E-Pub Articles Ahead of Print ::: Medicinal Chemistry

ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)


Volume 13, 8 Issues, 2017


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Medicinal Chemistry

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Editor-in-Chief:
Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece


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Articles Ahead of Print

Synthesis, Cytotoxicity Evaluation, Molecular Docking and Utility of Novel Chalcones as Precursors for Heterocycles Incorporating Pyrazole Moiety


Sobhi M. Gomha*, Magda A. Abdallah, Ikhlass M. Abbas and Mariam S.H. Kazem


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Anthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes


Humera Jahan*, Muhammad Iqbal Choudhary, Amber Atta, Khalid Mohammad Khan and Atta-ur- Rahman


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Vitamins Based Novel Target Pathways/Molecules as Possible Emerging Drug Targets for the Management of Tuberculosis


Abha Sharma, Keert Jain and Swaran J.S. Flora*


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Design, Synthesis, and Evaluation of (2-(Pyridinyl)methylene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity


Maya Z. Gibson, Minh A. Nguyen and Sarah K. Zingales*


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Synthesis, Structure and Antiproliferative Activity of New pyrazolo[4,3- e]triazolo[4,5-b][1,2,4]triazine Derivatives


Mariusz Mojzych*, Pawel Tarasiuk, Zbigniew Karczmarzyk, Malgorzata Juszczak, Wojciech Rzeski, Andrzej Fruziński and Artur Wozny


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9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one is a Potentially Novel Antiplatelet Drug which Antagonizes the Effect of Thromboxane A2


Lenka Applova, Elma Veljovic, Samija Muratovic, Jana Karlickova, Katerina Macakova, Davorka Završnik, Luciano Saso, Kemal Duric and Premysl Mladenka*


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The Quantum Chemical and QSAR Studies on Acinetobacter Baumannii Oxphos Inhibitors


Hakan Sezgin Sayiner*, Afaf A.S. Abdalrahm, Murat A. Başaran, Vasyl Kovalishyn and Fatma Kandemirli*


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Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity


Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino


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Efficient One-Pot Access to Trisubstituted 2-Benzazepin-3-ones as Constrained Pseudopeptide Analogues and Privileged Scaffolds


Olivier Van der Poorten, Mouhamad Jida*, Dirk Tourwé and Steven Ballet


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Synthesis, β-catenin Translocation Capability and ALP Activation Activity of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives


Shicheng Hou , Henan Xu , Jianshu Hu , Jian Hou , Yan Wang , Zhe Jin , David C.C. Wan and Chun Hu*


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14-Formyl-15-aryloxy/methoxymatrine and 14-Aryloxymethylidenylmatrine Derivatives as Anti-HIV-1 Agents


Jiulin Huang, Si-Ying Xiang, Min Lv, Liu-Meng Yang, Yuanyuan Zhang, Yong-Tang Zheng and Hui Xu*


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USP7: Target Validation and Drug Discovery for Cancer Therapy


Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen and Hongbin Sun


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Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora


Rita Morigi, Beatrice Vitali, Cecilia Prata, Rogers A.Ñ. Palomino, Alessandra Graziadio, Alessandra Locatelli, Mirella Rambaldi and Alberto Leoni*


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Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt’s Lymphoma


Andrew J. Byrne, Sandra A. Bright, Darren Fayne, James P. McKeown, Thomas McCabe, Brendan Twamley, Clive Williams and Mary J. Meegan*


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Quinoline Fluorescent Probes for Zinc – from Diagnostic to Therapeutic Molecules in Treating Neurodegenerative Diseases


Barbara Czaplińsk, Ewelina Spaczyńska and Robert Musioł*


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New Perspectives of Alzheimer Disease Diagnosis – the Most Popular and Future Methods


Katarzyna Pietrzak, Kamila Czarnecka, Elżbieta M ikiciuk-Olasik and Paweł Szymański*


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The Role of Vitamin D in Multiple Sclerosis: Biology & Biochemistry, Epidemiology and Potential Roles in Treatment


Steve Simpson Jr*, Ingrid van der Mei and Bruce Taylor


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Scaffold Hopping Strategy for the Design, Synthesis and Biological Activity Evaluation of Novel Hexacyclic Scutellarein Derivatives with a 1,3-Oxazine Ring Fused at A-ring


