E-Pub Articles Ahead of Print ::: Current Medicinal Chemistry

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 24, 42 Issues, 2017


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Current Medicinal Chemistry

This journal supports open access

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  • 16th of 60 in Chemistry & Medicinal

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


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Articles Ahead of Print

Metallic Nanoclusters for Cancer Imaging and Therapy


Qing Zhang, Mingying Yang, Ye Zhu and Chuanbin Mao


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Diagnostic Devices for Circulating Biomarkers Detection and Quantification


Chiara Bedin*, Sara Crotti, Ennio Tasciotti and Marco Agostini


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Diet and Contaminants: Driving the Rise to Obesity Epidemics?


Agostino Di Ciaula and Piero Portincasa*


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Molecular Mechanisms Triggered by Bile Acids on Intestinal Ca2+ Absorption


Ana Marchionatti , Maria Rivoira, Valeria Rodriguez, Adriana Perez and Nori Tolosa de Talamoni*


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Metallodrugs in Targeted Cancer Therapeutics. Aiming at Chemoresistance- related Patterns and Immunosuppressive Tumor Networks


Athanasios Salifoglou*, Savvas Petanidis and Efrosini Kioseoglou


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New Treatments for Allergy: Advances in Peptide Immunotherapy


David Calzada , Selene Baos , Lucia Cremades and Blanca Olombrada Cardaba *


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G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets


Katrina N. Estep*, Thomas J . Butler, Jun Ding and Robert M. Brosh


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The Validation Path of Hypoxia PET Imaging: Focus on Brain Tumours


Natale Quartuccio* and Marie-Claude Asselin


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Obsessive-compulsive Disorder with Comorbid Bipolar Disorders: Clinical Features and Treatment Implications


Federico Mucci*, Cristina Toni, Ettore Favaretto, Giulia Vannucchi, Donatella Marazziti and Giulio Perugi


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Electrochemical MIP-Sensors for Drugs


Aysu Yarman*, Sevinc Kurbanoglu, Katharina J. Jetzschmann, Sibel A. Ozkan, Ulla Wollenberger and Frieder Scheller


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Overview on Anticancer Drug Design and Development


Sureyya Olgen*


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Catestatin: A Master Regulator of Cardiovascular Functions


Sushil K. Mahata*, Malapaka Kiranmayi and Nitish R. Mahapatra


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Biodegradable Black Phosphorus-based Nanomaterials in Biomedicine: Theranostic Applications


Zhen Wang, Zhiming Liu, Chengkang Su, Biwen Yang, Xixi Fei, Yi Li, Yuqing Hou, Henan Zhao, Yanxian Guo, Zhengfei Zhuang*, Huiqing Zhong and Zhouyi Guo*


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Potential Triazole-based Molecules for the Treatment of Neglected Diseases


Susimaire Pedersoli Mantoani, Peterson de Andrade, Talita Perez Cantuaria Chierrito, Andreza Silva Figueredo and Ivone Carvalho*


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Recent Advances in Peptide-Based Approaches for Cancer Treatment


Anne C. Conibear, Alanca Schmid, Meder Kamalov, Christian F.W. Becker and Claudia Bello*


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Electrochemical Nucleic Acid-Based Biosensing of Drugs of Abuse and Pharmaceuticals


Susana Campuzano, Maia Pedrero* and Jose M. Pingarron


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Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays


Lucie Korecka*, Karel Vytras and Zuzana Bilkova


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High-Throughput Screening Strategies for the Development of Anti- Virulence Inhibitors Against Staphylococcus aureus


Xiaodan Cai, Weihao Zheng and Zigang Li*


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Recent Progress of Crosslinking Strategies for Polymeric Micelles with Enhanced Drug Delivery in Cancer Therapy


Wei Fan, Luye Zhang, Yiwen Li and Haoxing Wu*


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Recent Advances and Challenges in Steroid Metabolomics for Biomarker Discovery


Alicja Kotlowska* and Piotr Szefer


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The Glutamate and the Immune Systems: New Targets for the Pharmacological Treatment of OCD


Donatella Marazziti*, Umberto Albert, Federico Mucci and Armando Piccinni


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Recent Developments on Phenstatins as Potent Antimitotic Agents


Xing Chen , Shi-Meng Wang , Gajjela Bharath Kumar, Grant A. L. Bare, Jing Leng, Syed Nasir Abbas Bukhari* and Hua-Li Qin*


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Antimicrobial Peptides of Marine Crustaceans: The Potential and Challenges of Developing Therapeutic Agents


Negar Talaei Zanjani , Monica Miranda-Saksena , Anthony L. Cunningham and Fariba Dehghani *


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New Molecular Targets and Strategies for Antimalarial Discovery


Anna Caroline Aguiar, Lorena R. F. de Sousa, Celia R. S. Garcia, Glaucius Oliva and Rafael V. C. Guido*


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Hairy Root Cultures for the Production of Anti-cancer Naphthoquinone Compounds


Małgorzata Jeziorek, Katarzyna Sykłowska-Baranek* and Agnieszka Pietrosiuk


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Inflammatory Biomarkers in Atrial Fibrillation


Effimia Zacharia, Nikolaos Papageorgiou*, Adam Ioannou, Gerasimos Siasos, Manolis Vavuranakis, George Latsios, Charalampos Vlachopoulos, Konstantinos Toutouzas, Spyridon Deftereos, Rui Providência and Dimitris Tousoulis


