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Current Gene Therapy

Volume 21, 5 Issues, 2021
ISSN: 1566-5232 (Print)
ISSN: 1875-5631 (Online)
This journal supports open access

Aims & Scope

Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases.

Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.

Current Gene Therapy

,

Volume 21

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Number 1



Preface   Open Access





Perspective   Open Access

Challenges of Gene Therapy for Neurodegenerative Disorders

, 21(1): 3 - 10

Md. Sahab Uddin*, Zeeshan Ahmad Khan, Dewan Md. Sumsuzzman, Asma Perveen and Ghulam Md. Ashraf*


DOI: 10.2174/1566523220999201105150442


Review Article

Exploring the Role of Gene Therapy for Neurological Disorders

, 21(1): 11 - 22

Nidhi Puranik, Dhananjay Yadav, Pallavi Singh Chauhan, Minseok Kwak* and Jun-O Jin*


DOI: 10.2174/1566523220999200917114101


Review Article

Targeted Delivery for Neurodegenerative Disorders Using Gene Therapy Vectors: Gene Next Therapeutic Goals

, 21(1): 23 - 42

Manisha Singh, Surinder P. Singh, Deepshikha Yadav, Mugdha Agarwal, Shriya Agarwal, Vinayak Agarwal, Geeta Swargiary, Sahil Srivastava, Sakshi Tyagi, Ramneek Kaur and Shalini Mani*


DOI: 10.2174/1566523220999200817164907


Review Article

Molecular Genetics of Early- and Late-Onset Alzheimer’s Disease

, 21(1): 43 - 52

Md. Sahab Uddin*, Sharifa Hasana, Md. Farhad Hossain, Md. Siddiqul Islam, Tapan Behl, Asma Perveen, Abdul Hafeez and Ghulam Md Ashraf*


DOI: 10.2174/1566523220666201123112822


Research Article

Standardizing the Effective Correlated Dosage of Olanzapine and Empagliflozin in Female Wistar Rats

, 21(1): 53 - 59

Ghulam Md. Ashraf*, Badrah S. Alghamdi, Fahad S. Alshehri, Mohammad Z. Alam, Haythum O. Tayeb and Frank I. Tarazi


DOI: 10.2174/1566523220999201111195047




Articles Ahead of Print

Gene Therapy Strategies for Glaucomatous Neurodegeneration


Rafael Lani-Louzada, Mariana Santana Dias, Rafael Linden, Vinicius de Toledo Ribas and Hilda Petrs-Silva*


DOI: 10.2174/1566523221666210126152000
View Abstract View on PubMed





Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment


Marcela Tavares Luiz, Larissa Bueno Tofani, Victor Hugo Sousa Araújo, Leonardo Delello Di Filippo, Jonatas Lobato Duarte, Juliana Maldonado Marchetti and Marlus Chorilli*


DOI: 10.2174/1566523220999201230205126
View Abstract View on PubMed



Gene Therapy of Mucopolysaccharidosis Type I Mice: Repeated Administrations and Safety Assessment of pIDUA/Nanoemulsion Complexes


Michelle Fraga, Roselena Silvestri Schuh*, Édina Poletto, Talita Giacomet de Carvalho, Raqueli Teresinha França, Camila Vieira Pinheiro, Gilherme Baldo, Roberto Giugliani, Helder Ferreira Teixeira and Ursula Matte


DOI: 10.2174/1566523221666210126151420
View Abstract



Teratogenic Toxicity Evaluation of Bladder Cancer-Specific Oncolytic Adenovirus on Mice


Keqing Lu, Fang Wang*, Baoliang Ma, Wenjuan Cao, Qi Guo, Hanzhang Wang, Ronald Rodriguez and Zhiping Wang*


DOI: 10.2174/1566523220999201217161258
View Abstract View on PubMed



Abstracts Ahead of Print

Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach


Md. Mominur Rahman, Kazi Sayma Ferdous, Muniruddin Ahmed, Mohammad Touhidul Islam, Md. Robin Khan, Asma Perveen, Ghulam Md Ashraf and Md. Sahab Uddin*


DOI: 10.2174/1566523221666210303100805
View Abstract





Cytoplasmic Trafficking of Nanoparticles Delivers Plasmid DNA for Macrophage Gene-Editing


So Yoon Lee, Jr Javier Fierro, An M. Tran , Daewoo Hong, Jamil Espinal and Huanyu Dou *


DOI: 10.2174/1566523221666210211101740
View Abstract




Published Contents

Editor's Choice

Challenges of Gene Therapy for Neurodegenerative Disorders

, 2021; 21(1): 3 - 10

Md. Sahab Uddin*, Zeeshan Ahmad Khan, Dewan Md. Sumsuzzman, Asma Perveen and Ghulam Md. Ashraf*


DOI: 10.2174/1566523220999201105150442






Gene Therapy for Hemophilia A: Where We Stand

, 2020; 20(2): 142 - 151

Miaojin Zhou, Zhiqing Hu, Chunhua Zhang, Lingqian Wu, Zhuo Li* and Desheng Liang*


