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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Volume 21, 18 Issues, 2021
ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)
This journal supports open access

Aims & Scope

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth/mini reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Anti-Cancer Agents in Medicinal Chemistry


Volume 21


Number 16

Review Article (Mini-Review)

Review Article

COVID-19: Our Current Knowledge of Epidemiology, Pathology, Therapeutic Approaches, and Diagnostic Methods

, 21(16): 2142 - 2162

Faroogh Marofi , Ramyar Azizi , Roza Motavalli, Ghasem Vahedi, Maryam Nasimi, Mehdi Yousefi , Yalda Motavalli , Safa Tahmasebi , Tohid Gharibi , Rebar N. Mohammed , Jalal Etemadi and Farhad M. Khiavi *

DOI: 10.2174/1871520621666210201101245

Anti-Cancer Agents in Medicinal Chemistry, Volume 21 (2021) - Number 17

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Molecular and Metabolomic Investigation of Celecoxib Antiproliferative Activity in Mono-and Combination Therapy Against Breast Cancer Cell Models

Sanaa K. Bardaweel*, Lina A. Dahabiyeh, Bushra M. Akileh, Dana D. Shalabi, Afnan K. AlHiary, Judy Pawling, James W. Dennis and Anas M. Abdel Rahman

DOI: 10.2174/1871520621666210910101349
View Abstract View on PubMed

The Acetyltransferase KAT5 Inhibitor NU 9056 Promotes Apoptosis and Inhibits JAK2/STAT3 Pathway in Extranodal NK/T Cell Lymphoma

Linyan Xu*, Yuanyuan Qin, Mengdi Liu, Jun Jiao, Dongyun Tu, Meng Zhang, Dongmei Yan, Xuguang Song, Cai Sun, Feng Zhu, Xiangmin Wang, Wei Sang* and Kailin Xu*

DOI: 10.2174/1871520621666210908103306
View Abstract View on PubMed

Bioactive Heterocyclic Compounds as Potential Therapeutics in the Treatment of Gliomas: A Review

Reyaz Hassan, Roohi Mohi-ud-din, Mohammad Ovais Dar, Abdul Jalil Shah, Prince Ahad Mir, Majeed Shaikh and Faheem Hyder Pottoo*

DOI: 10.2174/1871520621666210901112954
View Abstract View on PubMed

Abstracts Ahead of Print

Role of Mitochondrial Membrane Potential and Lactate Dehydrogenase A in Apoptosis

Sumera Zaib*, Aqsa Hayyat, Naba Ali, Asma Gul, Muhammad Naveed and Imtiaz Khan*

DOI: 10.2174/1871520621666211126090906
View Abstract

Current developments in the Pyran-Based Analogues as Anticancer Agents

Parul Grover , Monika Bhardwaj , Lovekesh Mehta, Garima Kapoor and Pooja A. Chawla *

DOI: 10.2174/1871520621666211119090302
View Abstract

Gallic acid: a dietary polyphenol that exhibits anti-neoplastic activities by modulating multiple oncogenic targets

Hardeep Singh Tuli*, Hiral Mistry, Ginpreet Kaur, Diwakar Aggarwal, Vivek Kumar Garg, Sonam Mittal, Mükerrem Betül Yerer, Katrin Sak and Md Asaduzzaman Khan

DOI: 10.2174/1871520621666211119085834
View Abstract

Rational Design of Anti-Angiogenic Peptides to Inhibit VEGF/VEGFR2 Interactions for Cancer Therapeutics

Samaneh Ghasemali, Safar Farajnia*, Abolfazl Barzegar*, Mohammad Rahmati-yamchi, Babak Negahdari, Leila Rahbarnia and Hamidreza Yousefi-nodeh

DOI: 10.2174/1871520621666211118104051
View Abstract

Molecular Docking and In Vitro Anticancer Screening of Synthesized Arylthiazole linked 2H-indol-2-one Derivatives as VEGFR-2 Kinase Inhibitors

Nishtha Shalmali, Sandhya Bawa*, Md Rahmat Ali, Sourav Kalra, Raj Kumar, Bushra Zeya, Moshahid Alam Rizvi, Sangh Partap and Asif Husain

DOI: 10.2174/1871520621666211118102139
View Abstract

Biosynthesized CdS Nanoparticle Induces ROS-dependent Apoptosis in Human Lung Cancer Cells

Tina Nasrin, Mousumi Patra, Sayed Modinur Rahaman, Tapan Kumar Das and Soni Shaikh*

