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Combinatorial Chemistry & High Throughput Screening

Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24, 10 Issues, 2021
ISSN: 1875-5402 (Online)
ISSN: 1386-2073 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:

  • Target identification and validation
  • Assay design, development, miniaturization and comparison
  • High throughput/high content/in silico screening and associated technologies
  • Label-free detection technologies and applications
  • Stem cell technologies
  • Biomarkers
  • ADMET/PK/PD methodologies and screening
  • Probe discovery and development, hit to lead optimization
  • Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
  • Chemical library design and chemical diversity
  • Chemo/bio-informatics, data mining
  • Compound management
  • Pharmacognosy
  • Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
  • Natural Product Analytical Studies
  • Bipharmaceutical studies of Natural products
  • Drug repurposing
  • Data management and statistical analysis
  • Laboratory automation, robotics, microfluidics, signal detection technologies
  • Current & Future Institutional Research Profile
  • Technology transfer, legal and licensing issues
  • Patents

In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discovery and development, in the settings of industry, academia or government.

Combinatorial Chemistry & High Throughput Screening

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Volume 24

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Number 1



Preface   Open Access



Review Article

Pathophysiological Effects of Sulfur Mustard on Skin and its Current Treatments: Possible Application of Phytochemicals

, 24(1): 3 - 19

Mehdi Hassanpour, Fateme Hajihassani, Mina Abdollahpourasl, Omid Cheraghi, Nasser Aghamohamadzade, Reza Rahbargazi, Mohammad Nouri, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami, Abolfazl Akbarzadeh, Yunes Panahi* and Amirhossein Sahebkar*


DOI: 10.2174/1386207323666200717150414


Review Article



Review Article



Research Article



Research Article



Research Article



Research Article



Articles Ahead of Print

Phyto-chlorophyllin prevents food additive induced genotoxicity and mitochondrial dysfunction via cytochrome c mediated pathway in mice model


Asmita Samadder*, Sudatta Dey, Priyanka Sow, Ruchira Das, Sisir Nandi, Jayeeta Das*, Banani Bhattacharjee, Arnob Chakrovorty, Maharaj Biswas and Pradeepta Guptaroy


DOI: 10.2174/1386207323666201230093510
View Abstract










Anti-Cancer and Antibacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles


Hashem Yaghoubi*, Amin Izadpanah*, Shahla Nedaei, Hossein Akbari, Elmira Mikaeili Agah, Ricardo Mostany, Bysani Chandrasekar, Eckhard Alt and Reza Izadpanah


DOI: 10.2174/1386207323999201117113401
View Abstract View on PubMed


Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice



Rhodamine B - as New Chromophore for the Determination of Melatonin in Biological, Food, and Pharmaceutical Samples

, 2020; 23(10): 1080 - 1089

Alexandrina Lungu-Moscalu, Catalina C. Negut, Cristina Stefanov, Raluca-Ioana S. van Staden*, Andrei A. Bunaciu and Jacobus F. van Staden


DOI: 10.2174/1386207323666200628111958



Inhibition of Cyclooxygenase Enzyme by Bioflavonoids in Horsegram Seeds Alleviates Pain and Inflammation

, 2020; 23(9): 931 - 938

Malarvizhi Ramalingam, Veeresh K. Sali, Meenakshi Bhardwaj, Sugumar Mani and Hannah R. Vasanthi*


DOI: 10.2174/1386207323666200127114551





iSP-RAAC: Identify Secretory Proteins of Malaria Parasite Using Reduced Amino Acid Composition

, 2020; 23(6): 536 - 545

Haoyue Zhang, Qilemuge Xi, Shenghui Huang, Lei Zheng, Wuritu Yang* and Yongchun Zuo*


DOI: 10.2174/1386207323666200402084518



Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives

, 2020; 23(5): 359 - 368

Marcel L. Almeida, Douglas C.F. Viana , Valécia C.M. da Costa, Flaviana A. dos Santos, Michelly C. Pereira, Maira G.R. Pitta , Moacyr J.B. de Melo Rêgo, Ivan R. Pitta and Marina G.R. Pitta*


DOI: 10.2174/1386207323666200319105239



Drug Target Group Prediction with Multiple Drug Networks

, 2020; 23(4): 274 - 284

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927




Open Access Articles


Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy

, 2020; 23(4): 334 - 344

Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*





Analysis of Chinese Herbal Formulae Recommended for COVID-19 in Dif- ferent Schemes in China: A Data Mining Approach

, 2020; 23: 1 - 11 (E-Pub Ahead of Print)

LiWei Yin, YaCen Gao, ZiPing Li*, MengYu Wang and KaiXin Chen




Elucidation of the Mechanisms and Molecular Targets of Qishen Yiqi Formula for the Treatment of Pulmonary Arterial Hypertension using a Bioinformatics/Network Topology-based Strategy

, 2020; 23: 1 - 15 (E-Pub Ahead of Print)

Peiliang Wu, Xiaona Xie, Mayun Chen, Junwei Sun, Luqiong Cai, Jinqiu Wei, Lin Yang, Xiaoying Huang and Liangxing Wang*




Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development

, 2019; 22(6): 379 - 386

Song-Bai Liu*, Xiu-Qin Qiu, Wei-Qiang Guo, Jin-Li Li, Qian Su, Jia-Hui Du, He-Juan Hu, Xiao-Xiao Wang, Yao-Hua Song, Xiao Lou* and Xiang-Bin Xu*




Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats

, 2019; 22(5): 326 - 332

Sarah Shin, No Soo Kim, Young Ah Kim, Hea Ry Oh and Ok-Sun Bang*







High Throughput Screening of Esterases, Lipases and Phospholipases in Mutant and Metagenomic Libraries: A Review

, 2016; 19(8): 605 - 615

Carlina Peña-García, Mónica Martínez-Martínez, Dolores Reyes-Duarte* and Manuel Ferrer*





Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

, 2016; 19(4): 262 - 274

Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh G. Santos, Marc A. Giulianotti and Robert J. Deschenes*




Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

, 2015; 18(1): 3 - 17

Arjan J. van Adrichem, Annika Fagerholm, Laura Turunen, Anna Lehto, Jani Saarela, Ari Koskinen, Gretchen A. Repasky and Krister Wennerberg*




Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

, 2014; 17(1): 80 - 88

Benjamin Rappaz, Billy Breton, Etienne Shaffer and Gerardo Turcatti*





Most Cited Articles


Research Article

Drug target group prediction with multiple drug networks

, 2020; 23(4): 274-284.

Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang and Aorigele


DOI: 10.2174/1386207322666190702103927



Research Article

Green route for the removal of pb from aquatic environment

, 2020; 23(7): 587-598.

Ahmed Refaat*, Hanan Elhaes, Nabila S. Ammar, Hanan S. Ibrahim and Medhat Ibrahim


DOI: 10.2174/1386207323666200127123349



Research Article

Lignans and neolignans anti-tuberculosis identified by qsar and molecular modeling

, 2020; 23(6): 504-516.

Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*


DOI: 10.2174/1386207323666200226094940



Research Article

Inhibition of cyclooxygenase enzyme by bioflavonoids in horsegram seeds alleviates pain and inflammation

, 2020; 23(9): 931-938.

Malarvizhi Ramalingam, Veeresh K. Sali, Meenakshi Bhardwaj, Sugumar Mani and Hannah R. Vasanthi*


DOI: 10.2174/1386207323666200127114551




Research Article

In vitro and in silico xanthine oxidase inhibitory activity of selected phytochemicals widely present in various edible plants

, 2020; 23(9): 917-930.

Arshad Mehmood, Ashfaq Ur Rehman, Muhammad Ishaq, Liang Zhao, Jiayi Li, Muhammad Usman, Lei Zhao*, Abdur Rehman, Oumeddour D. Zad and Chengtao Wang*


DOI: 10.2174/1386207323666200428075224


General Research Article

Mechanism of shuang-huang-lian oral liquid for treatment of mycoplasmal pneumonia in children on network pharmacology

, 2020; 23(9): 955-971.

Ling Shi, Qi-Guo Wu, Ju-Cheng Zhang, Guang-Ming Yang, Wei Liu and Ze-Feng Wang*


DOI: 10.2174/1386207323666200514073428


Review Article

Integrating bioinformatics strategies in cancer immunotherapy: Current and future perspectives

, 2020; 23(8): 687-698.

Houda N. Washah, Elliasu Y. Salifu, Opeyemi Soremekun, Ahmed A. Elrashedy, Geraldene Munsamy, Fisayo A. Olotu and Mahmoud E.S. Soliman*


DOI: 10.2174/1386207323666200427113734


General Research Article

Oxidative stress-induced toxicity and DNA stability in some agri-field based livestock/insect by widely used pesticides

, 2020; 23(9): 972-980.

Balaram Manna, Sangita M. Dutta, Subrata Dalapati and Smarajit Maiti*


DOI: 10.2174/1386207323666200415110745




Most Accessed Articles

Computational Method for Identifying Malonylation Sites by Using Random Forest Algorithm

, 2020; 23(4): 304-312.

ShaoPeng Wang, JiaRui Li, Xijun Sun, Yu-Hang Zhang, Tao Huang* and Yudong Cai*


DOI: 10.2174/1386207322666181227144318


A Study on the Mechanism of Lavender in the Treatment of Insomnia Based on Network Pharmacology

, 2020; 23(5): 419-432.

Yao Wang, Junbo Zou, Yanzhuo Jia, Yulin Liang, Xiaofei Zhang*, Chang-Li Wang, Xiao Wang*, Dongyan Guo, Yajun Shi and Ming Yang


DOI: 10.2174/1386207323666200401095008



Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy

, 2020; 23(4): 334-344.

Chunli Piao*, Zheyu Sun, De Jin, Han Wang, Xuemin Wu, Naiwen Zhang, Fengmei Lian* and Xiaolin Tong*


DOI: 10.2174/1386207323666200305093709



In vitro and in silico Xanthine Oxidase Inhibitory Activity of Selected Phytochemicals Widely Present in Various Edible Plants

, 2020; 23(9): 917-930.

Arshad Mehmood, Ashfaq Ur Rehman, Muhammad Ishaq, Liang Zhao, Jiayi Li, Muhammad Usman, Lei Zhao*, Abdur Rehman, Oumeddour D. Zad and Chengtao Wang*


DOI: 10.2174/1386207323666200428075224



Relating Substructures and Side Effects of Drugs with Chemical-chemical Interactions

, 2020; 23(4): 285-294.

Bo Zhou*, Xian Zhao, Jing Lu, Zuntao Sun, Min Liu, Yilu Zhou, Rongzhi Liu and Yihua Wang


DOI: 10.2174/1386207322666190702102752





Lignans and Neolignans Anti-tuberculosis Identified by QSAR and Molecular Modeling

, 2020; 23(6): 504-516.

Mayara S. Maia, Natália F. de Sousa, Gabriela C.S. Rodrigues, Alex F.M. Monteiro, Marcus T. Scotti and Luciana Scotti*


DOI: 10.2174/1386207323666200226094940






Editor-in-Chief

Gerald H. Lushington
LiS Consulting, Lawrence
KS
(USA)
Biography
View Full Editorial Board

COPE Compliant

Journal History

Combinatorial Chemistry & High Throughput Screening Journal was launched in 1998. Dr. Gerald H. Lushington serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.33

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