E-Pub Articles Ahead of Print ::: Mini-Reviews in Medicinal Chemistry

ISSN: 1875-5607 (Online)
ISSN: 1389-5575 (Print)


Volume 17, 18 Issues, 2017


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Mini-Reviews in Medicinal Chemistry

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Articles Ahead of Print

Quinoxalinone as a Privileged Platform in Drug Development


Leilei Shi, Wei Hu, Jifeng Wu, Huaiyu Zhou, Hua Zhou and Xun Li*


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Beyond The Therapeutic Effect of rTMS in Alzheimer’s Disease: A Possible Neuroprotective Role of Hippocampal BDNF? : A Minireview


Burak Yulug*, Lütfü Hanoglu, Elmir Ksanmemmedov, Ozge Arıcı Düz, Burcu Polat, Taha Hanoglu, Mehmet Yalçin Günal and Ertugrul Kilic


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Development, Potential Anticancer Activity and the Receptor Profile of Different Functionalized 1,3,5-Triazine Derivatives


Mona O. Sarhan, Mohamed A. Motaleb, Ismail T. Ibrahim, Wafaa. A. Zaghary* and Manal M. Anwar*


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Ultrasound Assisted One-pot and Sequential Synthesis of 3-methyleneisoindolin- 1-ones and their in vitro Evaluation


Kancharla Suman, Yarlagadda Bharath, V. Anuradha, Mandava V. Basaveswara Rao* and Manojit Pal*


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Therapeutic Potential of Alpinia officinarum


David Young*, Manoharan K Pillai and Mohamed Majid


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CORAL: Monte Carlo Method to Predict Endpoints for Medical Chemistry


Alla P. Toropova and Andrey A. Toropov*


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Pentoxifylline-Induced Apoptosis in Chronic Lymphocytic Leukemia: New Insights into Molecular Mechanism


Roberta Napolitano, Serena De Matteis, Alessandro Lucchesi, Silvia Carloni*, Delia Cangini, Gerardo Musuraca, Eliana Valentina Liardo, Marianna Norata and Pier Paolo Fattori


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Rational Approaches, Design Strategies, Structure Activity Relationship and Mechanistic Insights for Esterase Inhibitors


Harbinder Singh, Jatinder Vir Singh, Navdeep Kaur, Mohit Sanduja, Gurpreet Singh, Preet Mohinder Singh Bedi and Sahil Sharma*


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New Therapeutic Targets and Drugs for the Treatment of Asthma


Mateus Feitosa Alves, Diogo Vilar da Fonsec, Sílvia Adelaide Linhares de Melo, Marcus Tullius Scotti*, Luciana Scotti, Sócrates Golzio dos Santos and Margareth de Fátima Formiga Melo Diniz


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Aptamer Oligonucleotides as Potential Therapeutics in Hematologic Diseases


Weibin Li, Meng Zhao, Kaiyu Wang, Huihui Yan and XIaopeng lan*


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Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation


Naglaa A. Abdel Hafez, Huwaida M. E. Hassaneen, Thoraya A. Farghaly*, Sayed M. Riyadh and Heba S. A. Elzahabi


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Recent Advancement of Direct-acting Antiviral Agents (DAAs) in Hepatitis C Therapy


Debasis Das* and Mayank Pandya


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Pharmacophore Comparison and Development of Recently Discovered Long Chain Arylpiperazine and Sulfonamide Based 5-HT7 Ligands


Andrea Rague and Kevin Joseph Tidgewell*


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Synthesis, Anticancer Screening and Molecular Docking Studies of New Heterocycles with Trimethoxyphenyl Scaffold as Combretastatin Analogues


Korany A. Ali*, Naglaa A. Abdel Hafez, Mohamed A. Elsayed, Manal M. Elshahawi, Salwa M. El-Hallouty and Abd El-Galil E. Amr


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Recent Progress in Biological Activities of Indole and Indole Alkaloids


O. M Singh* and Thokchom Prasanta Singh


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Does Pharmacological Therapy Still Play a Role in Preventing Sudden Death in Surgically Treated Tetralogy of Fallot?


