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Current Drug Metabolism

Volume 21, 14 Issues, 2020
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access
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In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 21

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Number 5



Biography   Open Access



Editorial   Open Access



Review Article (Mini-Review)



Review Article (Mini-Review)

Exosome-based Tumor Therapy: Opportunities and Challenges

, 21(5): 339 - 351

Chunmei Li, Xiaoming Hou, Peng Zhang, Juan Li, Xiaoguang Liu, Yuping Wang, Quanlin Guan and Yongning Zhou*


DOI: 10.2174/1389200221666200515103354


Review Article (Mini-Review)

The Potential Role of Serum Exosomes in Preeclampsia

, 21(5): 352 - 356

Xuelin Gao, Lulu Shao, Xinying Ge, Long Zhang , Dexin Chen and Rongxia He*


DOI: 10.2174/1389200221666200525152441


General Research Article

Absorption, Metabolism and Excretion of Surufatinib in Rats and Humans

, 21(5): 357 - 367

Ke Li, Sheng Ma, Liyan Miao*, Songhua Fan, Bin Pan, Weihan Zhang, Weiguo Su, Yating Xiong, Zheming Gu, Lian Guo and Yang Sai*


DOI: 10.2174/1389200221666200514131721


General Research Article

Changes of Transporters and Drug-metabolizing Enzymes in Nephrotic Syndrome

, 21(5): 368 - 378

Yaqian Dong, Linna Gong, Xianyuan Lu, Mingguang Ye, Yu Lin, Shuting Xie, Jiaxing Zhang, Fenghua Zhou, Lan Tang, Wei Zou* and Menghua Liu*


DOI: 10.2174/1389200221666200512113731


General Research Article



Articles Ahead of Print



Role of Glucose Transporters in Drug Membrane Transport


Xin Wang, Kunkun Guo, Baolin Huang, Zimin Lin and Zheng Cai*


DOI: 10.2174/1389200221666200810125924
View Abstract




The Metabolism and Pharmacokinetics of Rhein and Aurantio-Obtusin


Shun-Li Xiao*, Liang-Jun Guan, Ren-Feng Jiang, Xiang-Gen Wang, Xing Li and Wei Cai


DOI: 10.2174/1389200221666200719002128
View Abstract View on PubMed


Application of Advanced Technologies in Natural Product Research: A Review with Special Emphasis on ADMET Profiling


Pobitra Borah, Sangeeta Hazarika, Satyendra Deka*, Katharigatta N. Venugopala, Anroop B. Nair, Mahesh Attimarad, Nagaraja Sreeharsha and Raghu Prasad Mailavaram


DOI: 10.2174/1389200221666200714144911
View Abstract View on PubMed


Applications of Machine Learning in Drug Target Discovery


Dongrui Gao, Qingyuan Chen, Yuanqi Zeng, Meng Jiang and Yongqing Zhang*


DOI: 10.2174/1567201817999200728142023
View Abstract


Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections


Ammara Riaz, Azhar Rasul, Nazia Kanwal, Ghulam Hussain, Muhammad Ajmal Shah*, Iqra Sarfraz, Rubab Ishfaq, Rabia Batool, Fariha Rukhsar and Şevki Adem


DOI: 10.2174/1389200221999200728144801
View Abstract View on PubMed



Abstracts Ahead of Print

Inhibition of Efflux Pumps by Monoterpene (α-Pinene) and impact on Staphylococcus aureusResistance to Tetracycline and Erythromycin


Priscilla Freitas, Ana Carolina Araújo, Cristina Barbosa, Débora Muniz, Saulo Tintino, Jaime Ribeiro-Filho, José Siqueira Júnior, José Maria Barbosa, Gabriela Sousa and Henrique Coutinho*


DOI: 10.2174/1389200221999200730212721
View Abstract


Published Contents

Editor's Choice

Exosome-based Tumor Therapy: Opportunities and Challenges

, 2020; 21(5): 339 - 351

Chunmei Li, Xiaoming Hou, Peng Zhang, Juan Li, Xiaoguang Liu, Yuping Wang, Quanlin Guan and Yongning Zhou*


DOI: 10.2174/1389200221666200515103354




Human Papillomavirus Induced Cervical and Oropharyngeal Cancers: From Mechanisms to Potential Immuno-therapeutic Strategies

, 2020; 21(3): 167 - 177

Mohd. Saeed*, Syed Mohd Faisal, Firoz Akhtar, Saheem Ahmad, Mousa M. Alreshidi, Mohd. Adnan Kausar, Shadab Kazmi, Amir Saeed, Mohd. Adnan and Ghulam Md Ashraf*


DOI: 10.2174/1389200221666200421121228



Has the Time Come to Employ Population and Individual Bioequivalence for the Evaluation of Generics?