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Next Generation Antineoplastic Agents: A Review on Structurally Modified Vinblastine (VBL) Analogues


Ashanul Haque , Md. Ataur Rahman , Md. Serajul Haque Faizi and Muhammad S. Khan*


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Fluorescein-Inspired Near-Infrared Chemodosimeter for Luminescence Bioimaging


Hai-Yan Wang, Huisheng Zhang, Siping Chen* and Yi Liu


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Biomarkers of Atrial Fibrillation in Hypertension


Costas Tsioufis*, Dimitrios Konstantinidis, Elias Nikolakopoulos, Evi Vemou, Theodoros Kalos, Georgios Georgiopoulos, Nikos Vogiatzakis, Aristos Ifantis, Konstantinos Konstantinou, V. Gennimata and Dimitris Tousoulis


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Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases


Ana Cristina Lima Leite*, José Wanderlan Pontes Espíndola, Marcos Veríssimo de Oliveira Cardoso and Gevanio Bezerra de Oliveira Filho


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Modern Approach to Medical Diagnostics - the Use of Separation Techniques in Microorganisms Detection


Agnieszka Chylewska*, Malgorzata Ogryzek and Mariusz Makowski


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An Update on Potential Molecular Mechanisms Underlying the Actions of Snake Venom L-amino Acid Oxidases (LAAOs)


Mauro Valentino Paloschi , Adriana Silva Pontes , Andreimar Martins Soares and Juliana Pavan Zuliani *


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Optical Sensors for Detection of Amino Acids


Aafrin M. Pettiwala and Prabhat K. Singh*


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Spirolactones: Recent Advances in Natural Products, Bioactive Compounds and Synthetic Strategies


Arianna Quintavalla*


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Ligand and Structure-based Modeling of Passive Diffusion through the Blood-Brain Barrier


Santiago Vilar*, Eduardo Sobarzo-Sánchez, Lourdes Santana and Eugenio Uriarte


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SIRT1 as a Therapeutic Target in Diabetic Complications


Justyna Strycharz , Żaneta Rygielska , Ewa Świderska , Józef Drzewoski , Janusz Szemraj , Leszek Szmigiero and Agnieszka Śliwińska *


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Cysteine-rich Proteins for Drug Delivery and Diagnosis


Guang Yang, Yue Lu, Hunter N. Bomba and Zhen Gu*


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Endothelial and Circulating Progenitor Cells in Hematological Diseases and Allogeneic Hematopoietic Stem Cell Transplantation


Annalisa Ruggeri*, Annalisa Paviglianiti, Fernanda Volt, Chantal Kenzey, Hanadi Rafii, Vanderson Rocha and Eliane Gluckman


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Hyphenated Mass Spectrometry Techniques in the Diagnosis of Amyloidosis


Marta Spodzieja, Sylwia Rodziewicz-Motowidło and Aneta Szymanska*


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Peptides and their Metal Complexes in Neurodegenerative Diseases: from Structural Studies to Nanomedicine Prospects


Giuseppe Trapani, Cristina Satriano* and Diego La Mendola


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Benzothiazole-based Compounds in Antibacterial Drug Discovery


Marina Gjorgjieva, Tihomir Tomašič, Danijel Kikelj and Lucija Peterlin Masic*


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Autologous Cell Therapy for Vascular Regeneration: The Role of Proangiogenic Cells


Vanessa Bianconi, Francesca Fallarino, Massimo Raffaele Mannarino, Francesco Bagaglia, Meisam Naeimi Kararoudi, Caterina Oriana Aragona, Rita Romani and Matteo Pirro*


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Nanotechnology in Personalized Medicine: A Promising Tool for Alzheimer’s Disease Treatment


Laura de Matteis, Rafael Martin-Rapun and Jesus M De la Fuente*


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Click Reactions in Chemistry of Triterpenes – Advances Towards Development of Potential Therapeutics


Jan Pokorný , Lucie Borková and Milan Urban*


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The Use of Naphthoquinones and Furano-naphthoquinones as Antiinvasive Agents


Nga Yi Tsang, Wai I Chik, Lai Pan Sze, Siu Wai Tsang and Hongjie Zhang*


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Collagenolytic Enzymes and their Applications in Biomedicine


Anatoly Borisovich Shekhter*, Anastasia V. Balakireva, Natalia V. Kuznetsova, Marina N. Vukolova, Petr F. Litvitsky and Andrey A. Zamyatnin


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Potential of Plant-sourced Phenols for Inflammatory Bowel Disease


Hai-tao Xiao, Bo Wen, Xiang-Chun Shen and Zhao-xiang Bian*


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Metabolomics and Heart Diseases: From Basic to Clinical Approach


Ignasi Barba*, Mireia Andres and D Garcia Dorado


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Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry


Arlette Yumba Mpanga, Wiktoria Struck-Lewicka, Renata Bujak, Marcin Markuszewski, Marek Roslan, Roman Kaliszan and Michał Jan Markuszewski*


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Recent Applications of Silver Amalgam Electrodes for Analysis of Pharmaceuticals and Vitamins


Sylwia Smarzewska, Radovan Metelka*, Bogusław Baś and Karel Vytřas


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Virome and Inflammasomes, a Finely Tuned Balance with Important Consequences for the Host Health


