation-Driven Drug Discovery

, 29(31): 5156 - 5158

Concetta Altamura*, Diana Conte, Maria Rosaria Carratù and Jean-François Desaphy

DOI: 10.2174/1389450123666220418111200

Review Article

Potential Application of Cephalosporins Carried in Organic or Inorganic Nanosystems against Gram-Negative Pathogens

, 29(31): 5212 - 5229

Brenda Maria Silva Bezerra, Sara Efigênia Dantas de Mendonça y Araujo, Analara Cordeiro de Macêdo, Kammila Martins Nicolau Costa, Mariana Rillo Sato and João Augusto Oshiro-Junior*

DOI: 10.2174/0929867329666220329201817

Review Article

Chronic Kidney Disease-Mineral Bone Disease Biomarkers in Kidney Transplant Patients

, 29(31): 5230 - 5253

Ursula Gramiscelli Hasparyk, Flávia Maria Borges Vigil, Victória Soares Bartolomei, Vitor Moreira Nunes and Ana Cristina Simões e Silva*

DOI: 10.2174/0929867329666220318105856

Research Article

Betaine Modulating MIF-Mediated Oxidative Stress, Inflammation and Fibrogenesis in Thioacetamide-Induced Nephrotoxicity

, 29(31): 5254 - 5267

Bojan Jorgačević, Sanja Stanković, Jelena Filipović, Janko Samardžić, Danijela Vučević and Tatjana Radosavljević*

DOI: 10.2174/0929867329666220408102856

Current Medicinal Chemistry, Volume 29 (2022) - Number 34

This issue is in progress but contains articles that are final and fully citable.

Current Medicinal Chemistry, Volume 29 (2022) - Number 33

This issue is in progress but contains articles that are final and fully citable.

Current Medicinal Chemistry, Volume 29 (2022) - Number 32

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Acute Post-Streptococcal Glomerulonephritis in Children: A Comprehensive Review

Sérgio Veloso Brant Pinheiro, Victor Buchini de Freitas, Gustavo Valverde de Castro, Beatriz Cronemberger Rufino Madeiro, Stanley Almeida de Araújo, Thomas Felipe Silva Ribeiro and Ana Cristina Simões e Silva*

DOI: 10.2174/0929867329666220613103316
View Abstract View on PubMed

Exploring the Recent Trends in Management of Dementia and Frailty: Focus on Diagnosis and Treatment

Md. Mominur Rahman*, Sadia Afsana Mim, Md. Rezaul Islam, Anwar Parvez, Fahadul Islam, Mohammad Borhan Uddin, Md. Saidur Rahaman, Pollob Ahmed Shuvo, Muniruddin Ahmed, Nigel H Greig and Mohammad Amjad Kamal*

DOI: 10.2174/0929867329666220408102051
View Abstract View on PubMed

The Role of Alternative Toxicological Trials in Drug Discovery Programs. The Case of Caenorhabditis elegans and Other Methods

Gabriela Göethel*, Lucas Volnei Augsten, Gustavo Machado das Neves, Itamar Luís Gonçalves, João Pedro Silveira de Souza, Solange Cristina Garcia and Vera Lucia Eifler-Lima*

DOI: 10.2174/0929867329666220329190825
View Abstract View on PubMed

Antitumor and Antiparasitic Activity of Antimicrobial Peptides Derived from Snake Venom: A Systematic Review Approach

Gabriel A. de Moura, Juliana R. de Oliveira, Yasmim M. Rocha, Janaína de Oliveira Freitas, João Pedro V. Rodrigues, Vanessa P.G. Ferreira and Roberto Nicolete*

DOI: 10.2174/0929867329666220507011719
View Abstract View on PubMed

Abstracts Ahead of Print

Repurposing Metformin for Vascular Disease.

Chris R. Triggle*, Isra Marei, Kevin Ye, Hong Ding, Todd J. Anderson, Morley D. Hollenberg and Michael A. Hill

DOI: 10.2174/0929867329666220729154615
View Abstract

Resveratrol effects on molecular pathways and microRNAs in gastrointestinal cancers.

Amirhossein Davoodvandi, Pouya Mahdavi Sharif, Parisa Maleki Dana and Zatollah Asemi*

DOI: 10.2174/0929867329666220729153654
View Abstract

Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What’s New?