DOI: 10.2174/1566523220666200806110849




Nano-enhanced Optical Gene Delivery to Retinal Degenerated Mice

, 2019; 19(5): 318 - 329

Subrata Batabyal, Sivakumar Gajjeraman, Sulagna Bhattacharya, Weldon Wright and Samarendra Mohanty*


DOI: 10.2174/1566523219666191017114044



Partial Reprogramming As An Emerging Strategy for Safe Induced Cell Generation and Rejuvenation

, 2019; 19(4): 248 - 254

Marianne Lehmann, Martina Canatelli-Mallat, Priscila Chiavellini, Gloria M. Cónsole, Maria D. Gallardo and Rodolfo G. Goya*


DOI: 10.2174/1566523219666190902154511



Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy

, 2019; 19(3): 197 - 207

Angela L. McCall*, Sylvia G. Stankov, Gabrielle Cowen, Denise Cloutier, Zizhao Zhang, Lin Yang, Nathalie Clement, Darin J. Falk and Barry J. Byrne*


DOI: 10.2174/1566523219666190621113807




Open Access Articles

Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review

, 2020; 20(4): 285 - 288

Jingwen Li, Xinyi Wang, Na Li , Ying Jiang, Heqing Huang*, Tao Wang, Zhicheng Lin and Nian Xiong*




Hemophilia Gene Therapy: New Development from Bench to Bed Side

, 2019; 19(4): 264 - 273

Xiao-Lu Guo, Tsai-Hua Chung, Yue Qin, Jie Zheng, Huyong Zheng, Liyuan Sheng, Tung Wynn and Lung-Ji Chang*




A Recurrent Rare SOX9 Variant (M469V) is Associated with Congenital Vertebral Malformations

, 2019; 19(4): 242 - 247

Nan Wu, Lianlei Wang, Jianhua Hu*, Sen Zhao, Bowen Liu, Yaqi Li, Huakang Du, Yuanqiang Zhang, Xiaoxin Li, Zihui Yan, Shengru Wang, Yipeng Wang, Jianguo Zhang, Zhihong Wu, DISCO (Deciphering Disorders Involving Scoliosis & Comorbidities) study group and Guixing Qiu




Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy

, 2019; 19(3): 197 - 207

Angela L. McCall*, Sylvia G. Stankov, Gabrielle Cowen, Denise Cloutier, Zizhao Zhang, Lin Yang, Nathalie Clement, Darin J. Falk and Barry J. Byrne*




Three Cases of Leber’s Hereditary Optic Neuropathy with Rapid Increase in Visual Acuity After Gene Therapy

, 2019; 19(2): 134 - 138

Yong Zhang, Jia-jia Yuan, Hong-li Liu, Zhen Tian, Si-wei Liu and Bin Li*





Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Rα Signaling

, 2019; 19(1): 40 - 53

Sushmita Nair, Jing-Bo Wang, Shih-Ting Tsao, Yuchen Liu, Wei Zhu, William B. Slayton, Jan S. Moreb, Lujia Dong and Lung-Ji Chang*





Clinical Observation of Patients with Leber’s Hereditary Optic Neuropathy Before Gene Therapy

, 2018; 18(6): 386 - 392

Jiajia Yuan, Yong Zhang, Hongli Liu, Zhen Tian, Xin Li, Yichen Zheng, Qin Gao, Lin Song, Xiao Xiao, Jian Sun, Zhitao Wang and Bin Li*




Clinical-Grade Oncolytic Adenovirus Purification Using Polysorbate 20 as an Alternative for Cell Lysis

, 2018; 18(6): 366 - 374

Mafalda G. Moleirinho, Sara Rosa, Manuel J.T. Carrondo*, Ricardo J.S. Silva, Åsa Hagner-McWhirter, Gustaf Ahlén, Mats Lundgren, Paula M. Alves and Cristina Peixoto




Emerging Therapeutic Approaches for Diamond Blackfan Anemia

, 2018; 18(6): 327 - 335

Anna Aspesi*, Chiara Borsotti and Antonia Follenzi*




EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs

, 2018; 18(5): 275 - 285

Yan Wang, Yinping Xie, Lili Li, Yuan He, Di Zheng, Pengcheng Yu, Ling Yu, Lixu Tang, Yibin Wang* and Zhihua Wang*




Oncolytic Virotherapy for Breast Cancer Treatment

, 2018; 18(4): 192 - 205

Samia M. O`Bryan and J. Michael Mathis*




Genetics and Therapies for GM2 Gangliosidosis

, 2018; 18(2): 68 - 89

Maria Begona Cachon-Gonzalez*, Eva Zaccariotto and Timothy Martin Cox






Most Cited Articles

Review Article

The emerging role of stem cells in regenerative dentistry

, 2020; 20(4): 259-268.

Paolo Capparè*, Giulia Tetè, Maria Teresa Sberna and Paola Panina-Bordignon*


DOI: 10.2174/1566523220999200818115803


Review Article

Gene therapy, a novel therapeutic tool for neurological disorders: Current progress, challenges and future prospective

, 2020; 20(3): 184-194.

