New Emirates Medical Journal

Volume 3, 2 Issues, 2022
ISSN: 0250-6882 (Online)
This journal supports open access

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Open Access Article

Pituitary Stalk Interruption Syndrome in a Newborn with Encephalopathy: A Case Report

Mary J. Jose^{1, *}, Lara M. Leijser^{1, 3}, Anvita Pauranik², Harish Amin¹

¹ Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada

² Department of Diagnostic Imaging, Cumming School of Medicine, University of Calgary, Calgary, Canada

³ Alberta Children’s Hospital Research Institute, Calgary, Canada

Abstract

Background:

Pituitary Stalk Interruption Syndrome is a rare midline brain anomaly involving the pituitary gland that leads to a variable degree of pituitary hypofunction with a classic neuroimaging finding of the ectopic posterior pituitary, thin or absent pituitary stalk, and anterior pituitary hypoplasia.

Case Presentation:

We present the case of a term newborn who developed encephalopathy and respiratory distress during the neonatal period and was later diagnosed with Pituitary Stalk Interruption Syndrome.

Conclusion:

Genetic defects have been identified in 5% of cases, and at times there are associated extra pituitary malformations. In spite of being a well-described syndrome, a detailed description of its neonatal presentation and course is lacking in the literature.

Keywords: Neonatal encephalopathy, Pituitary stalk interruption syndrome, Ectopic posterior pituitary gland, Combined pituitary hormone deficiency, Central hypothyroidism, Growth hormone deficiency.

Article Information

Identifiers and Pagination:

Year: 2022
Volume: 3
Issue: 2
E-location ID: e030322201667
Publisher Id: e030322201667
DOI: 10.2174/03666220303155523

Article History:

Received Date: 30/5/2021
Revision Received Date: 8/9/2021
Acceptance Date: 20/12/2021
Electronic publication date: 15/03/2022
Collection year: 2022

© 2022 Jose et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the Department of Pediatrics, Section of Neonatology, Cumming School of Medicine, University of Calgary, HMRB room 274; 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada;
Tel: (403) 944-4638; E-mail: mailtomarysuma@yahoo.com

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Editor-in-Chief

Abdullah Shehab
Emirates Cardiac Society
Emirates Medical Association
Dubai
(United Arab Emirates)
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