Gabriele Bronzetti*, Maurizio Brighenti and Marco Bonvicini


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Cholinesterase Inhibitory Activity of Some semi-Rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site


Taibi Ben Hadda, Oualid Talhi, Artur S.M. Silva, Fatma Sezer Senol, Ilkay Erdogan Orhan, Abdur Rauf , Yahia N. Mabkhot, Khaldoun Bachari , Ismail Warad , Thoraya A. Farghaly *, Ismail I. Althagafi and Mohammad S. Mubarak


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Nutlin-3, A P53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment


Voon Yee-Lin*, Wong Pooi-Fong and Alan Khoo Soo-Beng


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Design, Synthesis and Antibacterial Evaluation of Compounds Based on New Benzoxepine-oxime-1,2,3-triazole Hybrid


Naveen Kuntala, Jhonsee Rani Telu, Venkanna Banothu, Sridhar Balasubramanian, Jaya Shree Anireddy and Sarbani Pal*


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Pomegranate as a Possible Treatment in Reducing Risk of Developing Wound Healing, Obesity, Neurodegenerative Disorders, and Diabetes Mellitus


Manaf AlMatar*, Md Rashedul Islam, Othman Albari, Işıl Var and Fatih Köksal


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A Focus on Pharmacological Management of Catecholaminergic Polymorphic Ventricular Tachycardia


Barbanti Claudio*, Maltret Alice and Sidi Daniel


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Medical Therapy for Long QT Syndrome


George Adamos*, Nicoletta Iacovidou and Theodoros Xanthos


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The Role of Quinidine in the Pharmacological Therapy of Ventricular Arrhythmias ‘Quinidine


Bojana Bozic*, Teodora Vidonja Uzelac, Aleksandra Kezic and Milica Bajcetic


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Substituted Benzamides from Antiinflammatory and p38 Kinase Inhibitors to Antitubercular Activity: Design, Synthesis and Screening


Ravindra Kulkarni, Umakant Mitkari, G Achaiah *, Stefan Laufer, D. V. R .N Bikshapti, V. M Chandrashekar, P. B Gurav , S. J Joshi and V. D Chipade


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Dietary Phytochemicals and Endrocrine-related Activities: An Update


Antonella Smeriglio, Marcella Denaro and Domenico Trombetta*


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Pharmacological Treatment of Vagal Hyperactivity, a Rare but Potentially Fatal Cause of Sudden Cardiac Death


Pier Paolo Bassareo*, Daniele Cocco, Valentina Bassareo, Bandino Stefano and Giuseppe Mercuro


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Ultrasound Assisted Synthesis of Quinoline Derivatives in the Presence of SnCl2·2H2O as a Precatalyst in Water: Evaluation of their Antibacterial Activities


A. S. G. Prasad, T. Bhaskara Rao, D. Rambabu, Mandava V. Basaveswara Rao and Manojit Pal*


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1,4-Benzothiazines-A Biologically Attractive Scaffold


Amit Rai, Ashok K Singh, Vinit Raj and Sudipta Saha*


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Artificial Virus as Trump-card to Resolve Exigencies in Targeted Gene Delivery


K. C. Ajithkumar and K. Pramod*


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Limitations of Current Therapeutic Options, Possible Drug Targets and Scope of Natural Products in Control of Leishmaniasis


Neeraj Tiwari, Mallikarjuna Rao Gedda, Vinod K. Tiwari, Surya P. Singh and Rakesh K. Singh*


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Rubiscolins - Highly Potent Peptides Derived from Plant Proteins


Renata Perlikowska* and Anna Janecka


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Chemistry of Heterocyclic Five and Six Membered Enamino Nitriles and Enamino Esters


Moustafa Sherief Moustafa*, Saleh Mohammed Al-Mousawi*, Hesham R. El-Seedi* and Mohamed Hilmy Elnagdi


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Recent Development of Oridonin Derivatives with Diverse Pharmacological Activities


Weiyan Cheng, Chuanhui Huang, Weifeng Ma, Xin Tian* and Xiaojian Zhang*


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Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine


Merina Mariyam, Kajal Ghosal*, Anne George, Sabu Thomas, Nandakumar Kalarikkal and Mahima S Latha


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Berberine Derivatives with Different Pharmacological Activities via Structural Modifications


Daipeng Xiao, Zhenbao Liu, Shanshan Zhang, Mi Zhou, Fen He, Ming Zou, Junying Peng, Xiong xie, Yanfei Liu* and Dongming Peng*


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Advance in Anti-tumor Mechanisms of Shikonin, Alkannin and their Derivatives