, 2020; 21(2): 112 - 125

Francis Micheal*, Mohanlal Sayana, Rajendra Prasad and Balamurali Musuvathi Motilal


DOI: 10.2174/1389200221666200401105119




Effect of Environmental Exposure and Pharmacogenomics on Drug Metabolism

, 2019; 20(14): 1103 - 1113

Basu Dev Banerjee*, Ranjeet Kumar, Krishna Latha Thamineni, Harendra Shah, Gaurav Kumar Thakur and Tusha Sharma


DOI: 10.2174/1389200221666200110153304



Therapeutic Study of Phytochemicals Against Cancer and Alzheimer’s Disease Management

, 2019; 20(13): 1006 - 1013

Syed Sayeed Ahmad, Tayyaba Waheed, Sayed Rozeen, Sufia Mahmood and Mohammad Amjad Kamal*


DOI: 10.2174/1389200221666200103092719



A Retrospective Look at Anti-EGFR Agents in Pancreatic Cancer Therapy

, 2019; 20(12): 958 - 966

Henu K. Verma, Praveen K. Kampalli, Saikrishna Lakkakula, Gayathri Chalikonda, Lakkakula V.K.S. Bhaskar* and Smaranika Pattnaik*


DOI: 10.2174/1389200220666191122104955




Assessment of miR-212 and Other Biomarkers in the Diagnosis and Treatment of HBV-infection-related Liver Diseases

, 2019; 20(10): 785 - 798

Yigan Zhang, Huaze Xi, Xin Nie, Peng Zhang, Ning Lan, Ying Lu, Jinrong Liu and Wenzhen Yuan*


DOI: 10.2174/1389200220666191011120434



Open Access Articles

Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum





Most Cited Articles

Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916


Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457



Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*


DOI: 10.2174/1389200220666181122124458




Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*


DOI: 10.2174/1389200219666181019094526


Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi


DOI: 10.2174/1389200220666190325141422


Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu


DOI: 10.2174/1389200219666180821094047


Review Article

Drug-drug interactions of P-gp substrates unrelated to CYP metabolism

, 2019; 20(2): 124-129.

Yumiko Akamine, Norio Yasui-Furukori and Tsukasa Uno*


DOI: 10.2174/1389200219666181003142036


Review Article

Iron oxide nanoparticles for breast cancer theranostics

, 2019; 20(6): 446-456.

Md. Salman Shakil, Md. Ashraful Hasan* and Satya Ranjan Sarker*


DOI: 10.2174/1389200220666181122105043


General Review Article

Advanced glycation end products (AGEs), glutathione and breast cancer: Factors, mechanism and therapeutic interventions

, 2019; 20(1): 65-71.

Anil K. Sharma, Var R. Sharma, Girish K. Gupta, Ghulam Md. Ashraf and Mohammad A. Kamal*


DOI: 10.2174/1389200219666180912104342




Review Article

Curcumin-a novel therapeutic agent in the prevention of colorectal cancer

, 2019; 20(12): 977-987.

Manoj K. Gupta, Ramakrishna Vadde and Vemula Sarojamma*


DOI: 10.2174/1389200220666191007153238



Most Accessed Articles

Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy

, 2020; 21(2): 145-162.

Beth Williamson , Nicola Colclough, Adrian John Fretland, Barry Christopher Jones, Rhys Dafydd Owen Jones and Dermot Francis McGinnity *


DOI: 10.2174/1389200221666200312104837


Pharmacokinetic and Pharmacodynamic Properties of Anti-VEGF Drugs After Intravitreal Injection

, 2015; 16(7): 572-584.

Francesco Semeraro, Francesco Morescalchi, Sarah Duse, Elena Gambicorti, Anna Cancarini and Ciro Costagliola


DOI: 10.2174/1389200216666151001120831


Essential Oils: Extraction Techniques, Pharmaceutical And Therapeutic Potential - A Review

, 2018; 19(13): 1100-1110.

Zarith Asyikin Abdul Aziz, Akil Ahmad, Siti Hamidah Mohd Setapar*, Alptug Karakucuk, Muhammad Mohsin Azim, David Lokhat, Mohd. Rafatullah, Magdah Ganash, Mohammad A. Kamal and Ghulam Md Ashraf*


DOI: 10.2174/1389200219666180723144850


Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens - Current Knowledge and Future Prospects

, 2018; 19(3): 236-263.

Kuldeep Dhama*, Kumaragurubaran Karthik, Rekha Khandia, Ashok Munjal, Ruchi Tiwari, Rajneesh Rana, Sandip Kumar Khurana, Sana Ullah, Rifat Ullah Khan, Mahmoud Alagawany, Mayada Ragab Farag, Maryam Dadar and Sunil Kumar Joshi


DOI: 10.2174/1389200219666180129145252



Use of Non-steroidal Anti-inflammatory Drugs in Pregnancy: Impact on the Fetus and Newborn

, 2012; 13(4): 474-490.

Roberto Antonucci, Marco Zaffanello, Elisabetta Puxeddu, Annalisa Porcella, Laura Cuzzolin, Maria Dolores Pilloni and Vassilios Fanos


DOI: 10.2174/138920012800166607


Stem Cells in Tumour Microenvironment Aid in Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment

, 2020; 21(1): 44-52.

Bhaskar Birru, ChandraSai Potla Durthi*, Santhosh Kacham, Madhuri Pola, Satish Babu Rajulapati, Sreenivasa Rao Parcha and Mohammad Amjad Kamal


DOI: 10.2174/1389200221666200214120226


Clinical Pharmacokinetics of Propranolol Hydrochloride: A Review

, 2020; 21(2): 89-105.

Muhammad Nasir Kalam , Muhammad Fawad Rasool , Asim Ur Rehman and Naveed Ahmed *


DOI: 10.2174/1389200221666200414094644




Editor-in-Chief

Ming Hu
University of Houston College of Pharmacy
Houston, TX
(USA)
Biography
View Full Editorial Board

Journal History

Current Drug Metabolism was launched in 2000. Dr. Michael Sinz serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 2.75

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