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Current Cancer Drug Targets

Volume 21, 11 Issues, 2021
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access

Aims & Scope

Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.

Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.

As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Cancer Drug Targets

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Volume 21

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Number 2



Review Article (Mini-Review)



Review Article

Management of Prostate Cancer with Systemic Therapy: A Prostate Cancer Unit Perspective

, 21(2): 107 - 116

Fabio Campodonico*, Marco Ennas, Silvia Zanardi , Ekaterini Zigoura, Arnoldo Piccardo, Luca Foppiani, Concetta Schiavone, Lino Squillace, Andrea Benelli, Andrea De Censi , Filippo Grillo-Ruggieri and Carlo Introini


DOI: 10.2174/1568009620666201021163919










Articles Ahead of Print





Paclitaxel Priming of TRAIL Expressing Mesenchymal Stromal Cells (MSCs- TRAIL) Increases Antitumor Efficacy of Their Secretome


Valentina Coccè, Arianna Bonomi, Loredana Cavicchini, Francesca Sisto, Aldo Giannì, Giampietro Farronato, Giulio Alessandri, Francesco Petrella, Valeria Sordi, Eugenio Parati, Gianpietro Bondiolotti, Francesca Paino and Augusto Pessina*


DOI: 10.2174/1568009620666201116112153
View Abstract View on PubMed







Abstracts Ahead of Print




The Clinical Application of Circulating Tumor Cells and DNAs as Prognostic and Predictive Biomarkers in Gastrointestinal Cancer


Sara Memarpour*, Ghazaleh Khalili-Tanha*, Awa Alizadeh Ghannad, Masoud Sharifian Razavi, Mona Joudi, Marjan Joodi, Gordon A. Ferns, Seyed Mahdi Hassanian, Majid Khazaei and Amir Avan*


DOI: 10.2174/1568009621666210311090531
View Abstract


Oncolytic adenoviral H101 synergizes with radiation in cervical cancer cells


Yixin Duan, Haixia Bai, Xiang Li , Depu Wang , Yin Wang, Meng Cao, Nana Zhang, Hongwei Chen * and Yili Wang*


DOI: 10.2174/1568009621666210308103541
View Abstract



Association of Polymorphism in Survivin gene and the risk of Liver Cancer resulting from Hepatitis C Virus among Egyptian patients


Amal A. Mohamed, Aymen S. Yassin, Basma S. Gomaa, Hossam Darwish, Rasha S. Mohamed, Sahar Makled, Ahmed Ramdan, Sherief Abd-Elsalam* and Marwa M. Raafat


DOI: 10.2174/1568009621666210302090917
View Abstract




Cross talk between COVID-19 and breast cancer


Hamendra Singh Parmar*, Aakruti Nayak*, Pramod Kumar Gavel, Hemchandra Jha, Shivani Bhagwat and Rajesh Sharma


DOI: 10.2174/1568009621666210216102236
View Abstract


Published Contents

Editor's Choice

Immunotherapy: A Potential Approach to Targeting Cancer Stem Cells

, 2021; 21(2): 117 - 131

Wenjun Wang, Ling Bai, Dongsheng Xu, Wei Li and Jiuwei Cui*


DOI: 10.2174/1568009620666200504111914



C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors

, 2021; 21(1): 2 - 20

Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*


DOI: 10.2174/1568009620666201016121005



Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: The NAPA Study

, 2020; 20(11): 887 - 895

Martina Catalano, Giandomenico Roviello*, Raffaele Conca, Alberto D’Angelo, Valeria Emma Palmieri, Benedetta Panella, Roberto Petrioli, Anna Ianza, Stefania Nobili, Enrico Mini and Monica Ramello


DOI: 10.2174/1568009620999200918122426



Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL

, 2020; 20(10): 811 - 817

Sven Nilsson, Alexander Stein, Christian Rolfo, Anne L. Kranich, Julia Mann, Konstantinos Papadimitriou, Susann Theile, Stefanie Amberg and Carsten Bokemeyer*


DOI: 10.2174/1568009620666200628105727



Cancer Stem Cells with Overexpression of Neuronal Markers Enhance Chemoresistance and Invasion in Retinoblastoma

, 2020; 20(9): 710 - 719

Sekaran Balaji, Radhakrishnan Santhi, Usha Kim, Veerappan Muthukkaruppan, Chidambaranathan G. Priya and Ayyasamy Vanniarajan*


DOI: 10.2174/1568009620666200504112711



Strategic Combination Therapies for Ovarian Cancer

, 2020; 20(8): 573 - 585

Xinran Li, Angel S.N. Ng, Victor C.Y. Mak, Karen K.L. Chan, Annie N.Y. Cheung and Lydia W.T. Cheung*


DOI: 10.2174/1568009620666200511084007




COVID-19 Pandemic: Experiences in China and Implications for its Prevention and Treatment Worldwide

, 2020; 20(6): 410 - 416

Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*


DOI: 10.2174/1568009620666200414151419



CDK9: Therapeutic Perspective in HCC Therapy

, 2020; 20(5): 318 - 324

Jędrzej Borowczak*, Krzysztof Szczerbowski, Ewa Stec, Dariusz Grzanka and Łukasz Szylberg


