Drug repurposing is a cost-effective method of discovering new treatments for diseases than traditional drug development methods. It involves virtual screening of chemical candidates with the aid of computational methods like molecular docking. Drug Repurposing against SARS-CoV2 focuses on current trends in drug repurposing against the novel coronavirus strains. The book aims to give readers an overview of drug repurposing against COVID-19 and various techniques involved in the process. The book consolidates available information on the pathophysiology, drug targets, and drug repurposing against COVID-19 into a single, convenient resource. Key features -An up-to-date compilation of the evidence that supports the drug repurposing for COVID-19. -How to use repurposing of available drugs for disease therapy. -Provides an improved understanding of pathophysiology and SARS-CoV2 viral entry pathways. - Provides references for further reading

The immune system is highly complex, it senses foreign invaders, thus protecting the body. The adaptive arm of the immune system confers long-term protection, whereas the innate immune system confers immediate protection. The immune system uses pattern recognition receptors that are able to sense the molecular patterns associated with pathogens. Toll-like receptors (TLRs) are important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity. This book covers the role of TLRs in several vector-borne Diseases. Starting with an introduction to these diseases, the book explains the different types of receptors involved in these diseases. The diseases are then covered in separate chapters, including: malaria, lymphatic filariasis, visceral leishmaniasis, dengue fever, chikungunya, West Nile fever, and Japanese encephalitis. The book is a handy reference for researchers and trainees involved in clinical medicine and infection control. It can also serve as supplementary reading material for Students undertaking courses in biotechnology, public health, entomology, immunology, epidemiology, and life sciences.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The eleventh volume of this series features reviews that cover the following topics related to the treatment of a variety of CNS disorders, related diseases, and basic research: - The Multi-target Directed Ligands candidate (MTDLs) prototypes for neurodegenerative diseases - Drugs for relapse prevention in addiction - Neuroprotective activities of cinnamic acids and their derivatives in neurodegenerative disorders - Phytosome for targeted delivery of natural compounds in treating alzheimer's disease - Physical activity as a non-pharmacologic method for treatment of alzheimer's disease

Illustrated Pediatric Dentistry is intended to be a guide to undergraduate and postgraduate students in their understanding of pediatric dentistry. This textbook is modernized with the latest information and techniques in pediatric dentistry. The chapters cover primary pediatric dentistry, its clinical aspects, preventive dentistry, and information about the latest trends in the specialty. The text will equip readers with the knowledge suited to the changing environment of this vital domain. This textbook's editor has over forty-four years of teaching experience in pediatric dentistry and gives their broad perspective through the book content. This book is also the amalgamation of the thoughts of numerous subject experts of international repute. Part 3 covers several topics relevant to practical dentistry such as, pediatric crowns, prosthetic management, pental pulp, pediatric endodontics, (including regenerative medicine and instruments), traumatic dental injuries, sports dentistry, Systemic Fluorides, (like SDF) and pit and fissure sealants. Special topics like fental caries vaccine and post-COVID dental practice round up this book. Key Features: - The 18, structured chapters keep the latest trends of the subject in mind - The book content is illustrated with quality clinical images, - Chapters cover contemporary concepts of problems experienced when treating multiple dental disorders - The contributions exhibit distinct clinical expertise and the capability of imparting inimitable knowledge to budding professionals - The book includes modern and current state-of-the-art techniques used in the clinic Topic outlines help to quickly review and easily locate content. Also, the Contents of the book are well structured and presented in a very lucid manner, making it easy to understand for students.

Cancer Genes is a comprehensive list of the most critical genes known to contribute to cancer imitation and progression. The book delves into their location on each chromosome, providing valuable insights into the mechanisms of cancer gene dysregulation and genetic mutations which provide cancer cells with an advantage during each stage of tumorigenesis. The reference will familiarize readers with the location of cancer genes and equip them with the necessary information to identify relevant gene expression targets for research aimed at preventing the disease. The book is divided into two volumes focusing on cancer-causing genes found in chromosome pairs 1-12 (volume 1), and chromosomes 13-23 (volume 2). A key features of the book is a detailed reference list for advanced readers. The compilation is therefore a quick and handy reference on cancer causing genes for researchers, medical professionals, and anyone interested in understanding the genetic basis of cancer.

