Experimental and Clinical Studies on the Effects of Nigella Sativa and its Constituents on Allergic and Immunological Disorders

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Various pharmacological effects were shown for Nigella sativa (N. sativa),

including anti-inflammatory, antioxidant, and immunomodulatory properties. The plant

also has been used in traditional medicine for the treatment of various diseases. In this

chapter, the effects of N. sativa and its constituents in allergic and immunologic

disorders based on the experimental and clinical studies are provided. Articles

published on the effect of N. sativa and its constituents on allergic and immunologic

disorders in the experimental and clinical studies were searched until July 2020. For

this purpose, keywords including; Nigella sativa, black seed, thymoquinone, alphahederin,

carvacrol, allergic disorders, and immunology disorders were searched in

different databases such as PubMed, Science Direct, Scopus, and Google Scholar.

Experimental studies showed various immunologic effects of N. sativa extracts and

their constituents, including their effects on Th1/Th2/ balance. Treating patients with

N. sativa seed, alleviate symptoms of allergic rhinitis and decrease the body

temperature in allergic patients which is due to immunomodulatory properties of the

plant. Treatment of Vitiligo patients with N. sativa also reduced the Vitiligo Area

Scoring Index (VASI). Various studies showed that N. sativa and its constituents

showed significant effects on allergic and immunologic disorders. Therefore, N. sativa

and its constituents could be good candidate drugs for treating allergic and

immunologic disorders.

Keywords: Alpha-hederin, Allergic disorders, Carvacrol, Clinical studies, Experimental studies, Nigella sativa, Immunologic disorders, Thymoquinone.

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Frontiers in Anti-infective Agents

DOI https://doi.org/10.2174/9789815040616122050006	Print ISSN 2452-3194
Publisher Name Bentham Science Publisher	Online ISSN 2214-6938

Frontiers in Clinical Drug Research – Anti Allergy Agents