Camilla Pecoraro, Daniela Carbone, Stella Maria Cascioferro, Barbara Parrino and Patrizia Diana*

DOI: 10.2174/0929867329666220729152741
View Abstract

Sulfonamide moiety as “molecular chimera” in the design of new drugs

Giulia Culletta, Marco Tutone*, Maria Zappalà and Anna Maria Almerico

DOI: 10.2174/0929867329666220729151500
View Abstract

Role of Tyrosine kinases and their inhibitors in cancer therapy: A Comprehensive Review

Vanktesh Kumar, Navjot Kaur, Sanjeev Sahu, Vikas Sharma*, Deepak Kumar, Ajit Sharma and Pankaj Wadhwa

DOI: 10.2174/0929867329666220727122952
View Abstract

The association between the risk of breast cancer and Epigallocatechin-3-Gallate intake: A literature review of a potential chemopreventive agent.

Efstratios Athanasiou*, Georgios-Ioannis Verras, Savvas Papageorgiou, Ioannis Kelesis, Athanasios Gatsis, Christina Karaoulani, Ioannis Stouras, Panagiotis Kanatas, Elmina-Marina Saitani, Maria-Eleni Oikonomou, Danae-Anastasia Vlassi, Maria Vasileiou, Christos Tsagkaris, Athanasios Alexiou and Mohammad Amjad Kamal

DOI: 10.2174/0929867329666220726153412
View Abstract

Published Contents

Open Access Articles

Dual Targeting Strategies on Histone Deacetylase 6 (HDAC6) and Heat Shock Protein 90 (Hsp90)

, 2022; 29(9): 1474 - 1502

Davide Bonanni, Andrea Citarella, Davide Moi, Luca Pinzi, Elisa Bergamini and Giulio Rastelli*

Deep Learning in the Quest for Compound Nomination for Fighting COVID-19

, 2021; 28(28): 5699 - 5732

Maria Mernea, Eliza C. Martin, Andrei-José Petrescu* and Speranta Avram*

Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling

, 2021; 28(18): 3476 - 3489

Nazarius S. Lamango*, Augustine T. Nkembo, Elizabeth Ntantie and Nada Tawfeeq

Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance

, 2021; 28(6): 1126 - 1142

Wei Li, Kun Liu, Yi Chen, Mingyue Zhu* and Mengsen Li*

Tumor in 3D: In Vitro Complex Cellular Models to Improve Nanodrugs Cancer Therapy

, 2020; 27(42): 7234 - 7255

Soraia Fernandes*, Marco Cassani, Stefania Pagliari, Petr Filipensky, Francesca Cavalieri and Giancarlo Forte*

Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints

, 2020; 27(37): 6356 - 6372

Massimo De Martinis, Maria Maddalena Sirufo and Lia Ginaldi*

Most Cited Articles

Review Article

Role of ox-LDL and LOX-1 in atherogenesis

, 2019; 26(9): 1693-1700.

Ajoe John Kattoor, Sri Harsha Kanuri and Jawahar L. Mehta*

DOI: 10.2174/0929867325666180508100950

Review Article

Targeting cxcl12/cxcr4 axis in tumor immunotherapy

, 2019; 26(17): 3026-3041.

Weiqiang Zhou, Shanchun Guo*, Mingli Liu, Matthew E. Burow and Guangdi Wang*

DOI: 10.2174/0929867324666170830111531

Review Article

Immune checkpoint inhibitors: Basics and challenges

, 2019; 26(17): 3009-3025.

Bin Li*, Ho Lam Chan and Pingping Chen*

DOI: 10.2174/0929867324666170804143706

Review Article

Plant-derived products as antibacterial and antifungal agents in human health care

, 2019; 26(29): 5501-5541.

Ladislav Kokoska*, Pavel Kloucek , Olga Leuner* and Pavel Novy

DOI: 10.2174/0929867325666180831144344

Review Article

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases

, 2019; 26(18): 3225-3241.

Miguel D. Ferrer, Carla Busquets-Cortés, Xavier Capó, Silvia Tejada, Josep A. Tur, Antoni Pons and Antoni Sureda*

DOI: 10.2174/0929867325666180514112124

Review Article

Role of autophagy in Parkinson’s disease

, 2019; 26(20): 3702-3718.

Silvia Cerri and Fabio Blandini*

DOI: 10.2174/0929867325666180226094351

General Review Article

Metal–organic framework (MoF)-based nanomaterials for biomedical applications

, 2019; 26(18): 3341-3369.

Zhidong Luo, Shuran Fan, Chuying Gu, Weicong Liu, Jinxiang Chen, Baohong Li* and Jianqiang Liu*

DOI: 10.2174/0929867325666180214123500

General Review Article

Homocysteine and hyperhomocysteinaemia

, 2019; 26(16): 2948-2961.

Bozidarka L. Zaric*, Milan Obradovic, Vladan Bajic , Mohamed A. Haidara , Milos Jovanovic and Esma R. Isenovic*

DOI: 10.2174/0929867325666180313105949

Review Article

Metal-organic framework (Mof)-based drug delivery

, 2020; 27(35): 5949-5969.