Giulia Freer, Fabrizio Maggi and Mauro Pistello*


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Recent Developments in the Separation of Low Molecular Weight Heparin Anticoagulants


Radosław Sadowski, Renata Gadzała-Kopciuch* and Bogusław Buszewski


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Platelet Oxidative Stress and its Relationship with Cardiovascular Diseases in Type 2 Diabetes Mellitus Patients


Mohammed El Haouari*


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Electronic Noses in Medical Diagnostics


Wojciech Wojnowski*, Anna Partyka, Tomasz Dymerski, Jacek Gębicki and Jacek Namieśnik


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Biomarkers of Alcohol Consumption in Body Fluids - Possibilities and Limitations of Application in Toxicological Analysis


Mateusz K. Woźniak*, Marek Wiergowski, Jacek Namieśnik and Marek Biziuk


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Recent Research Trends on Bismuth Compounds in Cancer Chemoand Radiotherapy


Mateusz Kowalik, Joanna Masternak and Barbara Barszcz*


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Gaultheria Ethnobotany and Bioactivity: Blueberry Relatives with Anti- inflammatory, Antioxidant, and Anticancer Constituents


Bin-sheng Luo, Rong-hui Gu, Edward J. Kennelly* and Chunlin Long


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Circulating MicroRNAs: Valuable Biomarkers for the Diagnosis and Prognosis of Gastric Cancer


Najibeh Shekari , Behzad Baradaran , Dariush Shanehbandi and Tohid Kazemi*


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Exposing “Bright” Metals: Promising Advances in Photoactivated Anticancer Transition Metal Complexes


Aleksandra Bjelosevic, Benjamin J. Pages, Lawson K. Spare, Krishant M. Deo, Dale L. Ang and Janice R. Aldrich-Wright*


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Polyphenols in Food: Cancer Prevention and Apoptosis Induction


Ashita Sharma, Mandeep Kaur, Jatinder Kaur Katnoria and Avinash Kaur Nagpal*


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Influenza Virus: Small Molecule Therapeutics and Mechanisms of Antiviral


Julianna Han, Jasmine Perez, Adam Schafer, Han Cheng, Norton Peet, Lijun Rong and Balaji Manicassamy*


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Structural Design and Physicochemical Foundations of Hydrogels for Biomedical Applications


Qingyong Li , Wen Li , Jie Xu, Zhengxiang Ning, Jiaoyan Ren* and Wenzhen Liao*


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Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity


Maricela Viola-Rhenals*, Kush Rohit Patel, Laura Jaimes-Santamaria, Guojun Wu, Jinbao Liu and Q Ping Dou


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Development of Potential Small Molecule Therapeutics for Treatment of Ebola Virus


Adam Michael Schafer, Han Cheng, Charles Lee, Ruikun Du, Julianna Han, Jasmine Perez, Norton Peet, Balaji Manicassamy and Lijun Rong*


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Sunitinib in the Treatment of Thyroid Cancer


Ferrari Silvia Martina, Centanni Marco, Virili Camilla, Miccoli Mario, Ferrari Paola, Ruffilli Ilaria, Ragusa Francesca, Antonelli Alessandro* and Fallahi Poupak


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Smart Organic-Inorganic Nanogels for Activatable Theranostics


Fangyuan Li, Zeyu Liang and Daishun Ling*


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Old Drugs and New Targets as an Outlook for the Treatment of Tuberculosis


Jan Zitko* and Martin Doležal


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Molecular Mechanisms of Epigenetic Regulators as Activatable Targets in Cancer Theranostics


Yinglu Li*, Zhiming Li and Wei-Guo Zhu*


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Protective Effects of the Caffeine Against Neurodegenerative Diseases


Ester Tellone*, Antonio Galtieri, Annamaria Russo and Silvana Ficarra


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Rutin as Neuroprotective Agent: From Bench to Bedside


Barbara Budzynska, Caterina Faggio, Marta Kruk-Slomka, Dunja Samec, Seyed Fazel Nabavi, Antoni Sureda, Kasi Pandima Devi and Seyed Mohammad Nabavi*


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Pharmacotranscriptomic Biomarkers in Glucocorticoid Treatment of Pediatric Inflammatory Bowel Disease


Marianna Lucafò, Biljana Stankovic, Nikola Kotur, Alessia Di Silvestre, Stefano Martelossi, Alessandro Ventura, Branka Zukic, Sonya Pavlovic* and Giuliana Decorti


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Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines


Resmi C Panicker, Anthony G. Coyne and Rajavel Srinivasan*


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Role of Positron Emission Tomography for Central Nervous System Involvement in Systemic Autoimmune Diseases: Status and Perspectives


Daniele Mauro *, Gaetano Barbagallo , Salvatore D’Angelo, Sannino Pasqualina, Saverio Naty , Caterina Bruno, Ignazio Olivieri , Rosa Daniela Grembiale and Francesco Ursini


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Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites


Francesco Miceli, Maria Virginia Soldovieri, Paolo Ambrosino, Laura Manocchio, Alessandro Medoro, Ilaria Mosca and Maurizio Taglialatela*


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Pathophysiological Role of Mitochondrial Potassium Channels and their Modulation by Drugs


Valentina Citi, Vincenzo Calderone, Alma Martelli, Maria Cristina Breschi and Lara Testai*


