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New Emirates Medical Journal

Volume 3, 2 Issues, 2022
ISSN: 0250-6882 (Online)
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Open Access Article

EBV Reactivation in A Case of DRESS Syndrome Associated with Lamotrigine: A Case Report



Mahmoud Ahmed Kiblawi1, *, Mohamad El Saleh1, Ashraf El Ghul1
1 Department of Internal Medicine, Sheikh Shakhbout Medical City, Abu Dhabi, UAE

Abstract

Background:

Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is a rare, T-cell mediated hypersensitivity reaction that develops secondary to a drug reaction. Several drugs have been associated with DRESS syndrome, most commonly carbamazepine. The mechanism is not clearly understood. It is a life-threatening condition that can present with skin rash, hematologic abnormalities, lymphadenopathy, and organ failure.

Case Presentation:

The authors report a case of 43-year-old gentleman who developed DRESS syndrome secondary to lamotrigine and was found to have EBV reactivation. Patient was managed with supportive care; topical steroids and the culprit drug were discontinued. He had full recovery almost 2 weeks following treatment. DRESS syndrome can occur 2 weeks following exposure to an offending drug in susceptible individuals.

Conclusion:

Lamotrigine and EBV reactivation are not frequently reported in patients with DRESS syndrome. Therefore, physicians should be vigilant about this rare drug related hypersensitivity reaction in order to prevent life threatening complications.

Keywords: DRESS Syndrome, Lamotrigine, EBV reactivation, Drug reaction, Hypersensitivity reaction, Rash.


Article Information


Identifiers and Pagination:

Year: 2022
Volume: 3
Issue: 2
E-location ID: e301221199645
Publisher Id: e301221199645
DOI: 10.2174/03666211230091347

Article History:

Received Date: 13/9/2021
Revision Received Date: 14/11/2021
Acceptance Date: 17/12/2021
Electronic publication date: 04/04/2022
Collection year: 2022

© 2022 Kiblawi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Department of Internal Medicine, Sheikh Shakhbout Medical City, Abu Dhabi, UAE; E-mail: ma7moud@live.ca





Editor-in-Chief

Abdullah Shehab
Emirates Cardiac Society
Emirates Medical Association
Dubai
(United Arab Emirates)
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Acceptance rate = 40%

Average review speed: 45 days average

18 days from acceptance to publication