Toll-Like Receptors in Vector-borne Diseases

Chikungunya Virus and Toll like Receptors

Author(s): Jayalakshmi Krishnan *

Pp: 45-51 (7)

DOI: 10.2174/9789815124545123010009

* (Excluding Mailing and Handling)


Infected mosquitoes of Aedes species spread Chikungunya fever upon the biting of the mosquitoes. Chikungunya fever first came to the limelight upon an outbreak in southern Tanzania in 1952. These days almost all countries in the world are reporting Chikungunya fever. There is no vaccine for the Chikungunya virus. The infection causes severe joint pain, nausea, vomiting, conductivities, headache, and muscle pain, followed by fever. Clinical manifestations occur after 2-7 days of the mosquito bite. This chapter addresses key issues on Chikungunya viral infection in brain cells with reference to the triggering of events associated with toll-like receptors.

Keywords: Chikungunya fever (CHIKF), Chikungunya virus(CHIKV), IFN-α levels, TLR polymorphism in Dengue and CHIKV.

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