Jian Cao, Xuejiao Li and Hongqi Tian*

DOI: 10.2174/0929867326666190618152518

Review Article

Applications of cellulose-based materials in sustained drug delivery systems

, 2019; 26(14): 2485-2501.

Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi* and Yonghao Ni

DOI: 10.2174/0929867324666170705143308

General Review Article

Aptamer-based targeted drug delivery systems: Current potential and challenges

, 2020; 27(13): 2189-2219.

Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu* and Yanfei Liu*

DOI: 10.2174/0929867325666181008142831

Review Article

Medical applications of collagen and collagen-based materials

, 2019; 26(3): 506-516.

Anatoly B. Shekhter, Alexey L. Fayzullin*, Marina N. Vukolova, Tatyana G. Rudenko, Varvara D. Osipycheva and Petr F. Litvitsky

DOI: 10.2174/0929867325666171205170339

Most Accessed Articles

Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications

, 2021; 28(2): 308-328.

Amiri, Atefeh; Pourhanifeh, Mohammad Hossein; Mirzaei, Hamid Reza; Nahand, Javid Sadri; Moghoofei, Mohsen; Sahebnasagh, Roxana; Mirzaei, Hamed; Hamblin, Michael R.

DOI: 10.2174/0929867327666200204141952

Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder

, 2021; 28(2): 360-376.

Amiri, Atefeh; Mahjoubin-Tehran, Maryam; Asemi, Zatollah; Shafiee, Alimohammad; Hajighadimi, Sarah; Moradizarmehri, Sanaz; Mirzaei, Hamid Reza; Mirzaei, Hamed

DOI: 10.2174/0929867326666191212102407

Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy

, 2021; 28(2): 329-345.

Zhu, Shunqin; Yu, Qin; Huo, Chunsong; Li, Yuanpeng; He, Linshen; Ran, Botian; Chen, Ji; Li, Yonghao; Liu, Wanhong

DOI: 10.2174/0929867327666200121124404

Nanoparticles in Combating Cancer: Opportunities and Limitations: A Brief Review

, 2021; 28(2): 346-359.

Pedziwiatr-Werbicka, Elzbieta; Horodecka, Katarzyna; Shcharbin, Dzmitry; Bryszewska, Maria

DOI: 10.2174/0929867327666200130101605

Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids

, 2021; 28(2): 238-252.

Gomez-Zorita, Saioa; Milton-Laskibar, Inaki; Aguirre, Leixuri; Fernandez-Quintela, Alfredo; Xiao, Jianbo; Portillo, Maria P.

DOI: 10.2174/0929867326666191029112626

New Perspectives in the Pharmacological Potential of Naringin in Medicine

, 2021; 28(10): 1987-2007.

Angelica Rivoira, Maria; Rodriguez, Valeria; Talamoni, German; Tolosa de Talamoni, Nori

DOI: 10.2174/0929867327666200604171351

Current Scenario and Future Prospect in the Management of COVID-19

, 2021; 28(2): 284-307.

Borah, Pobitra; Deb, Pran Kishore; Deka, Satyendra; Venugopala, Katharigatta N.; Singh, Vinayak; Mailavaram, Raghu Prasad; Kalia, Kiran; Tekade, Rakesh Kumar

DOI: 10.2174/0929867327666200908113642

Protective Role of Natural Products in Glioblastoma Multiforme: A Focus on Nitric Oxide Pathway

, 2021; 28(2): 377-400.

Afshari, Amir R.; Mollazadeh, Hamid; Mohtashami, Elmira; Soltani, Arash; Soukhtanloo, Mohammad; Hosseini, Azar; Jalili-Nik, Mohammad; Vahedi, Mohammad Mahdi; Roshan, Mostafa Karimi; Sahebkar, Amirhossein

DOI: 10.2174/0929867327666200130104757

Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data

, 2021; 28(2): 213-237.

Mastinu, Andrea; Ribaudo, Giovanni; Ongaro, Alberto; Bonini, Sara Anna; Memo, Maurizio; Gianoncelli, Alessandra

DOI: 10.2174/0929867327666200210144847

Deep Learning in Drug Target Interaction Prediction: Current and Future Perspectives

, 2021; 28(11): 2100-2113.

Abbasi, Karim; Razzaghi, Parvin; Poso, Antti; Ghanbari-Ara, Saber; Masoudi-Nejad, Ali

DOI: 10.2174/0929867327666200907141016


Atta-ur-Rahman, FRS
(31099 citations)
Kings College
University of Cambridge
View Full Editorial Board

Nobel Laureates on Editorial Board

Prof. John Gurdon

Prof. Jean-Marie Lehn

Prof. Ferid Murad

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