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The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-obesity Effect


Qiu Jin , Huahua Yu and Pengcheng Li *


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The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations


Anutthaman Parthasarathy, Sasikala K. Anandamma and Karunakaran A. Kalesh*


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Biomarkers of Atrial Fibrillation in Metabolic Syndrome


Christos Georgakopoulos, Charalambos Vlachopoulos*, Georgios Lazaros and Dimitris Tousoulis


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The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes


Stefano Palazzolo, Samer Bayda, Mohamad Hadla, Isabella Caligiuri, Giuseppe Corona, Giuseppe Toffoli and Flavio Rizzolio*


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Hemicellulose from Plant Biomass in Medical and Pharmaceutical Application: A Critical Review


Xinxin Liu, Qixuan Lin, Yuhuan Yan, Fenf Peng, Runcang Sun and Junli Ren*


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Endocytosis of Nanoscale Systems for Cancer Treatments


Kai Chen, Xue Li, Hongyan Zhu, Qiyong Gong and Kui Luo*


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Improving Metabolic Control Through Functional Foods


John G. Jones* and Joao C.P. Silva


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Effects of Isolated Isoflavones Intake on Health


Antonella Smeriglio*, Antonella Calderaro, Marcella Denaro, Giuseppina Laganà and Ersilia Bellocco


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Current Progress of Lipid Analysis in Metabolic Diseases by Mass Spectrometry Methods


Adriana Mika*, Tomasz Sledzinski and Piotr Stepnowski


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Recent Advances in the Development of Pharmaceutical Agents for Metabolic Disorders: A Computational Perspective


Sridhara Janardhan, Varvara Dubovskaja, Alexey Lagunin, Venkateswara Rao, Narahari Sastry and Vladimir Poroikov*


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Cannabis Phenolics and their Bioactivities


Federica Pollastro*, Alberto Minassi and Luigia Grazia Fresu


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Phenolic Compounds from Edible Algae: Bioactivity and Health Benefits


Lidia Montero , Andrea del Pilar Sánchez-Camargo, Elena Ibáñez* and Bienvenida Gilbert-López


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Gut Microbiota as a Therapeutic Target for Metabolic Disorders


Hirofumi Okubo , Yusuke Nakatsu, Akifumi Kushiyama , Takeshi Yamamotoya , Yasuka Matsunaga , Masa-ki Inoue, Midori Fujishiro, Hideaki Sakoda , Haruya Ohno , Masayasu Yoneda, Hiraku Ono and Tomoichiro Asano *


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Circulating Stem/Progenitor Cells as Prognostic Biomarkers in Macro- and Microvascular Disease a Narrative Review of Prospective Observational Studies


Mauro Rigato and Gian Paolo Fadini*


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Modulation of ABC Transporters by Nuclear Receptors: Physiological, Pathological and Pharmacological Aspects


Juan Pablo Rigalli, Guillermo Nicolás Tocchetti and Johanna Weiss*


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Structure-based Approaches Targeting Parasite Cysteine Proteases


Rafael Pinto Vieira, Viviane Corrêa Santos and Rafaela Salgado Ferreira*


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Anesthetic Agents and Neuronal Autophagy. What We Know and What We Don’t.


Lili Xu , Jianjun Shen , Patrick M. McQuillan and Zhiyong Hu *


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Recent Advances and Perspectives in Liposomes for Cutaneous Drug Delivery


Amanda C. Caritá , Josimar O. Eloy , Marlus Chorilli, Robert J. Lee and Gislaine Ricci Leonardi*


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Bisphenol A in Reproduction: Epigenetic Effects


Rosanna Chianese, Jacopo Troisi, Sean Richards, Marika Scafuro , Silvia Fasano, Maurizio Guida , Riccardo Pierantoni and Rosaria Meccariello*


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Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients


Paola Savoia*, Elisa Zavattaro and Ottavio Cremona


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Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy


Aleksandra Hecel, Paulina Kolkowska, Karolina Krzywoszynska, Agnieszka Szebesczyk, Magdalena Rowinska-Zyrek and Henryk Kozlowski*


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Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose


Zhentao Huang, Qingxin Yao, Simin Wei, Jiali Chen and Yuan Gao*


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Organic Nanotheranostics for Photoacoustic Imaging-Guided Phototherapy


Houjuan Zhu , Chen Xie , Peng Chen and Kanyi Pu*


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Protozoan Parasites Glycosylphosphatidylinositol Anchors: Structures, Functions and Trends for Drug Discovery


Ana Luísa Malaco Morotti, Maristela Braga Martins-Teixeira and Ivone Carvalho*


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Role of Infrared Spectroscopy and Imaging in Cancer Diagnosis


Saroj Kumar *, Alagiri Srinivasan and Fredrik Nikolajeff


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New Drugs from Old Natural Compounds: Scarcely Investigated Sesquiterpenes as New Possible Therapeutic Agents


Stefania Suta, Filippo Maggi, Marcello Nicoletti, Valeria Baldan and Stefano Dall`Acqua*


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ATP-binding Cassette Exporters: Structure and Mechanism with a Focus on P-glycoprotein and MRP1


Maite Rocío Arana and Guillermo Altenberg*


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The Renal Outer Medullary Potassium Channel (ROMK): An Intriguing Pharmacological Target for an Innovative Class of Diuretic Drugs