DOI: 10.2174/1871520621666211115113226
View Abstract

Naturally Occurring O-heterocycles as Anticancer Agents

Satya Kumar Avula, Biswanath Das*, Rene Csuk and Ahmed Al-Harrasi*

DOI: 10.2174/1871520621666211108091444
View Abstract

In Vitro Antitumor Evaluation of Acrylic Acid Derivatives Bearing Quinolinone Moiety as Novel Anticancer Agents

Islam Zaki *, Sarah A. Eid , Mohamed S. Elghareb, Al-Shimaa M. Abas, Fatten Z. Mohammed and Gaber Mersal

DOI: 10.2174/1871520621666211103105255
View Abstract

Published Contents

Editor's Choice

Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole- Based Anticancer Agents as Potent Angiogenesis Inhibitors

, 2021; 21(15): 2041 - 2049

Burcugül Altuğ-Tasa, Betül Kaya-Çavuşoğlu*, Ayşe T. Koparal, Gülhan Turan, Ali S. Koparal and Zafer A. Kaplancıklı

DOI: 10.2174/1871520621666201231143535

Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple- Negative Breast Cancer Cell Migration

, 2021; 21(14): 1901 - 1910

Wanessa F. Altei, Bianca C. Pachane, Lucimara J. Martins, Ralph C. Gomes, Ricardo N. Santos, Daniara C. Fernandes, Heloisa S. Selistre-de-Araújo, Fernando Coelho * and Adriano D. Andricopulo*

DOI: 10.2174/1871520621666201207092836

Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti-Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents

, 2021; 21(10): 1228 - 1239

Paul Awolade, Nosipho Cele, Oluwakemi Ebenezer, Nagaraju Kerru, Lalitha Gummidi, Liang Gu, Gabriella Palma, Mandeep Kaur and Parvesh Singh*

DOI: 10.2174/1871520620666200929153138

On the Cytotoxicity of Chiral Ruthenium Complexes Containing Sulfur Amino Acids against Breast Tumor Cells (MDA-231 and MCF-7)

, 2021; 21(9): 1172 - 1182

Celisnolia M. Leite*, João Honorato de Araujo-Neto, Rodrigo S. Corrêa, Legna Colina-Vegas, Diego Martínez-Otero, Paulo R. Martins, Cristiane G. Silva and Alzir A. Batista*

DOI: 10.2174/1871520620666200824114816

Synthesis and Evaluation of Cytotoxic Activity of Certain Benzo[h]chromene Derivatives

, 2021; 21(8): 963 - 986

Samir M. Awad, Mosaad S. Mohamed, Marwa Abd El-Fattah Khodair and Rania H. Abd El-Hameed*

DOI: 10.2174/1871520620666200925103742

Open Access Articles

The Killing of Human Neuroblastoma Cells by the Small Molecule JQ1 Occurs in a p53-Dependent Manner

, 2020; 20(13): 1613 - 1625

Joseph Mazar*, Caleb Gordon, Varun Naga and Tamarah J. Westmoreland

Cytotoxic Sesquiterpenes from Sonchus oleraceus

, 2020; 20(6): 709 - 714

Hongying Zhang, Yiding Wang, Shaojiu Wang, Qian Wang, Tianjing Wang, Jie Zhu* and Bing Liu

Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug- Resistant Cells

, 2020; 20(6): 687 - 699

Gongshen Jin*, Kangwei Wang, Yonghong Liu, Xianhu Liu, Xiaojing Zhang and Hao Zhang

Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis

, 2019; 19(10): 1253 - 1261

Naipeng Cui, Dan-Dan Lin, Yang Shen, Jian-Guo Shi, Bing Wang, Ming-Zhi Zhao, Lishuang Zheng, Hua Chen* and Jian-Hong Shi*

New Strategies for Therapeutic Cancer Vaccines

, 2019; 19(2): 213 - 221

Hanjiao Qin, Jiyao Sheng, Dan Zhang, Xuewen Zhang, Linlin Liu*, Bingjin Li*, Guangquan Li* and Zhuo Zhang

Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?