Xu Zhang, Jia-Hua Cui, Qing-Qing Meng, Shao-Shun Li, Wen Zhou and Sui Xiao


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Recent Advances on 3-hydroxyflavone Derivatives: Structures and Properties


Burcu Butun, Gulacti Topcu and Turan Ozturk*


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Synthesis of Hybrids of Dihydropyrimidine and Pyridazinone as potential Anti-Breast Cancer Agents


Wasim Akhtar, Garima Verma, Mohemmed Faraz Khan, Mohammad Shaquiquzzaman, Arpana Rana, Tarique Anwer, Mymoona Akhter and M. Mumtaz Alam


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Phenothiazine: A Better Scaffold against Tuberculosis


Satheeshkumar Sellamuthu, Mohammad Faizan Bhat, Ashok Kumar and Sushil Kumar Singh


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Small Molecule Efflux Pump Inhibitors in Mycobacterium tuberculosis: A Rational Drug Design Perspective


Erika Kapp, Sarel F. Malan* and Samantha L. Sampson


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Design of Ru-arene Complexes for Antitumor Drugs


Wei Su, Yuchun Li and Peiyuan Li*


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Chemokines and Relevant microRNAs in the Atherogenic Process


Dimitry A Chistiakov, Alexander N Orekhov and Yuri V Bobryshev*


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Bone Degeneration, Inflammation and Secondary Complications of Arthritis: Potential Targets and their Natural Inhibitors


Mahadevappa Hemshekhar, Ram M. Thushara, Somanatahpura K. NaveenKumar, Paul Manoj, Mahalingam S. Sundaram, Kempaiah Kemparaju and Kesturu S. Girish


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An Overview on Application of Natural Substances Incorporated with Electrospun Nanofibrous Scaffolds to Development of Innovative Wound Dressings


Nosratollah Zarghami, Roghayeh Sheervalilou, Amir Fattahi, Abbas Mohajeri, Mehdi Dadashpour and Younes Pilehvar-Soltanahmadi


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Imidazole: An Essential Edifice for the Identification of New Lead Compounds and Drug Development


Nishtha Shalmali, Md. Rahmat Ali and Sandhya Bawa


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Promises of Machine Learning Approaches in Prediction of Absorption of Compounds


Rajnish Kumar, Anju Sharma, Mohammed Haris Siddiqui and Rajesh Kumar Tiwari*


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Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016


G. Chawla, B. Naaz and A. A. Siddiqui


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Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin


Solomon Habtemariam and Abebech Belai


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Some Important Dietary Polyphenolic Compounds: An Anti-inflammatory and Immunoregulatory Perspective


Mayank Kinger, Sushil Kumar and Vinod Kumar


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Ellagitannins: Bioavailability, Purification and Biotechnological Degradation


Pedro Aguilar-Zárate, Jorge E. Wong-Paz, Juan J. Buenrostro-Figueroa, Juan A. Ascacio, Juan C. Contreras-Esquivel and Cristóbal N. Aguilar


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Aryl Butenes Active against K562 Cells and Lacking Tyrosinase Inhibitory Activity as New Leads in the Treatment of Leukemia


Mehdi El Arbi, Emna Ketata, Aref Neifar, Wafa Mihoubi, Girish K. Gupta, Pascal Pigeon, Siden Top, Ali Gargouri and Gérard Jaouen


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Microbe-bio-Chemical Insight: Reviewing Interactions between Dietary Polyphenols and Gut Microbiota


Rishi Mahajan, Gunjan Goel and Sampan Attri


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Facile and Solvent-free Domino Synthesis of New Quinolidinyl-2,4- thiazolidinones: Antifungal Activity and Molecular Docking


Dnyaneshwar D. Subhedar, Mubarak H. Shaikh, Santosh G. Tupe, Mukund V. Deshpande, Vijay M. Khedkar, Prakash C. Jha and Bapurao B. Shingate


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Semantic Dementia: A Mini-Review


Blanka Klimova, Michal Novotny and Kamil Kuca


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Drug Discovery for Paediatric Chagas Disease


Sreekanth Thota and Carlos M. Morel


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Natural Products as a Source of Antiarrhythmic Drugs


Arkadiy O. Bryzgalov, Tatjana G. Tolstikova, Elvira E. Shults and Kristina O. Petrova


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Redox-Active Selenium in Health and Disease: A Conceptual Review