Vincenzo Calderone*, Alma Martelli, Eugenia Piragine, Valentina Citi, Lara Testai and Maria Cristina Breschi


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Fighting Type-2 Diabetes: Present and Future Perspectives


Cai-Guo Yu , Ying Fu, Yuan Fang , Ning Zhang, Rong-Xin Sun , Dong Zhao, Ying-Mei Feng and Bao-Yu Zhang*


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Biological Therapy of Hematologic Malignancies: Toward a Chemotherapy- free Era


Pavel Klener*, Tomas Etrych and Pavel Klener


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Multicolorful Carbon Dots for Tumor Theranostics


Haitao Wang, Jingran Bi, Beiwei Zhu and Mingqian Tan*


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Nanoscale Functional Biomaterials for Cancer Theranostics


Linying Liu, Xiaoshuang Li, Lei Chen and Xin Zhang*


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Nutraceuticals and "Repurposed" Drugs of Phytochemical Origin in Prevention and Interception of Chronic Degenerative Disease and Cancer


Adriana Albini, Barbara Bassani, Denisa Baci, Katiuscia Dallaglio, Matteo Gallazzi, Paola Corradino, Antonino Bruno and Douglas Noonan*


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Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems


Xiao Sun, Guilong Zhang and Zhengyan Wu*


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From Ocean to Bedside: the Therapeutic Potential of Molluscan Hemocyanins


Negar Talaei Zanjani, Monica Miranda Saksena , Fariba Dehghani * and Anthony L. Cunningham *


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Polymer Conjugated Gold Nanoparticles in Biomedical Applications


Stanley Anniebell and Subash C.B. Gopinath


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Recent Advances in New Discovered Molecular Targets in Testicular Germ Cell Tumors


Paolo Chieffi*


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Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy


Qicai Xiao, Juan Wu , Xin Pang, Yue Jiang , Pan Wang, Albert Wingnang Leung, Liqian Gao , Sheng Jiang and Chuanshan Xu*


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In Vitro and In Vivo Experimental Model-based Approaches for Investigating Anti-inflammatory Properties of Coumarins


Silvana Virginia Gagliotti Vigil de Mello and Tânia Silvia Fröde *


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Cu2+ Biological Imaging Probes Based on Different Sensing Mechanisms


Jiawei Li, Fangjun Huo and Caixia Yin*


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Untargeted Metabolomics Provides Insight into the Mechanisms Underlying Resistant Hypertension


Renata Bujak, Arlette Yumba-Mpanga, Wiktoria Struck-Lewicka, Marta Kordalewska, Katarzyna Polonis, Małgorzata Patejko, Monika Mironiuk, Anna Szyndle, Marzena Chrostowska, Michał Hoffmann, Ryszard T. Smoleński, Roman Kaliszan, Krzysztof Narkiewicz and Michał J. Markuszewski*


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Amino Acid Degrading Enzymes and their Application in Cancer Therapy


Vadim S Pokrovsky*, Olga E Chepikova, Denis Zh Davydov, Andrey A Zamyatnin, Alexander N Lukashev and Elena V Lukasheva


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Bacterial Protein Mimetic of Peptide Hormone as a New Class of Protein- based Drugs


S. O. Fetissov*, Romain Legrand and Nicolas Lucas


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Steroidal Oximes: Useful Compounds with Antitumor Activities


Catarina Canário, Samuel Silvestre, Amílcar Falcão and Gilberto Alves*


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VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Target for Modulating Apoptosis


Varda Shoshan-Barmatz*, Yakov Krelin and Quan Chen


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Cardioprotective Potential of Iron Chelators and Prochelators


Hana Jansova and Tomas Simunek*


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MicroRNAs in Neuroblastoma: Biomarkers with Therapeutic Potential


Angela Galardi, Marta Colletti , Pietro Businaro , Concetta Quintarelli , Franco Locatelli and Angela Di Giannatale*


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Inflammation and Cancer: In Medio Stat Nano


Roberto Molinaro, Claudia Corbo, Megan Livingston, Michael Evangelopoulos, Alessandro Parodi, Christian Boada, Marco Agostini and Ennio Tasciotti*


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Endothelial Progenitor Cells at the Interface of Chronic Kidney Disease: From Biology to Therapeutic Advancement


Giuseppe Coppolino*, Valeria Cernaro, Giordano Placida, Giuseppe Leonardi, Giorgio Basile and Davide Bolignano


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Stem Cell Differentiation Stage Factors and their Role in Triggering Symmetry Breaking Processes during Cancer Development: A Quantum Field Theory Model for Reprogramming Cancer Cells to Healthy Phenotypes


Pier Mario Biava*, Fabio Burigana, Roberto Germano, Philip Kurian, Claudio Verzegnassi and Giuseppe Vitiello


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Pollution and Sun Exposure: A Deleterious Synergy. Mechanisms and Opportunities for Skin Protection


Laurent Marrot*


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Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations


Roman V Kholodenko*, Daniel V. Kalinovsky, Igor I Doronin, Eugene D Ponomarev and Irina V Kholodenko


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Histone Deacetylase Inhibitors in Tumor Immunotherapy


Li-Ming Zhao* and Jie-Huan Zhang


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Endothelial Progenitor Cells as Mediators of the Crosstalk between Vascular Repair and Immunity: Lessons from Systemic Autoimmune Diseases


Javier Rodríguez-Carrio*, Patricia López and Ana Suárez


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Tungsten or Wolfram: Friend or Foe?