, 2018; 18(8): 1091 - 1099

Chengshui Liao*, Xiangchao Cheng, Mingyuan Liu*, Xuelin Wang and Pascal Boireau

Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation

, 2018; 18(7): 1001 - 1008

Na Li, Kun Zhang, Xin Mu, Qiong Tian, Wenli Liu, Tianyuan Gao, Xiaona Ma* and Jian Zhang*

Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals

, 2016; 16(11): 1385 - 1402

Alessandra Bosutti, Fabrizio Zanconati, Gabriele Grassi, Barbara Dapas, Sabina Passamonti and Bruna Scaggiante

Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

, 2016; 16(7): 810 - 815

Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi

The Use of Anthracyclines for Therapy of CNS Tumors

, 2015; 15(6): 721 - 727

Martina da Ros, Anna Lisa Iorio, Maurizio Lucchesi, Alessia Stival, Maurizio de Martino and Iacopo Sardi

Most Cited Articles

Review Article

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention

, 2019; 19(1): 38-47.

Alessandro Colapietro, Andrea Mancini, Anna Maria D'Alessandro and Claudio Festuccia*

DOI: 10.2174/1871520619666181231112453

Review Article

Phytochemicals in anticancer drug development

, 2019; 19(2): 172-183.

Rohit Dutt, Vandana Garg, Naveen Khatri and Anil K. Madan*

DOI: 10.2174/1871520618666181106115802

Review Article

Nitrogen-containing heterocycles as anticancer agents: An overview

, 2020; 20(18): 2150-2168.

Damanpreet K. Lang, Rajwinder Kaur*, Rashmi Arora, Balraj Saini and Sandeep Arora

DOI: 10.2174/1871520620666200705214917

Research Article

Synthesis and biological evaluation of novel heterocyclic imines linked coumarin- thiazole hybrids as anticancer agents

, 2019; 19(4): 557-566.

Nerella S. Goud, Mahammad S. Ghouse, Jatoth Vishnu, Jakkula Pranay, Ravi Alvala, Venu Talla, Insaf A. Qureshi and Mallika Alvala*

DOI: 10.2174/1871520619666190207140120

Research Article

Molecular docking study, cytotoxicity, cell cycle arrest and apoptotic induction of novel chalcones incorporating thiadiazolyl isoquinoline in cervical cancer

, 2020; 20(1): 70-83.

Mohamed A. Tantawy, Farid M. Sroor*, Magda F. Mohamed*, Mostafa E. El-Naggar, Fatma M. Saleh, Hamdi M. Hassaneen and Ismail A. Abdelhamid*

DOI: 10.2174/1871520619666191024121116

Review Article

Quercetin loaded nanoparticles in targeting cancer: Recent development

, 2019; 19(13): 1560-1576.

Manjula Vinayak* and Akhilendra K. Maurya

DOI: 10.2174/1871520619666190705150214

Review Article

Garlic and its active compounds: A potential candidate in the prevention of cancer by modulating various cell signalling pathways

, 2019; 19(11): 1314-1324.

Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi and Arshad H. Rahmani*

DOI: 10.2174/1871520619666190409100955

Research Article

Hybridized quinoline derivatives as anticancer agents: Design, synthesis, biological evaluation and molecular docking

, 2019; 19(4): 439-452.

Mohamed R. Selim, Medhat A. Zahran, Amany Belal*, Moustafa S. Abusaif*, Said A. Shedid, Ahmed B.M. Mehany, Gameel A.M. Elhagali and Yousry A. Ammar*

DOI: 10.2174/1871520618666181112121058

Research Article

Let-7a could serve as a biomarker for chemo-responsiveness to docetaxel in gastric cancer

, 2019; 19(3): 304-309.

Najibeh Shekari, Faezeh Asghari, Navideh Haghnavaz, Dariush Shanehbandi, Vahid Khaze, Behzad Baradaran and Tohid Kazemi*

DOI: 10.2174/1871520619666181213110258

Research Article

Novel inhibitors of DNA repair enzyme TDP1 combining monoterpenoid and adamantane fragments

, 2019; 19(4): 463-472.

Evgenii S. Mozhaitsev, Alexandra L. Zakharenko, Evgeniy V. Suslov*, Dina V. Korchagina, Olga D. Zakharova, Inna A. Vasil'eva, Arina A. Chepanova, Ellena Black, Jinal Patel, Raina Chand, Jóhannes Reynisson, Ivanhoe K.H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov and Olga I. Lavrik

DOI: 10.2174/1871520619666181207094243

Review Article

A review of chemotherapy and photodynamic therapy for lung cancer treatment

, 2021; 21(2): 149-161.

Ahmed El-Hussein*, Sello L. Manoto, Saturnin Ombinda-Lemboumba, Ziya A. Alrowaili and Patience Mthunzi-Kufa

DOI: 10.2174/1871520620666200403144945

Most Accessed Articles

Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple- Negative Breast Cancer Cell Migration

, 2021; 21(14): 1901-1910.