Ashif Iqubal, Mohammad Kashif Iqubal, Aamir Khan, Javed Ali, Sanjula Baboota and Syed Ehtaishamul Haque*


DOI: 10.2174/1566523220999200716111502


Research Article

Combined analysis of clinical data on HGF gene therapy to treat critical limb ischemia in Japan

, 2020; 20(1): 25-35.

Ryuichi Morishita*, Munehisa Shimamura, Yasushi Takeya, Hironori Nakagami, Mitsuaki Chujo, Tetsuya Ishihama, Ei Yamada and Hiromi Rakugi


DOI: 10.2174/1566523220666200516171447



Review Article

Dissecting the therapeutic relevance of gene therapy in neuroaids: An evolving epidemic

, 2020; 20(3): 174-183.

Bushra Nabi, Saleha Rehman, Faheem Hyder Pottoo, Sanjula Baboota and Javed Ali*


DOI: 10.2174/1566523220666200615151805


Review Article

Exosomes: Structure, biogenesis, types and application in diagnosis and gene and drug delivery

, 2020; 20(3): 195-206.

Shriya Agarwal, Vinayak Agarwal, Mugdha Agarwal and Manisha Singh*


DOI: 10.2174/1566523220999200731011702



Research Article

Mirna-146a improves immunomodulatory effects of msc-derived exosomes in rheumatoid arthritis

, 2020; 20(4): 297-312.

Fataneh Tavasolian, Ahmad Zavaran Hosseini*, Sara Soudi and Mahmood Naderi


DOI: 10.2174/1566523220666200916120708



Research Article

γ-Aminobutyric Acid Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Inducing TNFAIP3

, 2020; 20(2): 152-161.

Hanwen Li, Yongyao Wu, Ning Huang, Qi Zhao, Quan Yuan* and Bin Shao*


DOI: 10.2174/1566523220999200727122502


Review Article

NF1, neurofibromin and gene therapy: Prospects of next-generation therapy

, 2020; 20(2): 100-108.

Xi-Wei Cui, Jie-Yi Ren, Yi-Hui Gu, Qing-Feng Li* and Zhi-Chao Wang*


DOI: 10.2174/1566523220666200806111451


Review Article

Systemic therapy for hepatocellular carcinoma: Advances and hopes

, 2020; 20(2): 84-99.

Chen-Hao Zhang, Ming Li, You-Pei Lin and Qiang Gao*


DOI: 10.2174/1566523220666200628014530


Review Article

Nanoparticle based gene therapy approach: A pioneering rebellion in the management of psychiatric disorders

, 2020; 20(3): 164-173.

Saleha Rehman, Bushra Nabi, Faheem Hyder Pottoo, Sanjula Baboota and Javed Ali*


DOI: 10.2174/1566523220666200607185903


Review Article

Gene therapy in the management of parkinson’s disease: Potential of gdnf as a promising therapeutic strategy

, 2020; 20(3): 207-222.

Tapan Behl*, Ishnoor Kaur, Arun Kumar, Vineet Mehta, Gokhan Zengin and Sandeep Arora


DOI: 10.2174/1566523220999200817164051




Most Accessed Articles


NF1, Neurofibromin and Gene Therapy: Prospects of Next-Generation Therapy

, 2020; 20(2): 100-108.

Xi-Wei Cui, Jie-Yi Ren, Yi-Hui Gu, Qing-Feng Li* and Zhi-Chao Wang*


DOI: 10.2174/1566523220666200806111451


Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review

, 2020; 20(4): 285-288.

Jingwen Li, Xinyi Wang, Na Li , Ying Jiang, Heqing Huang*, Tao Wang, Zhicheng Lin and Nian Xiong*


DOI: 10.2174/1566523220999200820172829


Gene Therapy for Hemophilia A: Where We Stand

, 2020; 20(2): 142-151.

Miaojin Zhou, Zhiqing Hu, Chunhua Zhang, Lingqian Wu, Zhuo Li* and Desheng Liang*


DOI: 10.2174/1566523220666200806110849


Gene Therapy, A Novel Therapeutic Tool for Neurological Disorders: Current Progress, Challenges and Future Prospective

, 2020; 20(3): 184-194.

Ashif Iqubal, Mohammad Kashif Iqubal, Aamir Khan, Javed Ali, Sanjula Baboota and Syed Ehtaishamul Haque*


DOI: 10.2174/1566523220999200716111502








Exploring the Role of Gene Therapy for Neurological Disorders

, 2021; 21(1): 11-22.

Nidhi Puranik, Dhananjay Yadav, Pallavi Singh Chauhan, Minseok Kwak* and Jun-O Jin*


DOI: 10.2174/1566523220999200917114101







Editor-in-Chief

graphic
Liang Cheng
College of Bioinformatics Science and Technology
Harbin Medical University
Harbin, Heilongjiang
(China)
Biography
View Full Editorial Board

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Journal History

Current Gene Therapy Journal was launched in 2001. Dr. Ignacio Anegon was the founding editor of the journal.
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