Maria Antonietta Zoroddu*, Serenella Medici, Massimiliano Peana, Valeria Marina Nurchi, Joanna I. Lachowicz, F Laulicht-Glickc and Max Costa


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Hydrogel Dressings for Advanced Wound Management


Antonio Francesko, Petya Petkova and Tzanko Tzanov*


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Applications of Multi-Target Computer-Aided Methodologies in Molecular Design of CNS Drugs


Oleg A. Raevsky, Azat Mukhametov, Veniamin Y. Grigorev, Alexey Ustyugov, Shwu-Chen Tsay, Reuben Jih-Ru Hwu, Nagendra Sastry Yarla, George E. Barreto, Gjumrakch Aliev* and Sergey O Bachurin


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Mechanisms and Drug Targets for Pancreatic Cancer Chemoprevention


Deepanshi Dhar, Komal Raina and Rajesh Agarwal*


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Microwave-Induced Bismuth Salts-Mediated Synthesis of Molecules of Medicinal Interests


Debasish Bandyopadhyay*, Ashlee Chavez and Bimal K. Banik*


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Recent Advances in the Cancer Bioimaging with Graphene Quantum Dots


Keheng Li, Xinna Zhao, Gang Wei and Zhiqiang Su


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Biomarkers in Atrial Fibrillation and Heart Failure


Evangelos Oikonomou*, Theodoros Zografos, Georgios-Angelos Papamikroulis, Gerasimos Siasos , Georgia Vogiatzi , Panagiotis Theofilis, Alexandros Briasoulis, Spyridon Papaioannou, Manolis Vavuranakis, Vasiliki Gennimata and Dimitris Tousoulis


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The Role of Cannabinoid Receptors in Renal Diseases


Hélène François* and Lola Lecru


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Cancer Treatment by Using Traditional Chinese Medicine: Probing Active Compounds in Anti-multidrug Resistance During Drug Therapy


Jian-shu Lou, Ping Yao and Karl W.K. Tism*


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MicroRNAs in Atrial Fibrillation


Alexandros Briasoulis*, Shikha Sharma, Tesfaye Telila, Sagar Mallikethi-Reddy, Nikolaos Papageorgiou, Evangelos Oikonomou and Dimitris Tousoulis


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Anticancer and Reversing Multidrug Resistance Activities of Natural Isoquinoline Alkaloids and their Structure-activity Relationship


Zhi-Xing Qing, Jia-Lu Huang, Xue-Yi Yang, Jing-Hong Liu, Hua-Liang Cao, Feng Xiang, Pi Cheng and Jian-Guo Zeng*


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Perspectives of Plant Natural Products in Inhibition of Cancer Invasion and Metastasis by Regulating Multiple Signaling Pathways


Md Shahid Sarwar, Hong-Jie Zhang and Siu Wai Tsang*


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In Silico Models for Nanomedicine: Recent Developments


Pietro Mascheroni and Bernhard Aribo Schrefler*


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Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice


Annalisa Marcuzzi, Claudia Loganes, Claudio Celeghini and Giulio Kleiner*


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Oleuropein: Molecular Dynamics and Computation


Luigi Gentile, Nicola A. Uccella and Ganapathy Sivakumar*


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Repositioning Drugs for Rare Immune Diseases: Hopes and Challenges for a Precision Medicine


Erica Valencic, Alenka Smid, Ziga Jakopin, Alberto Tommasini and Irena Mlinaric-Rascan*


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TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis


Sally E. Dickinson and Georg T. Wondrak*


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Known Triterpenes and their Derivatives as Scaffolds for the Development of New Therapeutic Agents for Cancer


Gregorio Peron*, Giovanni Marzaro and Stefano Dall’Acqua


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Atrial Fibrillation: Biomarkers Determining Prognosis


Savas Mazaris, Gerasimos Siasos*, Evangelos Oikonomou, Vicky Tsigkou, Manolis Vavuranakis, Eleni Kokkou, Marina Zaromitidou, Georgios-Angelos Papamikroulis, Athanasios G Papavassiliou, Spyridon Papaioannou, Nikolaos Papageorgiou, George Latsios, Christodoulos Stefanadis and Dimitris Tousoulis


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Tyrosinase Electrochemical Biosensors Monitoring Medicinally Significant Substances


Milan Sýs and Karel Vytřas*


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Molecular Docking and Drug Discovery in β-Adrenergic Receptors


Santiago Vilar*, Eduardo Sobarzo-Sánchez, Lourdes Santana and Eugenio Uriarte


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The Battle for Iron Between Humans and Microbes


Peggy L. Carver*


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Biosensing Technologies for Therapeutic Drug Monitoring


Anna Meneghello, Stefano Tartaggia, Maria Domenica Alvau, Federico Polo* and Giuseppe Toffoli


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Transient Production of Recombinant Pharmaceutical Proteins in Plants: Evolution and Perspectives


Lilya Kopertekh* and Joachim Schiemann


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Chemistry in the Bioactivity of Chlorophylls: An Overview


Antonio Pérez-Gálvez , Isabel Viera and María Roca *


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Tackling Chronic Pain and Inflammation through the Purinergic System