Wanessa F. Altei, Bianca C. Pachane, Lucimara J. Martins, Ralph C. Gomes, Ricardo N. Santos, Daniara C. Fernandes, Heloisa S. Selistre-de-Araújo, Fernando Coelho * and Adriano D. Andricopulo*

DOI: 10.2174/1871520621666201207092836

The Synergistic Cytotoxic and Apoptotic Effect of Resveratrol and Naringenin on Y79 Retinoblastoma Cell Line

, 2021; 21(16): 2243-2249.

Rasul Rakhshan, Hesam A. Atashi, Mohammad Hoseinian, Aryan Jafari, Amirparsa Haghighi, Fatemeh Ziyadloo, Nasim Razizadeh, Haniyeh Ghasemian, Mohammad M.K. Nia, Anita B. Sefidi and Hamid Z. Arani*

DOI: 10.2174/1871520621666210112121051

Anti-MDR Effects of Quercetin and its Nanoemulsion in Multidrug-Resistant Human Leukemia Cells

, 2021; 21(14): 1911-1920.

Maiara B. Marques, Ayane P. Machado, Priscila A. Santos, Michele Carrett-Dias, Gabriela S. Araújo, Barbara da Silva Alves, Bárbara Santos de Oliveira, Flavio M.R. da Silva Júnior, Cristiana L. Dora, Andrés D. Cañedo, Daza M.V.B. Filgueira, Estela Fernandes e Silva* and Ana Paula de Souza Votto

DOI: 10.2174/1871520621999210104200722

Potential Interactions between miRNAs and Hypoxia: A New Layer in Cancer Hypoxia

, 2021; 21(17): 2315-2326.

Behnam Emaogolizadeh-Gurd Tapeh, Mohammad R. Alivand and Saeed Solalii*

DOI: 10.2174/1871520621666210201100326

COVID-19: Our Current Knowledge of Epidemiology, Pathology, Therapeutic Approaches, and Diagnostic Methods

, 2021; 21(16): 2142-2162.

Faroogh Marofi , Ramyar Azizi , Roza Motavalli, Ghasem Vahedi, Maryam Nasimi, Mehdi Yousefi , Yalda Motavalli , Safa Tahmasebi , Tohid Gharibi , Rebar N. Mohammed , Jalal Etemadi and Farhad M. Khiavi *

DOI: 10.2174/1871520621666210201101245

Resveratrol as an Enhancer of Apoptosis in Cancer: A Mechanistic Review

, 2021; 21(17): 2327-2336.

Milad Ashrafizadeh, Shahram Taeb, Hamed Haghi-Aminjan, Shima Afrashi, Kave Moloudi, Ahmed E. Musa, Masoud Najafi* and Bagher Farhood*

DOI: 10.2174/1871520620666201020160348

Lemongrass (Cymbopogon citratus (D.C.) Stapf) Presents Antitumoral Effect and Improves Chemotherapy Activity in Prostate Cancer Cells

, 2021; 21(17): 2337-2350.

Lucas F. Gomes, Pâmela J.H. Longhi, Larissa Machado, Ivana B. Mânica da Cruz, Marco A.E. Montano, Mathias Martins, Sérgio A. Machado, Jovani A. Steffani and Francine C. Cadoná*

DOI: 10.2174/1871520621666210112111711

Emerging Molecular Functions of MicroRNA-9: Cancer Pathology and Therapeutic Implications

, 2021; 21(17): 2304-2314.

Behnam Emamgolizadeh Gurt Tapeh , Bashir Mosayyebi, Behzad Mansoori , Zahra Alipoor Gravand, Hamzeh Sarvnaz and Ali Mohammadi *

DOI: 10.2174/1871520621666210217094839

Design, Synthesis and Biological Evaluation of 4, 6-Coumarin Derivatives as Anti- Cancer and Apoptosis-Inducing Agents

, 2021; 21(17): 2351-2367.

Guoyi Yan*, Jiang Luo , Xuan Han, Wenjuan Zhang , Chunlan Pu, Meng Zhou, Xinxin Zhong, Xueyan Hou, Man Zhou Hou and Rui Li *

DOI: 10.2174/1871520621666210129093857


Simone Carradori
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
View Full Editorial Board

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Journal History

Current Medicinal Chemistry - Anti-Cancer Agents was launched in 2001 and later renamed in 2006 as Anti-Cancer Agents in Medicinal Chemistry.

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