Yue Zhong , Yu-Ting Lu, Ying Sun, Nian-Guang Li, Ting Gu, Wen-Yu Wu, Shao-Peng Yu and Zhi-Hao Shi *


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An Update on the Role of Matrix Metalloproteinases in the Pathogenesis of Multiple Sclerosis


Marina Boziki* and Nikolaos Grigoriadis


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Myelin Oligodendrocyte Glycoprotein and Multiple Sclerosis


Maria-Eleni Androutsou, Anthi Tapeinou, Alexios Vlamis-Gardikas and Theodore Tselios*


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Is There a Link between Vitamin B and Multiple Sclerosis?


Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch and Vasso Apostolopoulos*


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Managing Neuropathic Pain in Multiple Sclerosis: Pharmacological Interventions


Samuel S. Duffy*, Justin G. Lees, Chamini J. Perera and Gila Moalem-Taylor


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Therapeutic Monoclonal Antibodies and Multiple Sclerosis: The Essentials


Ioannis Heliopoulos* and Athanasia Patousi


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Identification of 1-Aryl-1H-1,2,3-triazoles as Potential New Antiretroviral Agents


Daniel T.G. Gonzaga, Thiago M.L. Souza, Viviane M.M. Andrade, Vitor F. Ferreira and Fernando de C. da Silva*


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Drug Design, Synthesis and in vitro Evaluation of Substituted Benzofurans as Hsp90 Inhibitors


Sundeep Kadasi, Thadeu E. M.M. Costa, Neha Arukala, Mallika Toshakani, Chaitanya Duggineti, Sreekanth Thota, Sayan Dutta Gupta, Shiva Raj, Carmen Penido, Maria G Henriques and Nulgumnalli Manjunathaiah Raghavendra*


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1,1'-Carbonyldiimidazole (CDI) Mediated Facile Synthesis, Structural Characterization, Antimicrobial Activity, and in-silico Studies of Coumarin- 3-carboxamide Derivatives


Uzma Salar*, Khalid Mohammed Khan, Muhammad Imran Fakhri, Shafqat Hussain, Saima Tauseef, Shagufta Ameer, Abdul Wadood, Huma Khan and Shahnaz Perveen


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Biology-Oriented Synthesis (BIOS) of Piperine Derivatives and their Comparative Analgesic and Antiinflammatory Activities


Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar and Khalid Mohammed Khan*


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Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[ 1,2-a]quinoxalines


Alexia Jonet, Jean Guillon, Catherine Mullié, Anita Cohen, Guillaume Bentzinger, Jérémy Schneider, Nicolas Taudon, Sebastien Hutter, Nadine Azas, Stephane Moreau, Solene Savrimoutou, Patrice Agnamey, Alexandra Dassonville-Klimpt and Pascal Sonnet*


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Cell Cycle Arrest and Apoptosis Induction Activity of Nitidine Chloride on Acute Myeloid Leukemia Cells


Peng Li, Shuxin Yan, Xin Dong, Zhao Li, Yu Qiu, Chunyan Ji, Jingru Zhang, Min Ji, Wei Li, Hongchun Wang, Zhi Liu, Xing Li Wang, Jingjing Ye and Daoxin Ma*


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Evaluation of 1,3-benzoxathiol-2-one Derivatives as Potential Antifungal Agents


Luciana Terra, Eliza de L. Chazin, Paola de S. Sanches, Max Saito, Marcus V.N. de Souza, Claudia R.B. Gomes, James L. Wardell, Solange M.S.V. Wardell, Plínio C. Sathler, Gabriela C.C. Silva, Viviane O. Lione, Marcos Kalil, Ana Joffily, Helena C. Castro and Thatyana R.A. Vasconcelos*


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Quinolinic Carboxylic Acid Derivatives as Potential Multi-target Compounds for Neurodegeneration: Monoamine Oxidase and Cholinesterase Inhibition


Nehal Afreen Khan, Imtiaz Khan, Syed Mobasher Ali Abid, Sumera Zaib, Aliya Ibrar, Hina Andleeb, Shahid Hameed and Jamshed Iqbal*


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