Giulia Magni, Daniele Riccio and Stefania Ceruti*


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Recent Advances on Cellulose-Based Nano-Drug Delivery Systems: Design of Prodrugs and Nanoparticles


Lin Dai and Chuanling Si*


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Chronic Wounds: Innovations in Diagnostics and Therapeutics


Marieke Haalboom*


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Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management


Manee Patanaponpibul and Qiao-Hong Chen*


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Advances in the Prediction of Protein Aggregation Propensity


Irantzu Pallarès* and Salvador Ventura


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Clinical Approach to Diabetic Cardiomyopathy: A Review of Human Studies


Roberto Tarquini , Laura Pala , Simona Brancati , Giulia Vannini, Salvatore De Cosmo , Gianluigi Mazzoccoli* and Carlo Maria Rotella


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Review on Anti-Cancer Activity in Wild Plants of the Middle East


Einav Mayzlish-Gati, Marcelo Fridlender, Rameshprabu Nallathambi, Gopinath Selvaraj, Stalin Nadarajan and Hinanit Koltai*


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Lipid Oxidation Products in the Pathogenesis of Inflammation-related Gut Diseases


Barbara Sottero, Daniela Rossin, Giuseppe Poli and Fiorella Biasi*


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New Perspectives on Biomedical Applications of Iron Oxide Nanoparticles


Massimiliano Magro, Davide Baratella, Emanuela Bonaiuto, Jessica de Almeida Roger and Fabio Vianello*


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Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals


Mirjana B. Čolović, Vesna M. Vasić, Dragan M. Djuric and Danijela Z. Krstić*


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Pigment Epithelium-Derived Factor: A Novel Therapeutic Target for Cardiometabolic Diseases and Related Complications


Sho-ichi Yamagishi* and Takanori Matsui


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Anticancer Polyphenols from Cultured Plant Cells: Production and New Bioengineering Strategies


Victor Bulgakov*, Yulia V. Vereshchagina and Galina N. Veremeichik


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EPC Dysfunction and Immune Networks: Translating Opportunities for Clinical Setting in Personalized Medicine


Javier Rodríguez-Carrio*, Patricia López and Ana Suárez


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Microwave: An Important and Efficient Tool for the Synthesis of Biological Potent Organic Compounds


Kamlesh Kumari, Vijay K. Vishvakarma, Prashant Singh*, Rajan Patel and Ramesh Chandra


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Metabolic Imbalance of Homocysteine and Hydrogen Sulfide in Kidney Disease


Karmin O* and Yaw L. Siow


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The Role of Dietary Approach in Irritable Bowel Syndrome


Piero Portincasa*, Antony Lembo, Ornella De Bari, Domenica M. Di Palo, Anna Maggio, Ilaria Cataldo and Giuseppe Calamita


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Overview of Cantharidin and its Analogues


Guofang Wang , Jian Dong and Liping Deng *


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Chemopreventive Properties of Tolfenamic Acid: A Mechanistic Review


David Feldman, Elizabeth Leahy and Seong-Ho Lee *


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Sulfur Containing Acridine Derivatives in Preclinical Studies with Cancer Cell Lines


Salem Othman and Kožurková Mária *


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Hepatic AMP Kinase as a Potential Target for Treating Nonalcoholic Fatty Liver Disease: Evidence from Studies of Natural Products


Gang Xu , Kaixun Huang and Jun Zhou *


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Synthesis of Medicinally Privileged Heterocycles through Dielectric Heating


Debasish Bandyopadhyay* and Bimal K. Banik


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Design and Discovery of New Antibacterial Agents: Advances, Perspectives, Challenges


Josef Jampilek*


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Dihydroresveratrol Type Dihydrostilbenoids: Chemical Diversity, Chemosystematics, and Bioactivity


Sara Vitalini, Serhat Sezai Cicek, Sebastian Granica and Christian Zidorn*


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Anti-inflammatory Natural Prenylated Phenolic Compounds - Potential Lead Substances


Viliam Brezáni, Karel Šmejkal*, Jan Hošek and Veronika Tomášová


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Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus


Silvia Tejada, Samuel Pinya , Miquel Martorell, Xavier Capó, Josep A. Tur, Antoni Pons and Antoni Sureda*


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Fungal Production and Manipulation of Plant Hormones


Sandra Fonseca, Dhanya Radhakrishnan, Kalika Prasad and Andrea Chini*


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Innovative Opioid Peptides and Biased Agonism: Novel Avenues for More Effective and Safer Analgesics to Treat Chronic Pain


Andrea Bedini* and Santi Mario Spampinato


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Piperine as a Potential Anti-cancer Agent: A Review on Preclinical Studies


Azadeh Manayi, Seyed Mohammad Nabavi, William N. Setzer and Samineh Jafari*


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Expediting the Design, Discovery, and Development of Anticancer Drugs using Computational Approaches


Sun Choi, Stephani Joy Y. Macalino, Minghua Cui and Shaherin Basith


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Effects of Diets on Adipose Tissue


Silvia Ezquerro, Amaia Rodríguez, Piero Portincasa and Gema Frühbeck*


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Immunoprevention of Pancreatic Cancer


Chinthalapally Rao, Altaf Mohammed, Adam Asch and Naveena Janakiram


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Lignocellulosic Biomass Derived Functional Materials: Synthesis and Applications in Biomedical Engineering