DOI: 10.2174/1568009620666200212124357




Open Access Articles

Paclitaxel Priming of TRAIL Expressing Mesenchymal Stromal Cells (MSCs- TRAIL) Increases Antitumor Efficacy of Their Secretome

, 2021; 21: 1 - 10 (E-Pub Ahead of Print)

Valentina Coccè, Arianna Bonomi, Loredana Cavicchini, Francesca Sisto, Aldo Giannì, Giampietro Farronato, Giulio Alessandri, Francesco Petrella, Valeria Sordi, Eugenio Parati, Gianpietro Bondiolotti, Francesca Paino and Augusto Pessina*




Targeted Biological Effect of An Affitoxin Composed of an HPV16E7 Affibody Fused with Granzyme B (ZHPV16E7-GrB) Against Cervical Cancer in vitro and in vivo

, 2021; 21: 1 - 12 (E-Pub Ahead of Print)

Wenhuan Wang, Xiaochun Tan, Jie Jiang, Yiqi Cai, Fangfang Feng, Lifang Zhang* and Wenshu Li*





The Roles of Alternative Splicing in Tumor-immune Cell Interactions

, 2020; 20(10): 729 - 740

Yue Wang, Honglei Zhang*, Baowei Jiao*, Jianyun Nie*, Xiyin Li, Wenhuan Wang and Hairui Wang




Cancer Cell-derived Secretory Factors in Breast Cancer-associated Lung Metastasis: Their Mechanism and Future Prospects

, 2020; 20(3): 168 - 186

Tabinda Urooj*, Bushra Wasim, Shamim Mushtaq, Syed Nudrat Nawaid Shah and Muzna Shah





Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer

, 2019; 19(1): 74 - 80

Peng Liu, Hailin Tang, Jiali Wu, Xingsheng Qiu, Yanan Kong, Lijuan Zhang, Xinhua Xie* and Xiangsheng Xiao*




Role of MicroRNAs in Treatment Response in Prostate Cancer

, 2018; 18(10): 929 - 944

Anshuli Razdan, Paul de Souza* and Tara Laurine Roberts




Noxa: Role in Cancer Pathogenesis and Treatment

, 2018; 18(10): 914 - 928

Rami Z. Morsi, Rouba Hage-Sleiman, Hadile Kobeissy and Ghassan Dbaibo*








Platycodin D Induces Tumor Growth Arrest by Activating FOXO3a Expression in Prostate Cancer in vitro and in vivo

, 2014; 14(9): 860 - 871

Rui Zhou, Zongliang Lu, Kai Liu, Jing Guo, Jie Liu, Yong Zhou, Jian Yang, Mantian Mi and Hongxia Xu




Pleiotropic Role of HSF1 in Neoplastic Transformation

, 2014; 14(2): 144 - 155

Natalia Vydra, Agnieszka Toma and Wieslawa Widlak





Most Cited Articles

Review Article

Resveratrol as an adjuvant for normal tissues protection and tumor sensitization

, 2020; 20(2): 130-145.

Keywan Mortezaee, Masoud Najafi*, Bagher Farhood*, Amirhossein Ahmadi*, Dheyauldeen Shabeeb and Ahmed E. Musa


DOI: 10.2174/1568009619666191019143539


Review Article

Old and new approaches to target the hsp90 chaperone

, 2020; 20(4): 253-270.

Jackee Sanchez, Trever R. Carter, Mark S. Cohen* and Brian S.J. Blagg


DOI: 10.2174/1568009619666191202101330



Research Article

Circepsti1 acts as a cerna to regulate the progression of osteosarcoma

, 2020; 20(4): 288-294.

Xinyu Tan, Duxun Tan, Haomiao Li, Ye Lin, Zhishen Wen and Canjun Zeng*


DOI: 10.2174/1568009619666191107140948


Review Article

COVID-19 pandemic: Experiences in China and implications for its prevention and treatment worldwide

, 2020; 20(6): 410-416.

Ning-Ning Liu*, Jing-Cong Tan, Jingquan Li, Shenghui Li*, Yong Cai* and Hui Wang*


DOI: 10.2174/1568009620666200414151419


Review Article

Cancer cell-derived secretory factors in breast cancer-associated lung metastasis: Their mechanism and future prospects

, 2020; 20(3): 168-186.

Tabinda Urooj*, Bushra Wasim, Shamim Mushtaq, Syed Nudrat Nawaid Shah and Muzna Shah


DOI: 10.2174/1568009620666191220151856


Research Article

CDK12 promotes breast cancer progression and maintains stemness by activating c-myc/β-catenin signaling

, 2020; 20(2): 156-165.

Fang Peng, Chuansheng Yang, Yanan Kong, Xiaojia Huang, Yanyu Chen, Yangfan Zhou, Xinhua Xie* and Peng Liu*


DOI: 10.2174/1568009619666191118113220



Research Article

Effects of intermittent hypoxia on expression of glucose metabolism genes in MCF7 breast cancer cell line

, 2020; 20(3): 216-222.

