Toll-Like Receptors in Vector-borne Diseases

Japanese Encephalitis and Toll-like Receptors

Author(s): Jayalakshmi Krishnan *

Pp: 65-72 (8)

DOI: 10.2174/9789815124545123010011

* (Excluding Mailing and Handling)


Viral encephalitis is a major pathological situation. It can be caused either by DNA or RNA viruses. Japanese encephalitis belongs to the member of flavivirus and it is a mosquito-borne disease, causing viral disease. Japanese encephalitis can be prevented by a vaccine. TLR3 and TLR4 signal pathways are activated due to JE Japanese encephalitis infection. TLR3 and Retinoic acid-inducible I also participate in mediating inflammation owing to Japanese encephalitis infection. In this kind of virus infection first, the cells are infected, causing primary viremia, subsequently infecting the CNS tissues as well. More than 60% of the world's population is living in JE endemic places. 

Keywords: CNS inflammation, Flavirius infections, Murine microglia cells, TLR7 mRNA levels.

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