Handbook for Dental Chair Side Assistants is a timely and comprehensive resource designed to educate the dental chair side assistant and dental nurses about dentistry. This unique practical handbook covers the basic sciences emergencies and clinical aspects of all dental specialties. The theoretical knowledge and background about dental anatomy, dental microbiology, oral pathology, dental materials, dental radiology, dental procedures, common drugs, problems and dental instruments in dental practice is explained in simple and clear terms. The contents have been designed to give an optimum balance between clinical skills and theoretical foundation of the subject. The book is divided into 2 parts. Part 1 covers basic sciences and includes a guide to working in dental clinics. Part 2 includes a guide to medical emergencies, and information for different dental specialty settings. Key Features - Lucid yet simple explanations for learners - Covers basic and practical tips for dental assistants and nurses - Provides information for all dental specialties - Includes notes on advanced technology in dentistry - Illustrative and easy to retain information with colorful clinical pictures flowcharts and tabular data - A comprehensive summary for every chapter The book is useful reading material for undergraduate dental students and trainees.

Blood Oxidant Ties: The Evolving Concepts in Myocardial Injury and Cardiovascular Disease is an update on the recent advances in the development of antioxidant-based therapies. It starts with an overview of the mechanisms underlying the genesis of oxidative stress, summarizing the link between oxidative stress and a number of cardiovascular conditions. This is followed by an explanation of how oxidative stress interacts with lipid metabolism and the placental environment. Three chapters on the role of antioxidant-based therapy for cardiovascular diseases round up the book. Key Features - Outlines several cell-signaling pathways that are modulated by the interplay between reducing and oxidizing agents (redox status) and gene expression in the cardiovascular disease process - Brings information about maternal programming environment in the placenta - Covers development of novel nanotechnology-based antioxidant delivery systems for effective drug delivery - Includes references for further reading The book is aimed at a broad readership of scientific and medical professionals involved in research on cardiovascular diseases, pathophysiology, pharmacy, pharmaceutical science and life sciences. It also serves as a reference for scholars who want to understand the complex biochemical mechanisms of antioxidant agents.

This concise yet comprehensive book provides conceptual knowledge about forensic odontology in medical, dental, allied and litigation purposes. Written by authors that are highly knowledgeable, experienced and well-established in the field, this handbook lucidly explains basic and advanced components of dental forensics, beginning with anatomical attributes of the tooth, age assessment, dental anomalies and moving ahead to DNA fingerprinting from dental pulp, disaster victim identification from dentures, bite marks and oral autobiography which is a pragmatic approach in identification. Key features: - Gives an insight into basic and advanced aspects necessary to become an expert practitioner in forensic dentistry with a focus on how to provide apt evidence and explanations - Brings out remedial measures for challenges in disaster victim identification which can prove to be very helpful in crisis management - Provides references for further reading This book is intended as a handbook for readers who require a basic exposure to forensic dentistry. It will benefit learners and working professionals in forensic medicine, clinical settings, legal review, litigation, disaster management and allied roles involved in the criminal justice system.

Cancer Genes is a comprehensive list of the most critical genes known to contribute to cancer imitation and progression. The book delves into their location on each chromosome, providing valuable insights into the mechanisms of cancer gene dysregulation and genetic mutations which provide cancer cells with an advantage during each stage of tumorigenesis. The reference will familiarize readers with the location of cancer genes and equip them with the necessary information to identify relevant gene expression targets for research aimed at preventing the disease. The book is divided into two volumes focusing on cancer-causing genes found in chromosome pairs 1-12 (volume 1), and chromosomes 13-23 (volume 2). A key features of the book is a detailed reference list for advanced readers. The compilation is therefore a quick and handy reference on cancer causing genes for researchers, medical professionals, and anyone interested in understanding the genetic basis of cancer.