Boguslaw Lipinski


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Structural Modifications of Matrine-Type Alkaloids


Xiao-hua Cai, Hui Guo and Bing Xie


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Process Variables and Design of Experiments in Liposome and Nanoliposome Research


Alaleh Zoghi, Kianoush Khosravi-Darani and Abdelwahab Omri


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Elucidation of The Chromatographic Enantiomer Elution Order Through Computational Studies


Roccaldo Sardella, Federica Ianni, Antonio Macchiarulo, Lucia Pucciarini, Andrea Carotti and Benedetto Natalini


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Recent Process in the Inhibitors of UDP-3-O-(R-3-hydroxyacyl)-Nacetylglucosamine Deacetylase (LpxC) Against Gram-Negative Bacteria


Fang Liu and Shutao Ma


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Chemoprevention of Bladder Cancer: A Mini Review


N Rezakahn Khajeh, C Khoyilar, Y Wu, K Spradling, X Zi and RF Youssef


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A Comprehensive Review on the Biological and Pharmacological Activities of Rhodanine Based Compounds for Research and Development of Drugs


Jiachun Liu, Yan-Ling Wu, Huri Piao, Xiaoyin Zhao, Wen Zhang, Yanli Wang and Minrui Liu


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Phyto-glycosides as therapeutic target in the treatment of diabetes


Haroon Khan and Sumaira Khattak


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Tuberculosis and its Treatment: An Overview


Ranju Bansal, Deepika Sharma and Ranjit Singh


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Small Molecular as SIRT Modulators


Lei Yao, Xiangming Xu and Kai Chen


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A Review of Molecular Predictors of Response to Neoadjuvant Chemotherapy in Muscle-invasive Bladder Cancer


Stephan Degener, Douglas A. Mata, Ramy Youssef, Daniel Gödde, Zafer Tandogdu, Stephan Roth and Friedrich-Carl von Rundstedt


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A Review on Role of the Calcium Sensitive Inotropic Agent, Levosimendan and Its Metabolites


Mohammad Asif


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Arginine Deiminase Enzyme Evolving As A Potential Antitumor Agent


Rakesh Somani and Pratip K. Chaskar


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A Global View on Narcolepsy – A Review Study


Blanka Klimova, Petra Maresova, Michal Novotny and Kamil Kuca


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Synthetic and Natural Lipase Inhibitors


Ewa Białecka-Florjańczyk, Agata Urszula Fabiszewska, Jolanta Krzyczkowska and Alina Kuryłowicz


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21-hydroxy-6,19-epoxyprogesterone: a Promising Therapeutic Agent and a Molecular Tool for Deciphering Glucocorticoid Action


Adali Pecci, Lautaro D. Alvarez, Diego M. Presman and Gerardo Burton


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A Review on Pharmacological properties of Coumarins


Devulapally Srikrishna, Chandraiah Godugu and Pramod Kumar Dubey


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Recent Advances in the Discovery of HIF- 1α/p300 Inhibitors as Anti-cancer Agents


Jinlian Wei, Yingrui Yang, Mengchen Lu, Yonghua Lei, Lili Xu, Zhengyu Jiang, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Qidong You and Haopeng Sun


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Inosine 5’-Monophosphate Dehydrogenase (IMPDH) as a Potential Target for the Development of a New Generation of Antiprotozoan Agents


Jean Fotie


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Development of Amino Acid-Based Radiopharmaceuticals for Tumor Imaging


Junbo Zhang


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Antibacterial and Antibiofilm Potentials of Marine Pyrrole-2-aminoimidazole Alkaloids and Their Synthetic Analogs


Marina Gjorgjieva, Lucija Peterlin Mašič and Danijel Kikelj


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Prognostic Implications of Immunohistochemical Biomarkers in Non-Muscle-Invasive Bladder Cancer and Muscle-Invasive Bladder Cancer


Martin Boegemann and Laura-Maria Krabbe


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Tailored Mesoporous Silica Nanoparticles for Controlled Drug Delivery: Platform Fabrication, Targeted Delivery, and Computational Design and Analysis


Xiaodong She, Lijue Chen, Zhifeng Yi, Chengpeng Li, Canzhong He, Chunfang Feng, Tao Wang, Sarah Shigdar, Wei Duan and Lingxue Kong


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Controversies Related to Diabetes and Risk of Bladder Cancer


Kyle Spradling and Ramy F. Youssef


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