Lei Zhang, Linxin Zhong, Weitian Chua, Zhihua Xiang and Runcang Sun*


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Autophagy as a Molecular Target of Flavonoids Underlying their Protective Effects in Human Disease


Néstor Prieto-Domínguez, María V García-Mediavilla , Sonia Sánchez-Campos, José Luis Mauriz and Javier González-Gallego*


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Therapeutic Drug Monitoring in Pediatric IBD: Current Application and Future Perspectives


Sara Lega, Matteo Bramuzzo and Marla Dubinsky*


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Stimuli-responsive Carriers for Controlled Intracellular Drug Release


Yan Sheng*, Jiaming Hu, Junfeng Shi and Ly James Lee


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Induced Pluripotent Stem Cells as a Model for Therapy Personalization of Pediatric Patients: Disease Modeling and Drug Adverse Effects Prevention


Elena Genova, Marco Pelin, Katsunori Sasaki*, Yue Fengming, Gaetana Lanzi, Stefania Masneri, Alessandro Ventura, Gabriele Stocco and Giuliana Decorti


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Rational Drug Design of Antineoplastic Agents Using 3D-QSAR, Cheminformatic, and Virtual Screening Approaches


Jelica Vucicevic, Katarina Nikolic* and John B O Mitchell


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Applications of Cellulose-based Materials in Sustained Drug Delivery Systems


Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi* and Yonghao Ni


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Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents


Angelica M Merlot*, Danuta S Kalinowski, Zaklina Kovacevic, Patric J Jansson, Sumit Sahni, Michael L Huang, Darius L Lane, Hiu Lok and Des R Richardson


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Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids


Paramjit Tappia*, Adriana Adameova and Naranjan Dhalla


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The Panomics Approach in Neurodegenerative Disorders


Balazs Szatmari, Peter Balicza, Gyorgy Nemeth and Judit Mária Molnár*


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Impact of Diabetes on Cardiac and Vascular Disease: Role of Calcium Signaling


Tarik Smani*, Isabel Gallardo-Castillo, Javier Ávila-Médina, Manuel F. Jimenez-Navarro, Antonio Ordoñez and Abdelkrim Hmadcha


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Nanosafety: Towards Safer Nanoparticles by Design


Neus G. Bastús and Víctor Puntes*


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The Role of Redox Dysregulation in the Inflammatory Response to Acute Myocardial Ischaemia-reperfusion Injury - Adding Fuel to the Fire


Sauri Hernández-Reséndiz, Kroekkiat Chinda, Sang-Bing Ong, Hector Cabrera-Fuentes, Cecilia Zazueta and Derek Hausenloy*


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Reappraisal of Antimalarials in Interferonopathies: New Perspectives for Old Drugs


Elisa Piscianz, Eva Cuzzoni, Rajan Sharma, Alessandra Tesser, Pooja Sapra and Alberto Tommasini*


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Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy


Weiqiang Zhou, Shanchun Guo, Mingli Liu, Matthew E. Burow and Guangdi Wang*


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Sarcopenia, Aging and Prospective Interventional Strategies


Tyler B. Waltz, Elayne M. Fivenson , Marya Morevati , Chuanhao Li , Kevin G. Becker , Vilhelm A. Bohr and Evandro Fei Fang*


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Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants


Jack Ho Wong, Stephen Cho Wing Sze, Tzi Bun Ng*, Randy Chi Fai Cheung, Chit Tam, Kalin Yanbo Zhang, Xiuli Dan, Yau Sang Chan, William Chi Shing Cho, Charlene Cheuk Wing Ng, Mary Miu Yee Waye, Weicheng Liang, Jinfang Zhang, Jie Yang, Xiuyun Ye, Juan Lin, Xiujuan Ye, Hexiang Wang, Fang Liu, David Wai Chan, Hextan Yuen Sheung Ngan, Ou Sha , Guohui Li, Ryan Tse , Tak Fu Tse and Helen Chan


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Nanoparticles for SPECT and PET Imaging: Towards Personalized Medicine and Theranostics


Andras Polyak* and Tobias L. Ross*


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Biomarkers Associated with Atrial Fibrosis and Remodeling


Polychronis Dilaveris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Eleftherios Tsiamis, Konstantinos Gatzoulis and Dimitris Tousoulis*


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Revalorizing Lignocellulose for the Production of Natural Pharmaceuticals and Other High Value Bioproducts


Congqiang Zhang and Heng-Phon Too*


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Redox State in Atrial Fibrillation Pathogenesis and Relevant Therapeutic Approaches


Alexios S. Antonopoulos*, Athina Goliopoulou, Evangelos Oikonomou, Sotiris Tsalamandris, Georgios-Angelos Papamikroulis, George Lazaros, Eleftherios Tsiamis, George Latsios, Stella Brili, Spyridon Papaioannou, Vasiliki Gennimata and Dimitris Tousoulis


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Application of Monoterpenoids and their Derivatives for Treatment of Neurodegenerative Disorders


Konstantin P. Volcho, Sergey S. Laev, Ghulam Md Ashraf, Gjumrakch Aliev and Nariman F. Salakhutdinov


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Recent Advances in Obesity: The Role of Turmeric Tuber and Its Metabolites in the Prophylaxis and Therapeutical Strategies


Agata Jarząb and Wirginia Kukula-Koch*


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