Nanoparticles used in the detection of biomolecules are being possibly used due to their physical and chemical properties that optimize them with unique characteristics. These properties enable the diagnosis of several disease conditions to make them available for treatment. This study is intended to discuss the emergence of this area and help the researchers in further progress in this field.This study discusses the disadvantages of the use of currently available methods for diagnostic purposes. It also examines the advantages of the use of nanoparticles in this field of study. This study reviews the properties of metallic nanoparticles including gold and silver, and also quantum dot, silica nanoparticles, etc. Nanotechnology has extended the limitation of the current diagnostic procedures. The potential of using nanoparticles in the diagnosis of diseases is unlimited. Safety study is needed for in vivo uses. Nanobiotechnology in clinical uses will play a valuable role in the future development of nanomedicines also.
Keywords: Colorimetric detection, Electrochemical-based detection, ELISA, Emission-based detection, FLISA, Fluorescence based detection, FRET, Gold nanoparticle, Magnetic-based detection, MEF, Microarray detection, MRI, NMR, Plasmonics-based detection, Quantum dot, Quenching, SEIRF, SERS, Silica nanoparticle, Silver nanoparticle.