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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 23, 10 Issues, 2020
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

Ranking and Category

  • 67th of 79 in

    Biochemical Research Methods

  • 39th of 71 in

    Chemistry, Applied

  • 220th of 267 in

    Pharmacology & Pharmacy

Order Your Article Before Print

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 23

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Number 1



Biography   Open Access



Preface   Open Access

Preface

, 23(1): 2 - 3

Gerald H. Lushington H. Lushington


DOI: 10.2174/138620732301200316111656


Editorial   Open Access



Systematic Review Article

Effectiveness of Tolvaptan in the Treatment for Patients with Autosomal Dominant Polycystic Kidney Disease: A Meta-analysis

, 23(1): 6 - 16

Xuan Xie, Qian Cai, Xiao-Yuan Guo, Dong-Hai Bai, Hai-Zhong Sheng, Bao-Kui Wang*, Kai Yan, An-Ming Lu and Xin-Ran Wang


DOI: 10.2174/1386207322666191203092715


Research Article

Evaluation of Micro-RNA Levels, Apoptosis and Oxidative Stress Markers in Patients Recieving Chemotherapy

, 23(1): 17 - 27

Idris Kirhan*, Fehmi Kas, Hüseyin Taskiran, Hakan Buyukhatipoglu, Ataman Gönel and Ismail Koyuncu


DOI: 10.2174/1386207323666191224111348


Research Article



Research Article



Research Article



Articles Ahead of Print


Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives


Marcel Lucas de Almeida, Douglas Viana , Valécia Costa , Flaviana Santos , Michelly Pereira, Maira Pitta , Moacyr Rêgo , Ivan Pitta and Marina Galdino-Pitta *


DOI: 10.2174/1386207323666200319105239
View Abstract View on PubMed




Association of Virulence Genes with Antibiotic Resistance in Pakistani Uropathogenic E. coli Isolates


Khayam Ul Haq, Shazia Noreen, Sheikh Arslan Sehgal, Rana Adnan Tahir, Amjad Essa, Awais Ihsan, Mahreen ul Hassan, Waheed Iqbal, Masroor Hussain, Hamid Hussain and Sami Siraj*


DOI: 10.2174/1386207323666200402083234
View Abstract






A Study on the Mechanism of Lavender in the treatment of Insomnia based on Network Pharmacology


Yao Wang, Junbo Zou, Yanzhuo Jia, Yulin Liang, Xiaofei Zhang*, ChangLi Wang, Xiao Wang, Dongyan Guo, Yajun Shi and Ming Yang


DOI: 10.2174/1386207323666200401095008
View Abstract


Published Contents

Editor's Choice


Synthesis of 2-Substituted 4-Arylidene-5(4H)-oxazolones as Potential Cytotoxic Agents in the Presence of Lemon Juice as a Biocatalyst

, 2019; 22(9): 625 - 634

Malavattu G. Prasad, Chapala V. Lakshmi, Naresh K. Katari*, Krishnan Anand, Manojit Pal* and Sreekantha B. Jonnalagadda


DOI: 10.2174/1386207322666191024105150




Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique

, 2019; 22(7): 445 - 454

Kunhao Qin, Shengting Zhang, Jie Wang, Dongbo Liu, Yingying Xiang, Xiuling Ji and Yunlin Wei*


DOI: 10.2174/1386207322666190919143735





Recognition of Lung Adenocarcinoma-specific Gene Pairs Based on Genetic Algorithm and Establishment of a Deep Learning Prediction Model

, 2019; 22(4): 256 - 265

Zhongwei Zhao, Xiaoxi Fan, Lili Yang, Jingjing Song, Shiji Fang, Jianfei Tu, Minjiang Chen, Jie Li, Liyun Zheng, Fazong Wu, Dengke Zhang, Xihui Ying and Jiansong Ji*


DOI: 10.2174/1386207322666190530102245



Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma

, 2019; 22(3): 201 - 206

Jiangshan Lian, Xiaolin Zhang, Yingfeng Lu, Shaorui Hao, Zhe Zhang and Yida Yang*


DOI: 10.2174/1386207322666190404151020



Progress in Molecularly Imprinted Polymers for Biomedical Applications

, 2019; 22(2): 78 - 88

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526




Open Access Articles

Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*




Chemical Informatics and the Drug Discovery Knowledge Pyramid

, 2013; 16(10): 764 - 776

Gerald H. Lushington*, Yinghua Dong and Bhargav Theertham







Alternative Medicine Safety: Agaricus blazei and Propolis

, 2011; 14(7): 616 - 621

Kenji Sorimachi* and Takaaki Nakamoto





Most Cited Articles



Review Article

Progress in molecularly imprinted polymers for biomedical applications

, 2019; 22(2): 78-88.

Jane Ru Choi*, Kar Wey Yong*, Jean Yu Choi and Alistair C. Cowie


DOI: 10.2174/1386207322666190325115526


Research Article

New computational tool based on machine-learning algorithms for the identification of rhinovirus infection-related genes

, 2019; 22(10): 665-674.

Yan Xu, Yu-Hang Zhang, JiaRui Li, Xiao Y. Pan, Tao Huang* and Yu-Dong Cai*


DOI: 10.2174/1386207322666191129114741








Research Article

Identification of anti-cancer peptides based on multi-classifier system

, 2019; 22(10): 694-704.

Wanben Zhong, Bineng Zhong*, Hongbo Zhang, Ziyi Chen and Yan Chen


DOI: 10.2174/1386207322666191203141102


Research Article

Rare germline GLMN variants identified from blue rubber bleb nevus syndrome might impact mTOR signaling

, 2019; 22(10): 694-704.

Wanben Zhong, Bineng Zhong*, Hongbo Zhang, Ziyi Chen and Yan Chen


DOI: 10.2174/1386207322666191203110042



Research Article

Clustering and sampling of the c-met conformational space: a computational drug discovery study

, 2019; 22(9): 635-648.

Korosh Mashayekh, Shahrzad Sharifi, Tahereh Damghani, Maryam Elyasi, Mohammad S. Avestan and Somayeh Pirhadi*


DOI: 10.2174/1386207322666191024103902


Research Article

Same target, different therapeutic outcomes: The case of CAY10471 and fevipiprant on CRTh2 receptor in treatment of allergic rhinitis and asthma

, 2019; 22(8): 521-533.

Abdul R. Issahaku, Clement Agoni, Opeyemi S. Soremekun, Patrick A. Kubi, Ransford O. Kumi, Fisayo A. Olotu and Mahmoud E.S. Soliman*


DOI: 10.2174/1386207322666190919113006



Most Accessed Articles





Same Target, Different Therapeutic Outcomes: The Case of CAY10471 and Fevipiprant on CRTh2 Receptor in Treatment of Allergic Rhinitis and Asthma

, 2019; 22(8): 521-533.

Abdul R. Issahaku, Clement Agoni, Opeyemi S. Soremekun, Patrick A. Kubi, Ransford O. Kumi, Fisayo A. Olotu and Mahmoud E.S. Soliman*


DOI: 10.2174/1386207322666190919113006




Plasma Protein Binding in Drug Discovery and Development

, 2010; 13(2): 170-187.

Monique L. Howard, John J. Hill, Gerald R. Galluppi and Matthew A. McLean


DOI: 10.2174/138620710790596745


Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379-386.

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*


DOI: 10.2174/1386207322666190704095602





Editor-in-Chief

Gerald H. Lushington
LiS Consulting, Lawrence
KS
USA

Biography View Full Editorial Board

Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.33

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