Yazun Jarrar, Malek Zihlif*, Abdel Qader Al Bawab and Ahmad Sharab


DOI: 10.2174/1568009619666191116095847


Research Article

C/ebpα regulates foxc1 to modulate tumor growth by interacting with pparγ in hepatocellular carcinoma

, 2020; 20(1): 59-66.

Zhuo Xu, Shao-Hua Meng, Jian-Guo Bai, Chao Sun*, Li-Li Zhao*, Rui-Feng Tang, Zhao-Lin Yin, Jun-Wei Ji, Wei Yang and Guang-Jun Ma


DOI: 10.2174/1568009619666190912161003



Research Article

HOTAIR competitively binds mirna330 as a molecular sponge to increase the resistance of gastric cancer to trastuzumab

, 2020; 20(9): 700-709.

Liangyu Bie, Suxia Luo*, Dan Li, Yan Wei, Yu Mu, Xiaobing Chen, Saiqi Wang, Ping Guo and Xiaoyu Lu


DOI: 10.2174/1568009620666200504114000


Research Article

Overexpression of p62 induces autophagy and promotes proliferation, migration and invasion of nasopharyngeal carcinoma cells through promoting ERK signaling pathway

, 2020; 20(8): 624-637.

Qiong Wu, Manlin Xiang, Kun Wang, Zhen Chen, Lu Long, Ya Tao, Yunlai Liang, Yahui Yan, Zhiqiang Xiao, Shiyang Qiu and Bin Yi*


DOI: 10.2174/1568009620666200424145122


Research Article

Circrna SCARB1 promotes renal cell carcinoma progression via miR-510-5p/SDC3 axis

, 2020; 20(6): 461-470.

Jijian Sun*, Shijie Pan, Hongquan Cui and Hao Li


DOI: 10.2174/1568009620666200409130032


Review Article

Novel homeodomain transcription factor Nkx2.2 in the brain tumor development

, 2020; 20(5): 335-340.

Mubeena P.M. Mariyath, Mehdi H. Shahi*, Shirin Farheen, Mohd Tayyab, Nabeela Khanam and Asif Ali


DOI: 10.2174/1568009618666180102111539



Most Accessed Articles



C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors

, 2021; 21(1): 2-20.

Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*


DOI: 10.2174/1568009620666201016121005


CDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β -catenin Signaling

, 2020; 20(2): 156-165.

Fang Peng, Chuansheng Yang, Yanan Kong, Xiaojia Huang, Yanyu Chen, Yangfan Zhou, Xinhua Xie* and Peng Liu*


DOI: 10.2174/1568009619666191118113220


Clinical Outcomes and Safety of Patients Treated with NAb-Paclitaxel Plus Gemcitabine in Metastatic Pancreatic Cancer: The NAPA Study

, 2020; 20(11): 887-895.

Martina Catalano, Giandomenico Roviello*, Raffaele Conca, Alberto D’Angelo, Valeria Emma Palmieri, Benedetta Panella, Roberto Petrioli, Anna Ianza, Stefania Nobili, Enrico Mini and Monica Ramello


DOI: 10.2174/1568009620999200918122426



Identification of WDFY3 Neoantigens as Prognostic Markers in Longterm Survivors of Extrahepatic Cholangiocarcinoma

, 2020; 20(11): 875-886.

Yingyi Wang, Bao Jin, Na Zhou, Zhao Sun, Jiayi Li, Qiao Chen, Xiangan Wu, Yi Zhou, Yue Shi, Xin Lu, Xinting Sang, Yilei Mao, Shunda Du*, Wenze Wang* and Chunmei Bai*


DOI: 10.2174/1568009620999200918121456


Tyrosine Kinase Inhibitors (TKIs) in Lung Cancer Treatment: A Comprehensive Analysis

, 2021; 21(1): 55-69.

Sivakumar Murugesan, Jayakumar Murugesan, Seedevi Palaniappan , Sivasankar Palaniappan, Tamilselvi Murugan, Shahid S. Siddiqui and Sivakumar Loganathan*


DOI: 10.2174/1568009620666201009130008


Immune Checkpoint Inhibitors in AML-A New Frontier

, 2020; 20(7): 545-557.

Rohit Thummalapalli, Hanna A. Knaus, Ivana Gojo and Joshua F. Zeidner*


DOI: 10.2174/1568009620666200421081455




Selinexor (KPT-330), an Oral Selective Inhibitor of Nuclear Export (SINE) Compound, in Combination with FOLFOX in Patients with Metastatic Colorectal Cancer (mCRC) - Final Results of the Phase I Trial SENTINEL

, 2020; 20(10): 811-817.

Sven Nilsson, Alexander Stein, Christian Rolfo, Anne L. Kranich, Julia Mann, Konstantinos Papadimitriou, Susann Theile, Stefanie Amberg and Carsten Bokemeyer*


DOI: 10.2174/1568009620666200628105727



MUC Glycoproteins: Potential Biomarkers and Molecular Targets for Cancer Therapy

, 2021; 21(2): 132-152.

Chameli Ratan, Dalia Cicily K. D, Bhagyalakshmi Nair and Lekshmi. R. Nath*


DOI: 10.2174/1568009620666201116113334




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